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Fusion gene ID: 404 |
FusionGeneSummary for ACO2_C1QTNF7 |
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Fusion gene information | Fusion gene name: ACO2_C1QTNF7 | Fusion gene ID: 404 | Hgene | Tgene | Gene symbol | ACO2 | C1QTNF7 | Gene ID | 50 | 114905 |
Gene name | aconitase 2 | C1q and TNF related 7 | |
Synonyms | ACONM|HEL-S-284|ICRD|OCA8|OPA9 | CTRP7|ZACRP7 | |
Cytomap | 22q13.2 | 4p15.32 | |
Type of gene | protein-coding | protein-coding | |
Description | aconitate hydratase, mitochondrialaconitase 2, mitochondrialcitrate hydro-lyaseepididymis secretory sperm binding protein Li 284mitochondrial aconitase | complement C1q tumor necrosis factor-related protein 7C1q and tumor necrosis factor related protein 7complement-c1q tumor necrosis factor-related protein 7 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q99798 | Q9BXJ2 | |
Ensembl transtripts involved in fusion gene | ENST00000216254, ENST00000396512, ENST00000466237, | ENST00000295297, ENST00000510958, ENST00000429690, ENST00000444304, | |
Fusion gene scores | * DoF score | 12 X 4 X 8=384 | 1 X 1 X 1=1 |
# samples | 12 | 1 | |
** MAII score | log2(12/384*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ACO2 [Title/Abstract] AND C1QTNF7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ACO2 | GO:0006099 | tricarboxylic acid cycle | 9630632 |
Hgene | ACO2 | GO:0006101 | citrate metabolic process | 9630632 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-EE-A2ME-06A | ACO2 | chr22 | 41865186 | + | C1QTNF7 | chr4 | 15437360 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000216254 | ENST00000295297 | ACO2 | chr22 | 41865186 | + | C1QTNF7 | chr4 | 15437360 | + |
5CDS-intron | ENST00000216254 | ENST00000510958 | ACO2 | chr22 | 41865186 | + | C1QTNF7 | chr4 | 15437360 | + |
5CDS-5UTR | ENST00000216254 | ENST00000429690 | ACO2 | chr22 | 41865186 | + | C1QTNF7 | chr4 | 15437360 | + |
5CDS-5UTR | ENST00000216254 | ENST00000444304 | ACO2 | chr22 | 41865186 | + | C1QTNF7 | chr4 | 15437360 | + |
Frame-shift | ENST00000396512 | ENST00000295297 | ACO2 | chr22 | 41865186 | + | C1QTNF7 | chr4 | 15437360 | + |
5CDS-intron | ENST00000396512 | ENST00000510958 | ACO2 | chr22 | 41865186 | + | C1QTNF7 | chr4 | 15437360 | + |
5CDS-5UTR | ENST00000396512 | ENST00000429690 | ACO2 | chr22 | 41865186 | + | C1QTNF7 | chr4 | 15437360 | + |
5CDS-5UTR | ENST00000396512 | ENST00000444304 | ACO2 | chr22 | 41865186 | + | C1QTNF7 | chr4 | 15437360 | + |
intron-3CDS | ENST00000466237 | ENST00000295297 | ACO2 | chr22 | 41865186 | + | C1QTNF7 | chr4 | 15437360 | + |
intron-intron | ENST00000466237 | ENST00000510958 | ACO2 | chr22 | 41865186 | + | C1QTNF7 | chr4 | 15437360 | + |
intron-5UTR | ENST00000466237 | ENST00000429690 | ACO2 | chr22 | 41865186 | + | C1QTNF7 | chr4 | 15437360 | + |
intron-5UTR | ENST00000466237 | ENST00000444304 | ACO2 | chr22 | 41865186 | + | C1QTNF7 | chr4 | 15437360 | + |
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FusionProtFeatures for ACO2_C1QTNF7 |
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Hgene | Tgene |
ACO2 | C1QTNF7 |
Catalyzes the isomerization of citrate to isocitrate viacis-aconitate. {ECO:0000250|UniProtKB:P16276}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACO2_C1QTNF7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACO2_C1QTNF7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ACO2 | SRRM2, PSMD4, ATXN1L, APP, AK3, ACAT1, SIN3A, ACAA2, VCAM1, ITGA4, ASB9, CKB, IDH3A, IDH3G, MYH7B, SOD2, ALDH5A1, ALDOA, ALDOC, ATP1B1, ATP5F1, ATP5J, ESD, GPD1, GPD1L, GPD2, PITPNB, VAPA, NTRK1, SOD1, TRIM25 | C1QTNF7 | BAG3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACO2_C1QTNF7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACO2_C1QTNF7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACO2 | C3281192 | INFANTILE CEREBELLAR-RETINAL DEGENERATION | 2 | ORPHANET;UNIPROT |
Hgene | ACO2 | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human |
Hgene | ACO2 | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | ACO2 | C4225384 | OPTIC ATROPHY 9 | 1 | UNIPROT |