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Fusion gene ID: 40510 |
FusionGeneSummary for UBE2Z_TRIM37 |
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Fusion gene information | Fusion gene name: UBE2Z_TRIM37 | Fusion gene ID: 40510 | Hgene | Tgene | Gene symbol | UBE2Z | TRIM37 | Gene ID | 65264 | 4591 |
Gene name | ubiquitin conjugating enzyme E2 Z | tripartite motif containing 37 | |
Synonyms | HOYS7|USE1 | MUL|POB1|TEF3 | |
Cytomap | 17q21.32 | 17q22 | |
Type of gene | protein-coding | protein-coding | |
Description | ubiquitin-conjugating enzyme E2 ZE2 ubiquitin-conjugating enzyme ZUBA6-specific enzyme E2uba6-specific E2 conjugating enzyme 1ubiquitin carrier protein Zubiquitin conjugating enzyme E2Zubiquitin-protein ligase Z | E3 ubiquitin-protein ligase TRIM37RING-B-box-coiled-coil proteinRING-type E3 ubiquitin transferase TRIM37mulibrey nanism protein | |
Modification date | 20180527 | 20180522 | |
UniProtAcc | Q9H832 | O94972 | |
Ensembl transtripts involved in fusion gene | ENST00000360943, | ENST00000393066, ENST00000262294, ENST00000376149, ENST00000393065, ENST00000584889, | |
Fusion gene scores | * DoF score | 8 X 8 X 4=256 | 7 X 6 X 7=294 |
# samples | 10 | 7 | |
** MAII score | log2(10/256*10)=-1.35614381022528 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: UBE2Z [Title/Abstract] AND TRIM37 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | UBE2Z | GO:0043065 | positive regulation of apoptotic process | 17464193 |
Tgene | TRIM37 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 25470042 |
Tgene | TRIM37 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 11279055 |
Tgene | TRIM37 | GO:0035518 | histone H2A monoubiquitination | 25470042 |
Tgene | TRIM37 | GO:0036353 | histone H2A-K119 monoubiquitination | 25470042 |
Tgene | TRIM37 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 23077300 |
Tgene | TRIM37 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 23077300 |
Tgene | TRIM37 | GO:0051865 | protein autoubiquitination | 15885686 |
Tgene | TRIM37 | GO:0070842 | aggresome assembly | 15885686 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | KIRC | TCGA-BP-4983-01A | UBE2Z | chr17 | 46993549 | + | TRIM37 | chr17 | 57089807 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000360943 | ENST00000393066 | UBE2Z | chr17 | 46993549 | + | TRIM37 | chr17 | 57089807 | - |
Frame-shift | ENST00000360943 | ENST00000262294 | UBE2Z | chr17 | 46993549 | + | TRIM37 | chr17 | 57089807 | - |
Frame-shift | ENST00000360943 | ENST00000376149 | UBE2Z | chr17 | 46993549 | + | TRIM37 | chr17 | 57089807 | - |
Frame-shift | ENST00000360943 | ENST00000393065 | UBE2Z | chr17 | 46993549 | + | TRIM37 | chr17 | 57089807 | - |
5CDS-intron | ENST00000360943 | ENST00000584889 | UBE2Z | chr17 | 46993549 | + | TRIM37 | chr17 | 57089807 | - |
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FusionProtFeatures for UBE2Z_TRIM37 |
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Hgene | Tgene |
UBE2Z | TRIM37 |
Catalyzes the covalent attachment of ubiquitin to otherproteins (By similarity). Specific substrate for UBA6, not chargedwith ubiquitin by UBE1. May be involved in apoptosis regulation.{ECO:0000255|PROSITE-ProRule:PRU00388,ECO:0000269|PubMed:17464193, ECO:0000269|PubMed:17597759}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBE2Z_TRIM37 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UBE2Z_TRIM37 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
UBE2Z | PLEKHF2, LPL, RNF144B, RNF103, MDM2, RNF41, RNF130, RNF150, HLTF, SYVN1, RNF139, LNX2, RNF5, TRAIP, DZIP3, RAPSN, TRIM27, RNF166, TRIM46, UBR1, UBR2, UBR3, PPP1CA, UBA6, UBD, XPO1, WDR12, BAG3, TRIM65, REL, HMBOX1, AK8, MOV10, NXF1, UBA1 | TRIM37 | FAM124B, MAGEB18, TCEB3B, APEX2, FXR2, FAM107A, RIBC2, RHPN1, BYSL, ZNF655, DLGAP5, PNKP, PRC1, COPB1, KIAA0408, ZNF417, MCM10, EWSR1, MCRS1, NUDT18, PBK, TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6, TRIM37, TNFRSF1B, LTBR, NGFR, UBE2U, UBE2H, ELAVL1, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E2, UBE2E3, APTX, HSP90AA1, CCDC33, CDK5RAP2, LATS2, ANKRD11, ARNT2, CEP250, DDX6, RPL9, KAT5, FAM50B, RASD1, UBASH3A, KIF9, SCNM1, ZNF329, FAM161A, SSX2IP, CWF19L2, ZMAT2, CDC20B, C17orf59, CEP192, KIAA0753, CCDC14, RPGRIP1L, CNTROB, SPICE1, CEP128, CEP63, CEP89, RPGRIP1, XPO1, HIST2H2AC, EZH2, SUZ12, BMI1, HIST3H3, ZNF816, ZNF610, ZNF550, NCAPH2, ZNF263, ZNF211, ZNF214, CDC16, TPTE2, ZNF416, BBS7, CTNNB1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBE2Z_TRIM37 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBE2Z_TRIM37 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TRIM37 | C0524582 | Mulibrey Nanism | 4 | CTD_human;ORPHANET;UNIPROT |
Tgene | TRIM37 | C0016063 | Osteitis Fibrosa Disseminata | 1 | CTD_human |
Tgene | TRIM37 | C0019209 | Hepatomegaly | 1 | CTD_human;HPO |
Tgene | TRIM37 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |