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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40456

FusionGeneSummary for UBE2K_WDR19

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2K_WDR19
Fusion gene ID: 40456
HgeneTgene
Gene symbol

UBE2K

WDR19

Gene ID

3093

57728

Gene nameubiquitin conjugating enzyme E2 KWD repeat domain 19
SynonymsE2-25K|HIP2|HYPG|LIG|UBC1ATD5|CED4|DYF-2|IFT144|NPHP13|ORF26|Oseg6|PWDMP|SRTD5
Cytomap

4p14

4p14

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 KE2 ubiquitin-conjugating enzyme KE2(25K)HIP-2huntingtin-interacting protein 2ubiquitin carrier proteinubiquitin conjugating enzyme E2Kubiquitin-conjugating enzyme E2(25K)ubiquitin-conjugating enzyme E2-25 KDAubiquWD repeat-containing protein 19WD repeat membrane protein PWDMPintraflagellar transport 144 homolog
Modification date2018052320180523
UniProtAcc

P61086

Q8NEZ3

Ensembl transtripts involved in fusion geneENST00000261427, ENST00000295963, 
ENST00000438068, ENST00000503368, 
ENST00000445950, 
ENST00000399820, 
ENST00000288634, ENST00000506503, 
ENST00000515631, 
Fusion gene scores* DoF score9 X 6 X 9=4864 X 4 X 4=64
# samples 104
** MAII scorelog2(10/486*10)=-2.28095631383106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBE2K [Title/Abstract] AND WDR19 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2K

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

24882218

HgeneUBE2K

GO:0010994

free ubiquitin chain polymerization

24882218

HgeneUBE2K

GO:0070936

protein K48-linked ubiquitination

20061386


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-2E-A9G8-01AUBE2Kchr4

39757359

+WDR19chr4

39245868

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000261427ENST00000399820UBE2Kchr4

39757359

+WDR19chr4

39245868

+
Frame-shiftENST00000261427ENST00000288634UBE2Kchr4

39757359

+WDR19chr4

39245868

+
5CDS-intronENST00000261427ENST00000506503UBE2Kchr4

39757359

+WDR19chr4

39245868

+
5CDS-intronENST00000261427ENST00000515631UBE2Kchr4

39757359

+WDR19chr4

39245868

+
intron-3CDSENST00000295963ENST00000399820UBE2Kchr4

39757359

+WDR19chr4

39245868

+
intron-3CDSENST00000295963ENST00000288634UBE2Kchr4

39757359

+WDR19chr4

39245868

+
intron-intronENST00000295963ENST00000506503UBE2Kchr4

39757359

+WDR19chr4

39245868

+
intron-intronENST00000295963ENST00000515631UBE2Kchr4

39757359

+WDR19chr4

39245868

+
3UTR-3CDSENST00000438068ENST00000399820UBE2Kchr4

39757359

+WDR19chr4

39245868

+
3UTR-3CDSENST00000438068ENST00000288634UBE2Kchr4

39757359

+WDR19chr4

39245868

+
3UTR-intronENST00000438068ENST00000506503UBE2Kchr4

39757359

+WDR19chr4

39245868

+
3UTR-intronENST00000438068ENST00000515631UBE2Kchr4

39757359

+WDR19chr4

39245868

+
Frame-shiftENST00000503368ENST00000399820UBE2Kchr4

39757359

+WDR19chr4

39245868

+
Frame-shiftENST00000503368ENST00000288634UBE2Kchr4

39757359

+WDR19chr4

39245868

+
5CDS-intronENST00000503368ENST00000506503UBE2Kchr4

39757359

+WDR19chr4

39245868

+
5CDS-intronENST00000503368ENST00000515631UBE2Kchr4

39757359

+WDR19chr4

39245868

+
Frame-shiftENST00000445950ENST00000399820UBE2Kchr4

39757359

+WDR19chr4

39245868

+
Frame-shiftENST00000445950ENST00000288634UBE2Kchr4

39757359

+WDR19chr4

39245868

+
5CDS-intronENST00000445950ENST00000506503UBE2Kchr4

39757359

+WDR19chr4

39245868

+
5CDS-intronENST00000445950ENST00000515631UBE2Kchr4

39757359

+WDR19chr4

39245868

+

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FusionProtFeatures for UBE2K_WDR19


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2K

P61086

WDR19

Q8NEZ3

Component of the IFT complex A (IFT-A), a complexrequired for retrograde ciliary transport (PubMed:20889716).Involved in cilia function and/or assembly (By similarity).Associates with the BBSome complex to mediate ciliary transport(By similarity). {ECO:0000250|UniProtKB:Q3UGF1,ECO:0000269|PubMed:20889716}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2K_WDR19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2K_WDR19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UBE2KDSTYK, HTT, RNF2, UBE2I, DDX58, RNF125, RNF138, BFAR, UBOX5, RNF5, DTX3, MARCH7, SIAH1, TRIM27, RNF185, TRIM35, BIRC7, BIRC8, RNF4, TRIM34, RNF167, UHRF2, TRAF7, MKRN2, TRAIP, RING1, RNF41, MARCH3, RNF32, RNF114, LRSAM1, CBLC, DTX3L, DZIP3, MID1, MKRN3, TRIM39, RNF111, RNF144A, TRIM2, TRIM31, TRIM43, TRIM5, RBCK1, ITSN1, PRPF40A, CCNB1, DIABLO, BRCA1, UBC, CASP12, PIAS4, NUB1, NXF1, FZR1, NEDD4L, WWP2, ITCH, WDR1, WDR61, TXNDC17, TYMS, TXN, ANAPC11, IQCB1, BAG3, UBA1, TP53, MDM2, CDC6, PRRG4, REL, MIPOL1, DDI1, ZDHHC17, AMFR, BARD1, SENP1, MAP3K1, HNRNPA1, UBE2D2, RAB1A, TMEM189-UBE2V1, UBE2V1, UBE2N, RC3H2, TRIM63, SMURF1, CYHR1, ARL15, USP1, DLDWDR19C11orf74, IFT122, DDX39A, IFT43, TULP3, DNAJC7, TULP2, TKT, RAD51D, LRRC27, C6orf141, DOCK5, IFT140, WDR35, PISD, NIPSNAP1, TTC21B, PFKP, NTPCR, SCO1, ACSL3, NEK7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2K_WDR19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2K_WDR19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWDR19C3280616CRANIOECTODERMAL DYSPLASIA 42UNIPROT
TgeneWDR19C4225376SENIOR-LOKEN SYNDROME 82UNIPROT
TgeneWDR19C3280598SHORT-RIB THORACIC DYSPLASIA 5 WITH OR WITHOUT POLYDACTYLY1UNIPROT
TgeneWDR19C3280612NEPHRONOPHTHISIS 131UNIPROT