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Fusion gene ID: 40510 |
FusionGeneSummary for UBE2Z_TRIM37 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBE2Z_TRIM37 | Fusion gene ID: 40510 | Hgene | Tgene | Gene symbol | UBE2Z | TRIM37 | Gene ID | 65264 | 4591 |
| Gene name | ubiquitin conjugating enzyme E2 Z | tripartite motif containing 37 | |
| Synonyms | HOYS7|USE1 | MUL|POB1|TEF3 | |
| Cytomap | 17q21.32 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-conjugating enzyme E2 ZE2 ubiquitin-conjugating enzyme ZUBA6-specific enzyme E2uba6-specific E2 conjugating enzyme 1ubiquitin carrier protein Zubiquitin conjugating enzyme E2Zubiquitin-protein ligase Z | E3 ubiquitin-protein ligase TRIM37RING-B-box-coiled-coil proteinRING-type E3 ubiquitin transferase TRIM37mulibrey nanism protein | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | Q9H832 | O94972 | |
| Ensembl transtripts involved in fusion gene | ENST00000360943, | ENST00000393066, ENST00000262294, ENST00000376149, ENST00000393065, ENST00000584889, | |
| Fusion gene scores | * DoF score | 8 X 8 X 4=256 | 7 X 6 X 7=294 |
| # samples | 10 | 7 | |
| ** MAII score | log2(10/256*10)=-1.35614381022528 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBE2Z [Title/Abstract] AND TRIM37 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBE2Z | GO:0043065 | positive regulation of apoptotic process | 17464193 |
| Tgene | TRIM37 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 25470042 |
| Tgene | TRIM37 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 11279055 |
| Tgene | TRIM37 | GO:0035518 | histone H2A monoubiquitination | 25470042 |
| Tgene | TRIM37 | GO:0036353 | histone H2A-K119 monoubiquitination | 25470042 |
| Tgene | TRIM37 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 23077300 |
| Tgene | TRIM37 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 23077300 |
| Tgene | TRIM37 | GO:0051865 | protein autoubiquitination | 15885686 |
| Tgene | TRIM37 | GO:0070842 | aggresome assembly | 15885686 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-BP-4983-01A | UBE2Z | chr17 | 46993549 | + | TRIM37 | chr17 | 57089807 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000360943 | ENST00000393066 | UBE2Z | chr17 | 46993549 | + | TRIM37 | chr17 | 57089807 | - |
| Frame-shift | ENST00000360943 | ENST00000262294 | UBE2Z | chr17 | 46993549 | + | TRIM37 | chr17 | 57089807 | - |
| Frame-shift | ENST00000360943 | ENST00000376149 | UBE2Z | chr17 | 46993549 | + | TRIM37 | chr17 | 57089807 | - |
| Frame-shift | ENST00000360943 | ENST00000393065 | UBE2Z | chr17 | 46993549 | + | TRIM37 | chr17 | 57089807 | - |
| 5CDS-intron | ENST00000360943 | ENST00000584889 | UBE2Z | chr17 | 46993549 | + | TRIM37 | chr17 | 57089807 | - |
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FusionProtFeatures for UBE2Z_TRIM37 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBE2Z | TRIM37 |
| Catalyzes the covalent attachment of ubiquitin to otherproteins (By similarity). Specific substrate for UBA6, not chargedwith ubiquitin by UBE1. May be involved in apoptosis regulation.{ECO:0000255|PROSITE-ProRule:PRU00388,ECO:0000269|PubMed:17464193, ECO:0000269|PubMed:17597759}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBE2Z_TRIM37 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UBE2Z_TRIM37 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBE2Z | PLEKHF2, LPL, RNF144B, RNF103, MDM2, RNF41, RNF130, RNF150, HLTF, SYVN1, RNF139, LNX2, RNF5, TRAIP, DZIP3, RAPSN, TRIM27, RNF166, TRIM46, UBR1, UBR2, UBR3, PPP1CA, UBA6, UBD, XPO1, WDR12, BAG3, TRIM65, REL, HMBOX1, AK8, MOV10, NXF1, UBA1 | TRIM37 | FAM124B, MAGEB18, TCEB3B, APEX2, FXR2, FAM107A, RIBC2, RHPN1, BYSL, ZNF655, DLGAP5, PNKP, PRC1, COPB1, KIAA0408, ZNF417, MCM10, EWSR1, MCRS1, NUDT18, PBK, TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6, TRIM37, TNFRSF1B, LTBR, NGFR, UBE2U, UBE2H, ELAVL1, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E2, UBE2E3, APTX, HSP90AA1, CCDC33, CDK5RAP2, LATS2, ANKRD11, ARNT2, CEP250, DDX6, RPL9, KAT5, FAM50B, RASD1, UBASH3A, KIF9, SCNM1, ZNF329, FAM161A, SSX2IP, CWF19L2, ZMAT2, CDC20B, C17orf59, CEP192, KIAA0753, CCDC14, RPGRIP1L, CNTROB, SPICE1, CEP128, CEP63, CEP89, RPGRIP1, XPO1, HIST2H2AC, EZH2, SUZ12, BMI1, HIST3H3, ZNF816, ZNF610, ZNF550, NCAPH2, ZNF263, ZNF211, ZNF214, CDC16, TPTE2, ZNF416, BBS7, CTNNB1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBE2Z_TRIM37 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBE2Z_TRIM37 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TRIM37 | C0524582 | Mulibrey Nanism | 4 | CTD_human;ORPHANET;UNIPROT |
| Tgene | TRIM37 | C0016063 | Osteitis Fibrosa Disseminata | 1 | CTD_human |
| Tgene | TRIM37 | C0019209 | Hepatomegaly | 1 | CTD_human;HPO |
| Tgene | TRIM37 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
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