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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40510

FusionGeneSummary for UBE2Z_TRIM37

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2Z_TRIM37
Fusion gene ID: 40510
HgeneTgene
Gene symbol

UBE2Z

TRIM37

Gene ID

65264

4591

Gene nameubiquitin conjugating enzyme E2 Ztripartite motif containing 37
SynonymsHOYS7|USE1MUL|POB1|TEF3
Cytomap

17q21.32

17q22

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 ZE2 ubiquitin-conjugating enzyme ZUBA6-specific enzyme E2uba6-specific E2 conjugating enzyme 1ubiquitin carrier protein Zubiquitin conjugating enzyme E2Zubiquitin-protein ligase ZE3 ubiquitin-protein ligase TRIM37RING-B-box-coiled-coil proteinRING-type E3 ubiquitin transferase TRIM37mulibrey nanism protein
Modification date2018052720180522
UniProtAcc

Q9H832

O94972

Ensembl transtripts involved in fusion geneENST00000360943, ENST00000393066, 
ENST00000262294, ENST00000376149, 
ENST00000393065, ENST00000584889, 
Fusion gene scores* DoF score8 X 8 X 4=2567 X 6 X 7=294
# samples 107
** MAII scorelog2(10/256*10)=-1.35614381022528
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBE2Z [Title/Abstract] AND TRIM37 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2Z

GO:0043065

positive regulation of apoptotic process

17464193

TgeneTRIM37

GO:0000122

negative regulation of transcription by RNA polymerase II

25470042

TgeneTRIM37

GO:0032088

negative regulation of NF-kappaB transcription factor activity

11279055

TgeneTRIM37

GO:0035518

histone H2A monoubiquitination

25470042

TgeneTRIM37

GO:0036353

histone H2A-K119 monoubiquitination

25470042

TgeneTRIM37

GO:0051091

positive regulation of DNA binding transcription factor activity

23077300

TgeneTRIM37

GO:0051092

positive regulation of NF-kappaB transcription factor activity

23077300

TgeneTRIM37

GO:0051865

protein autoubiquitination

15885686

TgeneTRIM37

GO:0070842

aggresome assembly

15885686


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRCTCGA-BP-4983-01AUBE2Zchr17

46993549

+TRIM37chr17

57089807

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000360943ENST00000393066UBE2Zchr17

46993549

+TRIM37chr17

57089807

-
Frame-shitENST00000360943ENST00000262294UBE2Zchr17

46993549

+TRIM37chr17

57089807

-
Frame-shitENST00000360943ENST00000376149UBE2Zchr17

46993549

+TRIM37chr17

57089807

-
Frame-shitENST00000360943ENST00000393065UBE2Zchr17

46993549

+TRIM37chr17

57089807

-
5CDS-intronENST00000360943ENST00000584889UBE2Zchr17

46993549

+TRIM37chr17

57089807

-

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FusionProtFeatures for UBE2Z_TRIM37


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2Z

Q9H832

TRIM37

O94972

Catalyzes the covalent attachment of ubiquitin to otherproteins (By similarity). Specific substrate for UBA6, not chargedwith ubiquitin by UBE1. May be involved in apoptosis regulation.{ECO:0000255|PROSITE-ProRule:PRU00388,ECO:0000269|PubMed:17464193, ECO:0000269|PubMed:17597759}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2Z_TRIM37


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2Z_TRIM37


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UBE2ZPLEKHF2, LPL, RNF144B, RNF103, MDM2, RNF41, RNF130, RNF150, HLTF, SYVN1, RNF139, LNX2, RNF5, TRAIP, DZIP3, RAPSN, TRIM27, RNF166, TRIM46, UBR1, UBR2, UBR3, PPP1CA, UBA6, UBD, XPO1, WDR12, BAG3, TRIM65, REL, HMBOX1, AK8, MOV10, NXF1, UBA1TRIM37FAM124B, MAGEB18, TCEB3B, APEX2, FXR2, FAM107A, RIBC2, RHPN1, BYSL, ZNF655, DLGAP5, PNKP, PRC1, COPB1, KIAA0408, ZNF417, MCM10, EWSR1, MCRS1, NUDT18, PBK, TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6, TRIM37, TNFRSF1B, LTBR, NGFR, UBE2U, UBE2H, ELAVL1, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E2, UBE2E3, APTX, HSP90AA1, CCDC33, CDK5RAP2, LATS2, ANKRD11, ARNT2, CEP250, DDX6, RPL9, KAT5, FAM50B, RASD1, UBASH3A, KIF9, SCNM1, ZNF329, FAM161A, SSX2IP, CWF19L2, ZMAT2, CDC20B, C17orf59, CEP192, KIAA0753, CCDC14, RPGRIP1L, CNTROB, SPICE1, CEP128, CEP63, CEP89, RPGRIP1, XPO1, HIST2H2AC, EZH2, SUZ12, BMI1, HIST3H3, ZNF816, ZNF610, ZNF550, NCAPH2, ZNF263, ZNF211, ZNF214, CDC16, TPTE2, ZNF416, BBS7, CTNNB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2Z_TRIM37


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2Z_TRIM37


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTRIM37C0524582Mulibrey Nanism4CTD_human;ORPHANET;UNIPROT
TgeneTRIM37C0016063Osteitis Fibrosa Disseminata1CTD_human
TgeneTRIM37C0019209Hepatomegaly1CTD_human;HPO
TgeneTRIM37C0376634Craniofacial Abnormalities1CTD_human