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Fusion gene ID: 40417 |
FusionGeneSummary for UBE2G1_CXCL16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBE2G1_CXCL16 | Fusion gene ID: 40417 | Hgene | Tgene | Gene symbol | UBE2G1 | CXCL16 | Gene ID | 7326 | 58191 |
| Gene name | ubiquitin conjugating enzyme E2 G1 | C-X-C motif chemokine ligand 16 | |
| Synonyms | E217K|UBC7|UBE2G | CXCLG16|SR-PSOX|SRPSOX | |
| Cytomap | 17p13.2 | 17p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-conjugating enzyme E2 G1E2 ubiquitin-conjugating enzyme G1ubiquitin carrier protein G1ubiquitin conjugating enzyme E2G 1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)ub | C-X-C motif chemokine 16CXC chemokine ligand 16chemokine (C-X-C motif) ligand 16scavenger receptor for phosphatidylserine and oxidized low density lipoproteinsmall-inducible cytokine B16transmembrane chemokine CXCL16 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P62253 | Q9H2A7 | |
| Ensembl transtripts involved in fusion gene | ENST00000396981, ENST00000572484, | ENST00000293778, ENST00000576153, ENST00000574412, | |
| Fusion gene scores | * DoF score | 10 X 5 X 5=250 | 3 X 3 X 2=18 |
| # samples | 11 | 3 | |
| ** MAII score | log2(11/250*10)=-1.18442457113743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: UBE2G1 [Title/Abstract] AND CXCL16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBE2G1 | GO:0070534 | protein K63-linked ubiquitination | 20061386 |
| Hgene | UBE2G1 | GO:0070936 | protein K48-linked ubiquitination | 14593114|20061386 |
| Tgene | CXCL16 | GO:0034097 | response to cytokine | 18373975 |
| Tgene | CXCL16 | GO:0034341 | response to interferon-gamma | 18373975 |
| Tgene | CXCL16 | GO:0034612 | response to tumor necrosis factor | 18373975 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A08P-01A | UBE2G1 | chr17 | 4269566 | - | CXCL16 | chr17 | 4638803 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000396981 | ENST00000293778 | UBE2G1 | chr17 | 4269566 | - | CXCL16 | chr17 | 4638803 | - |
| 5CDS-5UTR | ENST00000396981 | ENST00000576153 | UBE2G1 | chr17 | 4269566 | - | CXCL16 | chr17 | 4638803 | - |
| 5CDS-5UTR | ENST00000396981 | ENST00000574412 | UBE2G1 | chr17 | 4269566 | - | CXCL16 | chr17 | 4638803 | - |
| 5UTR-3CDS | ENST00000572484 | ENST00000293778 | UBE2G1 | chr17 | 4269566 | - | CXCL16 | chr17 | 4638803 | - |
| 5UTR-5UTR | ENST00000572484 | ENST00000576153 | UBE2G1 | chr17 | 4269566 | - | CXCL16 | chr17 | 4638803 | - |
| 5UTR-5UTR | ENST00000572484 | ENST00000574412 | UBE2G1 | chr17 | 4269566 | - | CXCL16 | chr17 | 4638803 | - |
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FusionProtFeatures for UBE2G1_CXCL16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBE2G1 | CXCL16 |
| Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May beinvolved in degradation of muscle-specific proteins. Mediatespolyubiquitination of CYP3A4. {ECO:0000269|PubMed:19103148,ECO:0000269|PubMed:20061386}. | Acts as a scavenger receptor on macrophages, whichspecifically binds to OxLDL (oxidized low density lipoprotein),suggesting that it may be involved in pathophysiology such asatherogenesis (By similarity). Induces a strong chemotacticresponse. Induces calcium mobilization. Binds to CXCR6/Bonzo.{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBE2G1_CXCL16 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UBE2G1_CXCL16 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBE2G1 | PARK2, DIO2, RBCK1, AMFR, ELAVL1, HUWE1, ITCH, RBX1, APP, USP8, WWP2, MARCH6, UBA1, UBE2G1, MAP3K1, RDH5, CYP3A4, CUL9, UNK, APOA1BP, FBXL2, RC3H1, SMURF1, TRIM25 | CXCL16 | ELAVL1, APP, KRTAP5-9, MDFI, MTUS2, ADAMTSL4, CCDC155, KRTAP10-7, KRTAP10-9, KRTAP10-1, KRTAP10-3, NOTCH2NL, TMEM239, KRAS, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBE2G1_CXCL16 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBE2G1_CXCL16 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CXCL16 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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