![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 40450 |
FusionGeneSummary for UBE2K_G3BP2 |
![]() |
Fusion gene information | Fusion gene name: UBE2K_G3BP2 | Fusion gene ID: 40450 | Hgene | Tgene | Gene symbol | UBE2K | G3BP2 | Gene ID | 3093 | 9908 |
Gene name | ubiquitin conjugating enzyme E2 K | G3BP stress granule assembly factor 2 | |
Synonyms | E2-25K|HIP2|HYPG|LIG|UBC1 | - | |
Cytomap | 4p14 | 4q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ubiquitin-conjugating enzyme E2 KE2 ubiquitin-conjugating enzyme KE2(25K)HIP-2huntingtin-interacting protein 2ubiquitin carrier proteinubiquitin conjugating enzyme E2Kubiquitin-conjugating enzyme E2(25K)ubiquitin-conjugating enzyme E2-25 KDAubiqu | ras GTPase-activating protein-binding protein 2G3BP-2GAP SH3 domain-binding protein 2GTPase activating protein (SH3 domain) binding protein 2Ras-GTPase activating protein SH3 domain-binding protein 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P61086 | Q9UN86 | |
Ensembl transtripts involved in fusion gene | ENST00000261427, ENST00000295963, ENST00000438068, ENST00000503368, ENST00000445950, | ENST00000395719, ENST00000359707, ENST00000357854, ENST00000502654, | |
Fusion gene scores | * DoF score | 9 X 6 X 9=486 | 3 X 2 X 2=12 |
# samples | 10 | 3 | |
** MAII score | log2(10/486*10)=-2.28095631383106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: UBE2K [Title/Abstract] AND G3BP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | UBE2K | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 24882218 |
Hgene | UBE2K | GO:0010994 | free ubiquitin chain polymerization | 24882218 |
Hgene | UBE2K | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | COAD | TCGA-DM-A28A-01A | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000261427 | ENST00000395719 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
5CDS-5UTR | ENST00000261427 | ENST00000359707 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
5CDS-5UTR | ENST00000261427 | ENST00000357854 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
5CDS-intron | ENST00000261427 | ENST00000502654 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
intron-5UTR | ENST00000295963 | ENST00000395719 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
intron-5UTR | ENST00000295963 | ENST00000359707 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
intron-5UTR | ENST00000295963 | ENST00000357854 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
intron-intron | ENST00000295963 | ENST00000502654 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
3UTR-5UTR | ENST00000438068 | ENST00000395719 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
3UTR-5UTR | ENST00000438068 | ENST00000359707 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
3UTR-5UTR | ENST00000438068 | ENST00000357854 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
3UTR-intron | ENST00000438068 | ENST00000502654 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
5CDS-5UTR | ENST00000503368 | ENST00000395719 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
5CDS-5UTR | ENST00000503368 | ENST00000359707 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
5CDS-5UTR | ENST00000503368 | ENST00000357854 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
5CDS-intron | ENST00000503368 | ENST00000502654 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
5CDS-5UTR | ENST00000445950 | ENST00000395719 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
5CDS-5UTR | ENST00000445950 | ENST00000359707 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
5CDS-5UTR | ENST00000445950 | ENST00000357854 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
5CDS-intron | ENST00000445950 | ENST00000502654 | UBE2K | chr4 | 39757359 | + | G3BP2 | chr4 | 76587233 | - |
Top |
FusionProtFeatures for UBE2K_G3BP2 |
![]() |
Hgene | Tgene |
UBE2K | G3BP2 |
Probable scaffold protein that may be involved in mRNAtransport. {ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for UBE2K_G3BP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for UBE2K_G3BP2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
UBE2K | DSTYK, HTT, RNF2, UBE2I, DDX58, RNF125, RNF138, BFAR, UBOX5, RNF5, DTX3, MARCH7, SIAH1, TRIM27, RNF185, TRIM35, BIRC7, BIRC8, RNF4, TRIM34, RNF167, UHRF2, TRAF7, MKRN2, TRAIP, RING1, RNF41, MARCH3, RNF32, RNF114, LRSAM1, CBLC, DTX3L, DZIP3, MID1, MKRN3, TRIM39, RNF111, RNF144A, TRIM2, TRIM31, TRIM43, TRIM5, RBCK1, ITSN1, PRPF40A, CCNB1, DIABLO, BRCA1, UBC, CASP12, PIAS4, NUB1, NXF1, FZR1, NEDD4L, WWP2, ITCH, WDR1, WDR61, TXNDC17, TYMS, TXN, ANAPC11, IQCB1, BAG3, UBA1, TP53, MDM2, CDC6, PRRG4, REL, MIPOL1, DDI1, ZDHHC17, AMFR, BARD1, SENP1, MAP3K1, HNRNPA1, UBE2D2, RAB1A, TMEM189-UBE2V1, UBE2V1, UBE2N, RC3H2, TRIM63, SMURF1, CYHR1, ARL15, USP1, DLD | G3BP2 | STK24, NFKBIA, DDX10, RNH1, RPL3L, NUP214, USP10, FARS2, ASCC3, ATXN2L, NUP62, C3orf17, GNL2, UIMC1, UBAP2, DDX24, NUFIP2, RPF2, WDR36, RPL22L1, ING4, TERF2, TP53, MDM2, UBC, PTEN, ELAVL1, ARRB2, CUL3, CDK2, CUL1, COPS5, CAND1, ESR1, CA9, VCP, TARDBP, PIN1, DDX6, FXR2, IVNS1ABP, SUZ12, RNF2, BMI1, G3BP1, POM121, NUP153, NUP88, HNRNPA1, ADSL, IFI30, IGF2BP3, PABPC1, PABPC4, PRPF8, YARS, SFN, NTRK1, RPL10, NF2, SNW1, WWP2, TRIM25, KLHDC3, CYLD, LASP1, RPS6, CAPRIN1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for UBE2K_G3BP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for UBE2K_G3BP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |