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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40440

FusionGeneSummary for UBE2I_PRSS23

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2I_PRSS23
Fusion gene ID: 40440
HgeneTgene
Gene symbol

UBE2I

PRSS23

Gene ID

7329

11098

Gene nameubiquitin conjugating enzyme E2 Iserine protease 23
SynonymsC358B7.1|P18|UBC9SIG13|SPUVE|ZSIG13
Cytomap

16p13.3

11q14.2

Type of geneprotein-codingprotein-coding
DescriptionSUMO-conjugating enzyme UBC9RING-type E3 SUMO transferase UBC9SUMO-1-protein ligaseSUMO-protein ligaseubiquitin carrier protein 9ubiquitin carrier protein Iubiquitin conjugating enzyme 9ubiquitin conjugating enzyme E2Iubiquitin-conjugating enzyme serine protease 23protease, serine 23putative secreted protein Zsig13serine protease, umbilical endothelium
Modification date2018052320180524
UniProtAcc

P63279

O95084

Ensembl transtripts involved in fusion geneENST00000339021, ENST00000355803, 
ENST00000325437, ENST00000397514, 
ENST00000397515, ENST00000403747, 
ENST00000566587, ENST00000406620, 
ENST00000402301, 		ENST00000533902, 
ENST00000280258, ENST00000441050, 
ENST00000531521, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 9 X 3=216
# samples 211
** MAII scorelog2(2/8*10)=1.32192809488736log2(11/216*10)=-0.973527788638809
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBE2I [Title/Abstract] AND PRSS23 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2I

GO:0016925

protein sumoylation

15660128|19955185|21968017

HgeneUBE2I

GO:0045892

negative regulation of transcription, DNA-templated

16631117

HgeneUBE2I

GO:1903755

positive regulation of SUMO transferase activity

19955185


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ005300UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000339021ENST00000533902UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000339021ENST00000280258UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000339021ENST00000441050UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000339021ENST00000531521UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000355803ENST00000533902UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000355803ENST00000280258UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000355803ENST00000441050UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000355803ENST00000531521UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000325437ENST00000533902UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000325437ENST00000280258UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000325437ENST00000441050UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000325437ENST00000531521UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000397514ENST00000533902UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000397514ENST00000280258UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000397514ENST00000441050UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000397514ENST00000531521UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000397515ENST00000533902UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000397515ENST00000280258UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000397515ENST00000441050UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
3UTR-intronENST00000397515ENST00000531521UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000403747ENST00000533902UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000403747ENST00000280258UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000403747ENST00000441050UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000403747ENST00000531521UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000566587ENST00000533902UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000566587ENST00000280258UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000566587ENST00000441050UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000566587ENST00000531521UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000406620ENST00000533902UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000406620ENST00000280258UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000406620ENST00000441050UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000406620ENST00000531521UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000402301ENST00000533902UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000402301ENST00000280258UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000402301ENST00000441050UBE2Ichr16

1376802

-PRSS23chr11

86630697

+
intron-intronENST00000402301ENST00000531521UBE2Ichr16

1376802

-PRSS23chr11

86630697

+

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FusionProtFeatures for UBE2I_PRSS23


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2I

P63279

PRSS23

O95084

Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes theircovalent attachment to other proteins with the help of an E3ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formationof poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5.Essential for nuclear architecture and chromosome segregation.Sumoylates p53/TP53 at 'Lys-386'. {ECO:0000269|PubMed:11451954,ECO:0000269|PubMed:15809060, ECO:0000269|PubMed:17466333,ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:19744555,ECO:0000269|PubMed:20077568, ECO:0000269|PubMed:26524494,ECO:0000269|PubMed:8668529}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2I_PRSS23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2I_PRSS23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2I_PRSS23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2I_PRSS23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUBE2IC0024667Animal Mammary Neoplasms1CTD_human
HgeneUBE2IC0024668Mammary Neoplasms, Experimental1CTD_human
TgenePRSS23C0025202melanoma1CTD_human