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Fusion gene ID: 40379 |
FusionGeneSummary for UBC_MYC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBC_MYC | Fusion gene ID: 40379 | Hgene | Tgene | Gene symbol | UBC | MYC | Gene ID | 7316 | 5820 |
| Gene name | ubiquitin C | Pvt1 oncogene | |
| Synonyms | HMG20 | LINC00079|MIR1204HG|MYC|NCRNA00079|onco-lncRNA-100 | |
| Cytomap | 12q24.31 | 8q24.21 | |
| Type of gene | protein-coding | ncRNA | |
| Description | polyubiquitin-C | CXCR4/PVT1 fusionHIST1H2BD/PVT1 fusionMIR1204, MIR1205, MIR1206 and MIR1207 hostOncogene PVT-1 (MYC activator)PVT1/CASC8 fusionPVT1/CCDC26 fusionPVT1/IFRD1 fusionPVT1/IRF2BP2 fusionPVT1/LINC00824 fusionPVT1/MYC fusionPVT1/NFIL3 fusionPVT1/NSMCE | |
| Modification date | 20180523 | 20180520 | |
| UniProtAcc | P0CG48 | P01106 | |
| Ensembl transtripts involved in fusion gene | ENST00000536769, ENST00000538617, ENST00000546120, ENST00000339647, ENST00000536661, | ENST00000259523, ENST00000377970, ENST00000524013, | |
| Fusion gene scores | * DoF score | 6 X 6 X 1=36 | 7 X 5 X 4=140 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBC [Title/Abstract] AND MYC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF766594 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000536769 | ENST00000259523 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
| intron-3CDS | ENST00000536769 | ENST00000377970 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
| intron-3CDS | ENST00000536769 | ENST00000524013 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
| intron-3CDS | ENST00000538617 | ENST00000259523 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
| intron-3CDS | ENST00000538617 | ENST00000377970 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
| intron-3CDS | ENST00000538617 | ENST00000524013 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
| intron-3CDS | ENST00000546120 | ENST00000259523 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
| intron-3CDS | ENST00000546120 | ENST00000377970 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
| intron-3CDS | ENST00000546120 | ENST00000524013 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
| intron-3CDS | ENST00000339647 | ENST00000259523 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
| intron-3CDS | ENST00000339647 | ENST00000377970 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
| intron-3CDS | ENST00000339647 | ENST00000524013 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
| intron-3CDS | ENST00000536661 | ENST00000259523 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
| intron-3CDS | ENST00000536661 | ENST00000377970 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
| intron-3CDS | ENST00000536661 | ENST00000524013 | UBC | chr12 | 125399121 | + | MYC | chr8 | 128751111 | + |
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FusionProtFeatures for UBC_MYC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBC | MYC |
| Transcription factor that binds DNA in a non-specificmanner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.Binds to the VEGFA promoter, promoting VEGFA production andsubsequent sprouting angiogenesis (PubMed:24940000).{ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25956029}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBC_MYC |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UBC_MYC |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBC_MYC |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | MYC | P01106 | DB08813 | Nadroparin | Myc proto-oncogene protein | small molecule | approved|investigational |
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RelatedDiseases for UBC_MYC |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MYC | C0009375 | Colonic Neoplasms | 4 | CTD_human |
| Tgene | MYC | C0023904 | Liver Neoplasms, Experimental | 3 | CTD_human |
| Tgene | MYC | C2239176 | Liver carcinoma | 3 | CTD_human |
| Tgene | MYC | C0023903 | Liver neoplasms | 2 | CTD_human |
| Tgene | MYC | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Tgene | MYC | C0038356 | Stomach Neoplasms | 2 | CTD_human |
| Tgene | MYC | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Tgene | MYC | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | MYC | C0007129 | Merkel cell carcinoma | 1 | CTD_human |
| Tgene | MYC | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | MYC | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Tgene | MYC | C0007194 | Hypertrophic Cardiomyopathy | 1 | CTD_human |
| Tgene | MYC | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Tgene | MYC | C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human |
| Tgene | MYC | C0008924 | Cleft Lip | 1 | CTD_human |
| Tgene | MYC | C0008925 | Cleft Palate | 1 | CTD_human |
| Tgene | MYC | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Tgene | MYC | C0015695 | Fatty Liver | 1 | CTD_human |
| Tgene | MYC | C0017636 | Glioblastoma | 1 | CTD_human |
| Tgene | MYC | C0018923 | Hemangiosarcoma | 1 | CTD_human |
| Tgene | MYC | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Tgene | MYC | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | MYC | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Tgene | MYC | C0025149 | Medulloblastoma | 1 | CTD_human |
| Tgene | MYC | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | MYC | C0027819 | Neuroblastoma | 1 | CTD_human |
| Tgene | MYC | C0029463 | Osteosarcoma | 1 | CTD_human |
| Tgene | MYC | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| Tgene | MYC | C0085413 | Polycystic Kidney, Autosomal Dominant | 1 | CTD_human |
| Tgene | MYC | C0149721 | Left Ventricular Hypertrophy | 1 | CTD_human |
| Tgene | MYC | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Tgene | MYC | C0206093 | Neuroectodermal Tumors | 1 | CTD_human |
| Tgene | MYC | C0376628 | Chromosome Breakage | 1 | CTD_human |
| Tgene | MYC | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Tgene | MYC | C3463824 | MYELODYSPLASTIC SYNDROME | 1 | CTD_human |
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