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Fusion gene ID: 40594 |
FusionGeneSummary for UBR3_MEOX2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBR3_MEOX2 | Fusion gene ID: 40594 | Hgene | Tgene | Gene symbol | UBR3 | MEOX2 | Gene ID | 130507 | 4223 |
| Gene name | ubiquitin protein ligase E3 component n-recognin 3 (putative) | mesenchyme homeobox 2 | |
| Synonyms | ZNF650 | GAX|MOX2 | |
| Cytomap | 2q31.1 | 7p21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase UBR3N-recognin-3RING-type E3 ubiquitin transferase UBR3ubiquitin-protein ligase E3-alpha-3ubiquitin-protein ligase E3-alpha-IIIzinc finger protein 650 | homeobox protein MOX-2growth arrest-specific homeobox | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6ZT12 | P50222 | |
| Ensembl transtripts involved in fusion gene | ENST00000272793, ENST00000418381, ENST00000392631, ENST00000465630, | ENST00000262041, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 3=27 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: UBR3 [Title/Abstract] AND MEOX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MEOX2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17074759 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM693239 | UBR3 | chr2 | 170917928 | + | MEOX2 | chr7 | 15718919 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000272793 | ENST00000262041 | UBR3 | chr2 | 170917928 | + | MEOX2 | chr7 | 15718919 | + |
| 5CDS-intron | ENST00000418381 | ENST00000262041 | UBR3 | chr2 | 170917928 | + | MEOX2 | chr7 | 15718919 | + |
| 5CDS-intron | ENST00000392631 | ENST00000262041 | UBR3 | chr2 | 170917928 | + | MEOX2 | chr7 | 15718919 | + |
| intron-intron | ENST00000465630 | ENST00000262041 | UBR3 | chr2 | 170917928 | + | MEOX2 | chr7 | 15718919 | + |
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FusionProtFeatures for UBR3_MEOX2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBR3 | MEOX2 |
| E3 ubiquitin-protein ligase which is a component of theN-end rule pathway (By similarity). Does not bind to proteinsbearing specific N-terminal residues that are destabilizingaccording to the N-end rule, leading to their ubiquitination andsubsequent degradation (By similarity). May play a role in Shhsignaling by mediating the ubiquitination of Kif7 (By similarity).May be important for MYH9 function in certain tissues, possibly byregulating the ubiquitination of MYH9 and consequently affectingits interaction with MYO7A (PubMed:27331610).{ECO:0000250|UniProtKB:Q5U430, ECO:0000269|PubMed:27331610}. | Mesodermal transcription factor that plays a key role insomitogenesis and is required for sclerotome development (Bysimilarity). Activates expression of CDKN1A and CDKN2A inendothelial cells, acting as a regulator of vascular cellproliferation. While it activates CDKN1A in a DNA-dependentmanner, it activates CDKN2A in a DNA-independent manner(PubMed:22206000). May have a regulatory role when quiescentvascular smooth muscle cells reenter the cell cycle.{ECO:0000250|UniProtKB:P32443, ECO:0000269|PubMed:22206000}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBR3_MEOX2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UBR3_MEOX2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBR3_MEOX2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBR3_MEOX2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MEOX2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | MEOX2 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
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