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Fusion gene ID: 40456 |
FusionGeneSummary for UBE2K_WDR19 |
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Fusion gene information | Fusion gene name: UBE2K_WDR19 | Fusion gene ID: 40456 | Hgene | Tgene | Gene symbol | UBE2K | WDR19 | Gene ID | 3093 | 57728 |
Gene name | ubiquitin conjugating enzyme E2 K | WD repeat domain 19 | |
Synonyms | E2-25K|HIP2|HYPG|LIG|UBC1 | ATD5|CED4|DYF-2|IFT144|NPHP13|ORF26|Oseg6|PWDMP|SRTD5 | |
Cytomap | 4p14 | 4p14 | |
Type of gene | protein-coding | protein-coding | |
Description | ubiquitin-conjugating enzyme E2 KE2 ubiquitin-conjugating enzyme KE2(25K)HIP-2huntingtin-interacting protein 2ubiquitin carrier proteinubiquitin conjugating enzyme E2Kubiquitin-conjugating enzyme E2(25K)ubiquitin-conjugating enzyme E2-25 KDAubiqu | WD repeat-containing protein 19WD repeat membrane protein PWDMPintraflagellar transport 144 homolog | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P61086 | Q8NEZ3 | |
Ensembl transtripts involved in fusion gene | ENST00000261427, ENST00000295963, ENST00000438068, ENST00000503368, ENST00000445950, | ENST00000399820, ENST00000288634, ENST00000506503, ENST00000515631, | |
Fusion gene scores | * DoF score | 9 X 6 X 9=486 | 4 X 4 X 4=64 |
# samples | 10 | 4 | |
** MAII score | log2(10/486*10)=-2.28095631383106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: UBE2K [Title/Abstract] AND WDR19 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | UBE2K | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 24882218 |
Hgene | UBE2K | GO:0010994 | free ubiquitin chain polymerization | 24882218 |
Hgene | UBE2K | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCEC | TCGA-2E-A9G8-01A | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000261427 | ENST00000399820 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
Frame-shift | ENST00000261427 | ENST00000288634 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
5CDS-intron | ENST00000261427 | ENST00000506503 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
5CDS-intron | ENST00000261427 | ENST00000515631 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
intron-3CDS | ENST00000295963 | ENST00000399820 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
intron-3CDS | ENST00000295963 | ENST00000288634 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
intron-intron | ENST00000295963 | ENST00000506503 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
intron-intron | ENST00000295963 | ENST00000515631 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
3UTR-3CDS | ENST00000438068 | ENST00000399820 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
3UTR-3CDS | ENST00000438068 | ENST00000288634 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
3UTR-intron | ENST00000438068 | ENST00000506503 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
3UTR-intron | ENST00000438068 | ENST00000515631 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
Frame-shift | ENST00000503368 | ENST00000399820 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
Frame-shift | ENST00000503368 | ENST00000288634 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
5CDS-intron | ENST00000503368 | ENST00000506503 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
5CDS-intron | ENST00000503368 | ENST00000515631 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
Frame-shift | ENST00000445950 | ENST00000399820 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
Frame-shift | ENST00000445950 | ENST00000288634 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
5CDS-intron | ENST00000445950 | ENST00000506503 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
5CDS-intron | ENST00000445950 | ENST00000515631 | UBE2K | chr4 | 39757359 | + | WDR19 | chr4 | 39245868 | + |
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FusionProtFeatures for UBE2K_WDR19 |
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Hgene | Tgene |
UBE2K | WDR19 |
Component of the IFT complex A (IFT-A), a complexrequired for retrograde ciliary transport (PubMed:20889716).Involved in cilia function and/or assembly (By similarity).Associates with the BBSome complex to mediate ciliary transport(By similarity). {ECO:0000250|UniProtKB:Q3UGF1,ECO:0000269|PubMed:20889716}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBE2K_WDR19 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UBE2K_WDR19 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
UBE2K | DSTYK, HTT, RNF2, UBE2I, DDX58, RNF125, RNF138, BFAR, UBOX5, RNF5, DTX3, MARCH7, SIAH1, TRIM27, RNF185, TRIM35, BIRC7, BIRC8, RNF4, TRIM34, RNF167, UHRF2, TRAF7, MKRN2, TRAIP, RING1, RNF41, MARCH3, RNF32, RNF114, LRSAM1, CBLC, DTX3L, DZIP3, MID1, MKRN3, TRIM39, RNF111, RNF144A, TRIM2, TRIM31, TRIM43, TRIM5, RBCK1, ITSN1, PRPF40A, CCNB1, DIABLO, BRCA1, UBC, CASP12, PIAS4, NUB1, NXF1, FZR1, NEDD4L, WWP2, ITCH, WDR1, WDR61, TXNDC17, TYMS, TXN, ANAPC11, IQCB1, BAG3, UBA1, TP53, MDM2, CDC6, PRRG4, REL, MIPOL1, DDI1, ZDHHC17, AMFR, BARD1, SENP1, MAP3K1, HNRNPA1, UBE2D2, RAB1A, TMEM189-UBE2V1, UBE2V1, UBE2N, RC3H2, TRIM63, SMURF1, CYHR1, ARL15, USP1, DLD | WDR19 | C11orf74, IFT122, DDX39A, IFT43, TULP3, DNAJC7, TULP2, TKT, RAD51D, LRRC27, C6orf141, DOCK5, IFT140, WDR35, PISD, NIPSNAP1, TTC21B, PFKP, NTPCR, SCO1, ACSL3, NEK7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBE2K_WDR19 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBE2K_WDR19 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | WDR19 | C3280616 | CRANIOECTODERMAL DYSPLASIA 4 | 2 | UNIPROT |
Tgene | WDR19 | C4225376 | SENIOR-LOKEN SYNDROME 8 | 2 | UNIPROT |
Tgene | WDR19 | C3280598 | SHORT-RIB THORACIC DYSPLASIA 5 WITH OR WITHOUT POLYDACTYLY | 1 | UNIPROT |
Tgene | WDR19 | C3280612 | NEPHRONOPHTHISIS 13 | 1 | UNIPROT |