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Fusion gene ID: 40451 |
FusionGeneSummary for UBE2K_KLB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBE2K_KLB | Fusion gene ID: 40451 | Hgene | Tgene | Gene symbol | UBE2K | KLB | Gene ID | 3093 | 152831 |
| Gene name | ubiquitin conjugating enzyme E2 K | klotho beta | |
| Synonyms | E2-25K|HIP2|HYPG|LIG|UBC1 | BKL | |
| Cytomap | 4p14 | 4p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-conjugating enzyme E2 KE2 ubiquitin-conjugating enzyme KE2(25K)HIP-2huntingtin-interacting protein 2ubiquitin carrier proteinubiquitin conjugating enzyme E2Kubiquitin-conjugating enzyme E2(25K)ubiquitin-conjugating enzyme E2-25 KDAubiqu | beta-klothob-KlothobetaKlothoklotho beta likeklotho beta-like protein | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P61086 | Q86Z14 | |
| Ensembl transtripts involved in fusion gene | ENST00000261427, ENST00000295963, ENST00000438068, ENST00000503368, ENST00000445950, | ENST00000257408, | |
| Fusion gene scores | * DoF score | 9 X 6 X 9=486 | 1 X 1 X 1=1 |
| # samples | 10 | 1 | |
| ** MAII score | log2(10/486*10)=-2.28095631383106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: UBE2K [Title/Abstract] AND KLB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBE2K | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 24882218 |
| Hgene | UBE2K | GO:0010994 | free ubiquitin chain polymerization | 24882218 |
| Hgene | UBE2K | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A1FD-01A | UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435830 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261427 | ENST00000257408 | UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435830 | + |
| intron-3CDS | ENST00000295963 | ENST00000257408 | UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435830 | + |
| 3UTR-3CDS | ENST00000438068 | ENST00000257408 | UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435830 | + |
| In-frame | ENST00000503368 | ENST00000257408 | UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435830 | + |
| In-frame | ENST00000445950 | ENST00000257408 | UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435830 | + |
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FusionProtFeatures for UBE2K_KLB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBE2K | KLB |
| Contributes to the transcriptional repression ofcholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzymein bile acid synthesis. Probably inactive as a glycosidase.Increases the ability of FGFR1 and FGFR4 to bind FGF21 (Bysimilarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >KLB | chr4:39776553 | chr4:39435830 | ENST00000257408 | + | 0 | 5 | 517_967 | 275 | 1045 | Region | Note=Glycosyl hydrolase-1 2 |
| Tgene | >KLB | chr4:39776553 | chr4:39435830 | ENST00000257408 | + | 0 | 5 | 1018_1044 | 275 | 1045 | Topological domain | Cytoplasmic |
| Tgene | >KLB | chr4:39776553 | chr4:39435830 | ENST00000257408 | + | 0 | 5 | 997_1017 | 275 | 1045 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >UBE2K | chr4:39776553 | chr4:39435830 | ENST00000261427 | + | 5 | 7 | 160_200 | 133 | 201 | Domain | UBA |
| Hgene | >UBE2K | chr4:39776553 | chr4:39435830 | ENST00000445950 | + | 5 | 6 | 160_200 | 133 | 158 | Domain | UBA |
| Hgene | >UBE2K | chr4:39776553 | chr4:39435830 | ENST00000503368 | + | 3 | 5 | 160_200 | 82 | 150 | Domain | UBA |
| Tgene | KLB | chr4:39776553 | chr4:39435830 | ENST00000257408 | + | 0 | 5 | 77_508 | 275 | 1045 | Region | Note=Glycosyl hydrolase-1 1 |
| Tgene | KLB | chr4:39776553 | chr4:39435830 | ENST00000257408 | + | 0 | 5 | 1_996 | 275 | 1045 | Topological domain | Extracellular |
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FusionGeneSequence for UBE2K_KLB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_UBE2K_ENST00000261427_chr4_39776553_+_KLB_ENST00000257408_chr4_39435830_+_903aa MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVTGA ICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQS MVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRI LIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQI IRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARM KVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELG DLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWF AEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRL AVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAK SSIQFYNKVISSRGFPFENSSSRCSQTQENTECTVCLFLVQKKPLIFLGCCFFSTLVLLLSIAIFQRQKRRKFWKAKNLQHIPLKKGKRV >In-frame_UBE2K_ENST00000503368_chr4_39776553_+_KLB_ENST00000257408_chr4_39435830_+_852aa MANIAVQRIKREFKEVLKSEEVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQAHSKVWHN YNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFS FGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLL DGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVW NATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYY PTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPS QRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCAL NHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQE VLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFPFENSSSRCSQTQENTECTVCLFLVQKKPLIFLGCC >In-frame_UBE2K_ENST00000445950_chr4_39776553_+_KLB_ENST00000257408_chr4_39435830_+_903aa MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVTGA ICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQS MVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRI LIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQI IRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARM KVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELG DLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWF AEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRL AVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAK SSIQFYNKVISSRGFPFENSSSRCSQTQENTECTVCLFLVQKKPLIFLGCCFFSTLVLLLSIAIFQRQKRRKFWKAKNLQHIPLKKGKRV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_UBE2K_ENST00000261427_chr4_39776553_+_KLB_ENST00000257408_chr4_39435830_+_2709nt ATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGACGAGCAAAAATCAAATTAAAGTAGAT CTTGTAGATGAGAATTTTACAGAATTAAGAGGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATACCAACTAGAGATA AAAATACCAGAAACATACCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTTCCGTCACAGGGGCT ATTTGTTTGGATATCCTGAAAGATCAATGGGCAGCTGCAATGACTCTCCGCACGGTATTATTGTCATTGCAAGCACTATTGGCAGCTGCA GAGCCAGATGATCCACAGGATGCTGTAGTAGCAAATCAGGCTCACTCGAAAGTTTGGCATAACTACAACACACATTTCCGCCCACATCAG AAGGGTTGGTTATCGATCACGTTGGGATCTCATTGGATCGAGCCAAACCGGTCGGAAAACACGATGGATATATTCAAATGTCAACAATCC ATGGTTTCTGTGCTTGGATGGTTTGCCAACCCTATCCATGGGGATGGCGACTATCCAGAGGGGATGAGAAAGAAGTTGTTCTCCGTTCTA CCCATTTTCTCTGAAGCAGAGAAGCATGAGATGAGAGGCACAGCTGATTTCTTTGCCTTTTCTTTTGGACCCAACAACTTCAAGCCCCTA AACACCATGGCTAAAATGGGACAAAATGTTTCACTTAATTTAAGAGAAGCGCTGAACTGGATTAAACTGGAATACAACAACCCTCGAATC TTGATTGCTGAGAATGGCTGGTTCACAGACAGTCGTGTGAAAACAGAAGACACCACGGCCATCTACATGATGAAGAATTTCCTCAGCCAG GTGCTTCAAGCAATAAGGTTAGATGAAATACGAGTGTTTGGTTATACTGCCTGGTCTCTCCTGGATGGCTTTGAATGGCAGGATGCTTAC ACCATCCGCCGAGGATTATTTTATGTGGATTTTAACAGTAAACAGAAAGAGCGGAAACCTAAGTCTTCAGCACACTACTACAAACAGATC ATACGAGAAAATGGTTTTTCTTTAAAAGAGTCCACGCCAGATGTGCAGGGCCAGTTTCCCTGTGACTTCTCCTGGGGTGTCACTGAATCT GTTCTTAAGCCCGAGTCTGTGGCTTCGTCCCCACAGTTCAGCGATCCTCATCTGTACGTGTGGAACGCCACTGGCAACAGACTGTTGCAC CGAGTGGAAGGGGTGAGGCTGAAAACACGACCCGCTCAATGCACAGATTTTGTAAACATCAAAAAACAACTTGAGATGTTGGCAAGAATG AAAGTCACCCACTACCGGTTTGCTCTGGATTGGGCCTCGGTCCTTCCCACTGGCAACCTGTCCGCGGTGAACCGACAGGCCCTGAGGTAC TACAGGTGCGTGGTCAGTGAGGGGCTGAAGCTTGGCATCTCCGCGATGGTCACCCTGTATTATCCGACCCACGCCCACCTAGGCCTCCCC GAGCCTCTGTTGCATGCCGACGGGTGGCTGAACCCATCGACGGCCGAGGCCTTCCAGGCCTACGCTGGGCTGTGCTTCCAGGAGCTGGGG GACCTGGTGAAGCTCTGGATCACCATCAACGAGCCTAACCGGCTAAGTGACATCTACAACCGCTCTGGCAACGACACCTACGGGGCGGCG CACAACCTGCTGGTGGCCCACGCCCTGGCCTGGCGCCTCTACGACCGGCAGTTCAGGCCCTCACAGCGCGGGGCCGTGTCGCTGTCGCTG CACGCGGACTGGGCGGAACCCGCCAACCCCTATGCTGACTCGCACTGGAGGGCGGCCGAGCGCTTCCTGCAGTTCGAGATCGCCTGGTTC GCCGAGCCGCTCTTCAAGACCGGGGACTACCCCGCGGCCATGAGGGAATACATTGCCTCCAAGCACCGACGGGGGCTTTCCAGCTCGGCC CTGCCGCGCCTCACCGAGGCCGAAAGGAGGCTGCTCAAGGGCACGGTCGACTTCTGCGCGCTCAACCACTTCACCACTAGGTTCGTGATG CACGAGCAGCTGGCCGGCAGCCGCTACGACTCGGACAGGGACATCCAGTTTCTGCAGGACATCACCCGCCTGAGCTCCCCCACGCGCCTG GCTGTGATTCCCTGGGGGGTGCGCAAGCTGCTGCGGTGGGTCCGGAGGAACTACGGCGACATGGACATTTACATCACCGCCAGTGGCATC GACGACCAGGCTCTGGAGGATGACCGGCTCCGGAAGTACTACCTAGGGAAGTACCTTCAGGAGGTGCTGAAAGCATACCTGATTGATAAA GTCAGAATCAAAGGCTATTATGCATTCAAACTGGCTGAAGAGAAATCTAAACCCAGATTTGGATTCTTCACATCTGATTTTAAAGCTAAA TCCTCAATACAATTTTACAACAAAGTGATCAGCAGCAGGGGCTTCCCTTTTGAGAACAGTAGTTCTAGATGCAGTCAGACCCAAGAAAAT ACAGAGTGCACTGTCTGCTTATTCCTTGTGCAGAAGAAACCACTGATATTCCTGGGTTGTTGCTTCTTCTCCACCCTGGTTCTACTCTTA TCAATTGCCATTTTTCAAAGGCAGAAGAGAAGAAAGTTTTGGAAAGCAAAAAACTTACAACACATACCATTAAAGAAAGGCAAGAGAGTT >In-frame_UBE2K_ENST00000503368_chr4_39776553_+_KLB_ENST00000257408_chr4_39435830_+_2556nt ATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTCCGGTTTATCACTAAAATATGGCAT CCTAATATTAGTTCCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGGGCAGCTGCAATGACTCTCCGCACGGTATTATTG TCATTGCAAGCACTATTGGCAGCTGCAGAGCCAGATGATCCACAGGATGCTGTAGTAGCAAATCAGGCTCACTCGAAAGTTTGGCATAAC TACAACACACATTTCCGCCCACATCAGAAGGGTTGGTTATCGATCACGTTGGGATCTCATTGGATCGAGCCAAACCGGTCGGAAAACACG ATGGATATATTCAAATGTCAACAATCCATGGTTTCTGTGCTTGGATGGTTTGCCAACCCTATCCATGGGGATGGCGACTATCCAGAGGGG ATGAGAAAGAAGTTGTTCTCCGTTCTACCCATTTTCTCTGAAGCAGAGAAGCATGAGATGAGAGGCACAGCTGATTTCTTTGCCTTTTCT TTTGGACCCAACAACTTCAAGCCCCTAAACACCATGGCTAAAATGGGACAAAATGTTTCACTTAATTTAAGAGAAGCGCTGAACTGGATT AAACTGGAATACAACAACCCTCGAATCTTGATTGCTGAGAATGGCTGGTTCACAGACAGTCGTGTGAAAACAGAAGACACCACGGCCATC TACATGATGAAGAATTTCCTCAGCCAGGTGCTTCAAGCAATAAGGTTAGATGAAATACGAGTGTTTGGTTATACTGCCTGGTCTCTCCTG GATGGCTTTGAATGGCAGGATGCTTACACCATCCGCCGAGGATTATTTTATGTGGATTTTAACAGTAAACAGAAAGAGCGGAAACCTAAG TCTTCAGCACACTACTACAAACAGATCATACGAGAAAATGGTTTTTCTTTAAAAGAGTCCACGCCAGATGTGCAGGGCCAGTTTCCCTGT GACTTCTCCTGGGGTGTCACTGAATCTGTTCTTAAGCCCGAGTCTGTGGCTTCGTCCCCACAGTTCAGCGATCCTCATCTGTACGTGTGG AACGCCACTGGCAACAGACTGTTGCACCGAGTGGAAGGGGTGAGGCTGAAAACACGACCCGCTCAATGCACAGATTTTGTAAACATCAAA AAACAACTTGAGATGTTGGCAAGAATGAAAGTCACCCACTACCGGTTTGCTCTGGATTGGGCCTCGGTCCTTCCCACTGGCAACCTGTCC GCGGTGAACCGACAGGCCCTGAGGTACTACAGGTGCGTGGTCAGTGAGGGGCTGAAGCTTGGCATCTCCGCGATGGTCACCCTGTATTAT CCGACCCACGCCCACCTAGGCCTCCCCGAGCCTCTGTTGCATGCCGACGGGTGGCTGAACCCATCGACGGCCGAGGCCTTCCAGGCCTAC GCTGGGCTGTGCTTCCAGGAGCTGGGGGACCTGGTGAAGCTCTGGATCACCATCAACGAGCCTAACCGGCTAAGTGACATCTACAACCGC TCTGGCAACGACACCTACGGGGCGGCGCACAACCTGCTGGTGGCCCACGCCCTGGCCTGGCGCCTCTACGACCGGCAGTTCAGGCCCTCA CAGCGCGGGGCCGTGTCGCTGTCGCTGCACGCGGACTGGGCGGAACCCGCCAACCCCTATGCTGACTCGCACTGGAGGGCGGCCGAGCGC TTCCTGCAGTTCGAGATCGCCTGGTTCGCCGAGCCGCTCTTCAAGACCGGGGACTACCCCGCGGCCATGAGGGAATACATTGCCTCCAAG CACCGACGGGGGCTTTCCAGCTCGGCCCTGCCGCGCCTCACCGAGGCCGAAAGGAGGCTGCTCAAGGGCACGGTCGACTTCTGCGCGCTC AACCACTTCACCACTAGGTTCGTGATGCACGAGCAGCTGGCCGGCAGCCGCTACGACTCGGACAGGGACATCCAGTTTCTGCAGGACATC ACCCGCCTGAGCTCCCCCACGCGCCTGGCTGTGATTCCCTGGGGGGTGCGCAAGCTGCTGCGGTGGGTCCGGAGGAACTACGGCGACATG GACATTTACATCACCGCCAGTGGCATCGACGACCAGGCTCTGGAGGATGACCGGCTCCGGAAGTACTACCTAGGGAAGTACCTTCAGGAG GTGCTGAAAGCATACCTGATTGATAAAGTCAGAATCAAAGGCTATTATGCATTCAAACTGGCTGAAGAGAAATCTAAACCCAGATTTGGA TTCTTCACATCTGATTTTAAAGCTAAATCCTCAATACAATTTTACAACAAAGTGATCAGCAGCAGGGGCTTCCCTTTTGAGAACAGTAGT TCTAGATGCAGTCAGACCCAAGAAAATACAGAGTGCACTGTCTGCTTATTCCTTGTGCAGAAGAAACCACTGATATTCCTGGGTTGTTGC TTCTTCTCCACCCTGGTTCTACTCTTATCAATTGCCATTTTTCAAAGGCAGAAGAGAAGAAAGTTTTGGAAAGCAAAAAACTTACAACAC >In-frame_UBE2K_ENST00000445950_chr4_39776553_+_KLB_ENST00000257408_chr4_39435830_+_2709nt ATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGACGAGCAAAAATCAAATTAAAGTAGAT CTTGTAGATGAGAATTTTACAGAATTAAGAGGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATACCAACTAGAGATA AAAATACCAGAAACATACCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTTCCGTCACAGGGGCT ATTTGTTTGGATATCCTGAAAGATCAATGGGCAGCTGCAATGACTCTCCGCACGGTATTATTGTCATTGCAAGCACTATTGGCAGCTGCA GAGCCAGATGATCCACAGGATGCTGTAGTAGCAAATCAGGCTCACTCGAAAGTTTGGCATAACTACAACACACATTTCCGCCCACATCAG AAGGGTTGGTTATCGATCACGTTGGGATCTCATTGGATCGAGCCAAACCGGTCGGAAAACACGATGGATATATTCAAATGTCAACAATCC ATGGTTTCTGTGCTTGGATGGTTTGCCAACCCTATCCATGGGGATGGCGACTATCCAGAGGGGATGAGAAAGAAGTTGTTCTCCGTTCTA CCCATTTTCTCTGAAGCAGAGAAGCATGAGATGAGAGGCACAGCTGATTTCTTTGCCTTTTCTTTTGGACCCAACAACTTCAAGCCCCTA AACACCATGGCTAAAATGGGACAAAATGTTTCACTTAATTTAAGAGAAGCGCTGAACTGGATTAAACTGGAATACAACAACCCTCGAATC TTGATTGCTGAGAATGGCTGGTTCACAGACAGTCGTGTGAAAACAGAAGACACCACGGCCATCTACATGATGAAGAATTTCCTCAGCCAG GTGCTTCAAGCAATAAGGTTAGATGAAATACGAGTGTTTGGTTATACTGCCTGGTCTCTCCTGGATGGCTTTGAATGGCAGGATGCTTAC ACCATCCGCCGAGGATTATTTTATGTGGATTTTAACAGTAAACAGAAAGAGCGGAAACCTAAGTCTTCAGCACACTACTACAAACAGATC ATACGAGAAAATGGTTTTTCTTTAAAAGAGTCCACGCCAGATGTGCAGGGCCAGTTTCCCTGTGACTTCTCCTGGGGTGTCACTGAATCT GTTCTTAAGCCCGAGTCTGTGGCTTCGTCCCCACAGTTCAGCGATCCTCATCTGTACGTGTGGAACGCCACTGGCAACAGACTGTTGCAC CGAGTGGAAGGGGTGAGGCTGAAAACACGACCCGCTCAATGCACAGATTTTGTAAACATCAAAAAACAACTTGAGATGTTGGCAAGAATG AAAGTCACCCACTACCGGTTTGCTCTGGATTGGGCCTCGGTCCTTCCCACTGGCAACCTGTCCGCGGTGAACCGACAGGCCCTGAGGTAC TACAGGTGCGTGGTCAGTGAGGGGCTGAAGCTTGGCATCTCCGCGATGGTCACCCTGTATTATCCGACCCACGCCCACCTAGGCCTCCCC GAGCCTCTGTTGCATGCCGACGGGTGGCTGAACCCATCGACGGCCGAGGCCTTCCAGGCCTACGCTGGGCTGTGCTTCCAGGAGCTGGGG GACCTGGTGAAGCTCTGGATCACCATCAACGAGCCTAACCGGCTAAGTGACATCTACAACCGCTCTGGCAACGACACCTACGGGGCGGCG CACAACCTGCTGGTGGCCCACGCCCTGGCCTGGCGCCTCTACGACCGGCAGTTCAGGCCCTCACAGCGCGGGGCCGTGTCGCTGTCGCTG CACGCGGACTGGGCGGAACCCGCCAACCCCTATGCTGACTCGCACTGGAGGGCGGCCGAGCGCTTCCTGCAGTTCGAGATCGCCTGGTTC GCCGAGCCGCTCTTCAAGACCGGGGACTACCCCGCGGCCATGAGGGAATACATTGCCTCCAAGCACCGACGGGGGCTTTCCAGCTCGGCC CTGCCGCGCCTCACCGAGGCCGAAAGGAGGCTGCTCAAGGGCACGGTCGACTTCTGCGCGCTCAACCACTTCACCACTAGGTTCGTGATG CACGAGCAGCTGGCCGGCAGCCGCTACGACTCGGACAGGGACATCCAGTTTCTGCAGGACATCACCCGCCTGAGCTCCCCCACGCGCCTG GCTGTGATTCCCTGGGGGGTGCGCAAGCTGCTGCGGTGGGTCCGGAGGAACTACGGCGACATGGACATTTACATCACCGCCAGTGGCATC GACGACCAGGCTCTGGAGGATGACCGGCTCCGGAAGTACTACCTAGGGAAGTACCTTCAGGAGGTGCTGAAAGCATACCTGATTGATAAA GTCAGAATCAAAGGCTATTATGCATTCAAACTGGCTGAAGAGAAATCTAAACCCAGATTTGGATTCTTCACATCTGATTTTAAAGCTAAA TCCTCAATACAATTTTACAACAAAGTGATCAGCAGCAGGGGCTTCCCTTTTGAGAACAGTAGTTCTAGATGCAGTCAGACCCAAGAAAAT ACAGAGTGCACTGTCTGCTTATTCCTTGTGCAGAAGAAACCACTGATATTCCTGGGTTGTTGCTTCTTCTCCACCCTGGTTCTACTCTTA TCAATTGCCATTTTTCAAAGGCAGAAGAGAAGAAAGTTTTGGAAAGCAAAAAACTTACAACACATACCATTAAAGAAAGGCAAGAGAGTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_UBE2K_ENST00000261427_chr4_39776553_+_KLB_ENST00000257408_chr4_39435830_+_5843nt ACGCGAGCTCGTGGCTCGGGCGTATGGGGGCTCCAACGGGAGCGGCTGCGCCGCCCGGCCGGGTCAACGTCGTGCGCATGCGCCGACCCG GCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGG TCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAG CTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGACGAGCAAAAATC AAATTAAAGTAGATCTTGTAGATGAGAATTTTACAGAATTAAGAGGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGAT ACCAACTAGAGATAAAAATACCAGAAACATACCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTT CCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGGGCAGCTGCAATGACTCTCCGCACGGTATTATTGTCATTGCAAGCAC TATTGGCAGCTGCAGAGCCAGATGATCCACAGGATGCTGTAGTAGCAAATCAGGCTCACTCGAAAGTTTGGCATAACTACAACACACATT TCCGCCCACATCAGAAGGGTTGGTTATCGATCACGTTGGGATCTCATTGGATCGAGCCAAACCGGTCGGAAAACACGATGGATATATTCA AATGTCAACAATCCATGGTTTCTGTGCTTGGATGGTTTGCCAACCCTATCCATGGGGATGGCGACTATCCAGAGGGGATGAGAAAGAAGT TGTTCTCCGTTCTACCCATTTTCTCTGAAGCAGAGAAGCATGAGATGAGAGGCACAGCTGATTTCTTTGCCTTTTCTTTTGGACCCAACA ACTTCAAGCCCCTAAACACCATGGCTAAAATGGGACAAAATGTTTCACTTAATTTAAGAGAAGCGCTGAACTGGATTAAACTGGAATACA ACAACCCTCGAATCTTGATTGCTGAGAATGGCTGGTTCACAGACAGTCGTGTGAAAACAGAAGACACCACGGCCATCTACATGATGAAGA ATTTCCTCAGCCAGGTGCTTCAAGCAATAAGGTTAGATGAAATACGAGTGTTTGGTTATACTGCCTGGTCTCTCCTGGATGGCTTTGAAT GGCAGGATGCTTACACCATCCGCCGAGGATTATTTTATGTGGATTTTAACAGTAAACAGAAAGAGCGGAAACCTAAGTCTTCAGCACACT ACTACAAACAGATCATACGAGAAAATGGTTTTTCTTTAAAAGAGTCCACGCCAGATGTGCAGGGCCAGTTTCCCTGTGACTTCTCCTGGG GTGTCACTGAATCTGTTCTTAAGCCCGAGTCTGTGGCTTCGTCCCCACAGTTCAGCGATCCTCATCTGTACGTGTGGAACGCCACTGGCA ACAGACTGTTGCACCGAGTGGAAGGGGTGAGGCTGAAAACACGACCCGCTCAATGCACAGATTTTGTAAACATCAAAAAACAACTTGAGA TGTTGGCAAGAATGAAAGTCACCCACTACCGGTTTGCTCTGGATTGGGCCTCGGTCCTTCCCACTGGCAACCTGTCCGCGGTGAACCGAC AGGCCCTGAGGTACTACAGGTGCGTGGTCAGTGAGGGGCTGAAGCTTGGCATCTCCGCGATGGTCACCCTGTATTATCCGACCCACGCCC ACCTAGGCCTCCCCGAGCCTCTGTTGCATGCCGACGGGTGGCTGAACCCATCGACGGCCGAGGCCTTCCAGGCCTACGCTGGGCTGTGCT TCCAGGAGCTGGGGGACCTGGTGAAGCTCTGGATCACCATCAACGAGCCTAACCGGCTAAGTGACATCTACAACCGCTCTGGCAACGACA CCTACGGGGCGGCGCACAACCTGCTGGTGGCCCACGCCCTGGCCTGGCGCCTCTACGACCGGCAGTTCAGGCCCTCACAGCGCGGGGCCG TGTCGCTGTCGCTGCACGCGGACTGGGCGGAACCCGCCAACCCCTATGCTGACTCGCACTGGAGGGCGGCCGAGCGCTTCCTGCAGTTCG AGATCGCCTGGTTCGCCGAGCCGCTCTTCAAGACCGGGGACTACCCCGCGGCCATGAGGGAATACATTGCCTCCAAGCACCGACGGGGGC TTTCCAGCTCGGCCCTGCCGCGCCTCACCGAGGCCGAAAGGAGGCTGCTCAAGGGCACGGTCGACTTCTGCGCGCTCAACCACTTCACCA CTAGGTTCGTGATGCACGAGCAGCTGGCCGGCAGCCGCTACGACTCGGACAGGGACATCCAGTTTCTGCAGGACATCACCCGCCTGAGCT CCCCCACGCGCCTGGCTGTGATTCCCTGGGGGGTGCGCAAGCTGCTGCGGTGGGTCCGGAGGAACTACGGCGACATGGACATTTACATCA CCGCCAGTGGCATCGACGACCAGGCTCTGGAGGATGACCGGCTCCGGAAGTACTACCTAGGGAAGTACCTTCAGGAGGTGCTGAAAGCAT ACCTGATTGATAAAGTCAGAATCAAAGGCTATTATGCATTCAAACTGGCTGAAGAGAAATCTAAACCCAGATTTGGATTCTTCACATCTG ATTTTAAAGCTAAATCCTCAATACAATTTTACAACAAAGTGATCAGCAGCAGGGGCTTCCCTTTTGAGAACAGTAGTTCTAGATGCAGTC AGACCCAAGAAAATACAGAGTGCACTGTCTGCTTATTCCTTGTGCAGAAGAAACCACTGATATTCCTGGGTTGTTGCTTCTTCTCCACCC TGGTTCTACTCTTATCAATTGCCATTTTTCAAAGGCAGAAGAGAAGAAAGTTTTGGAAAGCAAAAAACTTACAACACATACCATTAAAGA AAGGCAAGAGAGTTGTTAGCTAAACTGATCTGTCTGCATGATAGACAGTTTAAAAATTCATCCCAGTTCCATATGCTGGTAACTTACAGG AGATATACCTGTATTATAGAAAGACAATCTGAGATACAGCTGTAACCAAGGTGATGACAATTGTCTCTGCTGTGTGGTTCAAAGAACATT CCCTTAGGTGTTGACATCAGTGAACTCAGTTCTTGGATGTAAACATAAAGGCTTCATCCTGACAGTAAGCTATGAGGATTACATGCTACA TTGCTTCTTAAAGTTTCATCAACTGTATTCCATCATTCTGCTTTAGCTTTCATCTCTACCAATAGCTACTTGTGGTACAATAAATTATTT TTAAGAAGTAAAACTCTGGGGCTGGACGCTGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGCCGAGGCGGGGAGATCACCTGAGGT GAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCATGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGACAGTGGCACC TGTAATCCCAGCTACTTGGGAGGCTGAGGCAGAAGTTTGAACCCAGGAAACAGGTTACAGTAGGCCAAAATTGCGCCACTGCACTCCAGC CTAGGCGACAACAGCAAGACTGTGTCCAAAAAAAAAAAAAAAAGCAAAAGCAAAACTTTGTTTTGTTAGACTCTACAGCAGAGATTTAAC ACCCTTCTTTAAACTGGGTAGTCAGTGATAGATAATATATATTCTGTCACTTCTAATAAGGTGCCTTCTCCTTTAGGTCAGGGTGGTTCT AAAATGGAAAGAAAACACAATAGGGTAAGTAGTGCTTGTCTAAGCCAGTTACAACACAGACTCTTAAAGAGGATCAAGCCCTTCATTTTT CTAACAACAAAAAATCACCTATAGAATATCTAATTTGTGATCTTTTACTAGATCTGATTTTTTAAAATAATGTAATTTCCGGCCAGGCAC GGTGGCACCGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTTAGGAGTTCGAGACTAGCCTGGCCAACATG GCAAAACCCCATCTCTACTAAAAATACAAAAGTTAGCCGGGCATGGTGGTGGGCACCTGTAATCCCAGCTACTCAGGAGGCCGAGGCAGG AGAATCGCTTGAACCCGAGAGGCAGAGGTTGCAATGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGGGACAGGGCAAGACTGTCTCT CAAAATAAAAAAAAATAATAAAAATAAAAATAAAAGTAATTTCCAAAACCTCATCTCATGGAAAGATCACAGGATGAAGGAAAGCTAGAC TCAACTCTGTGAATAGAAGTTGCTATACTGTAAGTAAAGCAACAATTCAGAATACTGAATGAGTTTAAATTGTTTTATATAGCACCCTTT TGGGCTAGGGTTAATTACTAGATCTGACTTGGATAATTTGACACTTTGGGAAATGAACTCTGTTCTTGAGACTTGTTCAGTGTATTTTAA ACATCTGAGGAAGAAAACTTAAATATGCACCTATTTATACCTATTCTTTCTTTAGGTCAACATTTAACACCCACTGCATACATTAATTTG TCCTTGTCTGCTCACTCCAGCAATTTAGACCTTAACAGTCACAAGAGACGTTCTTCTGTTACAAAGCCTTAGTAAATTAAGGCAGTTTTG ATTATATTCTAGGTCCACCTATGTCTGAAGCTAAATTCAGTATCTAACTGCTAATGAACAAGTTTCCAAAATACTGTAAAAATACAATTA GTCAATTTGAGTAAATGCAAATATGATGAGAAATCAATTTGCTATTTGGCCTGGCAAATGGGAACAGTAAAATTCTGCTTTACTCTTCTC TAGTCTCCTTGCCCCAGCTGCACCCACTACCCCAAAGTTGGCAGTTTTGAGGTATGATTTTCAAGGAATTTTTTTAGTATTAACATCTCC CTCTGAGAACTATGTACCTAAGGTCACGCATACAACTAGTCAATTCTGTTTTTATTACTCTAACTATGTAGAAACAGTAAGTCACTTAAA ACAATCACTTGGCTGGGTTTTTTCCCCTTTGTGCCACATTGATTCACCCTGACCCAAGAACTCCAGGGAAAATTCTTTAATGTCAACTGG GCAACTCATTAACCTCTCTTTAACATCAAGGGCTTGGGAAAAAAAAAAAAAAGGTTAGCCACAGGAATAACAAAAACCTGGAATTTATCT TTCAGGTTTTGCTTTCTCTTTCTCACTTTGTTTAAAGTATCTCGTACTCACAGTTCACAAATTAACCTTCACTGTCTCTTTCACATTAAG AGCTTATGCTTAAAGCATGCCCCCCTTTTCTAACTTGCTGGTTTACCATAAACTCCCCTAAGTAATAAAATTCCTAACCCAGTACTGAGA GTCCTCCTTCTCTGCCACTTGGGCATTATTTTACTAGTTTTTAAGCCATCATCGCACAAGAATCCAAAAACCCTTAAATTTTTTAACCAC TGGCAAATATGTACAGCAAATTAGGTTAAGCATTTAATCTGGCTCATGCTCTATCATACTAAATATTCAGGTTTATCATAAACTCCTTAA AAACCATCAAAGGTCAACCAGAAACTGATAACTCTTGAAAGGAGCAAACAGGTAAGATCTTTGGAGTTTAAGCTTTTCTGAGATGTGTTG TGAAAAATCTAACGTGTTTATCGTATATTCAATGTAACAACCTGGAGAATCACAACTATATTTAAAGAGCCTCTGGAAAATGAGGCCAGT >In-frame_UBE2K_ENST00000503368_chr4_39776553_+_KLB_ENST00000257408_chr4_39435830_+_5571nt GATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGA GGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCG GTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTTCC GTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGGGCAGCTGCAATGACTCTCCGCACGGTATTATTGTCATTGCAAGCACTA TTGGCAGCTGCAGAGCCAGATGATCCACAGGATGCTGTAGTAGCAAATCAGGCTCACTCGAAAGTTTGGCATAACTACAACACACATTTC CGCCCACATCAGAAGGGTTGGTTATCGATCACGTTGGGATCTCATTGGATCGAGCCAAACCGGTCGGAAAACACGATGGATATATTCAAA TGTCAACAATCCATGGTTTCTGTGCTTGGATGGTTTGCCAACCCTATCCATGGGGATGGCGACTATCCAGAGGGGATGAGAAAGAAGTTG TTCTCCGTTCTACCCATTTTCTCTGAAGCAGAGAAGCATGAGATGAGAGGCACAGCTGATTTCTTTGCCTTTTCTTTTGGACCCAACAAC TTCAAGCCCCTAAACACCATGGCTAAAATGGGACAAAATGTTTCACTTAATTTAAGAGAAGCGCTGAACTGGATTAAACTGGAATACAAC AACCCTCGAATCTTGATTGCTGAGAATGGCTGGTTCACAGACAGTCGTGTGAAAACAGAAGACACCACGGCCATCTACATGATGAAGAAT TTCCTCAGCCAGGTGCTTCAAGCAATAAGGTTAGATGAAATACGAGTGTTTGGTTATACTGCCTGGTCTCTCCTGGATGGCTTTGAATGG CAGGATGCTTACACCATCCGCCGAGGATTATTTTATGTGGATTTTAACAGTAAACAGAAAGAGCGGAAACCTAAGTCTTCAGCACACTAC TACAAACAGATCATACGAGAAAATGGTTTTTCTTTAAAAGAGTCCACGCCAGATGTGCAGGGCCAGTTTCCCTGTGACTTCTCCTGGGGT GTCACTGAATCTGTTCTTAAGCCCGAGTCTGTGGCTTCGTCCCCACAGTTCAGCGATCCTCATCTGTACGTGTGGAACGCCACTGGCAAC AGACTGTTGCACCGAGTGGAAGGGGTGAGGCTGAAAACACGACCCGCTCAATGCACAGATTTTGTAAACATCAAAAAACAACTTGAGATG TTGGCAAGAATGAAAGTCACCCACTACCGGTTTGCTCTGGATTGGGCCTCGGTCCTTCCCACTGGCAACCTGTCCGCGGTGAACCGACAG GCCCTGAGGTACTACAGGTGCGTGGTCAGTGAGGGGCTGAAGCTTGGCATCTCCGCGATGGTCACCCTGTATTATCCGACCCACGCCCAC CTAGGCCTCCCCGAGCCTCTGTTGCATGCCGACGGGTGGCTGAACCCATCGACGGCCGAGGCCTTCCAGGCCTACGCTGGGCTGTGCTTC CAGGAGCTGGGGGACCTGGTGAAGCTCTGGATCACCATCAACGAGCCTAACCGGCTAAGTGACATCTACAACCGCTCTGGCAACGACACC TACGGGGCGGCGCACAACCTGCTGGTGGCCCACGCCCTGGCCTGGCGCCTCTACGACCGGCAGTTCAGGCCCTCACAGCGCGGGGCCGTG TCGCTGTCGCTGCACGCGGACTGGGCGGAACCCGCCAACCCCTATGCTGACTCGCACTGGAGGGCGGCCGAGCGCTTCCTGCAGTTCGAG ATCGCCTGGTTCGCCGAGCCGCTCTTCAAGACCGGGGACTACCCCGCGGCCATGAGGGAATACATTGCCTCCAAGCACCGACGGGGGCTT TCCAGCTCGGCCCTGCCGCGCCTCACCGAGGCCGAAAGGAGGCTGCTCAAGGGCACGGTCGACTTCTGCGCGCTCAACCACTTCACCACT AGGTTCGTGATGCACGAGCAGCTGGCCGGCAGCCGCTACGACTCGGACAGGGACATCCAGTTTCTGCAGGACATCACCCGCCTGAGCTCC CCCACGCGCCTGGCTGTGATTCCCTGGGGGGTGCGCAAGCTGCTGCGGTGGGTCCGGAGGAACTACGGCGACATGGACATTTACATCACC GCCAGTGGCATCGACGACCAGGCTCTGGAGGATGACCGGCTCCGGAAGTACTACCTAGGGAAGTACCTTCAGGAGGTGCTGAAAGCATAC CTGATTGATAAAGTCAGAATCAAAGGCTATTATGCATTCAAACTGGCTGAAGAGAAATCTAAACCCAGATTTGGATTCTTCACATCTGAT TTTAAAGCTAAATCCTCAATACAATTTTACAACAAAGTGATCAGCAGCAGGGGCTTCCCTTTTGAGAACAGTAGTTCTAGATGCAGTCAG ACCCAAGAAAATACAGAGTGCACTGTCTGCTTATTCCTTGTGCAGAAGAAACCACTGATATTCCTGGGTTGTTGCTTCTTCTCCACCCTG GTTCTACTCTTATCAATTGCCATTTTTCAAAGGCAGAAGAGAAGAAAGTTTTGGAAAGCAAAAAACTTACAACACATACCATTAAAGAAA GGCAAGAGAGTTGTTAGCTAAACTGATCTGTCTGCATGATAGACAGTTTAAAAATTCATCCCAGTTCCATATGCTGGTAACTTACAGGAG ATATACCTGTATTATAGAAAGACAATCTGAGATACAGCTGTAACCAAGGTGATGACAATTGTCTCTGCTGTGTGGTTCAAAGAACATTCC CTTAGGTGTTGACATCAGTGAACTCAGTTCTTGGATGTAAACATAAAGGCTTCATCCTGACAGTAAGCTATGAGGATTACATGCTACATT GCTTCTTAAAGTTTCATCAACTGTATTCCATCATTCTGCTTTAGCTTTCATCTCTACCAATAGCTACTTGTGGTACAATAAATTATTTTT AAGAAGTAAAACTCTGGGGCTGGACGCTGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGCCGAGGCGGGGAGATCACCTGAGGTGA GGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCATGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGACAGTGGCACCTG TAATCCCAGCTACTTGGGAGGCTGAGGCAGAAGTTTGAACCCAGGAAACAGGTTACAGTAGGCCAAAATTGCGCCACTGCACTCCAGCCT AGGCGACAACAGCAAGACTGTGTCCAAAAAAAAAAAAAAAAGCAAAAGCAAAACTTTGTTTTGTTAGACTCTACAGCAGAGATTTAACAC CCTTCTTTAAACTGGGTAGTCAGTGATAGATAATATATATTCTGTCACTTCTAATAAGGTGCCTTCTCCTTTAGGTCAGGGTGGTTCTAA AATGGAAAGAAAACACAATAGGGTAAGTAGTGCTTGTCTAAGCCAGTTACAACACAGACTCTTAAAGAGGATCAAGCCCTTCATTTTTCT AACAACAAAAAATCACCTATAGAATATCTAATTTGTGATCTTTTACTAGATCTGATTTTTTAAAATAATGTAATTTCCGGCCAGGCACGG TGGCACCGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTTAGGAGTTCGAGACTAGCCTGGCCAACATGGC AAAACCCCATCTCTACTAAAAATACAAAAGTTAGCCGGGCATGGTGGTGGGCACCTGTAATCCCAGCTACTCAGGAGGCCGAGGCAGGAG AATCGCTTGAACCCGAGAGGCAGAGGTTGCAATGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGGGACAGGGCAAGACTGTCTCTCA AAATAAAAAAAAATAATAAAAATAAAAATAAAAGTAATTTCCAAAACCTCATCTCATGGAAAGATCACAGGATGAAGGAAAGCTAGACTC AACTCTGTGAATAGAAGTTGCTATACTGTAAGTAAAGCAACAATTCAGAATACTGAATGAGTTTAAATTGTTTTATATAGCACCCTTTTG GGCTAGGGTTAATTACTAGATCTGACTTGGATAATTTGACACTTTGGGAAATGAACTCTGTTCTTGAGACTTGTTCAGTGTATTTTAAAC ATCTGAGGAAGAAAACTTAAATATGCACCTATTTATACCTATTCTTTCTTTAGGTCAACATTTAACACCCACTGCATACATTAATTTGTC CTTGTCTGCTCACTCCAGCAATTTAGACCTTAACAGTCACAAGAGACGTTCTTCTGTTACAAAGCCTTAGTAAATTAAGGCAGTTTTGAT TATATTCTAGGTCCACCTATGTCTGAAGCTAAATTCAGTATCTAACTGCTAATGAACAAGTTTCCAAAATACTGTAAAAATACAATTAGT CAATTTGAGTAAATGCAAATATGATGAGAAATCAATTTGCTATTTGGCCTGGCAAATGGGAACAGTAAAATTCTGCTTTACTCTTCTCTA GTCTCCTTGCCCCAGCTGCACCCACTACCCCAAAGTTGGCAGTTTTGAGGTATGATTTTCAAGGAATTTTTTTAGTATTAACATCTCCCT CTGAGAACTATGTACCTAAGGTCACGCATACAACTAGTCAATTCTGTTTTTATTACTCTAACTATGTAGAAACAGTAAGTCACTTAAAAC AATCACTTGGCTGGGTTTTTTCCCCTTTGTGCCACATTGATTCACCCTGACCCAAGAACTCCAGGGAAAATTCTTTAATGTCAACTGGGC AACTCATTAACCTCTCTTTAACATCAAGGGCTTGGGAAAAAAAAAAAAAAGGTTAGCCACAGGAATAACAAAAACCTGGAATTTATCTTT CAGGTTTTGCTTTCTCTTTCTCACTTTGTTTAAAGTATCTCGTACTCACAGTTCACAAATTAACCTTCACTGTCTCTTTCACATTAAGAG CTTATGCTTAAAGCATGCCCCCCTTTTCTAACTTGCTGGTTTACCATAAACTCCCCTAAGTAATAAAATTCCTAACCCAGTACTGAGAGT CCTCCTTCTCTGCCACTTGGGCATTATTTTACTAGTTTTTAAGCCATCATCGCACAAGAATCCAAAAACCCTTAAATTTTTTAACCACTG GCAAATATGTACAGCAAATTAGGTTAAGCATTTAATCTGGCTCATGCTCTATCATACTAAATATTCAGGTTTATCATAAACTCCTTAAAA ACCATCAAAGGTCAACCAGAAACTGATAACTCTTGAAAGGAGCAAACAGGTAAGATCTTTGGAGTTTAAGCTTTTCTGAGATGTGTTGTG AAAAATCTAACGTGTTTATCGTATATTCAATGTAACAACCTGGAGAATCACAACTATATTTAAAGAGCCTCTGGAAAATGAGGCCAGTAC >In-frame_UBE2K_ENST00000445950_chr4_39776553_+_KLB_ENST00000257408_chr4_39435830_+_5711nt GGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCG GCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCA AGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGACGAGCAAAAATCAAATTAAAGTAGATCTTGTAGATGAGAATTTTACAGAATTAA GAGGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATACCAACTAGAGATAAAAATACCAGAAACATACCCATTTAATC CCCCTAAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTTCCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAAT GGGCAGCTGCAATGACTCTCCGCACGGTATTATTGTCATTGCAAGCACTATTGGCAGCTGCAGAGCCAGATGATCCACAGGATGCTGTAG TAGCAAATCAGGCTCACTCGAAAGTTTGGCATAACTACAACACACATTTCCGCCCACATCAGAAGGGTTGGTTATCGATCACGTTGGGAT CTCATTGGATCGAGCCAAACCGGTCGGAAAACACGATGGATATATTCAAATGTCAACAATCCATGGTTTCTGTGCTTGGATGGTTTGCCA ACCCTATCCATGGGGATGGCGACTATCCAGAGGGGATGAGAAAGAAGTTGTTCTCCGTTCTACCCATTTTCTCTGAAGCAGAGAAGCATG AGATGAGAGGCACAGCTGATTTCTTTGCCTTTTCTTTTGGACCCAACAACTTCAAGCCCCTAAACACCATGGCTAAAATGGGACAAAATG TTTCACTTAATTTAAGAGAAGCGCTGAACTGGATTAAACTGGAATACAACAACCCTCGAATCTTGATTGCTGAGAATGGCTGGTTCACAG ACAGTCGTGTGAAAACAGAAGACACCACGGCCATCTACATGATGAAGAATTTCCTCAGCCAGGTGCTTCAAGCAATAAGGTTAGATGAAA TACGAGTGTTTGGTTATACTGCCTGGTCTCTCCTGGATGGCTTTGAATGGCAGGATGCTTACACCATCCGCCGAGGATTATTTTATGTGG ATTTTAACAGTAAACAGAAAGAGCGGAAACCTAAGTCTTCAGCACACTACTACAAACAGATCATACGAGAAAATGGTTTTTCTTTAAAAG AGTCCACGCCAGATGTGCAGGGCCAGTTTCCCTGTGACTTCTCCTGGGGTGTCACTGAATCTGTTCTTAAGCCCGAGTCTGTGGCTTCGT CCCCACAGTTCAGCGATCCTCATCTGTACGTGTGGAACGCCACTGGCAACAGACTGTTGCACCGAGTGGAAGGGGTGAGGCTGAAAACAC GACCCGCTCAATGCACAGATTTTGTAAACATCAAAAAACAACTTGAGATGTTGGCAAGAATGAAAGTCACCCACTACCGGTTTGCTCTGG ATTGGGCCTCGGTCCTTCCCACTGGCAACCTGTCCGCGGTGAACCGACAGGCCCTGAGGTACTACAGGTGCGTGGTCAGTGAGGGGCTGA AGCTTGGCATCTCCGCGATGGTCACCCTGTATTATCCGACCCACGCCCACCTAGGCCTCCCCGAGCCTCTGTTGCATGCCGACGGGTGGC TGAACCCATCGACGGCCGAGGCCTTCCAGGCCTACGCTGGGCTGTGCTTCCAGGAGCTGGGGGACCTGGTGAAGCTCTGGATCACCATCA ACGAGCCTAACCGGCTAAGTGACATCTACAACCGCTCTGGCAACGACACCTACGGGGCGGCGCACAACCTGCTGGTGGCCCACGCCCTGG CCTGGCGCCTCTACGACCGGCAGTTCAGGCCCTCACAGCGCGGGGCCGTGTCGCTGTCGCTGCACGCGGACTGGGCGGAACCCGCCAACC CCTATGCTGACTCGCACTGGAGGGCGGCCGAGCGCTTCCTGCAGTTCGAGATCGCCTGGTTCGCCGAGCCGCTCTTCAAGACCGGGGACT ACCCCGCGGCCATGAGGGAATACATTGCCTCCAAGCACCGACGGGGGCTTTCCAGCTCGGCCCTGCCGCGCCTCACCGAGGCCGAAAGGA GGCTGCTCAAGGGCACGGTCGACTTCTGCGCGCTCAACCACTTCACCACTAGGTTCGTGATGCACGAGCAGCTGGCCGGCAGCCGCTACG ACTCGGACAGGGACATCCAGTTTCTGCAGGACATCACCCGCCTGAGCTCCCCCACGCGCCTGGCTGTGATTCCCTGGGGGGTGCGCAAGC TGCTGCGGTGGGTCCGGAGGAACTACGGCGACATGGACATTTACATCACCGCCAGTGGCATCGACGACCAGGCTCTGGAGGATGACCGGC TCCGGAAGTACTACCTAGGGAAGTACCTTCAGGAGGTGCTGAAAGCATACCTGATTGATAAAGTCAGAATCAAAGGCTATTATGCATTCA AACTGGCTGAAGAGAAATCTAAACCCAGATTTGGATTCTTCACATCTGATTTTAAAGCTAAATCCTCAATACAATTTTACAACAAAGTGA TCAGCAGCAGGGGCTTCCCTTTTGAGAACAGTAGTTCTAGATGCAGTCAGACCCAAGAAAATACAGAGTGCACTGTCTGCTTATTCCTTG TGCAGAAGAAACCACTGATATTCCTGGGTTGTTGCTTCTTCTCCACCCTGGTTCTACTCTTATCAATTGCCATTTTTCAAAGGCAGAAGA GAAGAAAGTTTTGGAAAGCAAAAAACTTACAACACATACCATTAAAGAAAGGCAAGAGAGTTGTTAGCTAAACTGATCTGTCTGCATGAT AGACAGTTTAAAAATTCATCCCAGTTCCATATGCTGGTAACTTACAGGAGATATACCTGTATTATAGAAAGACAATCTGAGATACAGCTG TAACCAAGGTGATGACAATTGTCTCTGCTGTGTGGTTCAAAGAACATTCCCTTAGGTGTTGACATCAGTGAACTCAGTTCTTGGATGTAA ACATAAAGGCTTCATCCTGACAGTAAGCTATGAGGATTACATGCTACATTGCTTCTTAAAGTTTCATCAACTGTATTCCATCATTCTGCT TTAGCTTTCATCTCTACCAATAGCTACTTGTGGTACAATAAATTATTTTTAAGAAGTAAAACTCTGGGGCTGGACGCTGTGGCTCACACC TGTAATCTCAGCACTTTGGGAGGCCGAGGCGGGGAGATCACCTGAGGTGAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCATGT CTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGACAGTGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGAAGTTTGAAC CCAGGAAACAGGTTACAGTAGGCCAAAATTGCGCCACTGCACTCCAGCCTAGGCGACAACAGCAAGACTGTGTCCAAAAAAAAAAAAAAA AGCAAAAGCAAAACTTTGTTTTGTTAGACTCTACAGCAGAGATTTAACACCCTTCTTTAAACTGGGTAGTCAGTGATAGATAATATATAT TCTGTCACTTCTAATAAGGTGCCTTCTCCTTTAGGTCAGGGTGGTTCTAAAATGGAAAGAAAACACAATAGGGTAAGTAGTGCTTGTCTA AGCCAGTTACAACACAGACTCTTAAAGAGGATCAAGCCCTTCATTTTTCTAACAACAAAAAATCACCTATAGAATATCTAATTTGTGATC TTTTACTAGATCTGATTTTTTAAAATAATGTAATTTCCGGCCAGGCACGGTGGCACCGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGC AGGTGGATCACCTGAGGTTAGGAGTTCGAGACTAGCCTGGCCAACATGGCAAAACCCCATCTCTACTAAAAATACAAAAGTTAGCCGGGC ATGGTGGTGGGCACCTGTAATCCCAGCTACTCAGGAGGCCGAGGCAGGAGAATCGCTTGAACCCGAGAGGCAGAGGTTGCAATGAGCCAA GATCGTGCCATTGCACTCCAGCCTGGGGGACAGGGCAAGACTGTCTCTCAAAATAAAAAAAAATAATAAAAATAAAAATAAAAGTAATTT CCAAAACCTCATCTCATGGAAAGATCACAGGATGAAGGAAAGCTAGACTCAACTCTGTGAATAGAAGTTGCTATACTGTAAGTAAAGCAA CAATTCAGAATACTGAATGAGTTTAAATTGTTTTATATAGCACCCTTTTGGGCTAGGGTTAATTACTAGATCTGACTTGGATAATTTGAC ACTTTGGGAAATGAACTCTGTTCTTGAGACTTGTTCAGTGTATTTTAAACATCTGAGGAAGAAAACTTAAATATGCACCTATTTATACCT ATTCTTTCTTTAGGTCAACATTTAACACCCACTGCATACATTAATTTGTCCTTGTCTGCTCACTCCAGCAATTTAGACCTTAACAGTCAC AAGAGACGTTCTTCTGTTACAAAGCCTTAGTAAATTAAGGCAGTTTTGATTATATTCTAGGTCCACCTATGTCTGAAGCTAAATTCAGTA TCTAACTGCTAATGAACAAGTTTCCAAAATACTGTAAAAATACAATTAGTCAATTTGAGTAAATGCAAATATGATGAGAAATCAATTTGC TATTTGGCCTGGCAAATGGGAACAGTAAAATTCTGCTTTACTCTTCTCTAGTCTCCTTGCCCCAGCTGCACCCACTACCCCAAAGTTGGC AGTTTTGAGGTATGATTTTCAAGGAATTTTTTTAGTATTAACATCTCCCTCTGAGAACTATGTACCTAAGGTCACGCATACAACTAGTCA ATTCTGTTTTTATTACTCTAACTATGTAGAAACAGTAAGTCACTTAAAACAATCACTTGGCTGGGTTTTTTCCCCTTTGTGCCACATTGA TTCACCCTGACCCAAGAACTCCAGGGAAAATTCTTTAATGTCAACTGGGCAACTCATTAACCTCTCTTTAACATCAAGGGCTTGGGAAAA AAAAAAAAAAGGTTAGCCACAGGAATAACAAAAACCTGGAATTTATCTTTCAGGTTTTGCTTTCTCTTTCTCACTTTGTTTAAAGTATCT CGTACTCACAGTTCACAAATTAACCTTCACTGTCTCTTTCACATTAAGAGCTTATGCTTAAAGCATGCCCCCCTTTTCTAACTTGCTGGT TTACCATAAACTCCCCTAAGTAATAAAATTCCTAACCCAGTACTGAGAGTCCTCCTTCTCTGCCACTTGGGCATTATTTTACTAGTTTTT AAGCCATCATCGCACAAGAATCCAAAAACCCTTAAATTTTTTAACCACTGGCAAATATGTACAGCAAATTAGGTTAAGCATTTAATCTGG CTCATGCTCTATCATACTAAATATTCAGGTTTATCATAAACTCCTTAAAAACCATCAAAGGTCAACCAGAAACTGATAACTCTTGAAAGG AGCAAACAGGTAAGATCTTTGGAGTTTAAGCTTTTCTGAGATGTGTTGTGAAAAATCTAACGTGTTTATCGTATATTCAATGTAACAACC TGGAGAATCACAACTATATTTAAAGAGCCTCTGGAAAATGAGGCCAGTACAGTGTGACTACATGTTTAATTTTCAATGTAATTTATTCCA |
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FusionGenePPI for UBE2K_KLB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBE2K | DSTYK, HTT, RNF2, UBE2I, DDX58, RNF125, RNF138, BFAR, UBOX5, RNF5, DTX3, MARCH7, SIAH1, TRIM27, RNF185, TRIM35, BIRC7, BIRC8, RNF4, TRIM34, RNF167, UHRF2, TRAF7, MKRN2, TRAIP, RING1, RNF41, MARCH3, RNF32, RNF114, LRSAM1, CBLC, DTX3L, DZIP3, MID1, MKRN3, TRIM39, RNF111, RNF144A, TRIM2, TRIM31, TRIM43, TRIM5, RBCK1, ITSN1, PRPF40A, CCNB1, DIABLO, BRCA1, UBC, CASP12, PIAS4, NUB1, NXF1, FZR1, NEDD4L, WWP2, ITCH, WDR1, WDR61, TXNDC17, TYMS, TXN, ANAPC11, IQCB1, BAG3, UBA1, TP53, MDM2, CDC6, PRRG4, REL, MIPOL1, DDI1, ZDHHC17, AMFR, BARD1, SENP1, MAP3K1, HNRNPA1, UBE2D2, RAB1A, TMEM189-UBE2V1, UBE2V1, UBE2N, RC3H2, TRIM63, SMURF1, CYHR1, ARL15, USP1, DLD | KLB |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBE2K_KLB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBE2K_KLB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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