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Fusion gene ID: 40488 |
FusionGeneSummary for UBE2R2_NFX1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBE2R2_NFX1 | Fusion gene ID: 40488 | Hgene | Tgene | Gene symbol | UBE2R2 | NFX1 | Gene ID | 54926 | 4799 |
| Gene name | ubiquitin conjugating enzyme E2 R2 | nuclear transcription factor, X-box binding 1 | |
| Synonyms | CDC34B|E2-CDC34B|UBC3B | NFX2|TEG-42|Tex42 | |
| Cytomap | 9p13.3 | 9p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-conjugating enzyme E2 R2E2 ubiquitin-conjugating enzyme R2ubiquitin carrier protein R2ubiquitin conjugating enzyme E2R 2ubiquitin-conjugating enzyme E2-CDC34Bubiquitin-conjugating enzyme UBC3Bubiquitin-protein ligase R2 | transcriptional repressor NF-X1nuclear transcription factor, X box-binding protein 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q712K3 | Q12986 | |
| Ensembl transtripts involved in fusion gene | ENST00000263228, | ENST00000379540, ENST00000379521, ENST00000318524, ENST00000463421, | |
| Fusion gene scores | * DoF score | 9 X 5 X 6=270 | 9 X 8 X 5=360 |
| # samples | 9 | 9 | |
| ** MAII score | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/360*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBE2R2 [Title/Abstract] AND NFX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBE2R2 | GO:0006513 | protein monoubiquitination | 20061386 |
| Hgene | UBE2R2 | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
| Tgene | NFX1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 7964459 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-56-7580-01A | UBE2R2 | chr9 | 33817932 | + | NFX1 | chr9 | 33366627 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000263228 | ENST00000379540 | UBE2R2 | chr9 | 33817932 | + | NFX1 | chr9 | 33366627 | + |
| 5CDS-intron | ENST00000263228 | ENST00000379521 | UBE2R2 | chr9 | 33817932 | + | NFX1 | chr9 | 33366627 | + |
| 5CDS-intron | ENST00000263228 | ENST00000318524 | UBE2R2 | chr9 | 33817932 | + | NFX1 | chr9 | 33366627 | + |
| 5CDS-3UTR | ENST00000263228 | ENST00000463421 | UBE2R2 | chr9 | 33817932 | + | NFX1 | chr9 | 33366627 | + |
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FusionProtFeatures for UBE2R2_NFX1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBE2R2 | NFX1 |
| Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzesmonoubiquitination and 'Lys-48'-linked polyubiquitination. May beinvolved in degradation of katenin. {ECO:0000269|PubMed:12037680,ECO:0000269|PubMed:20061386}. | Binds to the X-box motif of MHC class II genes andrepresses their expression. May play an important role inregulating the duration of an inflammatory response by limitingthe period in which MHC class II molecules are induced byinterferon-gamma. Isoform 3 binds to the X-box motif of TERTpromoter and represses its expression. Together with PABPC1 orPABPC4, isoform 1 acts as a coactivator for TERT expression.Mediates E2-dependent ubiquitination.{ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341,ECO:0000269|PubMed:17267499}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000318524 | + | 0 | 16 | 1084_1089 | -10 | 834 | Compositional bias | Note=Poly-Pro |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379521 | + | 0 | 21 | 1084_1089 | -21 | 1025 | Compositional bias | Note=Poly-Pro |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379540 | + | 20 | 24 | 1084_1089 | 1013 | 1121 | Compositional bias | Note=Poly-Pro |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000318524 | + | 0 | 16 | 994_1062 | -10 | 834 | Domain | R3H |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379521 | + | 0 | 21 | 994_1062 | -21 | 1025 | Domain | R3H |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000318524 | + | 0 | 16 | 358_409 | -10 | 834 | Zinc finger | RING-type%3B atypical |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000318524 | + | 0 | 16 | 453_471 | -10 | 834 | Zinc finger | Note=NF-X1-type 1 |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000318524 | + | 0 | 16 | 506_525 | -10 | 834 | Zinc finger | Note=NF-X1-type 2 |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000318524 | + | 0 | 16 | 567_586 | -10 | 834 | Zinc finger | Note=NF-X1-type 3 |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000318524 | + | 0 | 16 | 632_655 | -10 | 834 | Zinc finger | Note=NF-X1-type 4 |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000318524 | + | 0 | 16 | 694_713 | -10 | 834 | Zinc finger | Note=NF-X1-type 5 |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000318524 | + | 0 | 16 | 721_740 | -10 | 834 | Zinc finger | Note=NF-X1-type 6 |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000318524 | + | 0 | 16 | 832_854 | -10 | 834 | Zinc finger | Note=NF-X1-type 7 |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000318524 | + | 0 | 16 | 863_884 | -10 | 834 | Zinc finger | Note=NF-X1-type 8 |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379521 | + | 0 | 21 | 358_409 | -21 | 1025 | Zinc finger | RING-type%3B atypical |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379521 | + | 0 | 21 | 453_471 | -21 | 1025 | Zinc finger | Note=NF-X1-type 1 |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379521 | + | 0 | 21 | 506_525 | -21 | 1025 | Zinc finger | Note=NF-X1-type 2 |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379521 | + | 0 | 21 | 567_586 | -21 | 1025 | Zinc finger | Note=NF-X1-type 3 |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379521 | + | 0 | 21 | 632_655 | -21 | 1025 | Zinc finger | Note=NF-X1-type 4 |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379521 | + | 0 | 21 | 694_713 | -21 | 1025 | Zinc finger | Note=NF-X1-type 5 |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379521 | + | 0 | 21 | 721_740 | -21 | 1025 | Zinc finger | Note=NF-X1-type 6 |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379521 | + | 0 | 21 | 832_854 | -21 | 1025 | Zinc finger | Note=NF-X1-type 7 |
| Tgene | >NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379521 | + | 0 | 21 | 863_884 | -21 | 1025 | Zinc finger | Note=NF-X1-type 8 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >UBE2R2 | chr9:33817932 | chr9:33366627 | ENST00000263228 | + | 1 | 5 | 200_238 | 59 | 239 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Tgene | NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379540 | + | 20 | 24 | 994_1062 | 1013 | 1121 | Domain | R3H |
| Tgene | NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379540 | + | 20 | 24 | 358_409 | 1013 | 1121 | Zinc finger | RING-type%3B atypical |
| Tgene | NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379540 | + | 20 | 24 | 453_471 | 1013 | 1121 | Zinc finger | Note=NF-X1-type 1 |
| Tgene | NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379540 | + | 20 | 24 | 506_525 | 1013 | 1121 | Zinc finger | Note=NF-X1-type 2 |
| Tgene | NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379540 | + | 20 | 24 | 567_586 | 1013 | 1121 | Zinc finger | Note=NF-X1-type 3 |
| Tgene | NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379540 | + | 20 | 24 | 632_655 | 1013 | 1121 | Zinc finger | Note=NF-X1-type 4 |
| Tgene | NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379540 | + | 20 | 24 | 694_713 | 1013 | 1121 | Zinc finger | Note=NF-X1-type 5 |
| Tgene | NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379540 | + | 20 | 24 | 721_740 | 1013 | 1121 | Zinc finger | Note=NF-X1-type 6 |
| Tgene | NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379540 | + | 20 | 24 | 832_854 | 1013 | 1121 | Zinc finger | Note=NF-X1-type 7 |
| Tgene | NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379540 | + | 20 | 24 | 863_884 | 1013 | 1121 | Zinc finger | Note=NF-X1-type 8 |
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FusionGeneSequence for UBE2R2_NFX1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_UBE2R2_ENST00000263228_chr9_33817932_+_NFX1_ENST00000379540_chr9_33366627_+_167aa MAQQQMTSSQKALMLELKSLQEEPVEGFRITLVDESDLYNWEVAIFGPPNTLYEGGYFKGKNSKKSHSFPPMNRDHRRIIHDLAQVYGLE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_UBE2R2_ENST00000263228_chr9_33817932_+_NFX1_ENST00000379540_chr9_33366627_+_501nt ATGGCCCAGCAGCAGATGACCAGCTCGCAGAAGGCCCTGATGCTCGAGCTGAAATCCCTGCAGGAGGAACCGGTGGAGGGCTTCCGGATC ACCCTGGTGGACGAGTCCGACCTCTACAACTGGGAGGTGGCCATCTTCGGACCCCCCAACACCCTCTACGAAGGCGGCTACTTCAAGGGA AAGAATAGTAAGAAAAGCCACAGCTTCCCTCCCATGAACAGAGACCACCGCCGGATCATCCATGACTTGGCCCAAGTTTATGGCCTGGAG AGCGTGAGCTATGACAGTGAACCGAAGCGCAATGTGGTGGTCACTGCCATCAGGGGGAAGTCCGTTTGTCCTCCTACCACGCTGACAGGT GTGCTTGAAAGGGAAATGCAGGCACGGCCTCCACCACCGATTCCTCATCACAGACATCAGTCAGACAAGAATCCTGGGAGCAGTAATTTA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_UBE2R2_ENST00000263228_chr9_33817932_+_NFX1_ENST00000379540_chr9_33366627_+_1871nt TCGTGTGTGAGGAGGACCCCGGGCGGGCCCACGGGCCGTGTGGGGCCTGGTCTGGCCCGCCGGGTGTGTGAAGACCGGGGCCCGGTGCTG CCCGGCCGGAGGGCGAGCGGAGGGGAGGGGCCTGGTCCGGCCCGGCCGGTGCGTGAGGACTGGGGCCCGGGCCCGGCGCCGCCGCCGCCG CCGCCGCCGCGATGGCCCAGCAGCAGATGACCAGCTCGCAGAAGGCCCTGATGCTCGAGCTGAAATCCCTGCAGGAGGAACCGGTGGAGG GCTTCCGGATCACCCTGGTGGACGAGTCCGACCTCTACAACTGGGAGGTGGCCATCTTCGGACCCCCCAACACCCTCTACGAAGGCGGCT ACTTCAAGGGAAAGAATAGTAAGAAAAGCCACAGCTTCCCTCCCATGAACAGAGACCACCGCCGGATCATCCATGACTTGGCCCAAGTTT ATGGCCTGGAGAGCGTGAGCTATGACAGTGAACCGAAGCGCAATGTGGTGGTCACTGCCATCAGGGGGAAGTCCGTTTGTCCTCCTACCA CGCTGACAGGTGTGCTTGAAAGGGAAATGCAGGCACGGCCTCCACCACCGATTCCTCATCACAGACATCAGTCAGACAAGAATCCTGGGA GCAGTAATTTACAGAAAATAACCAAGGAGCCAATAATTGACTATTTTGACGTCCAGGACTAAGAAGATCATGATGCACTTAGATAAAAGA ATGATTAGGTATAGTGGAGACTTATTTGCCAGCAGATAAATCATGCCCGTTCCCCTCTGCCTGGCAGAATCACAGTCTCACATACTGTCT TGTACTGACACATCCAAAGCATGAGTGTGTCAGAAATCCCTTGTCTATTCCTGTCTGTATAAAGTGTTTCATTATGACCAGATCTCTGAT TGTATGGTCACTAGGTATGCAATCACGCATTCAAAGAGGCTCTTTACACCATCACTGTGATTGCTCTGAGAGTTGAGGGACTATTGGGCT TTATTTGGACAAACCAAACTTTTAGCCTGAAACCAACTTTATGCCACTAAGTCATAGCCTCAGTTGTCCCAGTTATTTGTCCTCCTGAAA ATGCCTGAAACATCAGACAGACATTGCTTGCTTTACCCAAACTGATCAAAATCTTTAGGAGCACAAATGAATTTTTTAGTCTGAAATACC AAATAATGAATTGGTATACCATATCCGGAATCACACATGTTATCTTAAACCCAGCCATCATACCTAAGTCTTTTGCCAAAACCTCTCATA GGTATATCTAGCTGAACTTATTTTGGCATTTTCAATGTGATCAGTTCTAGACCTAGAAGGGGGTCAGGCTGCTTTACAGAATTCTATTTC CTTAAGTCCCTGGCACTTCTCATACCACATCACTGAACCTGTTCAGTAACAATCAGTTTGGCCGTCCCCCATGATGGTAGGAAATATAGA GAGCAAGTTCTTCTGCCAGGGTCACACTGTGGTCTCTGAACTGACCAGTATATCCCTAACTCCTCTTTGATAGAGAAAGAGTCTCAAATG GACAACTGTCCTGTGTTGCTTTCCCTAGGCCTTCAGCAGCCTATTGGCTCTCCCTGCCTCTGAGCTCTGGACTCTGTTTGAATATTCCAA GTAGTATATGGACAGTCCAGGGCTTATGCCCAGCAGCCCACTGGAGGCATTCTTCAGGCTCCTTTAAGGCAGGTGCATTGATAGTTCCAT TAGTGTGACCCTTGCATTGGCACCCCTCCAGCCTGGAGGCCAGGCTTCCAGCAACTTCCTTCTGCCCTAGAGCAAGCCATGAGCCCCAGA |
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FusionGenePPI for UBE2R2_NFX1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBE2R2 | BTRC, RNF113B, ARIH2, CBLC, DTX3L, DZIP3, INF2, PNPLA2, ARHGDIA, FBXW5, RBX1, C9orf78, NUBP2, RAD23A, SFN, DRG2, EZR, GNPDA1, PAK2, UBR7, WDR4, YWHAE, YWHAG, YWHAH, UBC, UBA1, UBE2R2, MEOX1, APPBP2, FBXW11, UBE2D2, KRAS, CTNNB1, TCEANC2, IRF9, BATF3, MUL1, SIRT7 | NFX1 | UBE2N, MAML3, SIN3A, USP9X, PABPC1, EEF1A2, MATR3, PABPC3, HSPA1A, HNRNPM, HNRNPU, RPL13, SRSF4, HIST1H2AE, RPL7A, FAM208B, LARP1, DDX5, DMD, NCL, RPL13A, RPL17, RPL22, RPL3, RPL6, HNRNPA2B1, HNRNPH1, RPS19, RPS3A, SRSF3, APC2, YBX1, HIST1H4E, HECW2, SHMT2, MOV10, NXF1, BMI1, XPO1, FAM46A, APBA3, ZNF263, UBC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | NFX1 | chr9:33817932 | chr9:33366627 | ENST00000318524 | + | 0 | 16 | 9_26 | -10 | 834 | PABPC1 and PABC4 |
| Tgene | NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379521 | + | 0 | 21 | 9_26 | -21 | 1025 | PABPC1 and PABC4 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | NFX1 | chr9:33817932 | chr9:33366627 | ENST00000379540 | + | 20 | 24 | 9_26 | 1013 | 1121 | PABPC1 and PABC4 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBE2R2_NFX1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBE2R2_NFX1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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