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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40453

FusionGeneSummary for UBE2K_SLC9B2

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2K_SLC9B2
Fusion gene ID: 40453
HgeneTgene
Gene symbol

UBE2K

SLC9B2

Gene ID

3093

133308

Gene nameubiquitin conjugating enzyme E2 Ksolute carrier family 9 member B2
SynonymsE2-25K|HIP2|HYPG|LIG|UBC1NHA2|NHE10|NHEDC2
Cytomap

4p14

4q24

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 KE2 ubiquitin-conjugating enzyme KE2(25K)HIP-2huntingtin-interacting protein 2ubiquitin carrier proteinubiquitin conjugating enzyme E2Kubiquitin-conjugating enzyme E2(25K)ubiquitin-conjugating enzyme E2-25 KDAubiqusodium/hydrogen exchanger 9B2NHE domain-containing protein 2Na(+)/H(+) exchanger NHA2Na(+)/H(+) exchanger-like domain-containing protein 2Na+/H+ exchanger domain containing 2mitochondrial Na(+)/H(+) exchanger NHA2mitochondrial sodium/hydrogen exchan
Modification date2018052320180523
UniProtAcc

P61086

Q86UD5

Ensembl transtripts involved in fusion geneENST00000261427, ENST00000295963, 
ENST00000438068, ENST00000503368, 
ENST00000445950, 		ENST00000362026, 
ENST00000339611, ENST00000394785, 
ENST00000503103, ENST00000503230, 
ENST00000505838, 
Fusion gene scores* DoF score9 X 6 X 9=4862 X 2 X 2=8
# samples 102
** MAII scorelog2(10/486*10)=-2.28095631383106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: UBE2K [Title/Abstract] AND SLC9B2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2K

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

24882218

HgeneUBE2K

GO:0010994

free ubiquitin chain polymerization

24882218

HgeneUBE2K

GO:0070936

protein K48-linked ubiquitination

20061386

TgeneSLC9B2

GO:0006814

sodium ion transport

18508966


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-DD-A1EJ-01AUBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000261427ENST00000362026UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
Frame-shiftENST00000261427ENST00000339611UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
Frame-shiftENST00000261427ENST00000394785UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
Frame-shiftENST00000261427ENST00000503103UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
Frame-shiftENST00000261427ENST00000503230UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
5CDS-intronENST00000261427ENST00000505838UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
intron-3CDSENST00000295963ENST00000362026UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
intron-3CDSENST00000295963ENST00000339611UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
intron-3CDSENST00000295963ENST00000394785UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
intron-3CDSENST00000295963ENST00000503103UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
intron-3CDSENST00000295963ENST00000503230UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
intron-intronENST00000295963ENST00000505838UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
3UTR-3CDSENST00000438068ENST00000362026UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
3UTR-3CDSENST00000438068ENST00000339611UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
3UTR-3CDSENST00000438068ENST00000394785UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
3UTR-3CDSENST00000438068ENST00000503103UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
3UTR-3CDSENST00000438068ENST00000503230UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
3UTR-intronENST00000438068ENST00000505838UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
Frame-shiftENST00000503368ENST00000362026UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
Frame-shiftENST00000503368ENST00000339611UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
Frame-shiftENST00000503368ENST00000394785UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
Frame-shiftENST00000503368ENST00000503103UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
Frame-shiftENST00000503368ENST00000503230UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
5CDS-intronENST00000503368ENST00000505838UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
Frame-shiftENST00000445950ENST00000362026UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
Frame-shiftENST00000445950ENST00000339611UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
Frame-shiftENST00000445950ENST00000394785UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
Frame-shiftENST00000445950ENST00000503103UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
Frame-shiftENST00000445950ENST00000503230UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-
5CDS-intronENST00000445950ENST00000505838UBE2Kchr4

39757359

+SLC9B2chr4

103952965

-

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FusionProtFeatures for UBE2K_SLC9B2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2K

P61086

SLC9B2

Q86UD5

Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) inexchange for external protons across the membrane(PubMed:18000046, PubMed:28154142, PubMed:22948142,PubMed:18508966). Contributes to the regulation of intracellularpH, sodium homeostasis, and cell volume. Plays an important rolefor insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility(By similarity). It is controversial whether SLC9B2 plays a rolein osteoclast differentiation or not (By similarity).{ECO:0000250|UniProtKB:Q5BKR2, ECO:0000269|PubMed:18000046,ECO:0000269|PubMed:18508966, ECO:0000269|PubMed:22948142,ECO:0000269|PubMed:28154142}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2K_SLC9B2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2K_SLC9B2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UBE2KDSTYK, HTT, RNF2, UBE2I, DDX58, RNF125, RNF138, BFAR, UBOX5, RNF5, DTX3, MARCH7, SIAH1, TRIM27, RNF185, TRIM35, BIRC7, BIRC8, RNF4, TRIM34, RNF167, UHRF2, TRAF7, MKRN2, TRAIP, RING1, RNF41, MARCH3, RNF32, RNF114, LRSAM1, CBLC, DTX3L, DZIP3, MID1, MKRN3, TRIM39, RNF111, RNF144A, TRIM2, TRIM31, TRIM43, TRIM5, RBCK1, ITSN1, PRPF40A, CCNB1, DIABLO, BRCA1, UBC, CASP12, PIAS4, NUB1, NXF1, FZR1, NEDD4L, WWP2, ITCH, WDR1, WDR61, TXNDC17, TYMS, TXN, ANAPC11, IQCB1, BAG3, UBA1, TP53, MDM2, CDC6, PRRG4, REL, MIPOL1, DDI1, ZDHHC17, AMFR, BARD1, SENP1, MAP3K1, HNRNPA1, UBE2D2, RAB1A, TMEM189-UBE2V1, UBE2V1, UBE2N, RC3H2, TRIM63, SMURF1, CYHR1, ARL15, USP1, DLDSLC9B2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2K_SLC9B2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2K_SLC9B2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource