![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 40331 |
FusionGeneSummary for UBA6-AS1_NR2C2 |
![]() |
Fusion gene information | Fusion gene name: UBA6-AS1_NR2C2 | Fusion gene ID: 40331 | Hgene | Tgene | Gene symbol | UBA6-AS1 | NR2C2 | Gene ID | 550112 | 7182 |
Gene name | UBA6 antisense RNA 1 (head to head) | nuclear receptor subfamily 2 group C member 2 | |
Synonyms | - | TAK1|TR4 | |
Cytomap | 4q13.2 | 3p25.1 | |
Type of gene | ncRNA | protein-coding | |
Description | - | nuclear receptor subfamily 2 group C member 2Nuclear hormone receptor TR4orphan nuclear receptor TAK1orphan nuclear receptor TR4orphan receptor TR4testicular nuclear receptor 4 | |
Modification date | 20180329 | 20180519 | |
UniProtAcc | P49116 | ||
Ensembl transtripts involved in fusion gene | ENST00000500538, ENST00000499180, ENST00000511571, ENST00000498917, ENST00000506606, ENST00000514109, ENST00000502758, | ENST00000425241, ENST00000323373, ENST00000393102, ENST00000406272, ENST00000478572, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 6 X 2=72 |
# samples | 1 | 6 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: UBA6-AS1 [Title/Abstract] AND NR2C2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | NR2C2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9556573|10644740 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW892618 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000500538 | ENST00000425241 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000500538 | ENST00000323373 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000500538 | ENST00000393102 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000500538 | ENST00000406272 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000500538 | ENST00000478572 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000499180 | ENST00000425241 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000499180 | ENST00000323373 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000499180 | ENST00000393102 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000499180 | ENST00000406272 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000499180 | ENST00000478572 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000511571 | ENST00000425241 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000511571 | ENST00000323373 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000511571 | ENST00000393102 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000511571 | ENST00000406272 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000511571 | ENST00000478572 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000498917 | ENST00000425241 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000498917 | ENST00000323373 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000498917 | ENST00000393102 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000498917 | ENST00000406272 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000498917 | ENST00000478572 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000506606 | ENST00000425241 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000506606 | ENST00000323373 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000506606 | ENST00000393102 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000506606 | ENST00000406272 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000506606 | ENST00000478572 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000514109 | ENST00000425241 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000514109 | ENST00000323373 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000514109 | ENST00000393102 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000514109 | ENST00000406272 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000514109 | ENST00000478572 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000502758 | ENST00000425241 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000502758 | ENST00000323373 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000502758 | ENST00000393102 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000502758 | ENST00000406272 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
intron-intron | ENST00000502758 | ENST00000478572 | UBA6-AS1 | chr4 | 68917871 | + | NR2C2 | chr3 | 15088578 | - |
Top |
FusionProtFeatures for UBA6-AS1_NR2C2 |
![]() |
Hgene | Tgene |
UBA6-AS1 | NR2C2 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Orphan nuclear receptor that can act as a repressor oractivator of transcription. An important repressor of nuclearreceptor signaling pathways such as retinoic acid receptor,retinoid X, vitamin D3 receptor, thyroid hormone receptor andestrogen receptor pathways. May regulate gene expression duringthe late phase of spermatogenesis. Together with NR2C1, forms thecore of the DRED (direct repeat erythroid-definitive) complex thatrepresses embryonic and fetal globin transcription including thatof GATA1. Binds to hormone response elements (HREs) consisting oftwo 5'-AGGTCA-3' half site direct repeat consensus sequences.Plays a fundamental role in early embryonic development andembryonic stem cells. Required for normal spermatogenesis andcerebellum development. Appears to be important forneurodevelopmentally regulated behavior (By similarity). Activatestranscriptional activity of LHCG. Antagonist of PPARA-mediatedtransactivation. {ECO:0000250, ECO:0000269|PubMed:10347174,ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:17974920,ECO:0000269|PubMed:7779113, ECO:0000269|PubMed:9556573}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for UBA6-AS1_NR2C2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for UBA6-AS1_NR2C2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for UBA6-AS1_NR2C2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for UBA6-AS1_NR2C2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | NR2C2 | C0014175 | Endometriosis | 1 | CTD_human |