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Fusion gene ID: 40333 |
FusionGeneSummary for UBA6_TMPRSS11D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBA6_TMPRSS11D | Fusion gene ID: 40333 | Hgene | Tgene | Gene symbol | UBA6 | TMPRSS11D | Gene ID | 55236 | 9407 |
| Gene name | ubiquitin like modifier activating enzyme 6 | transmembrane serine protease 11D | |
| Synonyms | E1-L2|MOP-4|UBE1L2 | HAT | |
| Cytomap | 4q13.2 | 4q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-like modifier-activating enzyme 6UBA6, ubiquitin-activating enzyme E1monocyte protein 4ubiquitin-activating enzyme 6ubiquitin-activating enzyme E1-like 2ubiquitin-activating enzyme E1-like protein 2 | transmembrane protease serine 11Dairway trypsin-like proteasetransmembrane protease, serine 11D | |
| Modification date | 20180523 | 20180403 | |
| UniProtAcc | A0AVT1 | O60235 | |
| Ensembl transtripts involved in fusion gene | ENST00000322244, ENST00000420827, | ENST00000283916, ENST00000545541, ENST00000509584, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 2 X 2=4 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: UBA6 [Title/Abstract] AND TMPRSS11D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TMPRSS11D | GO:0006508 | proteolysis | 24227843 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-DD-A1EB-01A | UBA6 | chr4 | 68566767 | - | TMPRSS11D | chr4 | 68749743 | - |
| TCGA | RV | LUSC | TCGA-XC-AA0X-01A | UBA6 | chr4 | 68494789 | - | TMPRSS11D | chr4 | 68725396 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000322244 | ENST00000283916 | UBA6 | chr4 | 68566767 | - | TMPRSS11D | chr4 | 68749743 | - |
| 5CDS-intron | ENST00000322244 | ENST00000545541 | UBA6 | chr4 | 68566767 | - | TMPRSS11D | chr4 | 68749743 | - |
| 5CDS-intron | ENST00000322244 | ENST00000509584 | UBA6 | chr4 | 68566767 | - | TMPRSS11D | chr4 | 68749743 | - |
| 5CDS-5UTR | ENST00000420827 | ENST00000283916 | UBA6 | chr4 | 68566767 | - | TMPRSS11D | chr4 | 68749743 | - |
| 5CDS-intron | ENST00000420827 | ENST00000545541 | UBA6 | chr4 | 68566767 | - | TMPRSS11D | chr4 | 68749743 | - |
| 5CDS-intron | ENST00000420827 | ENST00000509584 | UBA6 | chr4 | 68566767 | - | TMPRSS11D | chr4 | 68749743 | - |
| Frame-shift | ENST00000322244 | ENST00000283916 | UBA6 | chr4 | 68494789 | - | TMPRSS11D | chr4 | 68725396 | - |
| 5CDS-intron | ENST00000322244 | ENST00000545541 | UBA6 | chr4 | 68494789 | - | TMPRSS11D | chr4 | 68725396 | - |
| 5CDS-intron | ENST00000322244 | ENST00000509584 | UBA6 | chr4 | 68494789 | - | TMPRSS11D | chr4 | 68725396 | - |
| intron-3CDS | ENST00000420827 | ENST00000283916 | UBA6 | chr4 | 68494789 | - | TMPRSS11D | chr4 | 68725396 | - |
| intron-intron | ENST00000420827 | ENST00000545541 | UBA6 | chr4 | 68494789 | - | TMPRSS11D | chr4 | 68725396 | - |
| intron-intron | ENST00000420827 | ENST00000509584 | UBA6 | chr4 | 68494789 | - | TMPRSS11D | chr4 | 68725396 | - |
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FusionProtFeatures for UBA6_TMPRSS11D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBA6 | TMPRSS11D |
| May play some biological role in the host defense systemon the mucous membrane independently of or in cooperation withother substances in airway mucous or bronchial secretions. Plays arole in the proteolytic processing of ACE2. Proteolyticallycleaves and activates the human coronavirus 229E (HCoV-229E) spikeglycoprotein which facilitate virus-cell membrane fusions; spikeproteins are synthesized and maintained in precursor intermediatefolding states and proteolysis permits the refolding and energyrelease required to create stable virus-cell linkages and membranecoalescence. Preferentially cleaves the C-terminal side ofarginine residues at the P1 position of certain peptides, cleavingBoc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently andhaving an optimum pH of 8.6 with this substrate.{ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:24227843}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBA6_TMPRSS11D |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UBA6_TMPRSS11D |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBA6 | UBE2D2, ELAVL1, AIPL1, UBC, UBD, UBE2Z, UCHL3, TSN, HDLBP, NPEPPS, USP48, VPS26B, UBE4B, SMAD9, CTPS1, FKBP9, H2AFV, HEXA, LIMD1, NOL3, OGFOD1, OXSR1, PDCD6IP, PGGT1B, TWF2, AHCYL1, EHD1, GNPDA1, NUBP2, PYGB, RAD23A, RAD23B, TRNT1, XPNPEP1, UBE2S, UBE2D1, UBE2D3, UBE2T, UBE2L3, UBE2G2, HMBOX1, CCDC8, UBE2L6, MBD5, SERPINB5, FYTTD1, OR5F1, ARHGAP25, ATG7, C1orf123, CLUH, DIAPH1, DYNLT1, ENOPH1, IMPDH2, MTRR, NUP188, NUP93, PFKP, SMS, SNF8, STRAP, NTRK1, FMR1, FXR1, EIF4A3, ITCH, LINC01587, CAPN6, PLEKHO1, ALDH3B1, RAB2B, SNRNP27, GTF2E2, MYLIP | TMPRSS11D |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBA6_TMPRSS11D |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBA6_TMPRSS11D |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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