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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40435

FusionGeneSummary for UBE2H_PON1

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2H_PON1
Fusion gene ID: 40435
HgeneTgene
Gene symbol

UBE2H

PON1

Gene ID

7328

5444

Gene nameubiquitin conjugating enzyme E2 Hparaoxonase 1
SynonymsE2-20K|GID3|UBC8|UBCH|UBCH2ESA|MVCD5|PON
Cytomap

7q32.2

7q21.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 H(E3-independent) E2 ubiquitin-conjugating enzyme HE2 ubiquitin-conjugating enzyme HGID complex subunit 3, UBC8 homologubiquitin carrier protein Hubiquitin conjugating enzyme E2Hubiquitin-conjugating enzyme E2-20Kubiserum paraoxonase/arylesterase 1A-esterase 1K-45PON 1aromatic esterase 1arylesterase 1arylesterase B-typeesterase Aparaoxonase B-typeserum aryldiakylphosphataseserum aryldialkylphosphatase 1
Modification date2018052320180527
UniProtAcc

P62256

P27169

Ensembl transtripts involved in fusion geneENST00000355621, ENST00000473814, 
ENST00000222381, ENST00000542556, 
Fusion gene scores* DoF score6 X 8 X 4=1923 X 3 X 3=27
# samples 113
** MAII scorelog2(11/192*10)=-0.803602787196497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UBE2H [Title/Abstract] AND PON1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2H

GO:0070936

protein K48-linked ubiquitination

20061386

HgeneUBE2H

GO:0070979

protein K11-linked ubiquitination

20061386

TgenePON1

GO:0010875

positive regulation of cholesterol efflux

15721011

TgenePON1

GO:0019439

aromatic compound catabolic process

15772423

TgenePON1

GO:0032411

positive regulation of transporter activity

15721011

TgenePON1

GO:0034445

negative regulation of plasma lipoprotein oxidation

15342686

TgenePON1

GO:0046395

carboxylic acid catabolic process

7638166

TgenePON1

GO:0046434

organophosphate catabolic process

7638166

TgenePON1

GO:0046470

phosphatidylcholine metabolic process

15721011

TgenePON1

GO:0051099

positive regulation of binding

15721011


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX485261UBE2Hchr7

129502984

-PON1chr7

94929189

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000355621ENST00000222381UBE2Hchr7

129502984

-PON1chr7

94929189

+
intron-intronENST00000355621ENST00000542556UBE2Hchr7

129502984

-PON1chr7

94929189

+
intron-intronENST00000473814ENST00000222381UBE2Hchr7

129502984

-PON1chr7

94929189

+
intron-intronENST00000473814ENST00000542556UBE2Hchr7

129502984

-PON1chr7

94929189

+

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FusionProtFeatures for UBE2H_PON1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2H

P62256

PON1

P27169

Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, toubiquitinate histone H2A. {ECO:0000269|PubMed:20061386,ECO:0000269|PubMed:8132613}. Hydrolyzes the toxic metabolites of a variety oforganophosphorus insecticides. Capable of hydrolyzing a broadspectrum of organophosphate substrates and lactones, and a numberof aromatic carboxylic acid esters. Mediates an enzymaticprotection of low density lipoproteins against oxidativemodification and the consequent series of events leading toatheroma formation. {ECO:0000269|PubMed:10479665,ECO:0000269|PubMed:15772423}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2H_PON1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2H_PON1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2H_PON1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePON1P27169DB01327CefazolinSerum paraoxonase/arylesterase 1 {ECO:0000303|PubMed:7916578}small moleculeapproved
TgenePON1P27169DB01593ZincSerum paraoxonase/arylesterase 1 {ECO:0000303|PubMed:7916578}small moleculeapproved|investigational

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RelatedDiseases for UBE2H_PON1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUBE2HC0004352Autistic Disorder1CTD_human
HgeneUBE2HC0032460Polycystic Ovary Syndrome1CTD_human
TgenePON1C0004153Atherosclerosis6CTD_human
TgenePON1C0700359Organophosphate poisoning4CTD_human
TgenePON1C0004352Autistic Disorder3CTD_human
TgenePON1C0005586Bipolar Disorder3PSYGENET
TgenePON1C0033578Prostatic Neoplasms3CTD_human
TgenePON1C1956346Coronary Artery Disease3CTD_human
TgenePON1C0007222Cardiovascular Diseases2CTD_human
TgenePON1C0010068Coronary heart disease2CTD_human
TgenePON1C0011849Diabetes Mellitus2CTD_human
TgenePON1C0011884Diabetic Retinopathy2CTD_human
TgenePON1C0020445Hypercholesterolemia, Familial2CTD_human
TgenePON1C0021364Male infertility2CTD_human
TgenePON1C0036341Schizophrenia2PSYGENET
TgenePON1C0598608Hyperhomocysteinemia2CTD_human
TgenePON1C0687132heavy drinking2PSYGENET
TgenePON1C0001828Agricultural Workers' Diseases1CTD_human
TgenePON1C0001969Alcoholic Intoxication1PSYGENET
TgenePON1C0003860Arteritis1CTD_human
TgenePON1C0003873Rheumatoid Arthritis1CTD_human
TgenePON1C0005612Birth Weight1CTD_human
TgenePON1C0006118Brain Neoplasms1CTD_human
TgenePON1C0009806Constipation1CTD_human
TgenePON1C0010073Coronary Artery Vasospasm1CTD_human
TgenePON1C0011581Depressive disorder1CTD_human;HPO
TgenePON1C0015695Fatty Liver1CTD_human
TgenePON1C0017662Glomerulonephritis, Membranoproliferative1CTD_human
TgenePON1C0018801Heart failure1CTD_human
TgenePON1C0019112Hemorrhoids1CTD_human
TgenePON1C0020443Hypercholesterolemia1CTD_human
TgenePON1C0020476Hyperlipoproteinemias1CTD_human
TgenePON1C0020550Hyperthyroidism1CTD_human
TgenePON1C0024121Lung Neoplasms1CTD_human
TgenePON1C0024299Lymphoma1CTD_human
TgenePON1C0028797Occupational Diseases1CTD_human
TgenePON1C0030569Secondary Parkinson Disease1CTD_human
TgenePON1C0080178Spina Bifida1CTD_human
TgenePON1C0206663Neuroectodermal Tumor, Primitive1CTD_human
TgenePON1C0235032Neurotoxicity Syndromes1CTD_human
TgenePON1C0282550Persian Gulf Syndrome1CTD_human
TgenePON1C0376545Hematologic Neoplasms1CTD_human
TgenePON1C0524620Metabolic Syndrome X1CTD_human
TgenePON1C0853193Bipolar I disorder1PSYGENET
TgenePON1C0948089Acute Coronary Syndrome1CTD_human
TgenePON1C1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgenePON1C4277682Chemical and Drug Induced Liver Injury1CTD_human