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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4048

FusionGeneSummary for BCL6_RHOH

check button Fusion gene summary
Fusion gene informationFusion gene name: BCL6_RHOH
Fusion gene ID: 4048
HgeneTgene
Gene symbol

BCL6

RHOH

Gene ID

604

399

Gene nameB cell CLL/lymphoma 6ras homolog family member H
SynonymsBCL5|BCL6A|LAZ3|ZBTB27|ZNF51ARHH|TTF
Cytomap

3q27.3

4p14

Type of geneprotein-codingprotein-coding
DescriptionB-cell lymphoma 6 proteinB-cell lymphoma 5 proteinB-cell lymphoma 6 protein transcriptBCL-5BCL-6cys-his2 zinc finger transcription factorlymphoma-associated zinc finger gene on chromosome 3protein LAZ-3zinc finger and BTB domain-containing proteinrho-related GTP-binding protein RhoHGTP-binding protein TTFTTF, translocation three fourras homolog gene family, member H
Modification date2018052720180523
UniProtAcc

P41182

Q15669

Ensembl transtripts involved in fusion geneENST00000406870, ENST00000232014, 
ENST00000450123, ENST00000496823, 
ENST00000505618, ENST00000381799, 
ENST00000514143, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 2=8
# samples 42
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: BCL6 [Title/Abstract] AND RHOH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBCL6

GO:0000122

negative regulation of transcription by RNA polymerase II

11929873|15577913

HgeneBCL6

GO:0006974

cellular response to DNA damage stimulus

15577913

HgeneBCL6

GO:0030308

negative regulation of cell growth

10490843

HgeneBCL6

GO:0043065

positive regulation of apoptotic process

10490843

TgeneRHOH

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

11809807


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDDLBCTCGA-G8-6906-01ABCL6chr3

187463198

-RHOHchr4

40244334

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000406870ENST00000505618BCL6chr3

187463198

-RHOHchr4

40244334

+
5UTR-5UTRENST00000406870ENST00000381799BCL6chr3

187463198

-RHOHchr4

40244334

+
5UTR-intronENST00000406870ENST00000514143BCL6chr3

187463198

-RHOHchr4

40244334

+
intron-5UTRENST00000232014ENST00000505618BCL6chr3

187463198

-RHOHchr4

40244334

+
intron-5UTRENST00000232014ENST00000381799BCL6chr3

187463198

-RHOHchr4

40244334

+
intron-intronENST00000232014ENST00000514143BCL6chr3

187463198

-RHOHchr4

40244334

+
intron-5UTRENST00000450123ENST00000505618BCL6chr3

187463198

-RHOHchr4

40244334

+
intron-5UTRENST00000450123ENST00000381799BCL6chr3

187463198

-RHOHchr4

40244334

+
intron-intronENST00000450123ENST00000514143BCL6chr3

187463198

-RHOHchr4

40244334

+
5UTR-5UTRENST00000496823ENST00000505618BCL6chr3

187463198

-RHOHchr4

40244334

+
5UTR-5UTRENST00000496823ENST00000381799BCL6chr3

187463198

-RHOHchr4

40244334

+
5UTR-intronENST00000496823ENST00000514143BCL6chr3

187463198

-RHOHchr4

40244334

+

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FusionProtFeatures for BCL6_RHOH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCL6

P41182

RHOH

Q15669

Transcriptional repressor mainly required for germinalcenter (GC) formation and antibody affinity maturation which hasdifferent mechanisms of action specific to the lineage andbiological functions. Forms complexes with different corepressorsand histone deacetylases to repress the transcriptional expressionof different subsets of target genes. Represses its target genesby binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptionalactivity of transcription factors. In GC B-cells, represses genesthat function in differentiation, inflammation, apoptosis and cellcycle control, also autoregulates its transcriptional expressionand up-regulates, indirectly, the expression of some genesimportant for GC reactions, such as AICDA, through the repressionof microRNAs expression, like miR155. An important function is toallow GC B-cells to proliferate very rapidly in response to T-celldependent antigens and tolerate the physiological DNA breaksrequired for immunglobulin class switch recombination and somatichypermutation without inducing a p53/TP53-dependent apoptoticresponse. In follicular helper CD4(+) T-cells (T(FH) cells),promotes the expression of T(FH)-related genes but inhibits thedifferentiation of T(H)1, T(H)2 and T(H)17 cells. Also requiredfor the establishment and maintenance of immunological memory forboth T- and B-cells. Suppresses macrophage proliferation throughcompetition with STAT5 for STAT-binding motifs binding on certaintarget genes, such as CCL2 and CCND2. In response to genotoxicstress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controlsneurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets,such as HES5, including the recruitment of the deacetylase SIRT1and resulting in an epigenetic silencing leading to neuronaldifferentiation. {ECO:0000269|PubMed:10981963,ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651,ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082,ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238,ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045,ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614,ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289,ECO:0000269|PubMed:9649500}. Negative regulator of hematopoietic progenitor cellproliferation, survival and migration. Critical regulator ofthymocyte development and T-cell antigen receptor (TCR) signalingby mediating recruitment and activation of ZAP70. Required forphosphorylation of CD3Z, membrane translocation of ZAP70 andsubsequent activation of the ZAP70-mediated pathways. Essentialfor efficient beta-selection and positive selection by promotingthe ZAP70-dependent phosphorylation of the LAT signalosome duringpre-TCR and TCR signaling. Crucial for thymocyte maturation duringDN3 to DN4 transition and during positive selection. Playscritical roles in mast cell function by facilitatingphosphorylation of SYK in Fc epsilon RI-mediated signaltransduction. Essential for the phosphorylation of LAT, LCP2,PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (Bysimilarity). Binds GTP but lacks intrinsic GTPase activity and isresistant to Rho-specific GTPase-activating proteins. Inhibits theactivation of NF-kappa-B by TNF and IKKB and the activation ofCRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42.Negatively regulates leukotriene production in neutrophils.{ECO:0000250, ECO:0000269|PubMed:11809807,ECO:0000269|PubMed:19414807}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BCL6_RHOH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BCL6_RHOH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BCL6HDAC5, HDAC4, HDAC7, BCOR, NCOR2, NCOR1, HDAC1, IRF4, SIN3A, JUN, JUND, JUNB, ZBTB7A, PML, ZBTB16, BACH2, SPI1, BCL6B, EP300, HDAC2, MTA3, MBD3, CHD3, CREBBP, EBF1, HDAC9, PPARGC1A, HNF1A, YY1, E2F3, BCL11A, ATF7, POU2F3, SMARCA4, HELZ2, KDM2A, KMT2B, TRAF3IP3, ZNF443, ZMYND8, SAE1, DDX6, ERCC5, PARP12, LSM1, OSBPL1A, MAPK8IP3, MED23, WNT16, TNFRSF8, ARNT2, LPAR2, EPHB6, NKRF, SMO, LPAR4, PRKD3, PIKFYVE, EIF2AK3, DROSHA, EHMT1, IDI2, TRIB3, SPTLC2, PCDH9, PANX3, CSMD1, ARHGAP35, PPAP2B, SENP7, EIF4ENIF1, CACNA1A, WNK4, DNAH9, KIF13B, HSF4, WDR35, UTP6, OLA1, FBXO11, CDK19, CDK8, MED6, MED17, FOXM1, PIN1, HBEGF, HSP90AA1, NACC1, BCL6, PATZ1, RUNX1T1, CTBP1, RAF1, CUL3, PELI1, AES, KIFC3, SIAH1, TRAF1, BLZF1, ZBTB7B, CUTC, LIMS3, TP53, TWIST1, CTNNB1, IL32, PRKCE, ZBTB17, USP7, HDAC3, CARKDRHOHLRIF1, UTP14A, ARHGDIA, ARHGDIB, ARHGDIG


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BCL6_RHOH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BCL6_RHOH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBCL6C0024305Lymphoma, Non-Hodgkin1CTD_human
HgeneBCL6C0079772T-Cell Lymphoma1CTD_human