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Fusion gene ID: 40536 |
FusionGeneSummary for UBE4B_MED18 |
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Fusion gene information | Fusion gene name: UBE4B_MED18 | Fusion gene ID: 40536 | Hgene | Tgene | Gene symbol | UBE4B | MED18 | Gene ID | 10277 | 54797 |
Gene name | ubiquitination factor E4B | mediator complex subunit 18 | |
Synonyms | E4|HDNB1|UBOX3|UFD2|UFD2A | SRB5|p28b | |
Cytomap | 1p36.22 | 1p35.3 | |
Type of gene | protein-coding | protein-coding | |
Description | ubiquitin conjugation factor E4 BRING-type E3 ubiquitin transferase E4 BUFD2A-III/UBE4B-III splice isoformhomologous to yeast UFD2homozygously deleted in neuroblastoma-1ubiquitin-fusion degradation protein 2ubiquitination factor E4B (UFD2 homolog, y | mediator of RNA polymerase II transcription subunit 18TRAP/mediator complex subunit p28bmediator of RNA polymerase II transcription, subunit 18 homolog | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O95155 | Q9BUE0 | |
Ensembl transtripts involved in fusion gene | ENST00000253251, ENST00000377157, ENST00000343090, ENST00000377153, ENST00000475795, | ENST00000479574, ENST00000373842, ENST00000398997, | |
Fusion gene scores | * DoF score | 12 X 8 X 8=768 | 2 X 1 X 2=4 |
# samples | 14 | 2 | |
** MAII score | log2(14/768*10)=-2.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: UBE4B [Title/Abstract] AND MED18 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | UBE4B | GO:0008626 | granzyme-mediated apoptotic signaling pathway | 11802788 |
Hgene | UBE4B | GO:0009411 | response to UV | 11802788 |
Hgene | UBE4B | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 23509263 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | GBM | TCGA-12-3652-01A | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000253251 | ENST00000479574 | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
5CDS-5UTR | ENST00000253251 | ENST00000373842 | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
5CDS-5UTR | ENST00000253251 | ENST00000398997 | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
5CDS-3UTR | ENST00000377157 | ENST00000479574 | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
5CDS-5UTR | ENST00000377157 | ENST00000373842 | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
5CDS-5UTR | ENST00000377157 | ENST00000398997 | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
5CDS-3UTR | ENST00000343090 | ENST00000479574 | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
5CDS-5UTR | ENST00000343090 | ENST00000373842 | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
5CDS-5UTR | ENST00000343090 | ENST00000398997 | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
intron-3UTR | ENST00000377153 | ENST00000479574 | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
intron-5UTR | ENST00000377153 | ENST00000373842 | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
intron-5UTR | ENST00000377153 | ENST00000398997 | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
3UTR-3UTR | ENST00000475795 | ENST00000479574 | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
3UTR-5UTR | ENST00000475795 | ENST00000373842 | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
3UTR-5UTR | ENST00000475795 | ENST00000398997 | UBE4B | chr1 | 10190871 | + | MED18 | chr1 | 28657108 | + |
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FusionProtFeatures for UBE4B_MED18 |
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Hgene | Tgene |
UBE4B | MED18 |
Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBE4B_MED18 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UBE4B_MED18 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
UBE4B | TP73, VCP, ATXN3, XPC, UBE2D3, UBE4B, CBL, UBE2D2, MDM2, TP53, UBXN1, VAV2, ELAVL1, FEZ1, TP63, UBL7, USP34, NDUFA2, VPS26A, SSSCA1, SRPRB, ZPR1, ATP6V1F, VPS36, AHCYL1, MRPL53, VPS35, UBE2D1, UBQLN1, IGBP1, TTC9C, UBE2C, VPS4B, PSMB1, USP9X, UBXN7, ZFYVE19, UBE2V1, UFM1, SULT1A1, SBDS, ZRANB2, TRIP6, UCHL3, THY1, NDUFA7, UBA6, SF3B4, PPIF, HDLBP, SCO2, SARNP, UBE2L3, VPS29, TTK, CDC27, CDKN2A, NUDCD3, NUSAP1, PDE3A, RBM12, HGS, STAM, TRIP12, FBXW11, RAD23A, BTRC, FOXK1, STUB1, PCID2, TTC4, NTRK1, ESR1, TMEM165, CDC25A, RAD23B, TRIM25 | MED18 | MED10, MED9, MED29, MED19, MED28, MED26, MED20, MED1, MED13, MED12, MED17, MED21, MED4, CCNC, MED16, MED24, MED22, MED23, MED8, MED31, MED15, MED6, MED14, MED30, MED27, TADA2A, CDK19, MED11, PIP4K2B, EPAS1, CDK8, CAMK2B, TRIM39, HOMEZ, MED7, POLR2G, MED13L, MED12L, MED25, MTMR3, G6PD, BIRC5, MTMR4, RPAP2, GPN3, POLR2A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBE4B_MED18 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBE4B_MED18 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |