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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40399

FusionGeneSummary for UBE2D3_NRF1

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2D3_NRF1
Fusion gene ID: 40399
HgeneTgene
Gene symbol

UBE2D3

NRF1

Gene ID

7323

4899

Gene nameubiquitin conjugating enzyme E2 D3nuclear respiratory factor 1
SynonymsE2(17)KB3|UBC4/5|UBCH5CALPHA-PAL
Cytomap

4q24

7q32.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 D3(E3-independent) E2 ubiquitin-conjugating enzyme D3E2 ubiquitin-conjugating enzyme D3ubiquitin carrier protein D3ubiquitin conjugating enzyme E2D 3ubiquitin-conjugating enzyme E2(17)KB 3ubiquitin-conjugating enzyme nuclear respiratory factor 1alpha palindromic-binding protein
Modification date2018052320180523
UniProtAcc

P61077

Q16656

Ensembl transtripts involved in fusion geneENST00000453744, ENST00000394801, 
ENST00000394803, ENST00000394804, 
ENST00000343106, ENST00000321805, 
ENST00000350435, ENST00000338145, 
ENST00000349311, ENST00000504211, 
ENST00000357194, ENST00000505207, 
ENST00000507845, ENST00000502404, 
ENST00000513098, 
ENST00000393232, 
ENST00000353868, ENST00000539636, 
ENST00000311967, ENST00000223190, 
ENST00000393230, ENST00000393231, 
ENST00000477428, 
Fusion gene scores* DoF score4 X 3 X 2=244 X 4 X 3=48
# samples 44
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBE2D3 [Title/Abstract] AND NRF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2D3

GO:0000209

protein polyubiquitination

14765125|16522193

HgeneUBE2D3

GO:0006513

protein monoubiquitination

20347421

HgeneUBE2D3

GO:0016567

protein ubiquitination

9990509|21532592

HgeneUBE2D3

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

20347421

HgeneUBE2D3

GO:0051865

protein autoubiquitination

21068390

HgeneUBE2D3

GO:0070936

protein K48-linked ubiquitination

20061386

HgeneUBE2D3

GO:0070979

protein K11-linked ubiquitination

20061386


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV341784UBE2D3chr4

103717350

+NRF1chr7

129269870

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000453744ENST00000393232UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000453744ENST00000353868UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000453744ENST00000539636UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000453744ENST00000311967UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000453744ENST00000223190UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000453744ENST00000393230UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000453744ENST00000393231UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000453744ENST00000477428UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394801ENST00000393232UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394801ENST00000353868UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394801ENST00000539636UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394801ENST00000311967UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394801ENST00000223190UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394801ENST00000393230UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394801ENST00000393231UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394801ENST00000477428UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394803ENST00000393232UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394803ENST00000353868UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394803ENST00000539636UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394803ENST00000311967UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394803ENST00000223190UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394803ENST00000393230UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394803ENST00000393231UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394803ENST00000477428UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394804ENST00000393232UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394804ENST00000353868UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394804ENST00000539636UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394804ENST00000311967UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394804ENST00000223190UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394804ENST00000393230UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394804ENST00000393231UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000394804ENST00000477428UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000343106ENST00000393232UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000343106ENST00000353868UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000343106ENST00000539636UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000343106ENST00000311967UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000343106ENST00000223190UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000343106ENST00000393230UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000343106ENST00000393231UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000343106ENST00000477428UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000321805ENST00000393232UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000321805ENST00000353868UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000321805ENST00000539636UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000321805ENST00000311967UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000321805ENST00000223190UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000321805ENST00000393230UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000321805ENST00000393231UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000321805ENST00000477428UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000350435ENST00000393232UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000350435ENST00000353868UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000350435ENST00000539636UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000350435ENST00000311967UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000350435ENST00000223190UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000350435ENST00000393230UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000350435ENST00000393231UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000350435ENST00000477428UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000338145ENST00000393232UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000338145ENST00000353868UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000338145ENST00000539636UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000338145ENST00000311967UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000338145ENST00000223190UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000338145ENST00000393230UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000338145ENST00000393231UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000338145ENST00000477428UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000349311ENST00000393232UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000349311ENST00000353868UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000349311ENST00000539636UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000349311ENST00000311967UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000349311ENST00000223190UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000349311ENST00000393230UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000349311ENST00000393231UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000349311ENST00000477428UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000504211ENST00000393232UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000504211ENST00000353868UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000504211ENST00000539636UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000504211ENST00000311967UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000504211ENST00000223190UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000504211ENST00000393230UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000504211ENST00000393231UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000504211ENST00000477428UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000357194ENST00000393232UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000357194ENST00000353868UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000357194ENST00000539636UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000357194ENST00000311967UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000357194ENST00000223190UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000357194ENST00000393230UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000357194ENST00000393231UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000357194ENST00000477428UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000505207ENST00000393232UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000505207ENST00000353868UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000505207ENST00000539636UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000505207ENST00000311967UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000505207ENST00000223190UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000505207ENST00000393230UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000505207ENST00000393231UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000505207ENST00000477428UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000507845ENST00000393232UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000507845ENST00000353868UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000507845ENST00000539636UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000507845ENST00000311967UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000507845ENST00000223190UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000507845ENST00000393230UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000507845ENST00000393231UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000507845ENST00000477428UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000502404ENST00000393232UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000502404ENST00000353868UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000502404ENST00000539636UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000502404ENST00000311967UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000502404ENST00000223190UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000502404ENST00000393230UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000502404ENST00000393231UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000502404ENST00000477428UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000513098ENST00000393232UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000513098ENST00000353868UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000513098ENST00000539636UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000513098ENST00000311967UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000513098ENST00000223190UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000513098ENST00000393230UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000513098ENST00000393231UBE2D3chr4

103717350

+NRF1chr7

129269870

+
intron-intronENST00000513098ENST00000477428UBE2D3chr4

103717350

+NRF1chr7

129269870

+

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FusionProtFeatures for UBE2D3_NRF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2D3

P61077

NRF1

Q16656

Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperateswith the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for thepolyubiquitination of NFKBIA leading to its subsequent proteasomaldegradation. Acts as an initiator E2, priming the phosphorylatedNFKBIA target at positions 'Lys-21' and/or 'Lys-22' with amonoubiquitin. Ubiquitin chain elongation is then performed byCDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunctionwith RNF8, for the priming of PCNA. Monoubiquitination of PCNA,and its subsequent polyubiquitination, are essential events in theoperation of the DNA damage tolerance (DDT) pathway that isactivated after DNA damage caused by UV or chemical agents duringS-phase. Associates with the BRCA1/BARD1 E3 ligase complex toperform ubiquitination at DNA damage sites following ionizingradiation leading to DNA repair. Targets DAPK3 for ubiquitinationwhich influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 andTOPORS E3 ligases, functions ubiquitination of p53/TP53. SupportsNRDP1-mediated ubiquitination and degradation of ERBB3 and ofBRUCE which triggers apoptosis. In conjunction with the CBL E3ligase, targets EGFR for polyubiquitination at the plasma membraneas well as during its internalization and transport on endosomes.In conjunction with the STUB1 E3 quality control E3 ligase,ubiquitinates unfolded proteins to catalyze their immediatedestruction. {ECO:0000269|PubMed:10329681,ECO:0000269|PubMed:11743028, ECO:0000269|PubMed:12646252,ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15280377,ECO:0000269|PubMed:15496420, ECO:0000269|PubMed:16628214,ECO:0000269|PubMed:18284575, ECO:0000269|PubMed:18508924,ECO:0000269|PubMed:18515077, ECO:0000269|PubMed:18948756,ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20347421,ECO:0000269|PubMed:21532592}. Transcription factor that activates the expression ofthe EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulationof key metabolic genes to cellular growth and development.Implicated in the control of nuclear genes required forrespiration, heme biosynthesis, and mitochondrial DNAtranscription and replication.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2D3_NRF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2D3_NRF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2D3_NRF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2D3_NRF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNRF1C0006079Bowen's Disease1CTD_human