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Fusion gene ID: 40466 |
FusionGeneSummary for UBE2O_MXRA7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBE2O_MXRA7 | Fusion gene ID: 40466 | Hgene | Tgene | Gene symbol | UBE2O | MXRA7 | Gene ID | 63893 | 439921 |
| Gene name | ubiquitin conjugating enzyme E2 O | matrix remodeling associated 7 | |
| Synonyms | E2-230K | - | |
| Cytomap | 17q25.1 | 17q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | (E3-independent) E2 ubiquitin-conjugating enzymeE2/E3 hybrid ubiquitin-protein ligase UBE2Oubiquitin carrier protein Oubiquitin conjugating enzyme E2Oubiquitin-conjugating enzyme E2 of 230 kDaubiquitin-conjugating enzyme E2-230Kubiquitin-protein lig | matrix-remodeling-associated protein 7matrix-remodelling associated 7 | |
| Modification date | 20180523 | 20180529 | |
| UniProtAcc | Q9C0C9 | P84157 | |
| Ensembl transtripts involved in fusion gene | ENST00000319380, ENST00000587581, | ENST00000355797, ENST00000375036, ENST00000449428, ENST00000592148, ENST00000585519, ENST00000588114, ENST00000589082, | |
| Fusion gene scores | * DoF score | 6 X 2 X 6=72 | 5 X 4 X 4=80 |
| # samples | 7 | 7 | |
| ** MAII score | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/80*10)=-0.192645077942396 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBE2O [Title/Abstract] AND MXRA7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBE2O | GO:0006513 | protein monoubiquitination | 23455153|24703950 |
| Hgene | UBE2O | GO:0030513 | positive regulation of BMP signaling pathway | 23455153 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-C5-A7X5-01A | UBE2O | chr17 | 74448807 | - | MXRA7 | chr17 | 74684258 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000319380 | ENST00000355797 | UBE2O | chr17 | 74448807 | - | MXRA7 | chr17 | 74684258 | - |
| In-frame | ENST00000319380 | ENST00000375036 | UBE2O | chr17 | 74448807 | - | MXRA7 | chr17 | 74684258 | - |
| In-frame | ENST00000319380 | ENST00000449428 | UBE2O | chr17 | 74448807 | - | MXRA7 | chr17 | 74684258 | - |
| In-frame | ENST00000319380 | ENST00000592148 | UBE2O | chr17 | 74448807 | - | MXRA7 | chr17 | 74684258 | - |
| 5CDS-5UTR | ENST00000319380 | ENST00000585519 | UBE2O | chr17 | 74448807 | - | MXRA7 | chr17 | 74684258 | - |
| 5CDS-5UTR | ENST00000319380 | ENST00000588114 | UBE2O | chr17 | 74448807 | - | MXRA7 | chr17 | 74684258 | - |
| 5CDS-5UTR | ENST00000319380 | ENST00000589082 | UBE2O | chr17 | 74448807 | - | MXRA7 | chr17 | 74684258 | - |
| intron-3CDS | ENST00000587581 | ENST00000355797 | UBE2O | chr17 | 74448807 | - | MXRA7 | chr17 | 74684258 | - |
| intron-3CDS | ENST00000587581 | ENST00000375036 | UBE2O | chr17 | 74448807 | - | MXRA7 | chr17 | 74684258 | - |
| intron-3CDS | ENST00000587581 | ENST00000449428 | UBE2O | chr17 | 74448807 | - | MXRA7 | chr17 | 74684258 | - |
| intron-3CDS | ENST00000587581 | ENST00000592148 | UBE2O | chr17 | 74448807 | - | MXRA7 | chr17 | 74684258 | - |
| intron-5UTR | ENST00000587581 | ENST00000585519 | UBE2O | chr17 | 74448807 | - | MXRA7 | chr17 | 74684258 | - |
| intron-5UTR | ENST00000587581 | ENST00000588114 | UBE2O | chr17 | 74448807 | - | MXRA7 | chr17 | 74684258 | - |
| intron-5UTR | ENST00000587581 | ENST00000589082 | UBE2O | chr17 | 74448807 | - | MXRA7 | chr17 | 74684258 | - |
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FusionProtFeatures for UBE2O_MXRA7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBE2O | MXRA7 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | UBE2O | chr17:74448807 | chr17:74684258 | ENST00000319380 | - | 1 | 18 | 2_43 | 139 | 1293 | Compositional bias | Note=Ala-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >UBE2O | chr17:74448807 | chr17:74684258 | ENST00000319380 | - | 1 | 18 | 812_882 | 139 | 1293 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >UBE2O | chr17:74448807 | chr17:74684258 | ENST00000319380 | - | 1 | 18 | 512_536 | 139 | 1293 | Motif | Nuclear localization signal |
| Tgene | MXRA7 | chr17:74448807 | chr17:74684258 | ENST00000355797 | - | 0 | 4 | 7_27 | 114 | 205 | Transmembrane | Helical |
| Tgene | MXRA7 | chr17:74448807 | chr17:74684258 | ENST00000375036 | - | 0 | 5 | 7_27 | 114 | 487 | Transmembrane | Helical |
| Tgene | MXRA7 | chr17:74448807 | chr17:74684258 | ENST00000449428 | - | 0 | 4 | 7_27 | 114 | 171 | Transmembrane | Helical |
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FusionGeneSequence for UBE2O_MXRA7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_UBE2O_ENST00000319380_chr17_74448807_-_MXRA7_ENST00000355797_chr17_74684258_-_230aa MADPAAPTPAAPAPAQAPAPAPEAVPAPAAAPVPAPAPASDSASGPSSDSGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSE GEEEGRGSSGCSEAGGAGHEEGRASPLRRGYVRVQWYPEGVKQHVKETKEEEQDLDGEKGPSSEGPEEEDGEGFSFKYSPGKLRGNQYKK >In-frame_UBE2O_ENST00000319380_chr17_74448807_-_MXRA7_ENST00000375036_chr17_74684258_-_139aa MADPAAPTPAAPAPAQAPAPAPEAVPAPAAAPVPAPAPASDSASGPSSDSGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSE >In-frame_UBE2O_ENST00000319380_chr17_74448807_-_MXRA7_ENST00000449428_chr17_74684258_-_196aa MADPAAPTPAAPAPAQAPAPAPEAVPAPAAAPVPAPAPASDSASGPSSDSGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSE GEEEGRGSSGCSEAGGAGHEEGRASPLRRGYVRVQWYPEGVKQHVKETKEEEQDLDGEKGPSSEGPEEEDGEGFSFKYSPGKLRGNQYKK >In-frame_UBE2O_ENST00000319380_chr17_74448807_-_MXRA7_ENST00000592148_chr17_74684258_-_139aa MADPAAPTPAAPAPAQAPAPAPEAVPAPAAAPVPAPAPASDSASGPSSDSGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_UBE2O_ENST00000319380_chr17_74448807_-_MXRA7_ENST00000355797_chr17_74684258_-_690nt ATGGCGGATCCCGCAGCCCCCACGCCCGCAGCTCCCGCTCCAGCCCAGGCCCCGGCTCCAGCCCCGGAGGCAGTCCCGGCCCCAGCCGCA GCCCCCGTCCCGGCGCCGGCGCCCGCCTCGGACTCGGCCTCCGGGCCGTCCTCGGACTCCGGCCCAGAAGCCGGCTCGCAGCGCCTGCTG TTTTCTCACGACCTGGTGTCGGGCCGTTACCGTGGCTCCGTGCACTTCGGGCTGGTGCGCCTCATCCACGGCGAGGACTCGGACTCGGAG GGCGAGGAGGAGGGCCGCGGGAGCTCGGGGTGCTCCGAGGCCGGGGGCGCGGGCCACGAGGAGGGCCGGGCCAGCCCCCTGCGCCGCGGC TACGTGCGCGTCCAGTGGTACCCGGAGGGCGTCAAGCAGCATGTGAAGGAGACCAAGGAAGAGGAGCAGGACTTGGATGGTGAGAAGGGG CCATCATCGGAAGGGCCTGAGGAGGAGGACGGAGAAGGCTTCTCCTTCAAATACAGCCCCGGGAAGCTGAGGGGAAACCAGTACAAGAAG ATGATGACCAAAGAGGAGCTGGAGGAGGAGCAGAGAGTTCAGAAGGAACAGCTGGCTGCCATCTTCAAGCTCATGAAAGACAACAAGGAG >In-frame_UBE2O_ENST00000319380_chr17_74448807_-_MXRA7_ENST00000375036_chr17_74684258_-_417nt ATGGCGGATCCCGCAGCCCCCACGCCCGCAGCTCCCGCTCCAGCCCAGGCCCCGGCTCCAGCCCCGGAGGCAGTCCCGGCCCCAGCCGCA GCCCCCGTCCCGGCGCCGGCGCCCGCCTCGGACTCGGCCTCCGGGCCGTCCTCGGACTCCGGCCCAGAAGCCGGCTCGCAGCGCCTGCTG TTTTCTCACGACCTGGTGTCGGGCCGTTACCGTGGCTCCGTGCACTTCGGGCTGGTGCGCCTCATCCACGGCGAGGACTCGGACTCGGAG GGCGAGGAGGAGGGCCGCGGGAGCTCGGGGTGCTCCGAGGCCGGGGGCGCGGGCCACGAGGAGGGCCGGGCCAGCCCCCTGCGCCGCGGC >In-frame_UBE2O_ENST00000319380_chr17_74448807_-_MXRA7_ENST00000449428_chr17_74684258_-_588nt ATGGCGGATCCCGCAGCCCCCACGCCCGCAGCTCCCGCTCCAGCCCAGGCCCCGGCTCCAGCCCCGGAGGCAGTCCCGGCCCCAGCCGCA GCCCCCGTCCCGGCGCCGGCGCCCGCCTCGGACTCGGCCTCCGGGCCGTCCTCGGACTCCGGCCCAGAAGCCGGCTCGCAGCGCCTGCTG TTTTCTCACGACCTGGTGTCGGGCCGTTACCGTGGCTCCGTGCACTTCGGGCTGGTGCGCCTCATCCACGGCGAGGACTCGGACTCGGAG GGCGAGGAGGAGGGCCGCGGGAGCTCGGGGTGCTCCGAGGCCGGGGGCGCGGGCCACGAGGAGGGCCGGGCCAGCCCCCTGCGCCGCGGC TACGTGCGCGTCCAGTGGTACCCGGAGGGCGTCAAGCAGCATGTGAAGGAGACCAAGGAAGAGGAGCAGGACTTGGATGGTGAGAAGGGG CCATCATCGGAAGGGCCTGAGGAGGAGGACGGAGAAGGCTTCTCCTTCAAATACAGCCCCGGGAAGCTGAGGGGAAACCAGTACAAGAAG >In-frame_UBE2O_ENST00000319380_chr17_74448807_-_MXRA7_ENST00000592148_chr17_74684258_-_417nt ATGGCGGATCCCGCAGCCCCCACGCCCGCAGCTCCCGCTCCAGCCCAGGCCCCGGCTCCAGCCCCGGAGGCAGTCCCGGCCCCAGCCGCA GCCCCCGTCCCGGCGCCGGCGCCCGCCTCGGACTCGGCCTCCGGGCCGTCCTCGGACTCCGGCCCAGAAGCCGGCTCGCAGCGCCTGCTG TTTTCTCACGACCTGGTGTCGGGCCGTTACCGTGGCTCCGTGCACTTCGGGCTGGTGCGCCTCATCCACGGCGAGGACTCGGACTCGGAG GGCGAGGAGGAGGGCCGCGGGAGCTCGGGGTGCTCCGAGGCCGGGGGCGCGGGCCACGAGGAGGGCCGGGCCAGCCCCCTGCGCCGCGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_UBE2O_ENST00000319380_chr17_74448807_-_MXRA7_ENST00000355797_chr17_74684258_-_5792nt CGCCTCCCCGCGCCTCGTTCGCCGCCGCTGTCGCCGCCGCCGCCCGAGACTCGCGCAGAGCAGTTATGGCGGATCCCGCAGCCCCCACGC CCGCAGCTCCCGCTCCAGCCCAGGCCCCGGCTCCAGCCCCGGAGGCAGTCCCGGCCCCAGCCGCAGCCCCCGTCCCGGCGCCGGCGCCCG CCTCGGACTCGGCCTCCGGGCCGTCCTCGGACTCCGGCCCAGAAGCCGGCTCGCAGCGCCTGCTGTTTTCTCACGACCTGGTGTCGGGCC GTTACCGTGGCTCCGTGCACTTCGGGCTGGTGCGCCTCATCCACGGCGAGGACTCGGACTCGGAGGGCGAGGAGGAGGGCCGCGGGAGCT CGGGGTGCTCCGAGGCCGGGGGCGCGGGCCACGAGGAGGGCCGGGCCAGCCCCCTGCGCCGCGGCTACGTGCGCGTCCAGTGGTACCCGG AGGGCGTCAAGCAGCATGTGAAGGAGACCAAGGAAGAGGAGCAGGACTTGGATGGTGAGAAGGGGCCATCATCGGAAGGGCCTGAGGAGG AGGACGGAGAAGGCTTCTCCTTCAAATACAGCCCCGGGAAGCTGAGGGGAAACCAGTACAAGAAGATGATGACCAAAGAGGAGCTGGAGG AGGAGCAGAGAGTTCAGAAGGAACAGCTGGCTGCCATCTTCAAGCTCATGAAAGACAACAAGGAGACGTTTGGCGAGATGTCCGACGGCG ACGTGCAGGAGCAGCTCCGGCTCTACGACATGTAGACTGCGCCCACGGGATGCACAGCGGCCATGCCTGATGCTGTCCCCACCCTTGCCC CATGCCCTTGTTCTTTCCAGACTTCTGTAGGCCTAATTTTCCCTTATAAACATAGATGCAGGCGTACATTCTATAGGTACTTGCCGAGTT CTTGCAGTGTGTATATTACTTTGCAGGAATCAAAATTGTTTTATTCAGAAGACAAAGTCCCTGACCCCTCTGGTTTCTGCTTGCTGGTGA GGTTCCAGCTGTTATTGGGCTCTGAGGCCCTCTCCTGATCCAAATCTTTTTTTGTTTGTTTGAGATGGAGTCTCACTCTGTCTCCCAGGC TGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCACCTCCCTGATTCAAGCGACTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGA TTGCAGGCATGCACCATCACACCTGGCTAATTTTGTATTTTCAGTAGAGACAGCGTTTTGCCATGCTGGCCAGGCTCGTCTCGAACTCCT GACCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACACGCGTGAGCCACCATGCCCGGCCAATACTACACTCTTATTC TGCCTTACGAGGATTTCTGGAAGCTTCTGTAACTGTAGGGAAGAAAGCTGTAGGGGAGCATGGTTTTTTTGTTTTGTTTTTGTTTTTGAG ACGAGGTCTCACTGTCACCCAGGCTGGAGTGCAGTGGTGCCATCATGACTCACTGCAGCCTTGACCTCCCAGGCGCACAAAATCCTCCTC TCAGCCTGAGTAACTGGGACTACAGGTGTGTACCACTACATCCAGCTAAAGGAGAGCGTTTTTTTCTTTTTCTTTTTGAGACAGAGTCTC ACTCTGGCGCCTGGTCACTGTGCCCTTCACCTTCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCTAGTAGCTGGGATTACAGGCATG CACCACCATACCCAGCTAATTTCTGTATTTTTAGTAGAGATGGAGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGT GATCCACCTGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACCATGCCCAGCTGGGAGCGTTCTTTCAGCAAAAAGTCTAA TTCAGAGACTCACCTTCCATCCTGGCACTAAACAATAGTACTAGAGGTAAGATCTGCCAAGAATTTCTCTCACTTAAGCAGGATACTTAC TTTAAATATAATTAGGCAAGACTTATTTGAGTACTTGCCTAATTGTATTTAATTAGAACTATGCTGGATGCTGTAGACAGAAGAAATAAA ATACTCAACTTGGTCCCTATCTTCCAGCAGGTTAGAGGCCTTTAGGGAAGAAAAGCCTGTGTGCAGGGAAAGAGAACCTCACCAGAAAGT ATTCAATAAAATGCCAAAGTGATCTTACAGAACAGTGCCTGTGACACCGGAGGGGATTGTTCTGTCTTTGTGAGTGAACATACAATGATG GGGATAACTGGTCCTCATACCATGCAGGTCCCATTTCTGATCACCCCACTGGCAGGACAATTCACAGTTCTTGAGCAAACTGAGTTAGGG AGGGTATGCTAACGACAGAACCTATGCAAGTTCTTAGAAATATTTTTTGTTTGCTGAAATAAAGCTCAATCAACACACTACCTTAAAAAA AAAGTGGAGCAGTGGCATTTCCATGCCTCATGCTCACCATCATGAGGTTAACTTCCCGCCGTCGCCTCTTGCCTGCCAGGGGTTTTTCGG GAGCCCCTCTCTGTTCCACTCTGATTCCTTTTGTTTCTTGCTGACCATTCACTCTCTGTGTCTGTTGTTGGATCCAAATACGAGTGTTTT TCTTTCTTTTTGTGGTCAGTGCTTTTTTCCTTCTTGAAATTGTTTTAATGTGTTTTGTCAAAAGCATTTAACCATGTTATGATTTAAGAA TTCTCTGTTCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAATATGGCAAAACCCTGTCTCTACTACAAATACAAAAATTAGCCAGG CGTGGTAGCGCACGCCTGTAATCCCAGCTACTCAGGAGACTGAGGCAGGAGAATCGCTTGAACTCAGAAGGCGGAGGTTCCAGTGAGCCA TCGCGCCACTGCACTCTAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAATTATTTGTTCTGTCTC AGGTCTTAGGGACCCCTTACCTCAGCTAATGTCTCTGTCCCCTAAATGCACATCGGTGGGCAGGGCAAACCCGTAGGTGCCCTTATCCCT CCCAAGGCTGCACTGCAAAGCTCCTGTGTTTCCATTGCCCACTTTCTTCTCCCTCTCCTTTCTTTTCTGATTATACCAAACAGGAATGAC TCGTGTACTTGAGTCAAAATCCTGATGGCATTGGGAAAAGTAAACTGAAGGAATTTTTGTACACTTGTACCAGCTAAGATGTTCTGACTG CAACGACAGAAAACTCCAGCTCAACTGGCTTAAACAAGAACAGGGCTCTCTCACGTGAGAAGCCAAGAGTTAGAACAACTCCAGGCCCAG AATGGTCGGAGCTCAAGCTGCAGTTCTCTTAGCTCAGTCTTCCTCGTACTGTGGGCTTTTATTGGAGACTAGCTCTCCTCATGGTGGCAA GATGGCTGCAGGAGTTCAGGTATCTCATCCAGAAGCAAGAAAAGGGCATGTCTTGCTTGCGTCTCTAGGCGTAAGGGAACTGGTCCAGAT GTCCCCGCCCCACATCCCTTCAGATCCCAATTGGCCAGAATATGGCACGTGCCCATGTTTCAACCAATCATGGGCAAGGACATGGGACCA GCATGATTGGCCTAGACCCCTGGAGCCTGGGGCTGGGCCCAGCATCCCCTGAATACATGGCCATCTGGAGGAGAAGGTAACTGAATTTCA CTGGGGATCTGTGATAAAAGGGAGCATGGGTGTTGGGGAGACACCTGTTCCAGTTGGGTTTCCTATGAGGTCCAGGACAGGGCTTGGTGG GCACTCGGAAGCCAGTGTCTGAAGTGCTCAGCATCCTCCTCTTCCTCGGTGGTGGGTGTCCACCGCCCAGGCCCCACCCCTGGCCTTGGA CACTTCATGGAAACACTGCTGATTTGCTGTGGTGTTGGGTGGCTCCTATCTATTCCCCGTAAGTGCTGGCCTCTGTTGACACCATTTCTG CTACCTCATCTGAGATTGTTCTCATCAGCTCACAGAGATTCATTTCAGTGAATGAACCAAATCTAAGCTAAAAAGCATAAAGGAGGGCAG AAAGAAACAGCAGTGTGGGAGAAAGAGCGCAAACACCGAGAGAAAGATGTCTACCTGGCAGCCATGTCAGAGAATCACCAGTATGTATGT CACTGCCACCAAGAACCTAAGAGCCACAGAGGCCTACAGAAGCCAATCCCAATGGAACTCTCTCTGGGTGTGGGGGTTGAGAGAACCTAA AGCATTCAGCTGCACAGAGCCTCTTTCCAGCGATGGGAACCAGTCTCAAAGCCTTTACATCTCTCCCCTGCCCTCCATCACTGCTGAGAA CCCTGCCCCAGGCTGGCCTGCCTACATGACACAAATAGCAGTGGACTGTCACTCATCAGTATCTGCAGTTCTGTTTACCAAAGCCTGCTT GCTAGAGACGTTTCAGGGCCTCCTTCCCTCAAAGCGTCCACTGTACCTCCATCTGGATACAATTAGCTGGCTCCCCACTTCCTGGACTGA CGGTAACCACCTTTTCCAATGACCCTGAAGAAAACATGCAATCTAAGCTGCTTTAAGAGTAACCTACAACTGAGGACAAATTTTCTATCA ACTCCCAGTACCCCTCTCTGCCGTGGCTGATTTGTTACTGGTTTTCCTTTTTTTTTTTTAATTTGAAAATGTAAGTAATTATACTAAGAC CAGATCACTCTGAGATTGTTTTATTCTAATTTGTCCTAAGGACCTGCCTGTACTTAGAGCCTGATAGAAAGCCCAAGTTGATCTACTGGG CAGCTCTCTGGGCCTGGAAGGAAGAGCACACAACAAGACTTCAACAGTGAGCCTGGCTAGGTCCAGGCAGACCATGATTTCTGAAAGCAA CAGTATAGTCCACATGGAATCAGGCTGCTGATGAACAGCAGCGAGAGGCTGCCTCTGAATCATATCTGCAGGGTCACCTGCGCCTGGTGG AGGCCCACAGTCATCCATTAGGCCCCAGTATCCTATGTGGGAGTATCCACGTCTAGTCTCTACTTCTCACTGCAGGAGAGGTGGCAGATG AGGAGGTTTCCTACTTTAAAGAAAGTAGAAGTTGTTTCCTTTCTTCCCTCCTCACAGCCTTGAGGGGGAGGTTGTGCCCAGCCTGACAGC AGCTGCCTTGCCCAAGATTACATCCTGTTCTGGGGGCAGCCCACCTCCAAACCAAGTCACTAGTGGGGTACAAAGGCCTGCCCTCTCTGC CAAAAGGCAGGTGCTGATGGACCATTCCAGTTCTAGAGTTCCCAAAGAGACGTCTTTTTGGAGAGCGGCAGGGTACCAGAAATCCTTCAC TCAGGCTATAGCATGGCCACCAATTATAAGTAACTTGAGGCCCACCCAGCCAAACATGCCTTTCCGGGTCTAGTGCTGGGTTCCAGAACA GGAAGCCTGGCAGATTCCTACTGCCACAGATTCTTTTTACTATTATTATTGTCACCTTATTTTTCTTTTGGTGGAACCCCTCTAGGGCTT CCACCGGATTCTCCACCATTTACGCTATCAATTTTATCAGTTTTGGTTTTATCGTTTCAGTGCTTCTTTTTGCTAACGGTAGCAGCCAAT ATACATCATCTCTGGAGACAAATCACGCCATAGAAAATATTGTAGTTTTCCTCATTTTTCTTAACGCCACAGAGTCAGCTGGGCTGTAGT ACCAGCCCGGATGTACCAGTTTACTCAGCCACTCCCCCTCTCATGGACATCTGCATGGTTTCCAGTCTTGCAAATTCATACAGTGCCACT >In-frame_UBE2O_ENST00000319380_chr17_74448807_-_MXRA7_ENST00000375036_chr17_74684258_-_2032nt CGCCTCCCCGCGCCTCGTTCGCCGCCGCTGTCGCCGCCGCCGCCCGAGACTCGCGCAGAGCAGTTATGGCGGATCCCGCAGCCCCCACGC CCGCAGCTCCCGCTCCAGCCCAGGCCCCGGCTCCAGCCCCGGAGGCAGTCCCGGCCCCAGCCGCAGCCCCCGTCCCGGCGCCGGCGCCCG CCTCGGACTCGGCCTCCGGGCCGTCCTCGGACTCCGGCCCAGAAGCCGGCTCGCAGCGCCTGCTGTTTTCTCACGACCTGGTGTCGGGCC GTTACCGTGGCTCCGTGCACTTCGGGCTGGTGCGCCTCATCCACGGCGAGGACTCGGACTCGGAGGGCGAGGAGGAGGGCCGCGGGAGCT CGGGGTGCTCCGAGGCCGGGGGCGCGGGCCACGAGGAGGGCCGGGCCAGCCCCCTGCGCCGCGGCTACGTGCGCGTCCAGTGGTACCCGG AGGGCGTCAAGCAGCATGTGAAGGAGACCAAGGAAGAGGAGCAGGACTTGGATGGTGAGAAGGGGCCATCATCGGAAGGGCCTGAGGAGG AGGACGGAGAAGGCTTCTCCTTCAAATACAGCCCCGGGAAGCTGAGGGGAAACCAGTACAAGAAGATGATGACCAAAGAGGAGCTGGAGG AGGAGCAGAGGATTGAGCTGACCTCTGACCTCACTTCCCTGTAGCAAGTTCCTTAGGTCCTGAGCCACAAATATTCTTGCAAATCCTTTT GAACTGAAGAATAACGAAGTTATCCTTAGCGTCCTCCTAAAGGCTTTTCCTTTTGGCATCTTAAAAGCTTGAGAGATAAAACGGAAACCC CAGAGAGGAGTCTGGGCAGGCTCCCAGGGTGCATGCTGCCTCCATAAATCTGCTGAGCTCTAGACCCTCAATCAGGACTTGTCCCTTGGC TAGCAGGATCCTGGGAACACCTTTGGCCCTGCCCTGTGTAGAGATGTTCATGTCTGTTCCTGTGGGTCACTTTGTTAAGCTGAAGAGTTT TAAGAGGTAGAGCTCAGACCCTGGACTGGGATTTTTCTTACCACTCAAACTTGCTATCCACACACCCTGCACACCTTAGATAAAAAGAAC ATTTTAAAAGCAGAGTTCACTTTCACTCCAGTCTCCCCTCTTTTGCCCTCACTGAAGCCAAACCACAGAAGACTTTGAGGAATGAGAGAC AAATGAGGTAGAGCTCACCTGTGCTCACCAGCTCCGTCAGGGTGGTCAGCCGACCCCTTTCCCTGGGAACCCCACTTCTCTCTGTGGCTG GCTTGGTTGTCGGGGGTGAGATGCCATATTGATTACAGGGCAGCAAAGAACCAGTACCAGGAATTTACTTGACCATTCCCCTTATTTTTC ATCTAGAGGAATCTCGGATTCAGCCCTTTCATTGCTAAGACACCTTTTCACTGAGGTTCTTACCAGCTCAGCCAAATCTCCACTCTGCTA TAGCAGAAGCAATAATGTTTGCTTTAAAAAGATTTCTTGACCTATGCCTTTTCTTAGAAAGTTTGATAGATTAGTTAGAACTTCAGATCA TCAGATCAGTCTCAAATGGGTTTCTTGGAATTTTATATTTGACAATATTTATACTATACCAAACTCATTTGCAGTTCTTAGGTTTGTTGG TTAAAACATTTTTTTAAAGCAGTAAGTTTATAGAAAATGTTTTCATTTAATGGAAGGCTGGGGAATGTCCAGCATCAACCCCTATGGCAT GCATTCCCAGGGGCCTTCTCATCTGGGCCTGGAACCTTTGGTTCAGGGCTTAGGGGAGAACAGGCCACATGGCAACAGCCACACAGTCAT TGCCTTCAACACAGAGCCACGTGTCCCCAAACAGCAATAGTCATGCCCTTGTCCAGGCTGGGATCTAATTGACACAATAGGTCGTTGACT CCCTCCTAGTAGAGCTATCTAGGTTTGTCTGGAAAGTTTCCGACCCTGGCTTATAGGCACCACACCTCATGTACTCCTCATGGCTTGGAT >In-frame_UBE2O_ENST00000319380_chr17_74448807_-_MXRA7_ENST00000449428_chr17_74684258_-_1951nt CGCCTCCCCGCGCCTCGTTCGCCGCCGCTGTCGCCGCCGCCGCCCGAGACTCGCGCAGAGCAGTTATGGCGGATCCCGCAGCCCCCACGC CCGCAGCTCCCGCTCCAGCCCAGGCCCCGGCTCCAGCCCCGGAGGCAGTCCCGGCCCCAGCCGCAGCCCCCGTCCCGGCGCCGGCGCCCG CCTCGGACTCGGCCTCCGGGCCGTCCTCGGACTCCGGCCCAGAAGCCGGCTCGCAGCGCCTGCTGTTTTCTCACGACCTGGTGTCGGGCC GTTACCGTGGCTCCGTGCACTTCGGGCTGGTGCGCCTCATCCACGGCGAGGACTCGGACTCGGAGGGCGAGGAGGAGGGCCGCGGGAGCT CGGGGTGCTCCGAGGCCGGGGGCGCGGGCCACGAGGAGGGCCGGGCCAGCCCCCTGCGCCGCGGCTACGTGCGCGTCCAGTGGTACCCGG AGGGCGTCAAGCAGCATGTGAAGGAGACCAAGGAAGAGGAGCAGGACTTGGATGGTGAGAAGGGGCCATCATCGGAAGGGCCTGAGGAGG AGGACGGAGAAGGCTTCTCCTTCAAATACAGCCCCGGGAAGCTGAGGGGAAACCAGTACAAGAAGATGATGACCAAAGAGGAGCTGGAGG AGGAGCAGAGAACTGAAGAATAACGAAGTTATCCTTAGCGTCCTCCTAAAGGCTTTTCCTTTTGGCATCTTAAAAGCTTGAGAGATAAAA CGGAAACCCCAGAGAGGAGTCTGGGCAGGCTCCCAGGGTGCATGCTGCCTCCATAAATCTGCTGAGCTCTAGACCCTCAATCAGGACTTG TCCCTTGGCTAGCAGGATCCTGGGAACACCTTTGGCCCTGCCCTGTGTAGAGATGTTCATGTCTGTTCCTGTGGGTCACTTTGTTAAGCT GAAGAGTTTTAAGAGGTAGAGCTCAGACCCTGGACTGGGATTTTTCTTACCACTCAAACTTGCTATCCACACACCCTGCACACCTTAGAT AAAAAGAACATTTTAAAAGCAGAGTTCACTTTCACTCCAGTCTCCCCTCTTTTGCCCTCACTGAAGCCAAACCACAGAAGACTTTGAGGA ATGAGAGACAAATGAGGTAGAGCTCACCTGTGCTCACCAGCTCCGTCAGGGTGGTCAGCCGACCCCTTTCCCTGGGAACCCCACTTCTCT CTGTGGCTGGCTTGGTTGTCGGGGGTGAGATGCCATATTGATTACAGGGCAGCAAAGAACCAGTACCAGGAATTTACTTGACCATTCCCC TTATTTTTCATCTAGAGGAATCTCGGATTCAGCCCTTTCATTGCTAAGACACCTTTTCACTGAGGTTCTTACCAGCTCAGCCAAATCTCC ACTCTGCTATAGCAGAAGCAATAATGTTTGCTTTAAAAAGATTTCTTGACCTATGCCTTTTCTTAGAAAGTTTGATAGATTAGTTAGAAC TTCAGATCATCAGATCAGTCTCAAATGGGTTTCTTGGAATTTTATATTTGACAATATTTATACTATACCAAACTCATTTGCAGTTCTTAG GTTTGTTGGTTAAAACATTTTTTTAAAGCAGTAAGTTTATAGAAAATGTTTTCATTTAATGGAAGGCTGGGGAATGTCCAGCATCAACCC CTATGGCATGCATTCCCAGGGGCCTTCTCATCTGGGCCTGGAACCTTTGGTTCAGGGCTTAGGGGAGAACAGGCCACATGGCAACAGCCA CACAGTCATTGCCTTCAACACAGAGCCACGTGTCCCCAAACAGCAATAGTCATGCCCTTGTCCAGGCTGGGATCTAATTGACACAATAGG TCGTTGACTCCCTCCTAGTAGAGCTATCTAGGTTTGTCTGGAAAGTTTCCGACCCTGGCTTATAGGCACCACACCTCATGTACTCCTCAT >In-frame_UBE2O_ENST00000319380_chr17_74448807_-_MXRA7_ENST00000592148_chr17_74684258_-_3994nt CGCCTCCCCGCGCCTCGTTCGCCGCCGCTGTCGCCGCCGCCGCCCGAGACTCGCGCAGAGCAGTTATGGCGGATCCCGCAGCCCCCACGC CCGCAGCTCCCGCTCCAGCCCAGGCCCCGGCTCCAGCCCCGGAGGCAGTCCCGGCCCCAGCCGCAGCCCCCGTCCCGGCGCCGGCGCCCG CCTCGGACTCGGCCTCCGGGCCGTCCTCGGACTCCGGCCCAGAAGCCGGCTCGCAGCGCCTGCTGTTTTCTCACGACCTGGTGTCGGGCC GTTACCGTGGCTCCGTGCACTTCGGGCTGGTGCGCCTCATCCACGGCGAGGACTCGGACTCGGAGGGCGAGGAGGAGGGCCGCGGGAGCT CGGGGTGCTCCGAGGCCGGGGGCGCGGGCCACGAGGAGGGCCGGGCCAGCCCCCTGCGCCGCGGCTACGTGCGCGTCCAGTGGTACCCGG AGGGCGTCAAGCAGCATGTGAAGGAGACCAAGCTGCTGACAGTTTCTCGTGGGCCCTTCCAAAAAACAAACCTTTTCTCTGCATTTTCGA GCACATGCGTGCATTTCCACTTTGCCATTTACAGCAAGATGACTGCGCTGCTCACGTGGGGCTGCTGCTTGCATTTTTCCCTCGATTTAT CTTGATGTACTTTTCATGTCAGCACCTATCAACGCCTCCTTTTTTTTTTTTTTTCTTTTTTTAAGATGCAGTCTTGCTGTGTCACTAGGC TGGAGTGCAATGGCGCAATCTTGGCTTACTGCAACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAACCTCCTGAGTAGCTGGGA TTAAAGGCACCTGCCACAACACTCGGCTAATTTTTTTTTGTATTTTTAGTAGAGACGGGGTTTTGCCATGTTGGCCAGGCTGGTCTCGAA TTCCCAACCTCAGCTGATCCACCCACCTAGGCCTCCCAAAATTCTGGGATTACAGGCGTGAGCGACCGCACCCGGTCCCCAGTTCTGTCT TTTCAACTGCACGCGGTCAGAGTCATTATATAAAAATCCTGATGGACATTTCTCCAGTCTGGAGCAGATCCCTAGAAGTGGGTTTGCTGT GTCAAATGGAGCGGCTCCTCTTCCTGCCCCCGGAAGAGGCCTGCCCACTCCGACCTCAGCCATAGAGATACTTTGCTGTGCAAAATTTGG GAAACGTCAGGACACACAGGCACCACTTCGCCATAGATAGCACTAAGTCTGTGTGTACAAAGTGCCCAACAGGGAAGACGCTGTGTTGCC TGCGCAGCTCCCCCCAGGCAGCATTTTGTGTAGTCAAGGAAGTCCCTCAGGCCAGGCACAGTGGCTCACTCCTGTAATCCCAACACTCTG GGAGGCCGAGGCAGGCGGATCACCTGAGGTCAGGGGTTCGAGACCAGCCCGGCCAACATGGTGACATGCCATCTCTACTGAAAACACAAA AAAATTAGCTGGGCTTGGGTGGCGGGCGCCCGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTAAACCCAGGAGGCAGAC GTTGCAGTGAGCCGAGATCGCGCCACTGCACGCCAGCCTGGGCAACAAGAGCCAAAACTCTGTCTCAGAAACACACTCAGAAAAAAACAG AAACCAAACAAACAAAAAGTCACTCAGAGGAGCTCAAGGCCCCTCTGGGTTTGCCACTTCCGACCCGCTGTGGGGCTTGTAAAAACTTTG CCTCCCGGCACAGCTCAGTGTTTTGTTAGGGAGCCTCCCGTGAGCGGCCGACGCTGGCTGGGCTCCATGGGATCAGCTGGGGCTGCTCAT TCATTCATTTCCACATCTACCCACTGGGCTTCCAAGTTGAAGTTCCTGGGGCTCCCATGTCCCCTCCCCATGACCTTCAATCCCACAGAG CCCATGGGCACGGCACGTCGCTCTCATCCTCTGACATTCCTGCAAGCTGAAGTCACTTCTTCCTTCCACCAAGGCCATCCCGGGCCATTC CTCTGATCATCTGTTTATTGTGTCTCTGTGTGGGAGAGAACTGGCTGAAGAGGTGGGGCTCCAGTTTTGGGAACATGGACACTGAGAGAG TTGGGGATGGAAAACAACATAGAAGGAAGCAAAGCCAGAGGCTGCGATGGCCATGCTGCCTGGCCCTGGTCCCAGACAGACACCCCAGCC AGCTTTCCTCTTGCACCCTTTGTCTGCTGGCCGCAGCGTCGCAGTGGGAGTCCTGGGCCCACTTCTCCAAATGGCACACAGAAGCCTCAA CAGGCACCCACCTGGGAAAGGCCAAGGCCGAGGGCTTGGGGTGCACAGTCAAGAACACGCCTCAGCTCAGCATTTGTGAGCCGAGTCACT TTGGCCCATCGTTTGTACACAGCCCCCACCTGCTGGTTGACCATGACCACAGGGCAGGCGCTGCCACAGGGCGTGGGCAGGCTGGACCTT CGAGGGCCTCCTCTGTCTCCCCTACCTTCTGCCCCCCCACCACTTCCCATCACCCAGTCTGTGCCAAGGGCACTGACCCTGTCCTTGTCT TGCAGGAAGAGGAGCAGGACTTGGATGGTGAGAAGGGGCCATCATCGGAAGGGCCTGAGGAGGAGGACGGAGAAGGCTTCTCCTTCAAAT ACAGCCCCGGGAAGCTGAGGGGAAACCAGTACAAGAAGATGATGACCAAAGAGGAGCTGGAGGAGGAGCAGAGAACTGAAGAATAACGAA GTTATCCTTAGCGTCCTCCTAAAGGCTTTTCCTTTTGGCATCTTAAAAGCTTGAGAGATAAAACGGAAACCCCAGAGAGGAGTCTGGGCA GGCTCCCAGGGTGCATGCTGCCTCCATAAATCTGCTGAGCTCTAGACCCTCAATCAGGACTTGTCCCTTGGCTAGCAGGATCCTGGGAAC ACCTTTGGCCCTGCCCTGTGTAGAGATGTTCATGTCTGTTCCTGTGGGTCACTTTGTTAAGCTGAAGAGTTTTAAGAGGTAGAGCTCAGA CCCTGGACTGGGATTTTTCTTACCACTCAAACTTGCTATCCACACACCCTGCACACCTTAGATAAAAAGAACATTTTAAAAGCAGAGTTC ACTTTCACTCCAGTCTCCCCTCTTTTGCCCTCACTGAAGCCAAACCACAGAAGACTTTGAGGAATGAGAGACAAATGAGGTAGAGCTCAC CTGTGCTCACCAGCTCCGTCAGGGTGGTCAGCCGACCCCTTTCCCTGGGAACCCCACTTCTCTCTGTGGCTGGCTTGGTTGTCGGGGGTG AGATGCCATATTGATTACAGGGCAGCAAAGAACCAGTACCAGGAATTTACTTGACCATTCCCCTTATTTTTCATCTAGAGGAATCTCGGA TTCAGCCCTTTCATTGCTAAGACACCTTTTCACTGAGGTTCTTACCAGCTCAGCCAAATCTCCACTCTGCTATAGCAGAAGCAATAATGT TTGCTTTAAAAAGATTTCTTGACCTATGCCTTTTCTTAGAAAGTTTGATAGATTAGTTAGAACTTCAGATCATCAGATCAGTCTCAAATG GGTTTCTTGGAATTTTATATTTGACAATATTTATACTATACCAAACTCATTTGCAGTTCTTAGGTTTGTTGGTTAAAACATTTTTTTAAA GCAGTAAGTTTATAGAAAATGTTTTCATTTAATGGAAGGCTGGGGAATGTCCAGCATCAACCCCTATGGCATGCATTCCCAGGGGCCTTC TCATCTGGGCCTGGAACCTTTGGTTCAGGGCTTAGGGGAGAACAGGCCACATGGCAACAGCCACACAGTCATTGCCTTCAACACAGAGCC ACGTGTCCCCAAACAGCAATAGTCATGCCCTTGTCCAGGCTGGGATCTAATTGACACAATAGGTCGTTGACTCCCTCCTAGTAGAGCTAT CTAGGTTTGTCTGGAAAGTTTCCGACCCTGGCTTATAGGCACCACACCTCATGTACTCCTCATGGCTTGGATCTCTGTATTCAGCCTTTG |
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FusionGenePPI for UBE2O_MXRA7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBE2O | BAP1, RNF10, TRIM27, RAD21, SIRT7, SHBG, GRK5, WDR26, ZNF687, ECT2, TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6, PNKP, SMAD7, SMAD6, RNF11, POLA2, POP7, UBE2O, FTSJ3, UBC, APPL1, NXF1, NOL12, OSM, FRG1, WBSCR22, ANKRD1, HEXIM1, ZNF707, LUC7L, SFRP4, LUC7L2, NAP1L1, MGC39584, SYT11, HIST1H2BA, ZFP41, NTRK1, MYC, KIAA0753, HIST1H2BG, MED4, LCA5, GSTP1, ITGB3BP, C3orf17, PTRF, JPH4, FGFRL1, PLD1, PLEKHG4, E4F1, RPL18, AKT2, AKAP17A, MYO5A, LLGL2, AURKAIP1, LZTR1, ZNF556, ZNF92, CLK3, MRPL35, IFRD2, RPL15, ZNF563, BMP4, L3MBTL2, RIC8B, ZNF517, IKZF5, ZNF574, ZNF669, EPB41L5, CCDC33, MDK, TRIM11, TRIM25, TXNIP | MXRA7 | ELAVL1, MOV10, NXF1, GUCY1B3, PCDHA12 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBE2O_MXRA7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBE2O_MXRA7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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