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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40423

FusionGeneSummary for UBE2G1_SPNS3

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2G1_SPNS3
Fusion gene ID: 40423
HgeneTgene
Gene symbol

UBE2G1

SPNS3

Gene ID

7326

201305

Gene nameubiquitin conjugating enzyme E2 G1sphingolipid transporter 3 (putative)
SynonymsE217K|UBC7|UBE2G-
Cytomap

17p13.2

17p13.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 G1E2 ubiquitin-conjugating enzyme G1ubiquitin carrier protein G1ubiquitin conjugating enzyme E2G 1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)ubprotein spinster homolog 3SPNS sphingolipid transporter 3 (putative)spinster homolog 3
Modification date2018052320180519
UniProtAcc

P62253

Q6ZMD2

Ensembl transtripts involved in fusion geneENST00000396981, ENST00000572484, 
ENST00000355530, ENST00000333476, 
ENST00000576069, 
Fusion gene scores* DoF score10 X 5 X 5=2504 X 1 X 3=12
# samples 114
** MAII scorelog2(11/250*10)=-1.18442457113743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UBE2G1 [Title/Abstract] AND SPNS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2G1

GO:0070534

protein K63-linked ubiquitination

20061386

HgeneUBE2G1

GO:0070936

protein K48-linked ubiquitination

14593114|20061386


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A08J-01AUBE2G1chr17

4269566

-SPNS3chr17

4381867

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000396981ENST00000355530UBE2G1chr17

4269566

-SPNS3chr17

4381867

+
In-frameENST00000396981ENST00000333476UBE2G1chr17

4269566

-SPNS3chr17

4381867

+
5CDS-intronENST00000396981ENST00000576069UBE2G1chr17

4269566

-SPNS3chr17

4381867

+
5UTR-3CDSENST00000572484ENST00000355530UBE2G1chr17

4269566

-SPNS3chr17

4381867

+
5UTR-3CDSENST00000572484ENST00000333476UBE2G1chr17

4269566

-SPNS3chr17

4381867

+
5UTR-intronENST00000572484ENST00000576069UBE2G1chr17

4269566

-SPNS3chr17

4381867

+

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FusionProtFeatures for UBE2G1_SPNS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2G1

P62253

SPNS3

Q6ZMD2

Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May beinvolved in degradation of muscle-specific proteins. Mediatespolyubiquitination of CYP3A4. {ECO:0000269|PubMed:19103148,ECO:0000269|PubMed:20061386}. Sphingolipid transporter. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPNS3chr17:4269566chr17:4381867ENST00000333476+611260_280244386TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000333476+611309_329244386TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000333476+611343_365244386TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000333476+611377_397244386TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000333476+611411_431244386TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000333476+611450_470244386TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000355530+712377_397371513TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000355530+712411_431371513TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000355530+712450_470371513TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPNS3chr17:4269566chr17:4381867ENST00000333476+611112_132244386TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000333476+611145_165244386TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000333476+611173_193244386TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000333476+611204_224244386TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000333476+61150_70244386TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000333476+61184_104244386TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000355530+712112_132371513TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000355530+712145_165371513TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000355530+712173_193371513TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000355530+712204_224371513TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000355530+712260_280371513TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000355530+712309_329371513TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000355530+712343_365371513TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000355530+71250_70371513TransmembraneHelical
TgeneSPNS3chr17:4269566chr17:4381867ENST00000355530+71284_104371513TransmembraneHelical


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FusionGeneSequence for UBE2G1_SPNS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_UBE2G1_ENST00000396981_chr17_4269566_-_SPNS3_ENST00000355530_chr17_4381867_+_157aa
MTELQSALLLRRQLAGVPGPWGAASVLQLGSGCRHPAVCGGAQMPGDGRGTSDHGGPHPGRRWQPLSHRTYLXCPAGQAPXLLSAALPQP

>In-frame_UBE2G1_ENST00000396981_chr17_4269566_-_SPNS3_ENST00000333476_chr17_4381867_+_157aa
MTELQSALLLRRQLAGVPGPWGAASVLQLGSGCRHPAVCGGAQMPGDGRGTSDHGGPHPGRRWQPLSHRTYLXCPAGQAPXLLSAALPQP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_UBE2G1_ENST00000396981_chr17_4269566_-_SPNS3_ENST00000355530_chr17_4381867_+_472nt
ATGACGGAGCTGCAGTCGGCACTGCTACTGCGAAGACAGCTGGCAGGTGTTCCTGGGCCTTGGGGAGCTGCTTCTGTCCTGCAACTGGGC
AGTGGTTGCCGACATCCTGCTGTCTGTGGTGGTGCCCAGATGCCGGGGGACGGCAGAGGCACTTCAGATCACGGTGGGCCACATCCTGGG
AGACGCTGGCAGCCCCTATCTCACAGGACTTATCTCTAGTGTCCTGCGGGCCAGGCGCCCTGACTCCTATCTGCAGCGCTTCCGCAGCCT
GCAGCAGAGCTTCCTGTGCTGCGCCTTTGTCATCGCCCTGGGGGGCGGCTGCTTCCTGCTGACTGCGCTGTACCTGGAGAGAGACGAGAC
CCGGGCCTGGCAGCCTGTCACAGGGACCCCAGACAGCAATGATGTGGACAGCAACGACCTGGAGAGACAAGGCCTACTTTCGGGCGCTGG

>In-frame_UBE2G1_ENST00000396981_chr17_4269566_-_SPNS3_ENST00000333476_chr17_4381867_+_472nt
ATGACGGAGCTGCAGTCGGCACTGCTACTGCGAAGACAGCTGGCAGGTGTTCCTGGGCCTTGGGGAGCTGCTTCTGTCCTGCAACTGGGC
AGTGGTTGCCGACATCCTGCTGTCTGTGGTGGTGCCCAGATGCCGGGGGACGGCAGAGGCACTTCAGATCACGGTGGGCCACATCCTGGG
AGACGCTGGCAGCCCCTATCTCACAGGACTTATCTCTAGTGTCCTGCGGGCCAGGCGCCCTGACTCCTATCTGCAGCGCTTCCGCAGCCT
GCAGCAGAGCTTCCTGTGCTGCGCCTTTGTCATCGCCCTGGGGGGCGGCTGCTTCCTGCTGACTGCGCTGTACCTGGAGAGAGACGAGAC
CCGGGCCTGGCAGCCTGTCACAGGGACCCCAGACAGCAATGATGTGGACAGCAACGACCTGGAGAGACAAGGCCTACTTTCGGGCGCTGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_UBE2G1_ENST00000396981_chr17_4269566_-_SPNS3_ENST00000355530_chr17_4381867_+_952nt
ACCGGCAGCGAGGCGCCGCTCCCGCCGCCTCAGCCCGGCCTTCCTCGGCTCCGGCGCTCCGGTCGCGGGGCCCGGGTTCCTCGGCACACC
CCGCTCCAGCCGCCCCCAGAGCCTGTCCCCAGCCCTTCGGAAGCCCCGGCGCCAGCCCGGGCCCTCGGCAGGGAGGATGACGGAGCTGCA
GTCGGCACTGCTACTGCGAAGACAGCTGGCAGGTGTTCCTGGGCCTTGGGGAGCTGCTTCTGTCCTGCAACTGGGCAGTGGTTGCCGACA
TCCTGCTGTCTGTGGTGGTGCCCAGATGCCGGGGGACGGCAGAGGCACTTCAGATCACGGTGGGCCACATCCTGGGAGACGCTGGCAGCC
CCTATCTCACAGGACTTATCTCTAGTGTCCTGCGGGCCAGGCGCCCTGACTCCTATCTGCAGCGCTTCCGCAGCCTGCAGCAGAGCTTCC
TGTGCTGCGCCTTTGTCATCGCCCTGGGGGGCGGCTGCTTCCTGCTGACTGCGCTGTACCTGGAGAGAGACGAGACCCGGGCCTGGCAGC
CTGTCACAGGGACCCCAGACAGCAATGATGTGGACAGCAACGACCTGGAGAGACAAGGCCTACTTTCGGGCGCTGGCGCCTCTACAGAGG
AGCCCTGAGGTCCCTGCCTACACTCGTCCTGCCTGCAAGCCTCCCGTTGGTCCCCACAGCAGCAGTGCCTCGGTTCCTCTTTGGCTGTCC
TCGGGGACTCCGGCTGAGGCACATCTGCCACTTTTGAATTCCCGGCTGGAGAGCTGGCAGGACCCTGTGGCTGGGCTGGGAATGGAGCTG
TCAGCACTCTGCGTGGGAGGCCTGGGCCTGTGCCTGCATCCCGCTCAAGGCTGCCCCAGCCTGGGGTCTCCAGCCTGGCTGCTGCTGGGC

>In-frame_UBE2G1_ENST00000396981_chr17_4269566_-_SPNS3_ENST00000333476_chr17_4381867_+_947nt
ACCGGCAGCGAGGCGCCGCTCCCGCCGCCTCAGCCCGGCCTTCCTCGGCTCCGGCGCTCCGGTCGCGGGGCCCGGGTTCCTCGGCACACC
CCGCTCCAGCCGCCCCCAGAGCCTGTCCCCAGCCCTTCGGAAGCCCCGGCGCCAGCCCGGGCCCTCGGCAGGGAGGATGACGGAGCTGCA
GTCGGCACTGCTACTGCGAAGACAGCTGGCAGGTGTTCCTGGGCCTTGGGGAGCTGCTTCTGTCCTGCAACTGGGCAGTGGTTGCCGACA
TCCTGCTGTCTGTGGTGGTGCCCAGATGCCGGGGGACGGCAGAGGCACTTCAGATCACGGTGGGCCACATCCTGGGAGACGCTGGCAGCC
CCTATCTCACAGGACTTATCTCTAGTGTCCTGCGGGCCAGGCGCCCTGACTCCTATCTGCAGCGCTTCCGCAGCCTGCAGCAGAGCTTCC
TGTGCTGCGCCTTTGTCATCGCCCTGGGGGGCGGCTGCTTCCTGCTGACTGCGCTGTACCTGGAGAGAGACGAGACCCGGGCCTGGCAGC
CTGTCACAGGGACCCCAGACAGCAATGATGTGGACAGCAACGACCTGGAGAGACAAGGCCTACTTTCGGGCGCTGGCGCCTCTACAGAGG
AGCCCTGAGGTCCCTGCCTACACTCGTCCTGCCTGCAAGCCTCCCGTTGGTCCCCACAGCAGCAGTGCCTCGGTTCCTCTTTGGCTGTCC
TCGGGGACTCCGGCTGAGGCACATCTGCCACTTTTGAATTCCCGGCTGGAGAGCTGGCAGGACCCTGTGGCTGGGCTGGGAATGGAGCTG
TCAGCACTCTGCGTGGGAGGCCTGGGCCTGTGCCTGCATCCCGCTCAAGGCTGCCCCAGCCTGGGGTCTCCAGCCTGGCTGCTGCTGGGC


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FusionGenePPI for UBE2G1_SPNS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UBE2G1PARK2, DIO2, RBCK1, AMFR, ELAVL1, HUWE1, ITCH, RBX1, APP, USP8, WWP2, MARCH6, UBA1, UBE2G1, MAP3K1, RDH5, CYP3A4, CUL9, UNK, APOA1BP, FBXL2, RC3H1, SMURF1, TRIM25SPNS3CLCC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2G1_SPNS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2G1_SPNS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource