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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40320

FusionGeneSummary for UBA52_HERC6

check button Fusion gene summary
Fusion gene informationFusion gene name: UBA52_HERC6
Fusion gene ID: 40320
HgeneTgene
Gene symbol

UBA52

HERC6

Gene ID

7311

55008

Gene nameubiquitin A-52 residue ribosomal protein fusion product 1HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
SynonymsCEP52|HUBCEP52|L40|RPL40-
Cytomap

19p13.11

4q22.1

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-60S ribosomal protein L40ubiquitin carboxyl extension protein 52ubiquitin-52 amino acid fusion proteinubiquitin-CEP52probable E3 ubiquitin-protein ligase HERC6HECT domain and RCC1-like domain-containing protein 6HECT-type E3 ubiquitin transferase HERC6hect domain and RLD 6potential ubiquitin ligase
Modification date2018052320180522
UniProtAcc

P62987

Q8IVU3

Ensembl transtripts involved in fusion geneENST00000596304, ENST00000430157, 
ENST00000596273, ENST00000442744, 
ENST00000595683, ENST00000595158, 
ENST00000598780, ENST00000599551, 
ENST00000597451, ENST00000599595, 
ENST00000273960, ENST00000380265, 
ENST00000264346, 
Fusion gene scores* DoF score15 X 13 X 3=5851 X 1 X 1=1
# samples 171
** MAII scorelog2(17/585*10)=-1.78290187833307
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: UBA52 [Title/Abstract] AND HERC6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1N83523UBA52chr19

18684558

+HERC6chr4

89569931

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000596304ENST00000273960UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000596304ENST00000380265UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000596304ENST00000264346UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000430157ENST00000273960UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000430157ENST00000380265UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000430157ENST00000264346UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000596273ENST00000273960UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000596273ENST00000380265UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000596273ENST00000264346UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000442744ENST00000273960UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000442744ENST00000380265UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000442744ENST00000264346UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000595683ENST00000273960UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000595683ENST00000380265UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000595683ENST00000264346UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000595158ENST00000273960UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000595158ENST00000380265UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000595158ENST00000264346UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000598780ENST00000273960UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000598780ENST00000380265UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000598780ENST00000264346UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000599551ENST00000273960UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000599551ENST00000380265UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000599551ENST00000264346UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000597451ENST00000273960UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000597451ENST00000380265UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000597451ENST00000264346UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000599595ENST00000273960UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000599595ENST00000380265UBA52chr19

18684558

+HERC6chr4

89569931

-
5CDS-intronENST00000599595ENST00000264346UBA52chr19

18684558

+HERC6chr4

89569931

-

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FusionProtFeatures for UBA52_HERC6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBA52

P62987

HERC6

Q8IVU3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBA52_HERC6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBA52_HERC6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBA52_HERC6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBA52_HERC6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHERC6C0021400Influenza1CTD_human