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Fusion gene ID: 40534 |
FusionGeneSummary for UBE4B_EIF2S2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBE4B_EIF2S2 | Fusion gene ID: 40534 | Hgene | Tgene | Gene symbol | UBE4B | EIF2S2 | Gene ID | 10277 | 8894 |
| Gene name | ubiquitination factor E4B | eukaryotic translation initiation factor 2 subunit beta | |
| Synonyms | E4|HDNB1|UBOX3|UFD2|UFD2A | EIF2|EIF2B|EIF2beta|PPP1R67|eIF-2-beta | |
| Cytomap | 1p36.22 | 20q11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin conjugation factor E4 BRING-type E3 ubiquitin transferase E4 BUFD2A-III/UBE4B-III splice isoformhomologous to yeast UFD2homozygously deleted in neuroblastoma-1ubiquitin-fusion degradation protein 2ubiquitination factor E4B (UFD2 homolog, y | eukaryotic translation initiation factor 2 subunit 2eukaryotic translation initiation factor 2, subunit 2 beta, 38kDaprotein phosphatase 1, regulatory subunit 67 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O95155 | P20042 | |
| Ensembl transtripts involved in fusion gene | ENST00000253251, ENST00000377157, ENST00000343090, ENST00000377153, ENST00000475795, | ENST00000374980, | |
| Fusion gene scores | * DoF score | 12 X 8 X 8=768 | 5 X 3 X 5=75 |
| # samples | 14 | 5 | |
| ** MAII score | log2(14/768*10)=-2.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBE4B [Title/Abstract] AND EIF2S2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBE4B | GO:0008626 | granzyme-mediated apoptotic signaling pathway | 11802788 |
| Hgene | UBE4B | GO:0009411 | response to UV | 11802788 |
| Hgene | UBE4B | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 23509263 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-AJ-A3I9-01A | UBE4B | chr1 | 10093752 | + | EIF2S2 | chr20 | 32693351 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000253251 | ENST00000374980 | UBE4B | chr1 | 10093752 | + | EIF2S2 | chr20 | 32693351 | - |
| 5UTR-3CDS | ENST00000377157 | ENST00000374980 | UBE4B | chr1 | 10093752 | + | EIF2S2 | chr20 | 32693351 | - |
| In-frame | ENST00000343090 | ENST00000374980 | UBE4B | chr1 | 10093752 | + | EIF2S2 | chr20 | 32693351 | - |
| In-frame | ENST00000377153 | ENST00000374980 | UBE4B | chr1 | 10093752 | + | EIF2S2 | chr20 | 32693351 | - |
| intron-3CDS | ENST00000475795 | ENST00000374980 | UBE4B | chr1 | 10093752 | + | EIF2S2 | chr20 | 32693351 | - |
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FusionProtFeatures for UBE4B_EIF2S2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBE4B | EIF2S2 |
| eIF-2 functions in the early steps of protein synthesisby forming a ternary complex with GTP and initiator tRNA. Thiscomplex binds to a 40S ribosomal subunit, followed by mRNA bindingto form a 43S preinitiation complex. Junction of the 60S ribosomalsubunit to form the 80S initiation complex is preceded byhydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDPbinary complex. In order for eIF-2 to recycle and catalyze anotherround of initiation, the GDP bound to eIF-2 must exchange with GTPby way of a reaction catalyzed by eIF-2B. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >EIF2S2 | chr1:10093752 | chr20:32693351 | ENST00000374980 | - | 0 | 9 | 124_129 | 5 | 334 | Compositional bias | Note=Poly-Lys |
| Tgene | >EIF2S2 | chr1:10093752 | chr20:32693351 | ENST00000374980 | - | 0 | 9 | 14_21 | 5 | 334 | Compositional bias | Note=Poly-Lys |
| Tgene | >EIF2S2 | chr1:10093752 | chr20:32693351 | ENST00000374980 | - | 0 | 9 | 79_87 | 5 | 334 | Compositional bias | Note=Poly-Lys |
| Tgene | >EIF2S2 | chr1:10093752 | chr20:32693351 | ENST00000374980 | - | 0 | 9 | 281_305 | 5 | 334 | Zinc finger | C4-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >UBE4B | chr1:10093752 | chr20:32693351 | ENST00000253251 | + | 1 | 27 | 1227_1300 | 8 | 1174 | Domain | Note=U-box |
| Hgene | >UBE4B | chr1:10093752 | chr20:32693351 | ENST00000343090 | + | 1 | 28 | 1227_1300 | 8 | 1303 | Domain | Note=U-box |
| Hgene | >UBE4B | chr1:10093752 | chr20:32693351 | ENST00000377157 | + | 1 | 27 | 1227_1300 | -108 | 1062 | Domain | Note=U-box |
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FusionGeneSequence for UBE4B_EIF2S2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_UBE4B_ENST00000253251_chr1_10093752_+_EIF2S2_ENST00000374980_chr20_32693351_-_337aa MEELSADEMIFDPTMSKKKKKKKKPFMLDEEGDTQTEETQPSETKEVEPEPTEDKDLEADEEDTRKKDASDDLDDLNFFNQKKKKKKTKK IFDIDEAEEGVKDLKIESDVQEPTEPEDDLDIMLGNKKKKKKNVKFPDEDEILEKDEALEDEDNKKDDGISFSNQTGPAWAGSERDYTYE ELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQI >In-frame_UBE4B_ENST00000343090_chr1_10093752_+_EIF2S2_ENST00000374980_chr20_32693351_-_337aa MEELSADEMIFDPTMSKKKKKKKKPFMLDEEGDTQTEETQPSETKEVEPEPTEDKDLEADEEDTRKKDASDDLDDLNFFNQKKKKKKTKK IFDIDEAEEGVKDLKIESDVQEPTEPEDDLDIMLGNKKKKKKNVKFPDEDEILEKDEALEDEDNKKDDGISFSNQTGPAWAGSERDYTYE ELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQI >In-frame_UBE4B_ENST00000377153_chr1_10093752_+_EIF2S2_ENST00000374980_chr20_32693351_-_337aa MEELSADEMIFDPTMSKKKKKKKKPFMLDEEGDTQTEETQPSETKEVEPEPTEDKDLEADEEDTRKKDASDDLDDLNFFNQKKKKKKTKK IFDIDEAEEGVKDLKIESDVQEPTEPEDDLDIMLGNKKKKKKNVKFPDEDEILEKDEALEDEDNKKDDGISFSNQTGPAWAGSERDYTYE ELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_UBE4B_ENST00000253251_chr1_10093752_+_EIF2S2_ENST00000374980_chr20_32693351_-_1011nt ATGGAGGAGCTGAGCGCTGATGAGATGATTTTTGATCCTACTATGAGCAAGAAGAAAAAGAAGAAGAAGAAGCCTTTTATGTTAGATGAG GAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAAACAAAAGAAGTGGAGCCAGAGCCAACTGAGGACAAGGATTTGGAAGCTGAT GAAGAGGACACTAGGAAAAAAGATGCTTCTGATGATCTAGATGACTTGAACTTCTTTAATCAAAAGAAAAAGAAGAAAAAAACTAAAAAG ATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGATCTTAAGATTGAAAGTGATGTTCAAGAACCAACTGAACCAGAGGATGACCTT GACATTATGCTTGGCAATAAAAAGAAGAAAAAGAAGAATGTTAAGTTCCCAGATGAGGATGAAATACTAGAGAAAGATGAAGCTCTAGAA GATGAAGACAACAAAAAAGATGATGGTATCTCATTCAGTAATCAGACAGGCCCTGCTTGGGCAGGCTCAGAAAGAGACTACACATACGAG GAGCTGCTGAATCGAGTGTTCAACATCATGAGGGAAAAGAATCCAGATATGGTTGCTGGGGAGAAAAGGAAATTTGTCATGAAACCTCCA CAAGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTCAACTTTACAGATATCTGTAAACTATTACATCGTCAGCCCAAACATCTCCTT GCATTTTTGTTGGCTGAATTGGGTACAAGTGGTTCTATAGATGGTAATAACCAACTTGTAATCAAAGGAAGATTCCAACAGAAACAGATA GAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACTTGTCACACATGCCGATCACCGGACACAATCCTGCAGAAGGACACACGACTC TATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCCAGTATCAAAACCGGCTTCCAGGCTGTCACGGGCAAGCGAGCACAG >In-frame_UBE4B_ENST00000343090_chr1_10093752_+_EIF2S2_ENST00000374980_chr20_32693351_-_1011nt ATGGAGGAGCTGAGCGCTGATGAGATGATTTTTGATCCTACTATGAGCAAGAAGAAAAAGAAGAAGAAGAAGCCTTTTATGTTAGATGAG GAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAAACAAAAGAAGTGGAGCCAGAGCCAACTGAGGACAAGGATTTGGAAGCTGAT GAAGAGGACACTAGGAAAAAAGATGCTTCTGATGATCTAGATGACTTGAACTTCTTTAATCAAAAGAAAAAGAAGAAAAAAACTAAAAAG ATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGATCTTAAGATTGAAAGTGATGTTCAAGAACCAACTGAACCAGAGGATGACCTT GACATTATGCTTGGCAATAAAAAGAAGAAAAAGAAGAATGTTAAGTTCCCAGATGAGGATGAAATACTAGAGAAAGATGAAGCTCTAGAA GATGAAGACAACAAAAAAGATGATGGTATCTCATTCAGTAATCAGACAGGCCCTGCTTGGGCAGGCTCAGAAAGAGACTACACATACGAG GAGCTGCTGAATCGAGTGTTCAACATCATGAGGGAAAAGAATCCAGATATGGTTGCTGGGGAGAAAAGGAAATTTGTCATGAAACCTCCA CAAGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTCAACTTTACAGATATCTGTAAACTATTACATCGTCAGCCCAAACATCTCCTT GCATTTTTGTTGGCTGAATTGGGTACAAGTGGTTCTATAGATGGTAATAACCAACTTGTAATCAAAGGAAGATTCCAACAGAAACAGATA GAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACTTGTCACACATGCCGATCACCGGACACAATCCTGCAGAAGGACACACGACTC TATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCCAGTATCAAAACCGGCTTCCAGGCTGTCACGGGCAAGCGAGCACAG >In-frame_UBE4B_ENST00000377153_chr1_10093752_+_EIF2S2_ENST00000374980_chr20_32693351_-_1011nt ATGGAGGAGCTGAGCGCTGATGAGATGATTTTTGATCCTACTATGAGCAAGAAGAAAAAGAAGAAGAAGAAGCCTTTTATGTTAGATGAG GAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAAACAAAAGAAGTGGAGCCAGAGCCAACTGAGGACAAGGATTTGGAAGCTGAT GAAGAGGACACTAGGAAAAAAGATGCTTCTGATGATCTAGATGACTTGAACTTCTTTAATCAAAAGAAAAAGAAGAAAAAAACTAAAAAG ATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGATCTTAAGATTGAAAGTGATGTTCAAGAACCAACTGAACCAGAGGATGACCTT GACATTATGCTTGGCAATAAAAAGAAGAAAAAGAAGAATGTTAAGTTCCCAGATGAGGATGAAATACTAGAGAAAGATGAAGCTCTAGAA GATGAAGACAACAAAAAAGATGATGGTATCTCATTCAGTAATCAGACAGGCCCTGCTTGGGCAGGCTCAGAAAGAGACTACACATACGAG GAGCTGCTGAATCGAGTGTTCAACATCATGAGGGAAAAGAATCCAGATATGGTTGCTGGGGAGAAAAGGAAATTTGTCATGAAACCTCCA CAAGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTCAACTTTACAGATATCTGTAAACTATTACATCGTCAGCCCAAACATCTCCTT GCATTTTTGTTGGCTGAATTGGGTACAAGTGGTTCTATAGATGGTAATAACCAACTTGTAATCAAAGGAAGATTCCAACAGAAACAGATA GAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACTTGTCACACATGCCGATCACCGGACACAATCCTGCAGAAGGACACACGACTC TATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCCAGTATCAAAACCGGCTTCCAGGCTGTCACGGGCAAGCGAGCACAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_UBE4B_ENST00000253251_chr1_10093752_+_EIF2S2_ENST00000374980_chr20_32693351_-_3282nt GACGGGGTGGGACGGAGGCGGGGAGAGGACGCAGGCGAGAGGAACTCGGCGGCGCGGCGCCCGCGGCCTATTGGCTGCCACGTCCCGGCG CCAGAAGCCCCGCCTCCCTGACGGGGGTCACGTGATCCCTTTCAAAGATGGCCGCCCTGTTGTTTTGATGAATAATACTTGGTGGGGCGA GGGGGAAAGAGTAGGGGTGGAGGGGTAGGAGGATTTACTCTTCCAGCGAGAGCTACGCGCATCCCATCCTCCCCCTCCCCCCTACCCGGG CTCCGGCGTGGAGGCGGGGCGTGGCCGGCCTGCTTTGGGAGGGGAGGGGCTTCCCTTACAGTGCTGGGCTCTGCCAGGACGGCTGTGGGG TCGCCTTACCTCGGGGTATCCACTCTGCAGTCGACCAGTTCCCGCCAGGAGCAAAGGGTAGGAAGGAGAGCAGGATCTGCTGTAGGAACG CAGCTACCGCGCCACTATCACGAAGAAACAGCAGGCTCGGGGCACGAGACGAACTGGAGACCGCGCTGCCTAGCTGGGTAACCTGGGAAG CAGAGGGTAATAAGTGGCGCCTTAAGACAACCCTGTAGCAGCAGCAGTGGCGGCCAAAGGAGGCTGCTCAGGGAACAAGCGGCTGTAGTA GTCTGTGGGGCGACTGGAGTGACCGAAGCCAAGGCAGTTTAGTGCCTCTCGTGTTCTTATTTTTTAACCTCTGACTATGCAATTCTGAAA CCTCCCCCATTCGGGGGACCAGACAGCCTGATAGACACCTTCCACTCTCCTTCCTCCCGCCGTGGTCTCGAGAACAGAAGGATCTCTCCT TAACGCCTTTCACCATTAAGAGGAAAGCGATGGAGGAGCTGAGCGCTGATGAGATGATTTTTGATCCTACTATGAGCAAGAAGAAAAAGA AGAAGAAGAAGCCTTTTATGTTAGATGAGGAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAAACAAAAGAAGTGGAGCCAGAGC CAACTGAGGACAAGGATTTGGAAGCTGATGAAGAGGACACTAGGAAAAAAGATGCTTCTGATGATCTAGATGACTTGAACTTCTTTAATC AAAAGAAAAAGAAGAAAAAAACTAAAAAGATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGATCTTAAGATTGAAAGTGATGTTC AAGAACCAACTGAACCAGAGGATGACCTTGACATTATGCTTGGCAATAAAAAGAAGAAAAAGAAGAATGTTAAGTTCCCAGATGAGGATG AAATACTAGAGAAAGATGAAGCTCTAGAAGATGAAGACAACAAAAAAGATGATGGTATCTCATTCAGTAATCAGACAGGCCCTGCTTGGG CAGGCTCAGAAAGAGACTACACATACGAGGAGCTGCTGAATCGAGTGTTCAACATCATGAGGGAAAAGAATCCAGATATGGTTGCTGGGG AGAAAAGGAAATTTGTCATGAAACCTCCACAAGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTCAACTTTACAGATATCTGTAAAC TATTACATCGTCAGCCCAAACATCTCCTTGCATTTTTGTTGGCTGAATTGGGTACAAGTGGTTCTATAGATGGTAATAACCAACTTGTAA TCAAAGGAAGATTCCAACAGAAACAGATAGAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACTTGTCACACATGCCGATCACCGG ACACAATCCTGCAGAAGGACACACGACTCTATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCCAGTATCAAAACCGGCT TCCAGGCTGTCACGGGCAAGCGAGCACAGCTCCGTGCCAAAGCTAACTAATTTGCTAATCACTGATTTTGCAAAGCTTGTTGTGGAGATG TGGCTGGACAGGTTTGCCATCAGAGTGGATATACCGTTGTATTAAAAACAAGATAAAAAAGCTGCCAAGATTTTTGGCGAGTGGTTGGTC TGAAGTCCTTGCAAGACGCTGATGCTCAAGCTGTTGACATACTCATTGCCTACTTTAACACCTGTCAGAGAAACGTGATATGGGGTAAGG AGGTGCTTTTTTAAAATCGTTCATAGACTTCTGTAAAATGCAAGATAAATTAAAGTTATTATAACAGTGATTCTTTCAATTTGGTTTGTC CTTCAGTTTTCTTTTCTATAAATGTGCTTGGTGAAATCAGCAAGAAACCAACCATATAAAACAGTGTGTGCCGGGCTCTGACTGAGAAAC TGAACAATGGCAGGCGCTTCATCTGGGCAGCCATTTTTCTTCTCTGCTTCTCTTGAGATACATAGTTAAAGTAGACACGGCCTCCCACGC GAGTGTGGTGGGACCTTGAGACTTAGGAGGATTGCCTGTTTTCAGTGTCCAGGGAATGACTCCATAGATTTGAATTCTTTTCCGTATGTG GGGATGGTTGCTACTACCTCACCGCCAAGTCCTCCCCCAGCTGTTACCACATGAGGGAATACAAGGTGCTAGGTACCCTCCTTCCTCGTT GGCCACTAAGAGGTCTTAGAAACATAGCCTGTAAATGTGTCTTGTAACTGGCACACTAAAAAAGATCCTAGTTGAGCATCTCTCTTGGTG AGGAAGCGATGTGTGTGCGGTTCAGGAAACTCCTCCAAGAGGAGGAGGAGTCCAAACAGGGATGCCAGAGGAAGCTTTCCGTTTTCCTAG CCAACTTGTGTTCTGGGTTTGAAAAAGACCCACCACAAATGCTTTTTCTATTTTCTGATTTAAAAGTCGCTTTTGAATATGACCATGAGA AACCAAGAAATGCTGCTTGTGTGGTGCTCTGCTTCCTGAGGATTTGGCTGGAAGGGGATTCTCCGCTGGCACATGGGAGAAGGCCATCTT CTGTGTCGGTGCTGTGATCTGCCTTGTTCTCACTTGCTGAGGATAAGGGCATACACGCTGCTCCTCGCTTTCTTGTTGCCCGACTTCGTA CTAAGCAGCTCAGGAGCAGTCACTCAGACCCAAATGTCTTGACTGTGTTGTTTTTAATCACTGTGACCCTTAAAGTACAGGCCAAGTGTT GTCAAACACCTTGGCTAAAACAGTGGAGGGTGATGGGTAAAGCAGTAGAGGGCCCTCAACCCACACACTGGCTGAAACTGCCACCAACTG CCACGATGAACCCAACTGCTGTTTATGCCCCCATTTTCCTTTTTTTGTATCTACACCCACACGATTCCCAATGTTGGATATTTCTACATG >In-frame_UBE4B_ENST00000343090_chr1_10093752_+_EIF2S2_ENST00000374980_chr20_32693351_-_2518nt CTCTCCTTCCTCCCGCCGTGGTCTCGAGAACAGAAGGATCTCTCCTTAACGCCTTTCACCATTAAGAGGAAAGCGATGGAGGAGCTGAGC GCTGATGAGATGATTTTTGATCCTACTATGAGCAAGAAGAAAAAGAAGAAGAAGAAGCCTTTTATGTTAGATGAGGAAGGGGATACCCAA ACAGAGGAAACCCAGCCTTCAGAAACAAAAGAAGTGGAGCCAGAGCCAACTGAGGACAAGGATTTGGAAGCTGATGAAGAGGACACTAGG AAAAAAGATGCTTCTGATGATCTAGATGACTTGAACTTCTTTAATCAAAAGAAAAAGAAGAAAAAAACTAAAAAGATATTTGATATTGAT GAAGCTGAAGAAGGTGTAAAGGATCTTAAGATTGAAAGTGATGTTCAAGAACCAACTGAACCAGAGGATGACCTTGACATTATGCTTGGC AATAAAAAGAAGAAAAAGAAGAATGTTAAGTTCCCAGATGAGGATGAAATACTAGAGAAAGATGAAGCTCTAGAAGATGAAGACAACAAA AAAGATGATGGTATCTCATTCAGTAATCAGACAGGCCCTGCTTGGGCAGGCTCAGAAAGAGACTACACATACGAGGAGCTGCTGAATCGA GTGTTCAACATCATGAGGGAAAAGAATCCAGATATGGTTGCTGGGGAGAAAAGGAAATTTGTCATGAAACCTCCACAAGTCGTCCGAGTA GGAACCAAGAAAACTTCTTTTGTCAACTTTACAGATATCTGTAAACTATTACATCGTCAGCCCAAACATCTCCTTGCATTTTTGTTGGCT GAATTGGGTACAAGTGGTTCTATAGATGGTAATAACCAACTTGTAATCAAAGGAAGATTCCAACAGAAACAGATAGAAAATGTCTTGAGA AGATATATCAAGGAATATGTCACTTGTCACACATGCCGATCACCGGACACAATCCTGCAGAAGGACACACGACTCTATTTCCTACAGTGC GAAACTTGTCATTCTAGATGTTCTGTTGCCAGTATCAAAACCGGCTTCCAGGCTGTCACGGGCAAGCGAGCACAGCTCCGTGCCAAAGCT AACTAATTTGCTAATCACTGATTTTGCAAAGCTTGTTGTGGAGATGTGGCTGGACAGGTTTGCCATCAGAGTGGATATACCGTTGTATTA AAAACAAGATAAAAAAGCTGCCAAGATTTTTGGCGAGTGGTTGGTCTGAAGTCCTTGCAAGACGCTGATGCTCAAGCTGTTGACATACTC ATTGCCTACTTTAACACCTGTCAGAGAAACGTGATATGGGGTAAGGAGGTGCTTTTTTAAAATCGTTCATAGACTTCTGTAAAATGCAAG ATAAATTAAAGTTATTATAACAGTGATTCTTTCAATTTGGTTTGTCCTTCAGTTTTCTTTTCTATAAATGTGCTTGGTGAAATCAGCAAG AAACCAACCATATAAAACAGTGTGTGCCGGGCTCTGACTGAGAAACTGAACAATGGCAGGCGCTTCATCTGGGCAGCCATTTTTCTTCTC TGCTTCTCTTGAGATACATAGTTAAAGTAGACACGGCCTCCCACGCGAGTGTGGTGGGACCTTGAGACTTAGGAGGATTGCCTGTTTTCA GTGTCCAGGGAATGACTCCATAGATTTGAATTCTTTTCCGTATGTGGGGATGGTTGCTACTACCTCACCGCCAAGTCCTCCCCCAGCTGT TACCACATGAGGGAATACAAGGTGCTAGGTACCCTCCTTCCTCGTTGGCCACTAAGAGGTCTTAGAAACATAGCCTGTAAATGTGTCTTG TAACTGGCACACTAAAAAAGATCCTAGTTGAGCATCTCTCTTGGTGAGGAAGCGATGTGTGTGCGGTTCAGGAAACTCCTCCAAGAGGAG GAGGAGTCCAAACAGGGATGCCAGAGGAAGCTTTCCGTTTTCCTAGCCAACTTGTGTTCTGGGTTTGAAAAAGACCCACCACAAATGCTT TTTCTATTTTCTGATTTAAAAGTCGCTTTTGAATATGACCATGAGAAACCAAGAAATGCTGCTTGTGTGGTGCTCTGCTTCCTGAGGATT TGGCTGGAAGGGGATTCTCCGCTGGCACATGGGAGAAGGCCATCTTCTGTGTCGGTGCTGTGATCTGCCTTGTTCTCACTTGCTGAGGAT AAGGGCATACACGCTGCTCCTCGCTTTCTTGTTGCCCGACTTCGTACTAAGCAGCTCAGGAGCAGTCACTCAGACCCAAATGTCTTGACT GTGTTGTTTTTAATCACTGTGACCCTTAAAGTACAGGCCAAGTGTTGTCAAACACCTTGGCTAAAACAGTGGAGGGTGATGGGTAAAGCA GTAGAGGGCCCTCAACCCACACACTGGCTGAAACTGCCACCAACTGCCACGATGAACCCAACTGCTGTTTATGCCCCCATTTTCCTTTTT >In-frame_UBE4B_ENST00000377153_chr1_10093752_+_EIF2S2_ENST00000374980_chr20_32693351_-_2840nt TAGGAACGCAGCTACCGCGCCACTATCACGAAGAAACAGCAGGCTCGGGGCACGAGACGAACTGGAGACCGCGCTGCCTAGCTGGGTAAC CTGGGAAGCAGAGGGTAATAAGTGGCGCCTTAAGACAACCCTGTAGCAGCAGCAGTGGCGGCCAAAGGAGGCTGCTCAGGGAACAAGCGG CTGTAGTAGTCTGTGGGGCGACTGGAGTGACCGAAGCCAAGGCAGTTTAGTGCCTCTCGTGTTCTTATTTTTTAACCTCTGACTATGCAA TTCTGAAACCTCCCCCATTCGGGGGACCAGACAGCCTGATAGACACCTTCCACTCTCCTTCCTCCCGCCGTGGTCTCGAGAACAGAAGGA TCTCTCCTTAACGCCTTTCACCATTAAGAGGAAAGCGATGGAGGAGCTGAGCGCTGATGAGATGATTTTTGATCCTACTATGAGCAAGAA GAAAAAGAAGAAGAAGAAGCCTTTTATGTTAGATGAGGAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAAACAAAAGAAGTGGA GCCAGAGCCAACTGAGGACAAGGATTTGGAAGCTGATGAAGAGGACACTAGGAAAAAAGATGCTTCTGATGATCTAGATGACTTGAACTT CTTTAATCAAAAGAAAAAGAAGAAAAAAACTAAAAAGATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGATCTTAAGATTGAAAG TGATGTTCAAGAACCAACTGAACCAGAGGATGACCTTGACATTATGCTTGGCAATAAAAAGAAGAAAAAGAAGAATGTTAAGTTCCCAGA TGAGGATGAAATACTAGAGAAAGATGAAGCTCTAGAAGATGAAGACAACAAAAAAGATGATGGTATCTCATTCAGTAATCAGACAGGCCC TGCTTGGGCAGGCTCAGAAAGAGACTACACATACGAGGAGCTGCTGAATCGAGTGTTCAACATCATGAGGGAAAAGAATCCAGATATGGT TGCTGGGGAGAAAAGGAAATTTGTCATGAAACCTCCACAAGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTCAACTTTACAGATAT CTGTAAACTATTACATCGTCAGCCCAAACATCTCCTTGCATTTTTGTTGGCTGAATTGGGTACAAGTGGTTCTATAGATGGTAATAACCA ACTTGTAATCAAAGGAAGATTCCAACAGAAACAGATAGAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACTTGTCACACATGCCG ATCACCGGACACAATCCTGCAGAAGGACACACGACTCTATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCCAGTATCAA AACCGGCTTCCAGGCTGTCACGGGCAAGCGAGCACAGCTCCGTGCCAAAGCTAACTAATTTGCTAATCACTGATTTTGCAAAGCTTGTTG TGGAGATGTGGCTGGACAGGTTTGCCATCAGAGTGGATATACCGTTGTATTAAAAACAAGATAAAAAAGCTGCCAAGATTTTTGGCGAGT GGTTGGTCTGAAGTCCTTGCAAGACGCTGATGCTCAAGCTGTTGACATACTCATTGCCTACTTTAACACCTGTCAGAGAAACGTGATATG GGGTAAGGAGGTGCTTTTTTAAAATCGTTCATAGACTTCTGTAAAATGCAAGATAAATTAAAGTTATTATAACAGTGATTCTTTCAATTT GGTTTGTCCTTCAGTTTTCTTTTCTATAAATGTGCTTGGTGAAATCAGCAAGAAACCAACCATATAAAACAGTGTGTGCCGGGCTCTGAC TGAGAAACTGAACAATGGCAGGCGCTTCATCTGGGCAGCCATTTTTCTTCTCTGCTTCTCTTGAGATACATAGTTAAAGTAGACACGGCC TCCCACGCGAGTGTGGTGGGACCTTGAGACTTAGGAGGATTGCCTGTTTTCAGTGTCCAGGGAATGACTCCATAGATTTGAATTCTTTTC CGTATGTGGGGATGGTTGCTACTACCTCACCGCCAAGTCCTCCCCCAGCTGTTACCACATGAGGGAATACAAGGTGCTAGGTACCCTCCT TCCTCGTTGGCCACTAAGAGGTCTTAGAAACATAGCCTGTAAATGTGTCTTGTAACTGGCACACTAAAAAAGATCCTAGTTGAGCATCTC TCTTGGTGAGGAAGCGATGTGTGTGCGGTTCAGGAAACTCCTCCAAGAGGAGGAGGAGTCCAAACAGGGATGCCAGAGGAAGCTTTCCGT TTTCCTAGCCAACTTGTGTTCTGGGTTTGAAAAAGACCCACCACAAATGCTTTTTCTATTTTCTGATTTAAAAGTCGCTTTTGAATATGA CCATGAGAAACCAAGAAATGCTGCTTGTGTGGTGCTCTGCTTCCTGAGGATTTGGCTGGAAGGGGATTCTCCGCTGGCACATGGGAGAAG GCCATCTTCTGTGTCGGTGCTGTGATCTGCCTTGTTCTCACTTGCTGAGGATAAGGGCATACACGCTGCTCCTCGCTTTCTTGTTGCCCG ACTTCGTACTAAGCAGCTCAGGAGCAGTCACTCAGACCCAAATGTCTTGACTGTGTTGTTTTTAATCACTGTGACCCTTAAAGTACAGGC CAAGTGTTGTCAAACACCTTGGCTAAAACAGTGGAGGGTGATGGGTAAAGCAGTAGAGGGCCCTCAACCCACACACTGGCTGAAACTGCC ACCAACTGCCACGATGAACCCAACTGCTGTTTATGCCCCCATTTTCCTTTTTTTGTATCTACACCCACACGATTCCCAATGTTGGATATT |
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FusionGenePPI for UBE4B_EIF2S2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBE4B | TP73, VCP, ATXN3, XPC, UBE2D3, UBE4B, CBL, UBE2D2, MDM2, TP53, UBXN1, VAV2, ELAVL1, FEZ1, TP63, UBL7, USP34, NDUFA2, VPS26A, SSSCA1, SRPRB, ZPR1, ATP6V1F, VPS36, AHCYL1, MRPL53, VPS35, UBE2D1, UBQLN1, IGBP1, TTC9C, UBE2C, VPS4B, PSMB1, USP9X, UBXN7, ZFYVE19, UBE2V1, UFM1, SULT1A1, SBDS, ZRANB2, TRIP6, UCHL3, THY1, NDUFA7, UBA6, SF3B4, PPIF, HDLBP, SCO2, SARNP, UBE2L3, VPS29, TTK, CDC27, CDKN2A, NUDCD3, NUSAP1, PDE3A, RBM12, HGS, STAM, TRIP12, FBXW11, RAD23A, BTRC, FOXK1, STUB1, PCID2, TTC4, NTRK1, ESR1, TMEM165, CDC25A, RAD23B, TRIM25 | EIF2S2 | PLEKHM1, CRMP1, KIAA1377, ZBTB16, APLP1, CCDC90B, TLE1, TP53, UNC119, EIF5, PRKDC, H2AFX, DCC, HDGF, CAND1, APP, EIF2S1, PAXIP1, CSNK2A1, CSNK2B, UPF1, MMS19, HMGA1, GCN1L1, RPA3, RPA2, RPA1, SUZ12, RNF2, MAST3, ESR1, KLHL20, MBD5, SERPINB5, HOXB5, ZCCHC7, EIF2S3, PRMT7, CDC123, ETFA, RNF26, CYP1A1, RPS6KB2, DDX56, ATAD3B, CDC5L, ETF1, FBL, MRTO4, MYL9, SUB1, KIF23, NCAPD3, NEMF, NOP56, NOP58, NSA2, RPL15, RPL37A, NTRK1, NCK1, XPO1, COPS7A, EXOSC4, EXOSC1, FAU, UBA52, EIF5A, RPS19, RPS12, RPS10, NPM1, RAN, ATP5C1, VAT1, PA2G4, STIP1, CYLD, TRIM25, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBE4B_EIF2S2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBE4B_EIF2S2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | EIF2S2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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