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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40326

FusionGeneSummary for UBA52_SUGP2

check button Fusion gene summary
Fusion gene informationFusion gene name: UBA52_SUGP2
Fusion gene ID: 40326
HgeneTgene
Gene symbol

UBA52

SUGP2

Gene ID

7311

10147

Gene nameubiquitin A-52 residue ribosomal protein fusion product 1SURP and G-patch domain containing 2
SynonymsCEP52|HUBCEP52|L40|RPL40SFRS14|SRFS14
Cytomap

19p13.11

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-60S ribosomal protein L40ubiquitin carboxyl extension protein 52ubiquitin-52 amino acid fusion proteinubiquitin-CEP52SURP and G-patch domain-containing protein 2arginine/serine-rich-splicing factor 14splicing factor, arginine/serine-rich 14
Modification date2018052320180519
UniProtAcc

P62987

Q8IX01

Ensembl transtripts involved in fusion geneENST00000596304, ENST00000430157, 
ENST00000596273, ENST00000442744, 
ENST00000595683, ENST00000595158, 
ENST00000598780, ENST00000599551, 
ENST00000597451, ENST00000599595, 
ENST00000337018, ENST00000452918, 
ENST00000601879, ENST00000600377, 
ENST00000456085, ENST00000598202, 
Fusion gene scores* DoF score15 X 13 X 3=58511 X 10 X 6=660
# samples 1711
** MAII scorelog2(17/585*10)=-1.78290187833307
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/660*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBA52 [Title/Abstract] AND SUGP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP212026UBA52chr19

18685944

+SUGP2chr19

19103589

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000596304ENST00000337018UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000596304ENST00000452918UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000596304ENST00000601879UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000596304ENST00000600377UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000596304ENST00000456085UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000596304ENST00000598202UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000430157ENST00000337018UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000430157ENST00000452918UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000430157ENST00000601879UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000430157ENST00000600377UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000430157ENST00000456085UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000430157ENST00000598202UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000596273ENST00000337018UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000596273ENST00000452918UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000596273ENST00000601879UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000596273ENST00000600377UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000596273ENST00000456085UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000596273ENST00000598202UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000442744ENST00000337018UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000442744ENST00000452918UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000442744ENST00000601879UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000442744ENST00000600377UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000442744ENST00000456085UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000442744ENST00000598202UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000595683ENST00000337018UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000595683ENST00000452918UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000595683ENST00000601879UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000595683ENST00000600377UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000595683ENST00000456085UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000595683ENST00000598202UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000595158ENST00000337018UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000595158ENST00000452918UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000595158ENST00000601879UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000595158ENST00000600377UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000595158ENST00000456085UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000595158ENST00000598202UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000598780ENST00000337018UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000598780ENST00000452918UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000598780ENST00000601879UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000598780ENST00000600377UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000598780ENST00000456085UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000598780ENST00000598202UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000599551ENST00000337018UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000599551ENST00000452918UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000599551ENST00000601879UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000599551ENST00000600377UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000599551ENST00000456085UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000599551ENST00000598202UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000597451ENST00000337018UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000597451ENST00000452918UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000597451ENST00000601879UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000597451ENST00000600377UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000597451ENST00000456085UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000597451ENST00000598202UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000599595ENST00000337018UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000599595ENST00000452918UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-3UTRENST00000599595ENST00000601879UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000599595ENST00000600377UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000599595ENST00000456085UBA52chr19

18685944

+SUGP2chr19

19103589

-
5CDS-intronENST00000599595ENST00000598202UBA52chr19

18685944

+SUGP2chr19

19103589

-

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FusionProtFeatures for UBA52_SUGP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBA52

P62987

SUGP2

Q8IX01

May play a role in mRNA splicing. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBA52_SUGP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBA52_SUGP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for UBA52_SUGP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBA52_SUGP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource