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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40396

FusionGeneSummary for UBE2D3_ARPC5

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2D3_ARPC5
Fusion gene ID: 40396
HgeneTgene
Gene symbol

UBE2D3

ARPC5

Gene ID

7323

10092

Gene nameubiquitin conjugating enzyme E2 D3actin related protein 2/3 complex subunit 5
SynonymsE2(17)KB3|UBC4/5|UBCH5CARC16|dJ127C7.3|p16-Arc
Cytomap

4q24

1q25.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 D3(E3-independent) E2 ubiquitin-conjugating enzyme D3E2 ubiquitin-conjugating enzyme D3ubiquitin carrier protein D3ubiquitin conjugating enzyme E2D 3ubiquitin-conjugating enzyme E2(17)KB 3ubiquitin-conjugating enzyme actin-related protein 2/3 complex subunit 5Arp2/3 protein complex subunit p16actin related protein 2/3 complex, subunit 5, 16kDaarp2/3 complex 16 kDa subunit
Modification date2018052320180523
UniProtAcc

P61077

O15511

Ensembl transtripts involved in fusion geneENST00000453744, ENST00000394801, 
ENST00000394803, ENST00000394804, 
ENST00000343106, ENST00000321805, 
ENST00000350435, ENST00000338145, 
ENST00000349311, ENST00000504211, 
ENST00000357194, ENST00000505207, 
ENST00000507845, ENST00000502404, 
ENST00000513098, 
ENST00000367534, 
ENST00000462965, ENST00000359856, 
ENST00000294742, 
Fusion gene scores* DoF score4 X 3 X 2=243 X 3 X 2=18
# samples 43
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UBE2D3 [Title/Abstract] AND ARPC5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2D3

GO:0000209

protein polyubiquitination

14765125|16522193

HgeneUBE2D3

GO:0006513

protein monoubiquitination

20347421

HgeneUBE2D3

GO:0016567

protein ubiquitination

9990509|21532592

HgeneUBE2D3

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

20347421

HgeneUBE2D3

GO:0051865

protein autoubiquitination

21068390

HgeneUBE2D3

GO:0070936

protein K48-linked ubiquitination

20061386

HgeneUBE2D3

GO:0070979

protein K11-linked ubiquitination

20061386

TgeneARPC5

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP368716UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000453744ENST00000367534UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-5UTRENST00000453744ENST00000462965UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000453744ENST00000359856UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000453744ENST00000294742UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-intronENST00000394801ENST00000367534UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-5UTRENST00000394801ENST00000462965UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000394801ENST00000359856UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000394801ENST00000294742UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-intronENST00000394803ENST00000367534UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-5UTRENST00000394803ENST00000462965UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000394803ENST00000359856UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000394803ENST00000294742UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-intronENST00000394804ENST00000367534UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-5UTRENST00000394804ENST00000462965UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000394804ENST00000359856UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000394804ENST00000294742UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-intronENST00000343106ENST00000367534UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-5UTRENST00000343106ENST00000462965UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000343106ENST00000359856UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000343106ENST00000294742UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-intronENST00000321805ENST00000367534UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-5UTRENST00000321805ENST00000462965UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000321805ENST00000359856UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000321805ENST00000294742UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-intronENST00000350435ENST00000367534UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-5UTRENST00000350435ENST00000462965UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000350435ENST00000359856UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000350435ENST00000294742UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-intronENST00000338145ENST00000367534UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-5UTRENST00000338145ENST00000462965UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000338145ENST00000359856UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000338145ENST00000294742UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-intronENST00000349311ENST00000367534UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-5UTRENST00000349311ENST00000462965UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000349311ENST00000359856UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000349311ENST00000294742UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-intronENST00000504211ENST00000367534UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-5UTRENST00000504211ENST00000462965UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000504211ENST00000359856UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000504211ENST00000294742UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-intronENST00000357194ENST00000367534UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-5UTRENST00000357194ENST00000462965UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000357194ENST00000359856UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000357194ENST00000294742UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-intronENST00000505207ENST00000367534UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-5UTRENST00000505207ENST00000462965UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000505207ENST00000359856UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000505207ENST00000294742UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-intronENST00000507845ENST00000367534UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-5UTRENST00000507845ENST00000462965UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000507845ENST00000359856UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000507845ENST00000294742UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-intronENST00000502404ENST00000367534UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-5UTRENST00000502404ENST00000462965UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000502404ENST00000359856UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000502404ENST00000294742UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-intronENST00000513098ENST00000367534UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-5UTRENST00000513098ENST00000462965UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000513098ENST00000359856UBE2D3chr4

103718036

-ARPC5chr1

183596523

-
intron-3UTRENST00000513098ENST00000294742UBE2D3chr4

103718036

-ARPC5chr1

183596523

-

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FusionProtFeatures for UBE2D3_ARPC5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2D3

P61077

ARPC5

O15511

Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperateswith the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for thepolyubiquitination of NFKBIA leading to its subsequent proteasomaldegradation. Acts as an initiator E2, priming the phosphorylatedNFKBIA target at positions 'Lys-21' and/or 'Lys-22' with amonoubiquitin. Ubiquitin chain elongation is then performed byCDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunctionwith RNF8, for the priming of PCNA. Monoubiquitination of PCNA,and its subsequent polyubiquitination, are essential events in theoperation of the DNA damage tolerance (DDT) pathway that isactivated after DNA damage caused by UV or chemical agents duringS-phase. Associates with the BRCA1/BARD1 E3 ligase complex toperform ubiquitination at DNA damage sites following ionizingradiation leading to DNA repair. Targets DAPK3 for ubiquitinationwhich influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 andTOPORS E3 ligases, functions ubiquitination of p53/TP53. SupportsNRDP1-mediated ubiquitination and degradation of ERBB3 and ofBRUCE which triggers apoptosis. In conjunction with the CBL E3ligase, targets EGFR for polyubiquitination at the plasma membraneas well as during its internalization and transport on endosomes.In conjunction with the STUB1 E3 quality control E3 ligase,ubiquitinates unfolded proteins to catalyze their immediatedestruction. {ECO:0000269|PubMed:10329681,ECO:0000269|PubMed:11743028, ECO:0000269|PubMed:12646252,ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15280377,ECO:0000269|PubMed:15496420, ECO:0000269|PubMed:16628214,ECO:0000269|PubMed:18284575, ECO:0000269|PubMed:18508924,ECO:0000269|PubMed:18515077, ECO:0000269|PubMed:18948756,ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20347421,ECO:0000269|PubMed:21532592}. Functions as component of the Arp2/3 complex which isinvolved in regulation of actin polymerization and together withan activating nucleation-promoting factor (NPF) mediates theformation of branched actin networks.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2D3_ARPC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2D3_ARPC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2D3_ARPC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2D3_ARPC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource