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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40454

FusionGeneSummary for UBE2K_UBE2K

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2K_UBE2K
Fusion gene ID: 40454
HgeneTgene
Gene symbol

UBE2K

UBE2K

Gene ID

3093

3093

Gene nameubiquitin conjugating enzyme E2 Kubiquitin conjugating enzyme E2 K
SynonymsE2-25K|HIP2|HYPG|LIG|UBC1E2-25K|HIP2|HYPG|LIG|UBC1
Cytomap

4p14

4p14

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 KE2 ubiquitin-conjugating enzyme KE2(25K)HIP-2huntingtin-interacting protein 2ubiquitin carrier proteinubiquitin conjugating enzyme E2Kubiquitin-conjugating enzyme E2(25K)ubiquitin-conjugating enzyme E2-25 KDAubiquubiquitin-conjugating enzyme E2 KE2 ubiquitin-conjugating enzyme KE2(25K)HIP-2huntingtin-interacting protein 2ubiquitin carrier proteinubiquitin conjugating enzyme E2Kubiquitin-conjugating enzyme E2(25K)ubiquitin-conjugating enzyme E2-25 KDAubiqu
Modification date2018052320180523
UniProtAcc

P61086

P61086

Ensembl transtripts involved in fusion geneENST00000261427, ENST00000295963, 
ENST00000438068, ENST00000503368, 
ENST00000445950, 
ENST00000261427, 
ENST00000295963, ENST00000438068, 
ENST00000503368, ENST00000445950, 
Fusion gene scores* DoF score9 X 6 X 9=4863 X 3 X 3=27
# samples 103
** MAII scorelog2(10/486*10)=-2.28095631383106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UBE2K [Title/Abstract] AND UBE2K [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2K

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

24882218

HgeneUBE2K

GO:0010994

free ubiquitin chain polymerization

24882218

HgeneUBE2K

GO:0070936

protein K48-linked ubiquitination

20061386

TgeneUBE2K

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

24882218

TgeneUBE2K

GO:0010994

free ubiquitin chain polymerization

24882218

TgeneUBE2K

GO:0070936

protein K48-linked ubiquitination

20061386


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF667380UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000261427ENST00000261427UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000261427ENST00000295963UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000261427ENST00000438068UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000261427ENST00000503368UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000261427ENST00000445950UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000295963ENST00000261427UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000295963ENST00000295963UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000295963ENST00000438068UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000295963ENST00000503368UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000295963ENST00000445950UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000438068ENST00000261427UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000438068ENST00000295963UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000438068ENST00000438068UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000438068ENST00000503368UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000438068ENST00000445950UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000503368ENST00000261427UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000503368ENST00000295963UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000503368ENST00000438068UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000503368ENST00000503368UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000503368ENST00000445950UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000445950ENST00000261427UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000445950ENST00000295963UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000445950ENST00000438068UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000445950ENST00000503368UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+
intron-intronENST00000445950ENST00000445950UBE2Kchr4

39747346

+UBE2Kchr4

39739134

+

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FusionProtFeatures for UBE2K_UBE2K


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2K

P61086

UBE2K

P61086


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2K_UBE2K


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2K_UBE2K


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2K_UBE2K


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2K_UBE2K


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource