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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40541

FusionGeneSummary for UBE4B_RBP7

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE4B_RBP7
Fusion gene ID: 40541
HgeneTgene
Gene symbol

UBE4B

RBP7

Gene ID

10277

116362

Gene nameubiquitination factor E4Bretinol binding protein 7
SynonymsE4|HDNB1|UBOX3|UFD2|UFD2ACRABP4|CRBP4|CRBPIV
Cytomap

1p36.22

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionubiquitin conjugation factor E4 BRING-type E3 ubiquitin transferase E4 BUFD2A-III/UBE4B-III splice isoformhomologous to yeast UFD2homozygously deleted in neuroblastoma-1ubiquitin-fusion degradation protein 2ubiquitination factor E4B (UFD2 homolog, yretinoid-binding protein 7cellular retinoic acid-binding protein 4cellular retinoic acid-binding protein IVcellular retinol binding protein 7putative cellular retinol-binding protein CRBP IVretinol binding protein 7, cellular
Modification date2018052320180519
UniProtAcc

O95155

Q96R05

Ensembl transtripts involved in fusion geneENST00000253251, ENST00000377157, 
ENST00000343090, ENST00000377153, 
ENST00000475795, 
ENST00000294435, 
Fusion gene scores* DoF score12 X 8 X 8=7684 X 3 X 5=60
# samples 146
** MAII scorelog2(14/768*10)=-2.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/60*10)=0
Context

PubMed: UBE4B [Title/Abstract] AND RBP7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE4B

GO:0008626

granzyme-mediated apoptotic signaling pathway

11802788

HgeneUBE4B

GO:0009411

response to UV

11802788

HgeneUBE4B

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

23509263


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-56-8082-01AUBE4Bchr1

10093752

+RBP7chr1

10068231

+
TCGARVOVTCGA-13-1510-01AUBE4Bchr1

10132272

+RBP7chr1

10067628

+
TCGARVTHYMTCGA-4V-A9QJ-01AUBE4Bchr1

10093752

+RBP7chr1

10075840

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000253251ENST00000294435UBE4Bchr1

10093752

+RBP7chr1

10068231

+
5UTR-3CDSENST00000377157ENST00000294435UBE4Bchr1

10093752

+RBP7chr1

10068231

+
In-frameENST00000343090ENST00000294435UBE4Bchr1

10093752

+RBP7chr1

10068231

+
In-frameENST00000377153ENST00000294435UBE4Bchr1

10093752

+RBP7chr1

10068231

+
intron-3CDSENST00000475795ENST00000294435UBE4Bchr1

10093752

+RBP7chr1

10068231

+
In-frameENST00000253251ENST00000294435UBE4Bchr1

10132272

+RBP7chr1

10067628

+
5UTR-3CDSENST00000377157ENST00000294435UBE4Bchr1

10132272

+RBP7chr1

10067628

+
In-frameENST00000343090ENST00000294435UBE4Bchr1

10132272

+RBP7chr1

10067628

+
In-frameENST00000377153ENST00000294435UBE4Bchr1

10132272

+RBP7chr1

10067628

+
intron-3CDSENST00000475795ENST00000294435UBE4Bchr1

10132272

+RBP7chr1

10067628

+
Frame-shiftENST00000253251ENST00000294435UBE4Bchr1

10093752

+RBP7chr1

10075840

+
5UTR-3CDSENST00000377157ENST00000294435UBE4Bchr1

10093752

+RBP7chr1

10075840

+
Frame-shiftENST00000343090ENST00000294435UBE4Bchr1

10093752

+RBP7chr1

10075840

+
Frame-shiftENST00000377153ENST00000294435UBE4Bchr1

10093752

+RBP7chr1

10075840

+
intron-3CDSENST00000475795ENST00000294435UBE4Bchr1

10093752

+RBP7chr1

10075840

+

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FusionProtFeatures for UBE4B_RBP7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE4B

O95155

RBP7

Q96R05

Intracellular transport of retinol.{ECO:0000269|PubMed:12177003}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBE4Bchr1:10093752chr1:10068231ENST00000253251+1271227_130081174DomainNote=U-box
HgeneUBE4Bchr1:10093752chr1:10068231ENST00000343090+1281227_130081303DomainNote=U-box
HgeneUBE4Bchr1:10093752chr1:10068231ENST00000377157+1271227_1300-1081062DomainNote=U-box
HgeneUBE4Bchr1:10132272chr1:10067628ENST00000253251+2271227_1300701174DomainNote=U-box
HgeneUBE4Bchr1:10132272chr1:10067628ENST00000343090+2281227_1300701303DomainNote=U-box
HgeneUBE4Bchr1:10132272chr1:10067628ENST00000377157+2271227_1300-461062DomainNote=U-box


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FusionGeneSequence for UBE4B_RBP7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE4B_RBP7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UBE4BTP73, VCP, ATXN3, XPC, UBE2D3, UBE4B, CBL, UBE2D2, MDM2, TP53, UBXN1, VAV2, ELAVL1, FEZ1, TP63, UBL7, USP34, NDUFA2, VPS26A, SSSCA1, SRPRB, ZPR1, ATP6V1F, VPS36, AHCYL1, MRPL53, VPS35, UBE2D1, UBQLN1, IGBP1, TTC9C, UBE2C, VPS4B, PSMB1, USP9X, UBXN7, ZFYVE19, UBE2V1, UFM1, SULT1A1, SBDS, ZRANB2, TRIP6, UCHL3, THY1, NDUFA7, UBA6, SF3B4, PPIF, HDLBP, SCO2, SARNP, UBE2L3, VPS29, TTK, CDC27, CDKN2A, NUDCD3, NUSAP1, PDE3A, RBM12, HGS, STAM, TRIP12, FBXW11, RAD23A, BTRC, FOXK1, STUB1, PCID2, TTC4, NTRK1, ESR1, TMEM165, CDC25A, RAD23B, TRIM25RBP7HSH2D, PIK3R3, SOCS4, APPL2, DAPP1, DOK4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE4B_RBP7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE4B_RBP7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource