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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40379

FusionGeneSummary for UBC_MYC

check button Fusion gene summary
Fusion gene informationFusion gene name: UBC_MYC
Fusion gene ID: 40379
HgeneTgene
Gene symbol

UBC

MYC

Gene ID

7316

5820

Gene nameubiquitin CPvt1 oncogene
SynonymsHMG20LINC00079|MIR1204HG|MYC|NCRNA00079|onco-lncRNA-100
Cytomap

12q24.31

8q24.21

Type of geneprotein-codingncRNA
Descriptionpolyubiquitin-CCXCR4/PVT1 fusionHIST1H2BD/PVT1 fusionMIR1204, MIR1205, MIR1206 and MIR1207 hostOncogene PVT-1 (MYC activator)PVT1/CASC8 fusionPVT1/CCDC26 fusionPVT1/IFRD1 fusionPVT1/IRF2BP2 fusionPVT1/LINC00824 fusionPVT1/MYC fusionPVT1/NFIL3 fusionPVT1/NSMCE
Modification date2018052320180520
UniProtAcc

P0CG48

P01106

Ensembl transtripts involved in fusion geneENST00000536769, ENST00000538617, 
ENST00000546120, ENST00000339647, 
ENST00000536661, 
ENST00000259523, 
ENST00000377970, ENST00000524013, 
Fusion gene scores* DoF score6 X 6 X 1=367 X 5 X 4=140
# samples 67
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBC [Title/Abstract] AND MYC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF766594UBCchr12

125399121

+MYCchr8

128751111

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000536769ENST00000259523UBCchr12

125399121

+MYCchr8

128751111

+
intron-3CDSENST00000536769ENST00000377970UBCchr12

125399121

+MYCchr8

128751111

+
intron-3CDSENST00000536769ENST00000524013UBCchr12

125399121

+MYCchr8

128751111

+
intron-3CDSENST00000538617ENST00000259523UBCchr12

125399121

+MYCchr8

128751111

+
intron-3CDSENST00000538617ENST00000377970UBCchr12

125399121

+MYCchr8

128751111

+
intron-3CDSENST00000538617ENST00000524013UBCchr12

125399121

+MYCchr8

128751111

+
intron-3CDSENST00000546120ENST00000259523UBCchr12

125399121

+MYCchr8

128751111

+
intron-3CDSENST00000546120ENST00000377970UBCchr12

125399121

+MYCchr8

128751111

+
intron-3CDSENST00000546120ENST00000524013UBCchr12

125399121

+MYCchr8

128751111

+
intron-3CDSENST00000339647ENST00000259523UBCchr12

125399121

+MYCchr8

128751111

+
intron-3CDSENST00000339647ENST00000377970UBCchr12

125399121

+MYCchr8

128751111

+
intron-3CDSENST00000339647ENST00000524013UBCchr12

125399121

+MYCchr8

128751111

+
intron-3CDSENST00000536661ENST00000259523UBCchr12

125399121

+MYCchr8

128751111

+
intron-3CDSENST00000536661ENST00000377970UBCchr12

125399121

+MYCchr8

128751111

+
intron-3CDSENST00000536661ENST00000524013UBCchr12

125399121

+MYCchr8

128751111

+

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FusionProtFeatures for UBC_MYC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBC

P0CG48

MYC

P01106

Transcription factor that binds DNA in a non-specificmanner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.Binds to the VEGFA promoter, promoting VEGFA production andsubsequent sprouting angiogenesis (PubMed:24940000).{ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25956029}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBC_MYC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBC_MYC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBC_MYC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMYCP01106DB08813NadroparinMyc proto-oncogene proteinsmall moleculeapproved|investigational

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RelatedDiseases for UBC_MYC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMYCC0009375Colonic Neoplasms4CTD_human
TgeneMYCC0023904Liver Neoplasms, Experimental3CTD_human
TgeneMYCC2239176Liver carcinoma3CTD_human
TgeneMYCC0023903Liver neoplasms2CTD_human
TgeneMYCC0033578Prostatic Neoplasms2CTD_human
TgeneMYCC0038356Stomach Neoplasms2CTD_human
TgeneMYCC0001418Adenocarcinoma1CTD_human
TgeneMYCC0005695Bladder Neoplasm1CTD_human
TgeneMYCC0007129Merkel cell carcinoma1CTD_human
TgeneMYCC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneMYCC0007137Squamous cell carcinoma1CTD_human
TgeneMYCC0007194Hypertrophic Cardiomyopathy1CTD_human
TgeneMYCC0007621Neoplastic Cell Transformation1CTD_human
TgeneMYCC0007873Uterine Cervical Neoplasm1CTD_human
TgeneMYCC0008924Cleft Lip1CTD_human
TgeneMYCC0008925Cleft Palate1CTD_human
TgeneMYCC0014170Endometrial Neoplasms1CTD_human
TgeneMYCC0015695Fatty Liver1CTD_human
TgeneMYCC0017636Glioblastoma1CTD_human
TgeneMYCC0018923Hemangiosarcoma1CTD_human
TgeneMYCC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneMYCC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneMYCC0024121Lung Neoplasms1CTD_human
TgeneMYCC0025149Medulloblastoma1CTD_human
TgeneMYCC0027627Neoplasm Metastasis1CTD_human
TgeneMYCC0027819Neuroblastoma1CTD_human
TgeneMYCC0029463Osteosarcoma1CTD_human
TgeneMYCC0030297Pancreatic Neoplasm1CTD_human
TgeneMYCC0085413Polycystic Kidney, Autosomal Dominant1CTD_human
TgeneMYCC0149721Left Ventricular Hypertrophy1CTD_human
TgeneMYCC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneMYCC0206093Neuroectodermal Tumors1CTD_human
TgeneMYCC0376628Chromosome Breakage1CTD_human
TgeneMYCC0919267ovarian neoplasm1CTD_human
TgeneMYCC3463824MYELODYSPLASTIC SYNDROME1CTD_human