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Fusion gene ID: 40448 |
FusionGeneSummary for UBE2K_ENOPH1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBE2K_ENOPH1 | Fusion gene ID: 40448 | Hgene | Tgene | Gene symbol | UBE2K | ENOPH1 | Gene ID | 3093 | 58478 |
| Gene name | ubiquitin conjugating enzyme E2 K | enolase-phosphatase 1 | |
| Synonyms | E2-25K|HIP2|HYPG|LIG|UBC1 | E1|MASA|MST145|mtnC | |
| Cytomap | 4p14 | 4q21.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-conjugating enzyme E2 KE2 ubiquitin-conjugating enzyme KE2(25K)HIP-2huntingtin-interacting protein 2ubiquitin carrier proteinubiquitin conjugating enzyme E2Kubiquitin-conjugating enzyme E2(25K)ubiquitin-conjugating enzyme E2-25 KDAubiqu | enolase-phosphatase E12,3-diketo-5-methylthio-1-phosphopentane phosphataseacireductone synthase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P61086 | Q9UHY7 | |
| Ensembl transtripts involved in fusion gene | ENST00000261427, ENST00000295963, ENST00000438068, ENST00000503368, ENST00000445950, | ENST00000273920, ENST00000509635, | |
| Fusion gene scores | * DoF score | 9 X 6 X 9=486 | 4 X 3 X 3=36 |
| # samples | 10 | 4 | |
| ** MAII score | log2(10/486*10)=-2.28095631383106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: UBE2K [Title/Abstract] AND ENOPH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBE2K | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 24882218 |
| Hgene | UBE2K | GO:0010994 | free ubiquitin chain polymerization | 24882218 |
| Hgene | UBE2K | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
| Tgene | ENOPH1 | GO:0019509 | L-methionine salvage from methylthioadenosine | 15843022 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-30-1718-01A | UBE2K | chr4 | 39757359 | + | ENOPH1 | chr4 | 83375875 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261427 | ENST00000273920 | UBE2K | chr4 | 39757359 | + | ENOPH1 | chr4 | 83375875 | + |
| In-frame | ENST00000261427 | ENST00000509635 | UBE2K | chr4 | 39757359 | + | ENOPH1 | chr4 | 83375875 | + |
| intron-3CDS | ENST00000295963 | ENST00000273920 | UBE2K | chr4 | 39757359 | + | ENOPH1 | chr4 | 83375875 | + |
| intron-3CDS | ENST00000295963 | ENST00000509635 | UBE2K | chr4 | 39757359 | + | ENOPH1 | chr4 | 83375875 | + |
| 3UTR-3CDS | ENST00000438068 | ENST00000273920 | UBE2K | chr4 | 39757359 | + | ENOPH1 | chr4 | 83375875 | + |
| 3UTR-3CDS | ENST00000438068 | ENST00000509635 | UBE2K | chr4 | 39757359 | + | ENOPH1 | chr4 | 83375875 | + |
| In-frame | ENST00000503368 | ENST00000273920 | UBE2K | chr4 | 39757359 | + | ENOPH1 | chr4 | 83375875 | + |
| In-frame | ENST00000503368 | ENST00000509635 | UBE2K | chr4 | 39757359 | + | ENOPH1 | chr4 | 83375875 | + |
| In-frame | ENST00000445950 | ENST00000273920 | UBE2K | chr4 | 39757359 | + | ENOPH1 | chr4 | 83375875 | + |
| In-frame | ENST00000445950 | ENST00000509635 | UBE2K | chr4 | 39757359 | + | ENOPH1 | chr4 | 83375875 | + |
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FusionProtFeatures for UBE2K_ENOPH1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBE2K | ENOPH1 |
| Bifunctional enzyme that catalyzes the enolization of2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into theintermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate(HK-MTPenyl-1-P), which is then dephosphorylated to form theacireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). {ECO:0000255|HAMAP-Rule:MF_03117,ECO:0000269|PubMed:15843022}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ENOPH1 | chr4:39757359 | chr4:83375875 | ENST00000273920 | + | 2 | 6 | 153_154 | 129 | 262 | Region | Note=Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >UBE2K | chr4:39757359 | chr4:83375875 | ENST00000261427 | + | 4 | 7 | 160_200 | 99 | 201 | Domain | UBA |
| Hgene | >UBE2K | chr4:39757359 | chr4:83375875 | ENST00000445950 | + | 4 | 6 | 160_200 | 99 | 158 | Domain | UBA |
| Hgene | >UBE2K | chr4:39757359 | chr4:83375875 | ENST00000503368 | + | 2 | 5 | 160_200 | 48 | 150 | Domain | UBA |
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FusionGeneSequence for UBE2K_ENOPH1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_UBE2K_ENST00000261427_chr4_39757359_+_ENOPH1_ENST00000273920_chr4_83375875_+_232aa MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVTGA ICLDILKDQWFFADVVPAVRKWREAGMKVYIYSSGSVEAQKLLFGHSTEGDILELVDGHFDTKIGHKVESESYRKIADSIGCSTNNILFL >In-frame_UBE2K_ENST00000261427_chr4_39757359_+_ENOPH1_ENST00000509635_chr4_83375875_+_232aa MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVTGA ICLDILKDQWFFADVVPAVRKWREAGMKVYIYSSGSVEAQKLLFGHSTEGDILELVDGHFDTKIGHKVESESYRKIADSIGCSTNNILFL >In-frame_UBE2K_ENST00000503368_chr4_39757359_+_ENOPH1_ENST00000273920_chr4_83375875_+_181aa MANIAVQRIKREFKEVLKSEEVRFITKIWHPNISSVTGAICLDILKDQWFFADVVPAVRKWREAGMKVYIYSSGSVEAQKLLFGHSTEGD ILELVDGHFDTKIGHKVESESYRKIADSIGCSTNNILFLTDVTREASAAEEADVHVAVVVRPGNAGLTDDEKTYYSLITSFSELYLPSST >In-frame_UBE2K_ENST00000503368_chr4_39757359_+_ENOPH1_ENST00000509635_chr4_83375875_+_181aa MANIAVQRIKREFKEVLKSEEVRFITKIWHPNISSVTGAICLDILKDQWFFADVVPAVRKWREAGMKVYIYSSGSVEAQKLLFGHSTEGD ILELVDGHFDTKIGHKVESESYRKIADSIGCSTNNILFLTDVTREASAAEEADVHVAVVVRPGNAGLTDDEKTYYSLITSFSELYLPSST >In-frame_UBE2K_ENST00000445950_chr4_39757359_+_ENOPH1_ENST00000273920_chr4_83375875_+_232aa MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVTGA ICLDILKDQWFFADVVPAVRKWREAGMKVYIYSSGSVEAQKLLFGHSTEGDILELVDGHFDTKIGHKVESESYRKIADSIGCSTNNILFL >In-frame_UBE2K_ENST00000445950_chr4_39757359_+_ENOPH1_ENST00000509635_chr4_83375875_+_232aa MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVTGA ICLDILKDQWFFADVVPAVRKWREAGMKVYIYSSGSVEAQKLLFGHSTEGDILELVDGHFDTKIGHKVESESYRKIADSIGCSTNNILFL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_UBE2K_ENST00000261427_chr4_39757359_+_ENOPH1_ENST00000273920_chr4_83375875_+_696nt ATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGACGAGCAAAAATCAAATTAAAGTAGAT CTTGTAGATGAGAATTTTACAGAATTAAGAGGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATACCAACTAGAGATA AAAATACCAGAAACATACCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTTCCGTCACAGGGGCT ATTTGTTTGGATATCCTGAAAGATCAATGGTTCTTTGCAGATGTAGTTCCAGCAGTCAGGAAGTGGAGAGAGGCCGGAATGAAGGTGTAC ATCTATTCCTCAGGGAGTGTGGAGGCACAGAAACTGTTATTCGGGCATTCTACGGAGGGAGATATTCTTGAGCTTGTTGATGGTCACTTT GATACCAAGATTGGACACAAAGTAGAGAGTGAAAGTTACCGAAAGATTGCAGACAGCATTGGGTGCTCAACCAACAACATTTTGTTTCTG ACAGATGTTACTCGAGAGGCCAGTGCTGCTGAGGAAGCAGATGTGCACGTAGCTGTGGTGGTGAGACCAGGCAACGCAGGATTAACAGAT >In-frame_UBE2K_ENST00000261427_chr4_39757359_+_ENOPH1_ENST00000509635_chr4_83375875_+_696nt ATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGACGAGCAAAAATCAAATTAAAGTAGAT CTTGTAGATGAGAATTTTACAGAATTAAGAGGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATACCAACTAGAGATA AAAATACCAGAAACATACCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTTCCGTCACAGGGGCT ATTTGTTTGGATATCCTGAAAGATCAATGGTTCTTTGCAGATGTAGTTCCAGCAGTCAGGAAGTGGAGAGAGGCCGGAATGAAGGTGTAC ATCTATTCCTCAGGGAGTGTGGAGGCACAGAAACTGTTATTCGGGCATTCTACGGAGGGAGATATTCTTGAGCTTGTTGATGGTCACTTT GATACCAAGATTGGACACAAAGTAGAGAGTGAAAGTTACCGAAAGATTGCAGACAGCATTGGGTGCTCAACCAACAACATTTTGTTTCTG ACAGATGTTACTCGAGAGGCCAGTGCTGCTGAGGAAGCAGATGTGCACGTAGCTGTGGTGGTGAGACCAGGCAACGCAGGATTAACAGAT >In-frame_UBE2K_ENST00000503368_chr4_39757359_+_ENOPH1_ENST00000273920_chr4_83375875_+_543nt ATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTCCGGTTTATCACTAAAATATGGCAT CCTAATATTAGTTCCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGGTTCTTTGCAGATGTAGTTCCAGCAGTCAGGAAG TGGAGAGAGGCCGGAATGAAGGTGTACATCTATTCCTCAGGGAGTGTGGAGGCACAGAAACTGTTATTCGGGCATTCTACGGAGGGAGAT ATTCTTGAGCTTGTTGATGGTCACTTTGATACCAAGATTGGACACAAAGTAGAGAGTGAAAGTTACCGAAAGATTGCAGACAGCATTGGG TGCTCAACCAACAACATTTTGTTTCTGACAGATGTTACTCGAGAGGCCAGTGCTGCTGAGGAAGCAGATGTGCACGTAGCTGTGGTGGTG AGACCAGGCAACGCAGGATTAACAGATGATGAGAAGACTTACTACAGCCTCATCACATCCTTCAGTGAACTATACCTGCCTTCCTCAACC >In-frame_UBE2K_ENST00000503368_chr4_39757359_+_ENOPH1_ENST00000509635_chr4_83375875_+_543nt ATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTCCGGTTTATCACTAAAATATGGCAT CCTAATATTAGTTCCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGGTTCTTTGCAGATGTAGTTCCAGCAGTCAGGAAG TGGAGAGAGGCCGGAATGAAGGTGTACATCTATTCCTCAGGGAGTGTGGAGGCACAGAAACTGTTATTCGGGCATTCTACGGAGGGAGAT ATTCTTGAGCTTGTTGATGGTCACTTTGATACCAAGATTGGACACAAAGTAGAGAGTGAAAGTTACCGAAAGATTGCAGACAGCATTGGG TGCTCAACCAACAACATTTTGTTTCTGACAGATGTTACTCGAGAGGCCAGTGCTGCTGAGGAAGCAGATGTGCACGTAGCTGTGGTGGTG AGACCAGGCAACGCAGGATTAACAGATGATGAGAAGACTTACTACAGCCTCATCACATCCTTCAGTGAACTATACCTGCCTTCCTCAACC >In-frame_UBE2K_ENST00000445950_chr4_39757359_+_ENOPH1_ENST00000273920_chr4_83375875_+_696nt ATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGACGAGCAAAAATCAAATTAAAGTAGAT CTTGTAGATGAGAATTTTACAGAATTAAGAGGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATACCAACTAGAGATA AAAATACCAGAAACATACCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTTCCGTCACAGGGGCT ATTTGTTTGGATATCCTGAAAGATCAATGGTTCTTTGCAGATGTAGTTCCAGCAGTCAGGAAGTGGAGAGAGGCCGGAATGAAGGTGTAC ATCTATTCCTCAGGGAGTGTGGAGGCACAGAAACTGTTATTCGGGCATTCTACGGAGGGAGATATTCTTGAGCTTGTTGATGGTCACTTT GATACCAAGATTGGACACAAAGTAGAGAGTGAAAGTTACCGAAAGATTGCAGACAGCATTGGGTGCTCAACCAACAACATTTTGTTTCTG ACAGATGTTACTCGAGAGGCCAGTGCTGCTGAGGAAGCAGATGTGCACGTAGCTGTGGTGGTGAGACCAGGCAACGCAGGATTAACAGAT >In-frame_UBE2K_ENST00000445950_chr4_39757359_+_ENOPH1_ENST00000509635_chr4_83375875_+_696nt ATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGACGAGCAAAAATCAAATTAAAGTAGAT CTTGTAGATGAGAATTTTACAGAATTAAGAGGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATACCAACTAGAGATA AAAATACCAGAAACATACCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTTCCGTCACAGGGGCT ATTTGTTTGGATATCCTGAAAGATCAATGGTTCTTTGCAGATGTAGTTCCAGCAGTCAGGAAGTGGAGAGAGGCCGGAATGAAGGTGTAC ATCTATTCCTCAGGGAGTGTGGAGGCACAGAAACTGTTATTCGGGCATTCTACGGAGGGAGATATTCTTGAGCTTGTTGATGGTCACTTT GATACCAAGATTGGACACAAAGTAGAGAGTGAAAGTTACCGAAAGATTGCAGACAGCATTGGGTGCTCAACCAACAACATTTTGTTTCTG ACAGATGTTACTCGAGAGGCCAGTGCTGCTGAGGAAGCAGATGTGCACGTAGCTGTGGTGGTGAGACCAGGCAACGCAGGATTAACAGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_UBE2K_ENST00000261427_chr4_39757359_+_ENOPH1_ENST00000273920_chr4_83375875_+_1951nt ACGCGAGCTCGTGGCTCGGGCGTATGGGGGCTCCAACGGGAGCGGCTGCGCCGCCCGGCCGGGTCAACGTCGTGCGCATGCGCCGACCCG GCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGG TCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAG CTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGACGAGCAAAAATC AAATTAAAGTAGATCTTGTAGATGAGAATTTTACAGAATTAAGAGGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGAT ACCAACTAGAGATAAAAATACCAGAAACATACCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTT CCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGGTTCTTTGCAGATGTAGTTCCAGCAGTCAGGAAGTGGAGAGAGGCCG GAATGAAGGTGTACATCTATTCCTCAGGGAGTGTGGAGGCACAGAAACTGTTATTCGGGCATTCTACGGAGGGAGATATTCTTGAGCTTG TTGATGGTCACTTTGATACCAAGATTGGACACAAAGTAGAGAGTGAAAGTTACCGAAAGATTGCAGACAGCATTGGGTGCTCAACCAACA ACATTTTGTTTCTGACAGATGTTACTCGAGAGGCCAGTGCTGCTGAGGAAGCAGATGTGCACGTAGCTGTGGTGGTGAGACCAGGCAACG CAGGATTAACAGATGATGAGAAGACTTACTACAGCCTCATCACATCCTTCAGTGAACTATACCTGCCTTCCTCAACCTAGAGAAGGGTTG TTAAGGCAGACCGCCCTGTTCCCCAGAGTTGTCCCTGTAGTGTCTAGGTTTATTCTAATGGTAAAAGTAACTTACTTAAAAAACATATGT ACACATATGTATGCAAGTATGTATATATGTGTATGCTCAGATTAACTTCCATAGGTACATAAGTGAAAGAAGTCTCAGTTCAGTGAACAC AAAACTTATTTAAAGATGCTTTATATGTAGAAATTGTTTCAAATCATACTCTAACCCTTAGTGAGGGCAAAGTGTAGTTGGTAGAAGAAA TTGCTAAATACCTATCTAATGTGCTATGTTTATCAAATCGTGTACTAAAATGGAAAGCTAGTTTTGAGAAATTATTCAGAAGCCTTGTTA TTTTAAAAATGAAATATTTCAAAGACTGAATATTTTCAAAGAAAATGAATAATTCATTGCCCTTGTGATTTAGAAGATTATAACAGCTGT ATTTCATATTTGCCTCCTTATATATATCAAAGACCAAGGTATTTCCTTCTGCTTCAAAAGAACAAAATTGGGAAAGAAAACTCACTTGAG TCTTGATCAAACAAGTGTCTTTTACTTAAGAAGAAACTTGGTAATCATTGTGGCACCCACAGCAAGCAGTTGCCTTACCAGTGAAAAAGG TGCACTGAGGTAACATCTAAAACAGAGATGTGGTTCTTAATGTTTAACAGAACAGTTCTAATCCTGCCACGTGTTATCATTATAGATTTT ATAGTTGCCTTTCTAACTACTTAGCACAGTTTGAGAATACGTTAATTGCTATTTACTATTTAAAAAGTTTTACTGAAATCAGTCCATAAC ATTAAGATGAGCCCTAATATGTAAGATTTTCCTCTGGAATGGATGTGAGAAATGTAAATTTTATAACAGCAGTATTTATCCTGGTTTAAT >In-frame_UBE2K_ENST00000261427_chr4_39757359_+_ENOPH1_ENST00000509635_chr4_83375875_+_1915nt ACGCGAGCTCGTGGCTCGGGCGTATGGGGGCTCCAACGGGAGCGGCTGCGCCGCCCGGCCGGGTCAACGTCGTGCGCATGCGCCGACCCG GCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGG TCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAG CTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGACGAGCAAAAATC AAATTAAAGTAGATCTTGTAGATGAGAATTTTACAGAATTAAGAGGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGAT ACCAACTAGAGATAAAAATACCAGAAACATACCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTT CCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGGTTCTTTGCAGATGTAGTTCCAGCAGTCAGGAAGTGGAGAGAGGCCG GAATGAAGGTGTACATCTATTCCTCAGGGAGTGTGGAGGCACAGAAACTGTTATTCGGGCATTCTACGGAGGGAGATATTCTTGAGCTTG TTGATGGTCACTTTGATACCAAGATTGGACACAAAGTAGAGAGTGAAAGTTACCGAAAGATTGCAGACAGCATTGGGTGCTCAACCAACA ACATTTTGTTTCTGACAGATGTTACTCGAGAGGCCAGTGCTGCTGAGGAAGCAGATGTGCACGTAGCTGTGGTGGTGAGACCAGGCAACG CAGGATTAACAGATGATGAGAAGACTTACTACAGCCTCATCACATCCTTCAGTGAACTATACCTGCCTTCCTCAACCTAGAGAAGGGTTG TTAAGGCAGACCGCCCTGTTCCCCAGAGTTGTCCCTGTAGTGTCTAGGTTTATTCTAATGGTAAAAGTAACTTACTTAAAAAACATATGT ACACATATGTATGCAAGTATGTATATATGTGTATGCTCAGATTAACTTCCATAGGTACATAAGTGAAAGAAGTCTCAGTTCAGTGAACAC AAAACTTATTTAAAGATGCTTTATATGTAGAAATTGTTTCAAATCATACTCTAACCCTTAGTGAGGGCAAAGTGTAGTTGGTAGAAGAAA TTGCTAAATACCTATCTAATGTGCTATGTTTATCAAATCGTGTACTAAAATGGAAAGCTAGTTTTGAGAAATTATTCAGAAGCCTTGTTA TTTTAAAAATGAAATATTTCAAAGACTGAATATTTTCAAAGAAAATGAATAATTCATTGCCCTTGTGATTTAGAAGATTATAACAGCTGT ATTTCATATTTGCCTCCTTATATATATCAAAGACCAAGGTATTTCCTTCTGCTTCAAAAGAACAAAATTGGGAAAGAAAACTCACTTGAG TCTTGATCAAACAAGTGTCTTTTACTTAAGAAGAAACTTGGTAATCATTGTGGCACCCACAGCAAGCAGTTGCCTTACCAGTGAAAAAGG TGCACTGAGGTAACATCTAAAACAGAGATGTGGTTCTTAATGTTTAACAGAACAGTTCTAATCCTGCCACGTGTTATCATTATAGATTTT ATAGTTGCCTTTCTAACTACTTAGCACAGTTTGAGAATACGTTAATTGCTATTTACTATTTAAAAAGTTTTACTGAAATCAGTCCATAAC ATTAAGATGAGCCCTAATATGTAAGATTTTCCTCTGGAATGGATGTGAGAAATGTAAATTTTATAACAGCAGTATTTATCCTGGTTTAAT >In-frame_UBE2K_ENST00000503368_chr4_39757359_+_ENOPH1_ENST00000273920_chr4_83375875_+_1679nt GATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGA GGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCG GTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTTCC GTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGGTTCTTTGCAGATGTAGTTCCAGCAGTCAGGAAGTGGAGAGAGGCCGGA ATGAAGGTGTACATCTATTCCTCAGGGAGTGTGGAGGCACAGAAACTGTTATTCGGGCATTCTACGGAGGGAGATATTCTTGAGCTTGTT GATGGTCACTTTGATACCAAGATTGGACACAAAGTAGAGAGTGAAAGTTACCGAAAGATTGCAGACAGCATTGGGTGCTCAACCAACAAC ATTTTGTTTCTGACAGATGTTACTCGAGAGGCCAGTGCTGCTGAGGAAGCAGATGTGCACGTAGCTGTGGTGGTGAGACCAGGCAACGCA GGATTAACAGATGATGAGAAGACTTACTACAGCCTCATCACATCCTTCAGTGAACTATACCTGCCTTCCTCAACCTAGAGAAGGGTTGTT AAGGCAGACCGCCCTGTTCCCCAGAGTTGTCCCTGTAGTGTCTAGGTTTATTCTAATGGTAAAAGTAACTTACTTAAAAAACATATGTAC ACATATGTATGCAAGTATGTATATATGTGTATGCTCAGATTAACTTCCATAGGTACATAAGTGAAAGAAGTCTCAGTTCAGTGAACACAA AACTTATTTAAAGATGCTTTATATGTAGAAATTGTTTCAAATCATACTCTAACCCTTAGTGAGGGCAAAGTGTAGTTGGTAGAAGAAATT GCTAAATACCTATCTAATGTGCTATGTTTATCAAATCGTGTACTAAAATGGAAAGCTAGTTTTGAGAAATTATTCAGAAGCCTTGTTATT TTAAAAATGAAATATTTCAAAGACTGAATATTTTCAAAGAAAATGAATAATTCATTGCCCTTGTGATTTAGAAGATTATAACAGCTGTAT TTCATATTTGCCTCCTTATATATATCAAAGACCAAGGTATTTCCTTCTGCTTCAAAAGAACAAAATTGGGAAAGAAAACTCACTTGAGTC TTGATCAAACAAGTGTCTTTTACTTAAGAAGAAACTTGGTAATCATTGTGGCACCCACAGCAAGCAGTTGCCTTACCAGTGAAAAAGGTG CACTGAGGTAACATCTAAAACAGAGATGTGGTTCTTAATGTTTAACAGAACAGTTCTAATCCTGCCACGTGTTATCATTATAGATTTTAT AGTTGCCTTTCTAACTACTTAGCACAGTTTGAGAATACGTTAATTGCTATTTACTATTTAAAAAGTTTTACTGAAATCAGTCCATAACAT TAAGATGAGCCCTAATATGTAAGATTTTCCTCTGGAATGGATGTGAGAAATGTAAATTTTATAACAGCAGTATTTATCCTGGTTTAATTC >In-frame_UBE2K_ENST00000503368_chr4_39757359_+_ENOPH1_ENST00000509635_chr4_83375875_+_1643nt GATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGA GGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCG GTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTTCC GTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGGTTCTTTGCAGATGTAGTTCCAGCAGTCAGGAAGTGGAGAGAGGCCGGA ATGAAGGTGTACATCTATTCCTCAGGGAGTGTGGAGGCACAGAAACTGTTATTCGGGCATTCTACGGAGGGAGATATTCTTGAGCTTGTT GATGGTCACTTTGATACCAAGATTGGACACAAAGTAGAGAGTGAAAGTTACCGAAAGATTGCAGACAGCATTGGGTGCTCAACCAACAAC ATTTTGTTTCTGACAGATGTTACTCGAGAGGCCAGTGCTGCTGAGGAAGCAGATGTGCACGTAGCTGTGGTGGTGAGACCAGGCAACGCA GGATTAACAGATGATGAGAAGACTTACTACAGCCTCATCACATCCTTCAGTGAACTATACCTGCCTTCCTCAACCTAGAGAAGGGTTGTT AAGGCAGACCGCCCTGTTCCCCAGAGTTGTCCCTGTAGTGTCTAGGTTTATTCTAATGGTAAAAGTAACTTACTTAAAAAACATATGTAC ACATATGTATGCAAGTATGTATATATGTGTATGCTCAGATTAACTTCCATAGGTACATAAGTGAAAGAAGTCTCAGTTCAGTGAACACAA AACTTATTTAAAGATGCTTTATATGTAGAAATTGTTTCAAATCATACTCTAACCCTTAGTGAGGGCAAAGTGTAGTTGGTAGAAGAAATT GCTAAATACCTATCTAATGTGCTATGTTTATCAAATCGTGTACTAAAATGGAAAGCTAGTTTTGAGAAATTATTCAGAAGCCTTGTTATT TTAAAAATGAAATATTTCAAAGACTGAATATTTTCAAAGAAAATGAATAATTCATTGCCCTTGTGATTTAGAAGATTATAACAGCTGTAT TTCATATTTGCCTCCTTATATATATCAAAGACCAAGGTATTTCCTTCTGCTTCAAAAGAACAAAATTGGGAAAGAAAACTCACTTGAGTC TTGATCAAACAAGTGTCTTTTACTTAAGAAGAAACTTGGTAATCATTGTGGCACCCACAGCAAGCAGTTGCCTTACCAGTGAAAAAGGTG CACTGAGGTAACATCTAAAACAGAGATGTGGTTCTTAATGTTTAACAGAACAGTTCTAATCCTGCCACGTGTTATCATTATAGATTTTAT AGTTGCCTTTCTAACTACTTAGCACAGTTTGAGAATACGTTAATTGCTATTTACTATTTAAAAAGTTTTACTGAAATCAGTCCATAACAT TAAGATGAGCCCTAATATGTAAGATTTTCCTCTGGAATGGATGTGAGAAATGTAAATTTTATAACAGCAGTATTTATCCTGGTTTAATTC >In-frame_UBE2K_ENST00000445950_chr4_39757359_+_ENOPH1_ENST00000273920_chr4_83375875_+_1819nt GGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCG GCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCA AGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGACGAGCAAAAATCAAATTAAAGTAGATCTTGTAGATGAGAATTTTACAGAATTAA GAGGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATACCAACTAGAGATAAAAATACCAGAAACATACCCATTTAATC CCCCTAAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTTCCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAAT GGTTCTTTGCAGATGTAGTTCCAGCAGTCAGGAAGTGGAGAGAGGCCGGAATGAAGGTGTACATCTATTCCTCAGGGAGTGTGGAGGCAC AGAAACTGTTATTCGGGCATTCTACGGAGGGAGATATTCTTGAGCTTGTTGATGGTCACTTTGATACCAAGATTGGACACAAAGTAGAGA GTGAAAGTTACCGAAAGATTGCAGACAGCATTGGGTGCTCAACCAACAACATTTTGTTTCTGACAGATGTTACTCGAGAGGCCAGTGCTG CTGAGGAAGCAGATGTGCACGTAGCTGTGGTGGTGAGACCAGGCAACGCAGGATTAACAGATGATGAGAAGACTTACTACAGCCTCATCA CATCCTTCAGTGAACTATACCTGCCTTCCTCAACCTAGAGAAGGGTTGTTAAGGCAGACCGCCCTGTTCCCCAGAGTTGTCCCTGTAGTG TCTAGGTTTATTCTAATGGTAAAAGTAACTTACTTAAAAAACATATGTACACATATGTATGCAAGTATGTATATATGTGTATGCTCAGAT TAACTTCCATAGGTACATAAGTGAAAGAAGTCTCAGTTCAGTGAACACAAAACTTATTTAAAGATGCTTTATATGTAGAAATTGTTTCAA ATCATACTCTAACCCTTAGTGAGGGCAAAGTGTAGTTGGTAGAAGAAATTGCTAAATACCTATCTAATGTGCTATGTTTATCAAATCGTG TACTAAAATGGAAAGCTAGTTTTGAGAAATTATTCAGAAGCCTTGTTATTTTAAAAATGAAATATTTCAAAGACTGAATATTTTCAAAGA AAATGAATAATTCATTGCCCTTGTGATTTAGAAGATTATAACAGCTGTATTTCATATTTGCCTCCTTATATATATCAAAGACCAAGGTAT TTCCTTCTGCTTCAAAAGAACAAAATTGGGAAAGAAAACTCACTTGAGTCTTGATCAAACAAGTGTCTTTTACTTAAGAAGAAACTTGGT AATCATTGTGGCACCCACAGCAAGCAGTTGCCTTACCAGTGAAAAAGGTGCACTGAGGTAACATCTAAAACAGAGATGTGGTTCTTAATG TTTAACAGAACAGTTCTAATCCTGCCACGTGTTATCATTATAGATTTTATAGTTGCCTTTCTAACTACTTAGCACAGTTTGAGAATACGT TAATTGCTATTTACTATTTAAAAAGTTTTACTGAAATCAGTCCATAACATTAAGATGAGCCCTAATATGTAAGATTTTCCTCTGGAATGG ATGTGAGAAATGTAAATTTTATAACAGCAGTATTTATCCTGGTTTAATTCTAATACGATGTCATGTTAATTTCATGTTGTGATTAATAAA >In-frame_UBE2K_ENST00000445950_chr4_39757359_+_ENOPH1_ENST00000509635_chr4_83375875_+_1783nt GGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCG GCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCA AGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGACGAGCAAAAATCAAATTAAAGTAGATCTTGTAGATGAGAATTTTACAGAATTAA GAGGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATACCAACTAGAGATAAAAATACCAGAAACATACCCATTTAATC CCCCTAAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTTCCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAAT GGTTCTTTGCAGATGTAGTTCCAGCAGTCAGGAAGTGGAGAGAGGCCGGAATGAAGGTGTACATCTATTCCTCAGGGAGTGTGGAGGCAC AGAAACTGTTATTCGGGCATTCTACGGAGGGAGATATTCTTGAGCTTGTTGATGGTCACTTTGATACCAAGATTGGACACAAAGTAGAGA GTGAAAGTTACCGAAAGATTGCAGACAGCATTGGGTGCTCAACCAACAACATTTTGTTTCTGACAGATGTTACTCGAGAGGCCAGTGCTG CTGAGGAAGCAGATGTGCACGTAGCTGTGGTGGTGAGACCAGGCAACGCAGGATTAACAGATGATGAGAAGACTTACTACAGCCTCATCA CATCCTTCAGTGAACTATACCTGCCTTCCTCAACCTAGAGAAGGGTTGTTAAGGCAGACCGCCCTGTTCCCCAGAGTTGTCCCTGTAGTG TCTAGGTTTATTCTAATGGTAAAAGTAACTTACTTAAAAAACATATGTACACATATGTATGCAAGTATGTATATATGTGTATGCTCAGAT TAACTTCCATAGGTACATAAGTGAAAGAAGTCTCAGTTCAGTGAACACAAAACTTATTTAAAGATGCTTTATATGTAGAAATTGTTTCAA ATCATACTCTAACCCTTAGTGAGGGCAAAGTGTAGTTGGTAGAAGAAATTGCTAAATACCTATCTAATGTGCTATGTTTATCAAATCGTG TACTAAAATGGAAAGCTAGTTTTGAGAAATTATTCAGAAGCCTTGTTATTTTAAAAATGAAATATTTCAAAGACTGAATATTTTCAAAGA AAATGAATAATTCATTGCCCTTGTGATTTAGAAGATTATAACAGCTGTATTTCATATTTGCCTCCTTATATATATCAAAGACCAAGGTAT TTCCTTCTGCTTCAAAAGAACAAAATTGGGAAAGAAAACTCACTTGAGTCTTGATCAAACAAGTGTCTTTTACTTAAGAAGAAACTTGGT AATCATTGTGGCACCCACAGCAAGCAGTTGCCTTACCAGTGAAAAAGGTGCACTGAGGTAACATCTAAAACAGAGATGTGGTTCTTAATG TTTAACAGAACAGTTCTAATCCTGCCACGTGTTATCATTATAGATTTTATAGTTGCCTTTCTAACTACTTAGCACAGTTTGAGAATACGT TAATTGCTATTTACTATTTAAAAAGTTTTACTGAAATCAGTCCATAACATTAAGATGAGCCCTAATATGTAAGATTTTCCTCTGGAATGG |
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FusionGenePPI for UBE2K_ENOPH1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBE2K | DSTYK, HTT, RNF2, UBE2I, DDX58, RNF125, RNF138, BFAR, UBOX5, RNF5, DTX3, MARCH7, SIAH1, TRIM27, RNF185, TRIM35, BIRC7, BIRC8, RNF4, TRIM34, RNF167, UHRF2, TRAF7, MKRN2, TRAIP, RING1, RNF41, MARCH3, RNF32, RNF114, LRSAM1, CBLC, DTX3L, DZIP3, MID1, MKRN3, TRIM39, RNF111, RNF144A, TRIM2, TRIM31, TRIM43, TRIM5, RBCK1, ITSN1, PRPF40A, CCNB1, DIABLO, BRCA1, UBC, CASP12, PIAS4, NUB1, NXF1, FZR1, NEDD4L, WWP2, ITCH, WDR1, WDR61, TXNDC17, TYMS, TXN, ANAPC11, IQCB1, BAG3, UBA1, TP53, MDM2, CDC6, PRRG4, REL, MIPOL1, DDI1, ZDHHC17, AMFR, BARD1, SENP1, MAP3K1, HNRNPA1, UBE2D2, RAB1A, TMEM189-UBE2V1, UBE2V1, UBE2N, RC3H2, TRIM63, SMURF1, CYHR1, ARL15, USP1, DLD | ENOPH1 | RPS27, RAB10, MOV10, CBS, MCFD2, PGM3, PUS7, SMS, UBA6, HDHD1, IMPDH2, MANF, PRDX6, SNX2, TGM2, BAG3, KATNA1, TMEM132A, TMEM63B, MYO19, BAG6, TSC22D2, RNF41, CARD9, THEM4, VPS52 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBE2K_ENOPH1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBE2K_ENOPH1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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