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Fusion gene ID: 40580 |
FusionGeneSummary for UBQLN4_MEF2D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBQLN4_MEF2D | Fusion gene ID: 40580 | Hgene | Tgene | Gene symbol | UBQLN4 | MEF2D | Gene ID | 56893 | 4209 |
| Gene name | ubiquilin 4 | myocyte enhancer factor 2D | |
| Synonyms | A1U|A1Up|C1orf6|CIP75|UBIN | - | |
| Cytomap | 1q22 | 1q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquilin-4ataxin-1 interacting ubiquitin-like proteinataxin-1 ubiquitin-like interacting proteinataxin-1 ubiquitin-like-interacting protein A1Uconnexin43-interacting protein of 75 kDa | myocyte-specific enhancer factor 2DMADS box transcription enhancer factor 2, polypeptide D | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NRR5 | Q14814 | |
| Ensembl transtripts involved in fusion gene | ENST00000368309, ENST00000472638, | ENST00000464356, ENST00000348159, ENST00000353795, ENST00000340875, ENST00000368240, ENST00000360595, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 6 X 6=288 |
| # samples | 1 | 8 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBQLN4 [Title/Abstract] AND MEF2D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MEF2D | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20590529 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-85-8479-01A | UBQLN4 | chr1 | 156023385 | - | MEF2D | chr1 | 156453222 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000368309 | ENST00000464356 | UBQLN4 | chr1 | 156023385 | - | MEF2D | chr1 | 156453222 | - |
| 5CDS-5UTR | ENST00000368309 | ENST00000348159 | UBQLN4 | chr1 | 156023385 | - | MEF2D | chr1 | 156453222 | - |
| 5CDS-5UTR | ENST00000368309 | ENST00000353795 | UBQLN4 | chr1 | 156023385 | - | MEF2D | chr1 | 156453222 | - |
| 5CDS-5UTR | ENST00000368309 | ENST00000340875 | UBQLN4 | chr1 | 156023385 | - | MEF2D | chr1 | 156453222 | - |
| 5CDS-5UTR | ENST00000368309 | ENST00000368240 | UBQLN4 | chr1 | 156023385 | - | MEF2D | chr1 | 156453222 | - |
| 5CDS-intron | ENST00000368309 | ENST00000360595 | UBQLN4 | chr1 | 156023385 | - | MEF2D | chr1 | 156453222 | - |
| 5UTR-3CDS | ENST00000472638 | ENST00000464356 | UBQLN4 | chr1 | 156023385 | - | MEF2D | chr1 | 156453222 | - |
| 5UTR-5UTR | ENST00000472638 | ENST00000348159 | UBQLN4 | chr1 | 156023385 | - | MEF2D | chr1 | 156453222 | - |
| 5UTR-5UTR | ENST00000472638 | ENST00000353795 | UBQLN4 | chr1 | 156023385 | - | MEF2D | chr1 | 156453222 | - |
| 5UTR-5UTR | ENST00000472638 | ENST00000340875 | UBQLN4 | chr1 | 156023385 | - | MEF2D | chr1 | 156453222 | - |
| 5UTR-5UTR | ENST00000472638 | ENST00000368240 | UBQLN4 | chr1 | 156023385 | - | MEF2D | chr1 | 156453222 | - |
| 5UTR-intron | ENST00000472638 | ENST00000360595 | UBQLN4 | chr1 | 156023385 | - | MEF2D | chr1 | 156453222 | - |
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FusionProtFeatures for UBQLN4_MEF2D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBQLN4 | MEF2D |
| Plays a role in the regulation of protein degradationvia the ubiquitin-proteasome system (UPS). Mediates theproteasomal targeting of misfolded or accumulated proteins fordegradation by binding (via UBA domain) to their polyubiquitinchains and by interacting (via ubiquitin-like domain) with thesubunits of the proteasome (Ref. 6). Plays a role in theregulation of the proteasomal degradation of non-ubiquitinatedGJA1 (By similarity). Acts as an adapter protein that recruitsUBQLN1 to the autophagy machinery. Mediates the association ofUBQLN1 with autophagosomes and the autophagy-related protein LC3(MAP1LC3A/B/C) and may assist in the maturation of autophagosomesto autolysosomes by mediating autophagosome-lysosome fusion(PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8,ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205}. | Transcriptional activator which binds specifically tothe MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediatescellular functions not only in skeletal and cardiac muscledevelopment, but also in neuronal differentiation and survival.Plays diverse roles in the control of cell growth, survival andapoptosis via p38 MAPK signaling in muscle-specific and/or growthfactor-related transcription. Plays a critical role in theregulation of neuronal apoptosis (By similarity). {ECO:0000250,ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443,ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823,ECO:0000269|PubMed:15834131}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000340875 | - | 0 | 12 | 252_255 | -46 | 521 | Compositional bias | Note=Poly-Pro |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000340875 | - | 0 | 12 | 365_404 | -46 | 521 | Compositional bias | Note=Gln/Pro-rich |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000340875 | - | 0 | 12 | 3_31 | -46 | 521 | Compositional bias | Note=Arg/Lys-rich (basic) |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000340875 | - | 0 | 12 | 451_456 | -46 | 521 | Compositional bias | Note=Poly-Pro |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000348159 | - | 0 | 12 | 252_255 | -46 | 522 | Compositional bias | Note=Poly-Pro |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000348159 | - | 0 | 12 | 365_404 | -46 | 522 | Compositional bias | Note=Gln/Pro-rich |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000348159 | - | 0 | 12 | 3_31 | -46 | 522 | Compositional bias | Note=Arg/Lys-rich (basic) |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000348159 | - | 0 | 12 | 451_456 | -46 | 522 | Compositional bias | Note=Poly-Pro |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000353795 | - | 0 | 11 | 252_255 | -46 | 476 | Compositional bias | Note=Poly-Pro |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000353795 | - | 0 | 11 | 365_404 | -46 | 476 | Compositional bias | Note=Gln/Pro-rich |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000353795 | - | 0 | 11 | 3_31 | -46 | 476 | Compositional bias | Note=Arg/Lys-rich (basic) |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000353795 | - | 0 | 11 | 451_456 | -46 | 476 | Compositional bias | Note=Poly-Pro |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000360595 | - | 0 | 11 | 252_255 | -72 | 515 | Compositional bias | Note=Poly-Pro |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000360595 | - | 0 | 11 | 365_404 | -72 | 515 | Compositional bias | Note=Gln/Pro-rich |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000360595 | - | 0 | 11 | 3_31 | -72 | 515 | Compositional bias | Note=Arg/Lys-rich (basic) |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000360595 | - | 0 | 11 | 451_456 | -72 | 515 | Compositional bias | Note=Poly-Pro |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000368240 | - | 0 | 11 | 252_255 | -46 | 515 | Compositional bias | Note=Poly-Pro |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000368240 | - | 0 | 11 | 365_404 | -46 | 515 | Compositional bias | Note=Gln/Pro-rich |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000368240 | - | 0 | 11 | 3_31 | -46 | 515 | Compositional bias | Note=Arg/Lys-rich (basic) |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000368240 | - | 0 | 11 | 451_456 | -46 | 515 | Compositional bias | Note=Poly-Pro |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000340875 | - | 0 | 12 | 58_86 | -46 | 521 | DNA binding | Mef2-type |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000348159 | - | 0 | 12 | 58_86 | -46 | 522 | DNA binding | Mef2-type |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000353795 | - | 0 | 11 | 58_86 | -46 | 476 | DNA binding | Mef2-type |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000360595 | - | 0 | 11 | 58_86 | -72 | 515 | DNA binding | Mef2-type |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000368240 | - | 0 | 11 | 58_86 | -46 | 515 | DNA binding | Mef2-type |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000340875 | - | 0 | 12 | 3_57 | -46 | 521 | Domain | MADS-box |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000348159 | - | 0 | 12 | 3_57 | -46 | 522 | Domain | MADS-box |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000353795 | - | 0 | 11 | 3_57 | -46 | 476 | Domain | MADS-box |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000360595 | - | 0 | 11 | 3_57 | -72 | 515 | Domain | MADS-box |
| Tgene | >MEF2D | chr1:156023385 | chr1:156453222 | ENST00000368240 | - | 0 | 11 | 3_57 | -46 | 515 | Domain | MADS-box |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >UBQLN4 | chr1:156023385 | chr1:156453222 | ENST00000368309 | - | 1 | 11 | 13_87 | 36 | 602 | Domain | Ubiquitin-like |
| Hgene | >UBQLN4 | chr1:156023385 | chr1:156453222 | ENST00000368309 | - | 1 | 11 | 192_229 | 36 | 602 | Domain | STI1 1 |
| Hgene | >UBQLN4 | chr1:156023385 | chr1:156453222 | ENST00000368309 | - | 1 | 11 | 230_261 | 36 | 602 | Domain | STI1 2 |
| Hgene | >UBQLN4 | chr1:156023385 | chr1:156453222 | ENST00000368309 | - | 1 | 11 | 393_440 | 36 | 602 | Domain | STI1 3 |
| Hgene | >UBQLN4 | chr1:156023385 | chr1:156453222 | ENST00000368309 | - | 1 | 11 | 444_476 | 36 | 602 | Domain | STI1 4 |
| Hgene | >UBQLN4 | chr1:156023385 | chr1:156453222 | ENST00000368309 | - | 1 | 11 | 553_598 | 36 | 602 | Domain | UBA |
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FusionGeneSequence for UBQLN4_MEF2D |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_UBQLN4_ENST00000368309_chr1_156023385_-_MEF2D_ENST00000464356_chr1_156453222_-_36aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_UBQLN4_ENST00000368309_chr1_156023385_-_MEF2D_ENST00000464356_chr1_156453222_-_108nt ATGGCGGAGCCGAGCGGGGCCGAGACGAGGCCCCCCATTCGGGTCACCGTCAAGACCCCCAAGGACAAGGAGGAAATTGTGATCTGCGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_UBQLN4_ENST00000368309_chr1_156023385_-_MEF2D_ENST00000464356_chr1_156453222_-_5799nt GTTGGAGGCGCAGAAGCCGAGCCGGGCCGGCCGGGCGGGCGGGGAGGAGGAGGAGCCGGGCGGGCTGGCGGGCGGCCGGGTGGCGGCGGC GGCATGGCGGAGCCGAGCGGGGCCGAGACGAGGCCCCCCATTCGGGTCACCGTCAAGACCCCCAAGGACAAGGAGGAAATTGTGATCTGC GATCGAGCCTCGGTCAAGGAGGAGGCTGTGCAGAAGGTATCCTGCAGACCATGAACTGAGCACTGTTCCCAGACCGTTCATGAGCACAGT GTAAGGTGTGCCGAGACCCACCACCCAGCGAGCCCCTCCCCTCCGTAGCACTGAGGACCCCCGGAGAAGATGGGGAGGAAAAAGATTCAG ATCCAGCGAATCACCGACGAGCGGAACCGACAGGTGACTTTCACCAAGCGGAAGTTTGGCCTGATGAAGAAGGCGTATGAGCTGAGCGTG CTATGTGACTGCGAGATCGCACTCATCATCTTCAACCACTCCAACAAGCTGTTCCAGTACGCCAGCACCGACATGGACAAGGTGCTGCTC AAGTACACGGAGTACAATGAGCCACACGAGAGCCGCACCAACGCCGACATCATCGAGGCGCTGCACAAGAAGCACAGGGAATGTGAGAGC CCTGAGGTGGACGAGGTGTTTGCCCTGACCCCCCAGACGGAAGAGAAATATAAAAAGATAGACGAGGAGTTTGATAAAATGATGCAGAGT TATAGACTGGCCTCAACTGTCCCGGCCCCCAACTTTGCCATGCCTGTCACGGTGCCCGTGTCCAATCAGAGCTCACTGCAGTTCAGCAAT CCCAGCGGCTCCCTGGTCACCCCTTCCCTGGTGACATCATCCCTCACGGACCCGCGGCTCCTGTCCCCCCAGCAGCCAGCACTACAGAGG AACAGTGTGTCTCCTGGCCTGCCCCAGCGGCCAGCTAGTGCGGGGGCCATGCTGGGGGGTGACCTGAACAGTGCTAACGGAGCCTGCCCC AGCCCTGTTGGGAATGGCTACGTCAGTGCTCGGGCTTCCCCTGGCCTCCTCCCTGTGGCCAATGGCAACAGCCTAAACAAGGTCATCCCT GCCAAGTCTCCACCCCCACCTACCCACAGCACCCAGCTTGGAGCCCCCAGCCGCAAGCCCGACCTGCGAGTCATCACTTCCCAGGCAGGA AAGGGGTTAATGCATCACTTGAACAATGCCCAGCGCCTTGGGGTCTCCCAGTCTACTCATTCGCTCACCACCCCAGTGGTTTCTGTGGCA ACGCCGAGTTTACTCAGCCAGGGCCTCCCCTTCTCTTCCATGCCCACTGCCTACAACACAGATTACCAGTTGACCAGTGCAGAGCTCTCC TCCTTACCAGCCTTTAGTTCACCTGGGGGGCTGTCGCTAGGCAATGTCACTGCCTGGCAACAGCCACAGCAGCCCCAGCAGCCGCAGCAG CCACAGCCTCCACAGCAGCAGCCACCGCAGCCACAGCAGCCACAGCCACAGCAGCCTCAGCAGCCGCAACAGCCACCTCAGCAACAGTCC CACCTGGTCCCTGTATCTCTCAGCAACCTCATCCCGGGCAGCCCCCTGCCCCACGTGGGTGCTGCCCTCACAGTCACCACCCACCCCCAC ATCAGCATCAAGTCAGAACCGGTGTCCCCAAGCCGTGAGCGCAGCCCTGCGCCTCCCCCTCCAGCTGTGTTCCCAGCTGCCCGCCCTGAG CCTGGCGATGGTCTCAGCAGCCCAGCCGGGGGATCCTATGAGACGGGAGACCGGGATGACGGACGGGGGGACTTCGGGCCCACACTGGGC CTGCTGCGCCCAGCCCCAGAGCCTGAGGCTGAGGGCTCAGCTGTGAAGAGGATGCGGCTTGATACCTGGACATTAAAGTGACGATTCCCA CTCCCCTCCTCTCAGCCTCCCTGATGAAGAGTTGACAATCTCACCGCCCGCCCTTCCCTGCCCCGGGCTCCTCCCGCTCGACCCCCACTT CCTTTCTTGTGCTTCGTGTCCTGTTGACGGTTACATTTGTGTATAATTATTATATTATTATTATTATTATTATATTTTTTTTAATTTGGA TTCTCGCTTTGGAGAGGGGGATGCTCTCATCCCCTCTTTCTGTACCCCCCACCATTTTCACTGGCTGGGGGGCTCTCTTTTTCGCGGGAA GGGGGGACACTTTGCACGTTGTACACATATGCTGCAGGAAGGGGGTGGGGGGCCCAATAAGGCCTTTGGGAAAGGACAGGTGCCGAGCCC TGCATGTGGAGCCCTCCCACCCCACCCCCAGATAGAGGGAAATAACCAAAAAACTACCAAACAACAGAAACCCACACTCTAGACTGAAAC CCCAAAGTGGGCTTGATGGGTGGGTTTGTGTTTCAAGGGGAAAGTGAGGCAGAGGTTCTGAAAAGGGTCTCTGTTTTTGTGTTCATGTAG CCATAGGCACATGGAGCAGAATACTTAAGCCTGGCCCCCAAATGCCCCTGCACACACACGTGCCACACCTGCGCTGATTCTTGTGTGTGC TGCACCCCCAAGGTGTGTGGGTGCTGGCTGAGCTTTGGGCCGGGAAGGCAGCCTGGGAATCTGAGGCTGGAGACAGGGGTTTGAGGTGGG GGCCTCTCTGGAAGCACATTTGGAGGGAAAGACAAGAGAGCCATGAGGAGAGGGCTGAGGAGGGCAGAAGGGCTAGGCAGGGGGCAAATT GAGCCCCTCCCTTCCCCAGTTTTTCTCTAAGATATACAGTGCAATAGCTCCCCACCCCTCAGTTGACGCCAGCCCTGTAAAGCTGGCCAC AGTGTGCAGGGAGAATGGGGAGAGGGTCTTCAGTGAGGTGGCTGGGGCGAGAGTCGGCCTGGACTTCCCTGGGGTGCTCCAGGCCAGAGC TCTTTCATTGGGGCGAGTGTGGTGAGGGGACGTCCTTGGTCTTGCACGCACACTACCTGGGGGAGTCAACACTGGGATGGTCTGTGGGGT GGGAGGGCCTACGGATGGGTCCGTAGAGGTCCCACCTCCCTCATTCCTCCTTGGCCCCTCTCCCTAGCTTCTCCTGTTAGCTCCTTCTGC TCCTGACCCCACCTCCTTGCTCTTGGCGCCCCTATTGTCTCTGGCTACCTCCTTGTCCCACCACCTCCAGGCTGCATCCCACCTTCCCTC TTGGCTACTGTAATTGTAAATAGCGACCTTTGGAAAACGTTAGCGGTGTAACAGTCCAGGAAACTGTTTTTTTTTGTTGTTGTTGTATTG ATATGAAATGAGATTCTATTTTTGTCAAAGTATATTGTAATAATAATGACTCAAACGGCCCGTACTGTACAGACGAGATTCTTCTGCTGT TGTTCTTGCTCCCCTCCCCTCCTCTGAGTCCGCCCCTCCCTGCTGCCTCCTCAGTGGGGCAGTGGGCAAGGGGCCCAGGGGCAGCCGAAG CACGGGGTCCTGAGACCTCAGGCAGGATTGGAGATCAAACCAGAGGGGGCAGGCCCCCAGCCTGCTCTCTAGGATCACCCCCCGCCCTAA GGGGCCTGGCCTGGGGTGACGTGGCCAGGCAGACTGTCTGCCCCACTCCTTCACACAAGCCCAGCTCCTCTGCCCAAGGGGTGCGGCGCC CCCTTGGGGTTTCCTCCCAGTTGGAGAGTAGAGTTAAGACAAGGCCCAGTTTTGTGTTAGCCGACCGTCTTTGCCCACCTCTATGACCCA GCCTCTTGCAGTATTCCCATACTTGATGCAGGGAAGGAACCAGAAGCAGAGGGGCCTCTACGCAGGTACACACGTGTACCTGAGTGTGTT CATGAGGGCATCTGGTGTTTATGTGTCTGAGTGTAGCTTTGTATTTATGTGTGTGTGTGTGTGTATGTCTGATTGCACGGGTGTACTTTT GTATTTATGTGTGTGTGTGGTTGCACGGGTGTGCCTCTGTGTGTCTCTGACCCTGGCTGGGTGTGTGTGCAAATCTGTGTGACTGGAGCT CTAGGGGCATCTCTGTGTCTGAGTGTGCCTGGTGTGTGTTTACAAAGGGAGAGTTGGCTGCTCCAGCTCCACAGCCCTGGGACCCCAACT CCTGTCTTCCCTGCTCCTTTCCCTGTGTTCACCCTCAGCTCTGACACATTGAACTGCAGTTGGGGGGATTGGCAGTTAGCCCTCTGTGCT TCTCCCTGCAGCCCTACCTCTGCCAAGGTCTCTCCCTCCAGGGACCTCTGCTTCCACCCACATATGTCCACTTAGTCACCCACACTTGAC ACAGTTCCTGGAGTACCCTCTTCCCCCAACCCCAGACCTGCTTTCAGAGCAAAACTCAAGTCCCTCTTCCTCCGTGAAGCTTCTCCCTCA GCTGAGCAGTGATCACTTACTCACTCTTAACCCCAATCCGCTGACTGGGTGGGGACAGCACGTCCAGCCTTCCCACCTCTCCTGCAGGCT TCTAGACGGAGTTTCAAAAACTGATGAGCCTCGATCCAGGGCTTGAAAGAAGCCAGGGTGTAATCTTGTTCATGCATGCGTCCCCAGAGC CTCGCCCAGTGCCTGGCACATAGTAGGCACTCAATAAATGCTGAATGGGTGAATAGTTGAATGATAGGTGCTCAATAAATGAATGAATGG CCTTCCCTTCTCAGGCTATTCCCACCATTAGTCTGCCCACCTTTCTAGGCTGGGCTTGGCCACCATTAAACACGGGGTGGGGGTGAGGGC CCCTGCAATTCACGGTGCAATATTCACCAGTTTTGCCCTCTGCCTCATAAAGGCAAACCTGGCTTTTGATTACCATGTGTGGATGTTTCA GTGTCCTTTCTTCTCTGTCCCTGGGGATGGGGTGGTCTGTGAATATGTGACATTTCTGCAGTTCAGTATCCGAAGGTTTCTCTTGGGGGT AGGGGCTCCTGGGCGGCCAGATGAATGGGTCCCTGGGAACCCAGACCTCAGATGAGGACTTAATGTCTTCTTCCTCTCAAGCCAAATTCG CCTCCACCCACTCCCTCTGAAGAACTGGGCATTTGCCAAAGTAACCACTGGAGTCATCTAATGGCCCTCCCCCTCCCCAGGTTTCCCACA GCTTTCAGGGACAGTGGGCAAGAGGACACCCCCCCCCACCACCTCAGTGGAACACACCATTCTCCCCCCCTCAACAGCACACTCAGTGCA GCAAGACTGACCCCTGACCCCCTCCCAGCCCTCCCTACCTTGGACAGGAAGGAAGTAATGCACCTTCTCTTGCTGATTATTTATTTGTTT GGAGAGACAGAAATGTAAAAGTGTATCTAGAAATATCTATATCTCTATATATTTTTAACTGACTCTTTGGAATCCCCTGGGGTGGGGTGA GGGGTAAGTTTAGGCTTTCGCGGAGGGGAGGAGACATGGAGCCTGGGAACTCCTTGTTCTCCCCTCTGCTGCCTCTCCCCACCCCTTAAA GCAGTTGGTAGAAGGAATGGTATTTGTATGGGGGGAGGGAGGCTGGAATGGAGAATCTGGATTCTCTCCTCTTCCCCATTCTCCAGAGGG AGGGAGGTGGTGAGGAAGAGGAAGGGAGGGGCAGGATGGGCCATGGAGGTGCCCCACCCCCACACCTGACAATCACCCACACTCCTGGGG CTCTTCCTGGGTCCTGGGGCAGGGCGAGTCCAAGTGTGAGGCTGTTGATTTGTTTTCAATATTTCTTTTCGTGCTGTATGGTGATGCTTT CTTAGTATTCTACACAATAAGAAAAGACAAAGTCCTCGAGATTCTTATGAGTTTTGTTTGAAAACTCTTTCACTATATTTGTTGTAAAGA 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FusionGenePPI for UBQLN4_MEF2D |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBQLN4 | SERPINH1, ATXN1, NAE1, SCG5, ZBTB22, SMARCB1, RXRA, EEF1A1, UNC119, PTN, HSPA5, PRL, FKBP7, CTSB, SPP1, HERPUD1, PSMD4, RNF185, GJA1, DNAJB11, TNFRSF14, PSMD2, ADPGK, AGR2, AREG, BAG6, IGLC1, EAPP, UBR7, C19orf10, C1QTNF1, RUNX1T1, CCL21, CD99, CDSN, COL8A1, CPSF6, CSTF2, CSTF2T, DAZAP2, DKK3, DTX2, EDN1, EFEMP2, ELF5, FGFBP1, FKBP2, RSRC2, KLHL26, CCDC134, ERP27, CCDC33, FZD7, GABRD, GKAP1, GPX7, HAVCR1, HK2, PLA2G16, IGFBP6, IGHM, KLHL42, ITPRIPL1, ZG16B, MDK, C1orf94, MLLT6, NME3, NPHP1, NPPA, CYB5R1, NXF1, PDIA5, PDLIM7, PELI2, PIN1, PIP4K2B, BPIFA1, PPIB, PPIC, SRGN, QSOX1, RAI2, RIC8A, RNPS1, RPN1, SCMH1, SEMG1, SERPINE1, SERPINI2, MIEF2, SPAG8, SPINT1, STAM2, HSPA13, TFF1, PMEPA1, TRIM32, UBQLN1, USMG5, VIP, LAT2, ZG16, ZNF205, UBQLN4, MIF4GD, ADAM33, ARL4C, ATPIF1, CEND1, ERP29, CACNA1G, CCDC14, COPB1, CRIPT, DMPK, EPDR1, FA2H, SUPT20H, PRPF40A, GDI1, HGS, IMMT, ANKRD13D, CCDC107, C11orf49, MOAP1, CCDC136, NOMO1, NOMO3, NOTCH2NL, OAT, PBXIP1, PCDH17, PCDH8, PNMA1, PICK1, PTPRN, PTPRN2, RBM10, ROBO2, SCG2, SRSF2, SCAF1, STMN1, TGFB1I1, TNRC6B, TRAF2, TRIB2, UBQLN2, UROS, WAC, YWHAQ, ZDHHC3, ZFPM2, RAD23A, IMPDH2, ZFYVE19, ZPR1, UBE2B, AHCYL1, UBXN1, UBE2A, VPS4B, USP34, TYMS, STAM, TXN, PRDX3, VPS26A, UBE2C, TTC9C, CD2BP2, MAP1LC3A, SMAD9, RNF11, SMAD3, ORC5, SHFM1, UBC, ASNS, RAD23B, GJA5, GJC1, GJB1, KDELR1, SLC17A2, MTNR1B | MEF2D | YWHAQ, HDAC5, HDAC4, EP300, CABIN1, NFATC2, SP1, MAPK7, MEF2A, SNCA, CARM1, PRMT5, MAPK14, COPS5, HDAC3, KAT2B, SENP3, PRKACA, ASH2L, MEN1, RBBP5, KMT2D, HIRA, HDAC1, ASCL1, APP, CDK6, SHMT2, MOV10, NXF1, SKP2, FUS, XPO1, JUN, DNMT3L, MEF2B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBQLN4_MEF2D |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBQLN4_MEF2D |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MEF2D | C0338480 | Common Migraine | 1 | CTD_human |
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