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Fusion gene ID: 40305 |
FusionGeneSummary for UBA2_LRP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBA2_LRP3 | Fusion gene ID: 40305 | Hgene | Tgene | Gene symbol | UBA2 | LRP3 | Gene ID | 10054 | 4037 |
| Gene name | ubiquitin like modifier activating enzyme 2 | LDL receptor related protein 3 | |
| Synonyms | ARX|HRIHFB2115|SAE2 | - | |
| Cytomap | 19q13.11 | 19q13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SUMO-activating enzyme subunit 2SUMO-1 activating enzyme subunit 2SUMO1 activating enzyme subunit 2UBA2, ubiquitin-activating enzyme E1 homologanthracycline-associated resistance ARXubiquitin-like 1-activating enzyme E1B | low-density lipoprotein receptor-related protein 3105 kDa low-density lipoprotein receptor-related proteinCTD-2540B15.13LRP-3hLRp105 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UBT2 | O75074 | |
| Ensembl transtripts involved in fusion gene | ENST00000246548, ENST00000439527, ENST00000592791, ENST00000588585, | ENST00000253193, | |
| Fusion gene scores | * DoF score | 10 X 7 X 7=490 | 1 X 1 X 1=1 |
| # samples | 10 | 1 | |
| ** MAII score | log2(10/490*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: UBA2 [Title/Abstract] AND LRP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBA2 | GO:0016925 | protein sumoylation | 20164921 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A8BN-01A | UBA2 | chr19 | 34957919 | + | LRP3 | chr19 | 33687636 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000246548 | ENST00000253193 | UBA2 | chr19 | 34957919 | + | LRP3 | chr19 | 33687636 | + |
| In-frame | ENST00000439527 | ENST00000253193 | UBA2 | chr19 | 34957919 | + | LRP3 | chr19 | 33687636 | + |
| In-frame | ENST00000592791 | ENST00000253193 | UBA2 | chr19 | 34957919 | + | LRP3 | chr19 | 33687636 | + |
| intron-3CDS | ENST00000588585 | ENST00000253193 | UBA2 | chr19 | 34957919 | + | LRP3 | chr19 | 33687636 | + |
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FusionProtFeatures for UBA2_LRP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBA2 | LRP3 |
| The heterodimer acts as an E1 ligase for SUMO1, SUMO2,SUMO3, and probably SUMO4. It mediates ATP-dependent activation ofSUMO proteins followed by formation of a thioester bond between aSUMO protein and a conserved active site cysteine residue onUBA2/SAE2. {ECO:0000269|PubMed:11451954,ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128,ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651,ECO:0000269|PubMed:20164921}. | Probable receptor, which may be involved in theinternalization of lipophilic molecules and/or signaltransduction. Its precise role is however unclear, since it doesnot bind to very low density lipoprotein (VLDL) or to LRPAP1 invitro. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | UBA2 | chr19:34957919 | chr19:33687636 | ENST00000246548 | + | 16 | 17 | 117_122 | 580 | 641 | Nucleotide binding | ATP |
| Hgene | UBA2 | chr19:34957919 | chr19:33687636 | ENST00000246548 | + | 16 | 17 | 24_29 | 580 | 641 | Nucleotide binding | ATP |
| Hgene | UBA2 | chr19:34957919 | chr19:33687636 | ENST00000246548 | + | 16 | 17 | 56_59 | 580 | 641 | Nucleotide binding | ATP |
| Hgene | UBA2 | chr19:34957919 | chr19:33687636 | ENST00000246548 | + | 16 | 17 | 95_96 | 580 | 641 | Nucleotide binding | ATP |
| Tgene | >LRP3 | chr19:34957919 | chr19:33687636 | ENST00000253193 | + | 0 | 7 | 751_754 | 24 | 771 | Compositional bias | Note=Poly-Pro |
| Tgene | >LRP3 | chr19:34957919 | chr19:33687636 | ENST00000253193 | + | 0 | 7 | 165_201 | 24 | 771 | Domain | LDL-receptor class A 1 |
| Tgene | >LRP3 | chr19:34957919 | chr19:33687636 | ENST00000253193 | + | 0 | 7 | 211_250 | 24 | 771 | Domain | LDL-receptor class A 2 |
| Tgene | >LRP3 | chr19:34957919 | chr19:33687636 | ENST00000253193 | + | 0 | 7 | 254_365 | 24 | 771 | Domain | CUB 2 |
| Tgene | >LRP3 | chr19:34957919 | chr19:33687636 | ENST00000253193 | + | 0 | 7 | 415_453 | 24 | 771 | Domain | LDL-receptor class A 3 |
| Tgene | >LRP3 | chr19:34957919 | chr19:33687636 | ENST00000253193 | + | 0 | 7 | 43_159 | 24 | 771 | Domain | CUB 1 |
| Tgene | >LRP3 | chr19:34957919 | chr19:33687636 | ENST00000253193 | + | 0 | 7 | 454_490 | 24 | 771 | Domain | LDL-receptor class A 4 |
| Tgene | >LRP3 | chr19:34957919 | chr19:33687636 | ENST00000253193 | + | 0 | 7 | 37_496 | 24 | 771 | Topological domain | Extracellular |
| Tgene | >LRP3 | chr19:34957919 | chr19:33687636 | ENST00000253193 | + | 0 | 7 | 518_770 | 24 | 771 | Topological domain | Cytoplasmic |
| Tgene | >LRP3 | chr19:34957919 | chr19:33687636 | ENST00000253193 | + | 0 | 7 | 497_517 | 24 | 771 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBA2_LRP3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_UBA2_ENST00000246548_chr19_34957919_+_LRP3_ENST00000253193_chr19_33687636_+_1327aa MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFYPKANIV AYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPS EPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLLTMD KLWRKRKPPVPLDWAEVQSQGEETNASDQQNEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAAN LRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNPNCYVCASKPEV TVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGK DVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTVNIFLTGRLSSAVPALAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSW YIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQA SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLAC GRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLT VAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPA DRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVCGLLLVIALGCAFKLYS LRTQEYRAFETQMTRLEAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSASQASVLQNLRTAMRRQMRRHASRRGPSRRRLGRLWNRLFHR PRAPRGQIPLLTAARPSQTVLGDGFLQPAPGAAPDPPAPLMDTGSTRAAGDRPPSAPGRAPEVGPSGPPLPSGLRDPECRPVDKDRKVCR >In-frame_UBA2_ENST00000439527_chr19_34957919_+_LRP3_ENST00000253193_chr19_33687636_+_1231aa MNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPSEPIHCI VWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKR KPPVPLDWAEVQSQGEETNASDQQNEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAANLRMHIF SMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNV HKVTVLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEV VGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTVNIFLTGRLSSAVPALAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDR GDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQADE FRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGS FYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHAR ARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQ KSCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVCGLLLVIALGCAFKLYSLRTQEY RAFETQMTRLEAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSASQASVLQNLRTAMRRQMRRHASRRGPSRRRLGRLWNRLFHRPRAPRG QIPLLTAARPSQTVLGDGFLQPAPGAAPDPPAPLMDTGSTRAAGDRPPSAPGRAPEVGPSGPPLPSGLRDPECRPVDKDRKVCREPLVDG >In-frame_UBA2_ENST00000592791_chr19_34957919_+_LRP3_ENST00000253193_chr19_33687636_+_853aa MVAPDVQIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDAPEKVGPKQAEDAAK SITNGSDDGAQPSTSTVNIFLTGRLSSAVPALAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQ CSLDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQADEFRCDNGKCLPGPWQCNTV DECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPS DLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYC LPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPG TFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVCGLLLVIALGCAFKLYSLRTQEYRAFETQMTRLEAEFVRRE APPSYGQLIAQGLIPPVEDFPVYSASQASVLQNLRTAMRRQMRRHASRRGPSRRRLGRLWNRLFHRPRAPRGQIPLLTAARPSQTVLGDG FLQPAPGAAPDPPAPLMDTGSTRAAGDRPPSAPGRAPEVGPSGPPLPSGLRDPECRPVDKDRKVCREPLVDGPAPADAPREPCSAQDPHP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_UBA2_ENST00000246548_chr19_34957919_+_LRP3_ENST00000253193_chr19_33687636_+_3981nt ATGGCACTGTCGCGGGGGCTGCCCCGGGAGCTGGCTGAGGCGGTGGCCGGGGGCCGGGTGCTGGTGGTGGGGGCGGGCGGCATCGGCTGC GAGCTCCTCAAGAATCTCGTGCTCACCGGTTTCTCCCACATCGACCTGATTGATCTGGATACTATTGATGTAAGCAACCTCAACAGACAG TTTTTGTTTCAAAAGAAACATGTTGGAAGATCAAAGGCACAGGTTGCCAAGGAAAGTGTACTGCAGTTTTACCCGAAAGCTAATATCGTT GCCTACCATGACAGCATCATGAACCCTGACTATAATGTGGAATTTTTCCGACAGTTTATACTGGTTATGAATGCTTTAGATAACAGAGCT GCCCGAAACCATGTTAATAGAATGTGCCTGGCAGCTGATGTTCCTCTTATTGAAAGTGGAACAGCTGGGTATCTTGGACAAGTAACTACT ATCAAAAAGGGTGTGACCGAGTGTTATGAGTGTCATCCTAAGCCGACCCAGAGAACCTTTCCTGGCTGTACAATTCGTAACACACCTTCA GAACCTATACATTGCATCGTTTGGGCAAAGTACTTGTTCAACCAGTTGTTTGGGGAAGAAGATGCTGATCAAGAAGTATCTCCTGACAGA GCTGACCCTGAAGCTGCCTGGGAACCAACGGAAGCCGAAGCCAGAGCTAGAGCATCTAATGAAGATGGTGACATTAAACGTATTTCTACT AAGGAATGGGCTAAATCAACTGGATATGATCCAGTTAAACTTTTTACCAAGCTTTTTAAAGATGACATCAGGTATCTGTTGACAATGGAC AAACTATGGCGGAAAAGGAAACCTCCAGTTCCGTTGGACTGGGCTGAAGTACAAAGTCAAGGAGAAGAAACGAATGCATCAGATCAACAG AATGAACCCCAGTTAGGCCTGAAAGACCAGCAGGTTCTAGATGTAAAGAGCTATGCACGTCTTTTTTCAAAGAGCATCGAGACTTTGAGA GTTCATTTAGCAGAAAAGGGGGATGGAGCTGAGCTCATATGGGATAAGGATGACCCATCTGCAATGGATTTTGTCACCTCTGCTGCAAAC CTCAGGATGCATATTTTCAGTATGAATATGAAGAGTAGATTTGATATCAAATCAATGGCAGGGAACATTATTCCTGCTATTGCTACTACT AATGCAGTAATTGCTGGGTTGATAGTATTGGAAGGATTGAAGATTTTATCAGGAAAAATAGACCAGTGCAGAACAATTTTTTTGAATAAA CAACCAAACCCAAGAAAGAAGCTTCTTGTGCCTTGTGCACTGGATCCTCCCAACCCCAATTGTTATGTATGTGCCAGCAAGCCAGAGGTG ACTGTGCGGCTGAATGTCCATAAAGTGACTGTTCTCACCTTACAAGACAAGATAGTGAAAGAAAAATTTGCTATGGTAGCACCAGATGTC CAAATTGAAGATGGGAAAGGAACAATCCTAATATCTTCCGAAGAGGGAGAGACGGAAGCTAATAATCACAAGAAGTTGTCAGAATTTGGA ATTAGAAATGGCAGCCGGCTTCAAGCAGATGACTTCCTCCAGGACTATACTTTATTGATCAACATCCTTCATAGTGAAGACCTAGGAAAG GACGTTGAATTTGAAGTTGTTGGTGATGCCCCGGAAAAAGTGGGGCCCAAACAAGCTGAAGATGCTGCCAAAAGCATAACCAATGGCAGT GATGATGGAGCTCAGCCCTCCACCTCCACAGTGAACATCTTTCTCACCGGGAGACTCAGCAGTGCGGTTCCTGCCTTAGCGGCCTGCAGT GGGAAGCTGGAGCAGCACACGGAGCGGCGTGGGGTCATCTACAGCCCGGCCTGGCCCCTCAACTACCCGCCAGGCACCAACTGCAGCTGG TACATCCAGGGCGACCGTGGTGACATGATTACCATCAGCTTCCGCAACTTTGACGTGGAGGAGTCCCACCAGTGCTCCCTGGACTGGCTC CTGCTGGGCCCAGCAGCCCCACCCCGCCAGGAGGCCTTCCGCCTCTGTGGCTCCGCCATCCCACCTGCCTTCATCTCTGCCCGCGACCAT GTCTGGATTTTCTTCCACTCAGACGCCTCCAGCTCCGGCCAGGCCCAGGGCTTCCGTCTGTCTTACATCCGAGGGAAGCTGGGCCAGGCA TCCTGCCAGGCAGATGAGTTCCGCTGTGACAACGGCAAGTGCCTGCCCGGCCCGTGGCAGTGCAACACGGTGGACGAGTGTGGAGACGGC TCTGATGAGGGCAACTGCTCGGCGCCCGCCTCCGAGCCTCCAGGCAGCCTGTGCCCCGGGGGGACCTTCCCATGCAGCGGGGCGCGCTCC ACGCGCTGCCTGCCTGTGGAGCGGCGCTGTGACGGCTTGCAGGACTGCGGCGACGGCTCGGATGAGGCGGGCTGCCCCGACCTGGCGTGC GGCCGGCGGCTGGGCAGCTTCTACGGCTCCTTTGCCTCCCCAGACCTGTTCGGCGCCGCTCGCGGGCCCTCAGACCTTCACTGCACGTGG CTGGTGGACACACAGGACTCCCGGCGGGTGCTGCTGCAGCTGGAACTGCGGCTGGGCTATGACGACTACGTGCAGGTATACGAGGGCCTG GGCGAGCGCGGGGACCGCCTGCTGCAGACGCTGTCCTACCGCAGCAACCACCGGCCCGTGAGCCTGGAGGCCGCCCAGGGCCGCCTCACT GTGGCCTACCACGCGCGCGCCCGCAGCGCCGGCCACGGCTTCAATGCCACCTACCAGGTGAAGGGCTATTGCCTCCCCTGGGAGCAGCCG TGCGGGAGCAGTAGTGACAGTGACGGGGGCAGCCTGGGCGACCAGGGCTGCTTCTCAGAGCCACAGCGCTGTGATGGCTGGTGGCATTGT GCCAGCGGCCGAGACGAGCAGGGCTGCCCTGCCTGCCCGCCCGACCAGTACCCCTGCGAGGGTGGCAGTGGTCTGTGCTACACGCCTGCC GACCGCTGCAACAACCAGAAAAGCTGTCCCGACGGCGCCGACGAGAAGAACTGCTTCTCCTGCCAGCCCGGCACCTTCCACTGCGGTACC AACCTGTGCATCTTCGAGACGTGGCGCTGTGACGGCCAGGAAGACTGCCAGGACGGCAGCGATGAGCATGGGTGCCTGGCCGCCGTGCCC CGCAAGGTCATCACGGCGGCGCTCATTGGCAGCCTGGTGTGTGGCCTGCTGCTGGTCATCGCGCTGGGCTGCGCCTTCAAGCTCTACTCA CTGCGCACGCAGGAATACAGGGCCTTCGAGACCCAGATGACGCGCCTGGAGGCTGAGTTCGTGCGGCGGGAGGCACCCCCATCCTATGGT CAGCTCATCGCCCAGGGCCTCATTCCACCCGTGGAGGACTTTCCTGTCTACAGTGCGTCCCAGGCCTCTGTGCTGCAGAATCTTCGCACA GCCATGCGGAGACAGATGCGTCGGCACGCCTCCCGCCGGGGGCCCTCCCGCCGCCGCCTCGGCCGCCTCTGGAACCGGCTCTTTCACCGG CCGCGGGCGCCCCGAGGCCAGATCCCACTGCTGACCGCAGCACGCCCCTCACAGACCGTGCTGGGCGATGGCTTCCTCCAGCCTGCTCCA GGGGCTGCCCCCGACCCCCCAGCACCGCTCATGGACACAGGCAGCACCAGGGCGGCCGGAGACAGGCCCCCCAGTGCCCCCGGCCGTGCA CCGGAGGTGGGACCTTCAGGGCCACCCTTGCCCTCGGGCCTGCGAGACCCAGAGTGCAGGCCCGTGGACAAGGACAGAAAGGTCTGCAGG GAGCCACTGGTAGACGGCCCAGCTCCTGCAGATGCACCTCGGGAGCCCTGCTCAGCCCAGGACCCGCACCCCCAGGTCTCCACTGCCAGC AGCACCCTGGGCCCCCACTCGCCAGAGCCACTGGGGGTCTGCAGGAACCCCCCGCCCCCCTGCTCCCCAATGCTGGAGGCCAGCGATGAT >In-frame_UBA2_ENST00000439527_chr19_34957919_+_LRP3_ENST00000253193_chr19_33687636_+_3693nt ATGAACCCTGACTATAATGTGGAATTTTTCCGACAGTTTATACTGGTTATGAATGCTTTAGATAACAGAGCTGCCCGAAACCATGTTAAT AGAATGTGCCTGGCAGCTGATGTTCCTCTTATTGAAAGTGGAACAGCTGGGTATCTTGGACAAGTAACTACTATCAAAAAGGGTGTGACC GAGTGTTATGAGTGTCATCCTAAGCCGACCCAGAGAACCTTTCCTGGCTGTACAATTCGTAACACACCTTCAGAACCTATACATTGCATC GTTTGGGCAAAGTACTTGTTCAACCAGTTGTTTGGGGAAGAAGATGCTGATCAAGAAGTATCTCCTGACAGAGCTGACCCTGAAGCTGCC TGGGAACCAACGGAAGCCGAAGCCAGAGCTAGAGCATCTAATGAAGATGGTGACATTAAACGTATTTCTACTAAGGAATGGGCTAAATCA ACTGGATATGATCCAGTTAAACTTTTTACCAAGCTTTTTAAAGATGACATCAGGTATCTGTTGACAATGGACAAACTATGGCGGAAAAGG AAACCTCCAGTTCCGTTGGACTGGGCTGAAGTACAAAGTCAAGGAGAAGAAACGAATGCATCAGATCAACAGAATGAACCCCAGTTAGGC CTGAAAGACCAGCAGGTTCTAGATGTAAAGAGCTATGCACGTCTTTTTTCAAAGAGCATCGAGACTTTGAGAGTTCATTTAGCAGAAAAG GGGGATGGAGCTGAGCTCATATGGGATAAGGATGACCCATCTGCAATGGATTTTGTCACCTCTGCTGCAAACCTCAGGATGCATATTTTC AGTATGAATATGAAGAGTAGATTTGATATCAAATCAATGGCAGGGAACATTATTCCTGCTATTGCTACTACTAATGCAGTAATTGCTGGG TTGATAGTATTGGAAGGATTGAAGATTTTATCAGGAAAAATAGACCAGTGCAGAACAATTTTTTTGAATAAACAACCAAACCCAAGAAAG AAGCTTCTTGTGCCTTGTGCACTGGATCCTCCCAACCCCAATTGTTATGTATGTGCCAGCAAGCCAGAGGTGACTGTGCGGCTGAATGTC CATAAAGTGACTGTTCTCACCTTACAAGACAAGATAGTGAAAGAAAAATTTGCTATGGTAGCACCAGATGTCCAAATTGAAGATGGGAAA GGAACAATCCTAATATCTTCCGAAGAGGGAGAGACGGAAGCTAATAATCACAAGAAGTTGTCAGAATTTGGAATTAGAAATGGCAGCCGG CTTCAAGCAGATGACTTCCTCCAGGACTATACTTTATTGATCAACATCCTTCATAGTGAAGACCTAGGAAAGGACGTTGAATTTGAAGTT GTTGGTGATGCCCCGGAAAAAGTGGGGCCCAAACAAGCTGAAGATGCTGCCAAAAGCATAACCAATGGCAGTGATGATGGAGCTCAGCCC TCCACCTCCACAGTGAACATCTTTCTCACCGGGAGACTCAGCAGTGCGGTTCCTGCCTTAGCGGCCTGCAGTGGGAAGCTGGAGCAGCAC ACGGAGCGGCGTGGGGTCATCTACAGCCCGGCCTGGCCCCTCAACTACCCGCCAGGCACCAACTGCAGCTGGTACATCCAGGGCGACCGT GGTGACATGATTACCATCAGCTTCCGCAACTTTGACGTGGAGGAGTCCCACCAGTGCTCCCTGGACTGGCTCCTGCTGGGCCCAGCAGCC CCACCCCGCCAGGAGGCCTTCCGCCTCTGTGGCTCCGCCATCCCACCTGCCTTCATCTCTGCCCGCGACCATGTCTGGATTTTCTTCCAC TCAGACGCCTCCAGCTCCGGCCAGGCCCAGGGCTTCCGTCTGTCTTACATCCGAGGGAAGCTGGGCCAGGCATCCTGCCAGGCAGATGAG TTCCGCTGTGACAACGGCAAGTGCCTGCCCGGCCCGTGGCAGTGCAACACGGTGGACGAGTGTGGAGACGGCTCTGATGAGGGCAACTGC TCGGCGCCCGCCTCCGAGCCTCCAGGCAGCCTGTGCCCCGGGGGGACCTTCCCATGCAGCGGGGCGCGCTCCACGCGCTGCCTGCCTGTG GAGCGGCGCTGTGACGGCTTGCAGGACTGCGGCGACGGCTCGGATGAGGCGGGCTGCCCCGACCTGGCGTGCGGCCGGCGGCTGGGCAGC TTCTACGGCTCCTTTGCCTCCCCAGACCTGTTCGGCGCCGCTCGCGGGCCCTCAGACCTTCACTGCACGTGGCTGGTGGACACACAGGAC TCCCGGCGGGTGCTGCTGCAGCTGGAACTGCGGCTGGGCTATGACGACTACGTGCAGGTATACGAGGGCCTGGGCGAGCGCGGGGACCGC CTGCTGCAGACGCTGTCCTACCGCAGCAACCACCGGCCCGTGAGCCTGGAGGCCGCCCAGGGCCGCCTCACTGTGGCCTACCACGCGCGC GCCCGCAGCGCCGGCCACGGCTTCAATGCCACCTACCAGGTGAAGGGCTATTGCCTCCCCTGGGAGCAGCCGTGCGGGAGCAGTAGTGAC AGTGACGGGGGCAGCCTGGGCGACCAGGGCTGCTTCTCAGAGCCACAGCGCTGTGATGGCTGGTGGCATTGTGCCAGCGGCCGAGACGAG CAGGGCTGCCCTGCCTGCCCGCCCGACCAGTACCCCTGCGAGGGTGGCAGTGGTCTGTGCTACACGCCTGCCGACCGCTGCAACAACCAG AAAAGCTGTCCCGACGGCGCCGACGAGAAGAACTGCTTCTCCTGCCAGCCCGGCACCTTCCACTGCGGTACCAACCTGTGCATCTTCGAG ACGTGGCGCTGTGACGGCCAGGAAGACTGCCAGGACGGCAGCGATGAGCATGGGTGCCTGGCCGCCGTGCCCCGCAAGGTCATCACGGCG GCGCTCATTGGCAGCCTGGTGTGTGGCCTGCTGCTGGTCATCGCGCTGGGCTGCGCCTTCAAGCTCTACTCACTGCGCACGCAGGAATAC AGGGCCTTCGAGACCCAGATGACGCGCCTGGAGGCTGAGTTCGTGCGGCGGGAGGCACCCCCATCCTATGGTCAGCTCATCGCCCAGGGC CTCATTCCACCCGTGGAGGACTTTCCTGTCTACAGTGCGTCCCAGGCCTCTGTGCTGCAGAATCTTCGCACAGCCATGCGGAGACAGATG CGTCGGCACGCCTCCCGCCGGGGGCCCTCCCGCCGCCGCCTCGGCCGCCTCTGGAACCGGCTCTTTCACCGGCCGCGGGCGCCCCGAGGC CAGATCCCACTGCTGACCGCAGCACGCCCCTCACAGACCGTGCTGGGCGATGGCTTCCTCCAGCCTGCTCCAGGGGCTGCCCCCGACCCC CCAGCACCGCTCATGGACACAGGCAGCACCAGGGCGGCCGGAGACAGGCCCCCCAGTGCCCCCGGCCGTGCACCGGAGGTGGGACCTTCA GGGCCACCCTTGCCCTCGGGCCTGCGAGACCCAGAGTGCAGGCCCGTGGACAAGGACAGAAAGGTCTGCAGGGAGCCACTGGTAGACGGC CCAGCTCCTGCAGATGCACCTCGGGAGCCCTGCTCAGCCCAGGACCCGCACCCCCAGGTCTCCACTGCCAGCAGCACCCTGGGCCCCCAC TCGCCAGAGCCACTGGGGGTCTGCAGGAACCCCCCGCCCCCCTGCTCCCCAATGCTGGAGGCCAGCGATGATGAGGCCCTGTTGGTCTGT >In-frame_UBA2_ENST00000592791_chr19_34957919_+_LRP3_ENST00000253193_chr19_33687636_+_2559nt ATGGTAGCACCAGATGTCCAAATTGAAGATGGGAAAGGAACAATCCTAATATCTTCCGAAGAGGGAGAGACGGAAGCTAATAATCACAAG AAGTTGTCAGAATTTGGAATTAGAAATGGCAGCCGGCTTCAAGCAGATGACTTCCTCCAGGACTATACTTTATTGATCAACATCCTTCAT AGTGAAGACCTAGGAAAGGACGTTGAATTTGAAGTTGTTGGTGATGCCCCGGAAAAAGTGGGGCCCAAACAAGCTGAAGATGCTGCCAAA AGCATAACCAATGGCAGTGATGATGGAGCTCAGCCCTCCACCTCCACAGTGAACATCTTTCTCACCGGGAGACTCAGCAGTGCGGTTCCT GCCTTAGCGGCCTGCAGTGGGAAGCTGGAGCAGCACACGGAGCGGCGTGGGGTCATCTACAGCCCGGCCTGGCCCCTCAACTACCCGCCA GGCACCAACTGCAGCTGGTACATCCAGGGCGACCGTGGTGACATGATTACCATCAGCTTCCGCAACTTTGACGTGGAGGAGTCCCACCAG TGCTCCCTGGACTGGCTCCTGCTGGGCCCAGCAGCCCCACCCCGCCAGGAGGCCTTCCGCCTCTGTGGCTCCGCCATCCCACCTGCCTTC ATCTCTGCCCGCGACCATGTCTGGATTTTCTTCCACTCAGACGCCTCCAGCTCCGGCCAGGCCCAGGGCTTCCGTCTGTCTTACATCCGA GGGAAGCTGGGCCAGGCATCCTGCCAGGCAGATGAGTTCCGCTGTGACAACGGCAAGTGCCTGCCCGGCCCGTGGCAGTGCAACACGGTG GACGAGTGTGGAGACGGCTCTGATGAGGGCAACTGCTCGGCGCCCGCCTCCGAGCCTCCAGGCAGCCTGTGCCCCGGGGGGACCTTCCCA TGCAGCGGGGCGCGCTCCACGCGCTGCCTGCCTGTGGAGCGGCGCTGTGACGGCTTGCAGGACTGCGGCGACGGCTCGGATGAGGCGGGC TGCCCCGACCTGGCGTGCGGCCGGCGGCTGGGCAGCTTCTACGGCTCCTTTGCCTCCCCAGACCTGTTCGGCGCCGCTCGCGGGCCCTCA GACCTTCACTGCACGTGGCTGGTGGACACACAGGACTCCCGGCGGGTGCTGCTGCAGCTGGAACTGCGGCTGGGCTATGACGACTACGTG CAGGTATACGAGGGCCTGGGCGAGCGCGGGGACCGCCTGCTGCAGACGCTGTCCTACCGCAGCAACCACCGGCCCGTGAGCCTGGAGGCC GCCCAGGGCCGCCTCACTGTGGCCTACCACGCGCGCGCCCGCAGCGCCGGCCACGGCTTCAATGCCACCTACCAGGTGAAGGGCTATTGC CTCCCCTGGGAGCAGCCGTGCGGGAGCAGTAGTGACAGTGACGGGGGCAGCCTGGGCGACCAGGGCTGCTTCTCAGAGCCACAGCGCTGT GATGGCTGGTGGCATTGTGCCAGCGGCCGAGACGAGCAGGGCTGCCCTGCCTGCCCGCCCGACCAGTACCCCTGCGAGGGTGGCAGTGGT CTGTGCTACACGCCTGCCGACCGCTGCAACAACCAGAAAAGCTGTCCCGACGGCGCCGACGAGAAGAACTGCTTCTCCTGCCAGCCCGGC ACCTTCCACTGCGGTACCAACCTGTGCATCTTCGAGACGTGGCGCTGTGACGGCCAGGAAGACTGCCAGGACGGCAGCGATGAGCATGGG TGCCTGGCCGCCGTGCCCCGCAAGGTCATCACGGCGGCGCTCATTGGCAGCCTGGTGTGTGGCCTGCTGCTGGTCATCGCGCTGGGCTGC GCCTTCAAGCTCTACTCACTGCGCACGCAGGAATACAGGGCCTTCGAGACCCAGATGACGCGCCTGGAGGCTGAGTTCGTGCGGCGGGAG GCACCCCCATCCTATGGTCAGCTCATCGCCCAGGGCCTCATTCCACCCGTGGAGGACTTTCCTGTCTACAGTGCGTCCCAGGCCTCTGTG CTGCAGAATCTTCGCACAGCCATGCGGAGACAGATGCGTCGGCACGCCTCCCGCCGGGGGCCCTCCCGCCGCCGCCTCGGCCGCCTCTGG AACCGGCTCTTTCACCGGCCGCGGGCGCCCCGAGGCCAGATCCCACTGCTGACCGCAGCACGCCCCTCACAGACCGTGCTGGGCGATGGC TTCCTCCAGCCTGCTCCAGGGGCTGCCCCCGACCCCCCAGCACCGCTCATGGACACAGGCAGCACCAGGGCGGCCGGAGACAGGCCCCCC AGTGCCCCCGGCCGTGCACCGGAGGTGGGACCTTCAGGGCCACCCTTGCCCTCGGGCCTGCGAGACCCAGAGTGCAGGCCCGTGGACAAG GACAGAAAGGTCTGCAGGGAGCCACTGGTAGACGGCCCAGCTCCTGCAGATGCACCTCGGGAGCCCTGCTCAGCCCAGGACCCGCACCCC CAGGTCTCCACTGCCAGCAGCACCCTGGGCCCCCACTCGCCAGAGCCACTGGGGGTCTGCAGGAACCCCCCGCCCCCCTGCTCCCCAATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_UBA2_ENST00000246548_chr19_34957919_+_LRP3_ENST00000253193_chr19_33687636_+_4264nt CCCCACCCGCTTCCGGCCGCGGCTCGGTTCTCCCGCCTCCGCCTCCGCCGCGGCTCGTGGTTGTCCCGCCATGGCACTGTCGCGGGGGCT GCCCCGGGAGCTGGCTGAGGCGGTGGCCGGGGGCCGGGTGCTGGTGGTGGGGGCGGGCGGCATCGGCTGCGAGCTCCTCAAGAATCTCGT GCTCACCGGTTTCTCCCACATCGACCTGATTGATCTGGATACTATTGATGTAAGCAACCTCAACAGACAGTTTTTGTTTCAAAAGAAACA TGTTGGAAGATCAAAGGCACAGGTTGCCAAGGAAAGTGTACTGCAGTTTTACCCGAAAGCTAATATCGTTGCCTACCATGACAGCATCAT GAACCCTGACTATAATGTGGAATTTTTCCGACAGTTTATACTGGTTATGAATGCTTTAGATAACAGAGCTGCCCGAAACCATGTTAATAG AATGTGCCTGGCAGCTGATGTTCCTCTTATTGAAAGTGGAACAGCTGGGTATCTTGGACAAGTAACTACTATCAAAAAGGGTGTGACCGA GTGTTATGAGTGTCATCCTAAGCCGACCCAGAGAACCTTTCCTGGCTGTACAATTCGTAACACACCTTCAGAACCTATACATTGCATCGT TTGGGCAAAGTACTTGTTCAACCAGTTGTTTGGGGAAGAAGATGCTGATCAAGAAGTATCTCCTGACAGAGCTGACCCTGAAGCTGCCTG GGAACCAACGGAAGCCGAAGCCAGAGCTAGAGCATCTAATGAAGATGGTGACATTAAACGTATTTCTACTAAGGAATGGGCTAAATCAAC TGGATATGATCCAGTTAAACTTTTTACCAAGCTTTTTAAAGATGACATCAGGTATCTGTTGACAATGGACAAACTATGGCGGAAAAGGAA ACCTCCAGTTCCGTTGGACTGGGCTGAAGTACAAAGTCAAGGAGAAGAAACGAATGCATCAGATCAACAGAATGAACCCCAGTTAGGCCT GAAAGACCAGCAGGTTCTAGATGTAAAGAGCTATGCACGTCTTTTTTCAAAGAGCATCGAGACTTTGAGAGTTCATTTAGCAGAAAAGGG GGATGGAGCTGAGCTCATATGGGATAAGGATGACCCATCTGCAATGGATTTTGTCACCTCTGCTGCAAACCTCAGGATGCATATTTTCAG TATGAATATGAAGAGTAGATTTGATATCAAATCAATGGCAGGGAACATTATTCCTGCTATTGCTACTACTAATGCAGTAATTGCTGGGTT GATAGTATTGGAAGGATTGAAGATTTTATCAGGAAAAATAGACCAGTGCAGAACAATTTTTTTGAATAAACAACCAAACCCAAGAAAGAA GCTTCTTGTGCCTTGTGCACTGGATCCTCCCAACCCCAATTGTTATGTATGTGCCAGCAAGCCAGAGGTGACTGTGCGGCTGAATGTCCA TAAAGTGACTGTTCTCACCTTACAAGACAAGATAGTGAAAGAAAAATTTGCTATGGTAGCACCAGATGTCCAAATTGAAGATGGGAAAGG AACAATCCTAATATCTTCCGAAGAGGGAGAGACGGAAGCTAATAATCACAAGAAGTTGTCAGAATTTGGAATTAGAAATGGCAGCCGGCT TCAAGCAGATGACTTCCTCCAGGACTATACTTTATTGATCAACATCCTTCATAGTGAAGACCTAGGAAAGGACGTTGAATTTGAAGTTGT TGGTGATGCCCCGGAAAAAGTGGGGCCCAAACAAGCTGAAGATGCTGCCAAAAGCATAACCAATGGCAGTGATGATGGAGCTCAGCCCTC CACCTCCACAGTGAACATCTTTCTCACCGGGAGACTCAGCAGTGCGGTTCCTGCCTTAGCGGCCTGCAGTGGGAAGCTGGAGCAGCACAC GGAGCGGCGTGGGGTCATCTACAGCCCGGCCTGGCCCCTCAACTACCCGCCAGGCACCAACTGCAGCTGGTACATCCAGGGCGACCGTGG TGACATGATTACCATCAGCTTCCGCAACTTTGACGTGGAGGAGTCCCACCAGTGCTCCCTGGACTGGCTCCTGCTGGGCCCAGCAGCCCC ACCCCGCCAGGAGGCCTTCCGCCTCTGTGGCTCCGCCATCCCACCTGCCTTCATCTCTGCCCGCGACCATGTCTGGATTTTCTTCCACTC AGACGCCTCCAGCTCCGGCCAGGCCCAGGGCTTCCGTCTGTCTTACATCCGAGGGAAGCTGGGCCAGGCATCCTGCCAGGCAGATGAGTT CCGCTGTGACAACGGCAAGTGCCTGCCCGGCCCGTGGCAGTGCAACACGGTGGACGAGTGTGGAGACGGCTCTGATGAGGGCAACTGCTC GGCGCCCGCCTCCGAGCCTCCAGGCAGCCTGTGCCCCGGGGGGACCTTCCCATGCAGCGGGGCGCGCTCCACGCGCTGCCTGCCTGTGGA GCGGCGCTGTGACGGCTTGCAGGACTGCGGCGACGGCTCGGATGAGGCGGGCTGCCCCGACCTGGCGTGCGGCCGGCGGCTGGGCAGCTT CTACGGCTCCTTTGCCTCCCCAGACCTGTTCGGCGCCGCTCGCGGGCCCTCAGACCTTCACTGCACGTGGCTGGTGGACACACAGGACTC CCGGCGGGTGCTGCTGCAGCTGGAACTGCGGCTGGGCTATGACGACTACGTGCAGGTATACGAGGGCCTGGGCGAGCGCGGGGACCGCCT GCTGCAGACGCTGTCCTACCGCAGCAACCACCGGCCCGTGAGCCTGGAGGCCGCCCAGGGCCGCCTCACTGTGGCCTACCACGCGCGCGC CCGCAGCGCCGGCCACGGCTTCAATGCCACCTACCAGGTGAAGGGCTATTGCCTCCCCTGGGAGCAGCCGTGCGGGAGCAGTAGTGACAG TGACGGGGGCAGCCTGGGCGACCAGGGCTGCTTCTCAGAGCCACAGCGCTGTGATGGCTGGTGGCATTGTGCCAGCGGCCGAGACGAGCA GGGCTGCCCTGCCTGCCCGCCCGACCAGTACCCCTGCGAGGGTGGCAGTGGTCTGTGCTACACGCCTGCCGACCGCTGCAACAACCAGAA AAGCTGTCCCGACGGCGCCGACGAGAAGAACTGCTTCTCCTGCCAGCCCGGCACCTTCCACTGCGGTACCAACCTGTGCATCTTCGAGAC GTGGCGCTGTGACGGCCAGGAAGACTGCCAGGACGGCAGCGATGAGCATGGGTGCCTGGCCGCCGTGCCCCGCAAGGTCATCACGGCGGC GCTCATTGGCAGCCTGGTGTGTGGCCTGCTGCTGGTCATCGCGCTGGGCTGCGCCTTCAAGCTCTACTCACTGCGCACGCAGGAATACAG GGCCTTCGAGACCCAGATGACGCGCCTGGAGGCTGAGTTCGTGCGGCGGGAGGCACCCCCATCCTATGGTCAGCTCATCGCCCAGGGCCT CATTCCACCCGTGGAGGACTTTCCTGTCTACAGTGCGTCCCAGGCCTCTGTGCTGCAGAATCTTCGCACAGCCATGCGGAGACAGATGCG TCGGCACGCCTCCCGCCGGGGGCCCTCCCGCCGCCGCCTCGGCCGCCTCTGGAACCGGCTCTTTCACCGGCCGCGGGCGCCCCGAGGCCA GATCCCACTGCTGACCGCAGCACGCCCCTCACAGACCGTGCTGGGCGATGGCTTCCTCCAGCCTGCTCCAGGGGCTGCCCCCGACCCCCC AGCACCGCTCATGGACACAGGCAGCACCAGGGCGGCCGGAGACAGGCCCCCCAGTGCCCCCGGCCGTGCACCGGAGGTGGGACCTTCAGG GCCACCCTTGCCCTCGGGCCTGCGAGACCCAGAGTGCAGGCCCGTGGACAAGGACAGAAAGGTCTGCAGGGAGCCACTGGTAGACGGCCC AGCTCCTGCAGATGCACCTCGGGAGCCCTGCTCAGCCCAGGACCCGCACCCCCAGGTCTCCACTGCCAGCAGCACCCTGGGCCCCCACTC GCCAGAGCCACTGGGGGTCTGCAGGAACCCCCCGCCCCCCTGCTCCCCAATGCTGGAGGCCAGCGATGATGAGGCCCTGTTGGTCTGTTG ACCGCTGGGCTCGCTGGTGACCGCCACAGCCCCGCTTTGTAACCAGGGAATACACAGTCATTTCTACCCTGCCTCTGCGTCCTTTCTTAT GGAGAGGCCCTCCGGGGACCCCAGCGGAGGGGCTGGCCCCTAAGCCAGCTGGCTGCACTGGTGGGCGGGAGCTGTGGGACTGAACGGCGG >In-frame_UBA2_ENST00000439527_chr19_34957919_+_LRP3_ENST00000253193_chr19_33687636_+_4404nt AAAACAAATTCCCGGCTGTTAGGAGATGCGGGAGAGGATTGAGTCCCTCGCGGATGTTGTGACTTTAATTTTGAGGTCCCTGTCGTAACT CCGAAGTAACGACGCGGGGCGGAGGATGGCAATGATAGCGACCAACGCGTCCCGAGCGCTGGTCACGAGCGGGTTTACACACGGAACGCG CACCATCTTCATACCACCCGAGGAGTGCAAACGCTATTTCCACCCTGCTTTATTTTTAACAGATGAGGAAAGGGAGACGCAATGGGGTTG AGTAACTTACCCTGGGTCACGGAGCGAGTGGCAGGGCTCCCGCAGGCTGCGTGACTGTCATTGCTCTCACAGTAGACGATTGATCTGGAT ACTATTGATGTAAGCAACCTCAACAGACAGTTTTTGTTTCAAAAGAAACATGTTGGAAGATCAAAGGCACAGGTTGCCAAGGAAAGTGTA CTGCAGTTTTACCCGAAAGCTAATATCGTTGCCTACCATGACAGCATCATGAACCCTGACTATAATGTGGAATTTTTCCGACAGTTTATA CTGGTTATGAATGCTTTAGATAACAGAGCTGCCCGAAACCATGTTAATAGAATGTGCCTGGCAGCTGATGTTCCTCTTATTGAAAGTGGA ACAGCTGGGTATCTTGGACAAGTAACTACTATCAAAAAGGGTGTGACCGAGTGTTATGAGTGTCATCCTAAGCCGACCCAGAGAACCTTT CCTGGCTGTACAATTCGTAACACACCTTCAGAACCTATACATTGCATCGTTTGGGCAAAGTACTTGTTCAACCAGTTGTTTGGGGAAGAA GATGCTGATCAAGAAGTATCTCCTGACAGAGCTGACCCTGAAGCTGCCTGGGAACCAACGGAAGCCGAAGCCAGAGCTAGAGCATCTAAT GAAGATGGTGACATTAAACGTATTTCTACTAAGGAATGGGCTAAATCAACTGGATATGATCCAGTTAAACTTTTTACCAAGCTTTTTAAA GATGACATCAGGTATCTGTTGACAATGGACAAACTATGGCGGAAAAGGAAACCTCCAGTTCCGTTGGACTGGGCTGAAGTACAAAGTCAA GGAGAAGAAACGAATGCATCAGATCAACAGAATGAACCCCAGTTAGGCCTGAAAGACCAGCAGGTTCTAGATGTAAAGAGCTATGCACGT CTTTTTTCAAAGAGCATCGAGACTTTGAGAGTTCATTTAGCAGAAAAGGGGGATGGAGCTGAGCTCATATGGGATAAGGATGACCCATCT GCAATGGATTTTGTCACCTCTGCTGCAAACCTCAGGATGCATATTTTCAGTATGAATATGAAGAGTAGATTTGATATCAAATCAATGGCA GGGAACATTATTCCTGCTATTGCTACTACTAATGCAGTAATTGCTGGGTTGATAGTATTGGAAGGATTGAAGATTTTATCAGGAAAAATA GACCAGTGCAGAACAATTTTTTTGAATAAACAACCAAACCCAAGAAAGAAGCTTCTTGTGCCTTGTGCACTGGATCCTCCCAACCCCAAT TGTTATGTATGTGCCAGCAAGCCAGAGGTGACTGTGCGGCTGAATGTCCATAAAGTGACTGTTCTCACCTTACAAGACAAGATAGTGAAA GAAAAATTTGCTATGGTAGCACCAGATGTCCAAATTGAAGATGGGAAAGGAACAATCCTAATATCTTCCGAAGAGGGAGAGACGGAAGCT AATAATCACAAGAAGTTGTCAGAATTTGGAATTAGAAATGGCAGCCGGCTTCAAGCAGATGACTTCCTCCAGGACTATACTTTATTGATC AACATCCTTCATAGTGAAGACCTAGGAAAGGACGTTGAATTTGAAGTTGTTGGTGATGCCCCGGAAAAAGTGGGGCCCAAACAAGCTGAA GATGCTGCCAAAAGCATAACCAATGGCAGTGATGATGGAGCTCAGCCCTCCACCTCCACAGTGAACATCTTTCTCACCGGGAGACTCAGC AGTGCGGTTCCTGCCTTAGCGGCCTGCAGTGGGAAGCTGGAGCAGCACACGGAGCGGCGTGGGGTCATCTACAGCCCGGCCTGGCCCCTC AACTACCCGCCAGGCACCAACTGCAGCTGGTACATCCAGGGCGACCGTGGTGACATGATTACCATCAGCTTCCGCAACTTTGACGTGGAG GAGTCCCACCAGTGCTCCCTGGACTGGCTCCTGCTGGGCCCAGCAGCCCCACCCCGCCAGGAGGCCTTCCGCCTCTGTGGCTCCGCCATC CCACCTGCCTTCATCTCTGCCCGCGACCATGTCTGGATTTTCTTCCACTCAGACGCCTCCAGCTCCGGCCAGGCCCAGGGCTTCCGTCTG TCTTACATCCGAGGGAAGCTGGGCCAGGCATCCTGCCAGGCAGATGAGTTCCGCTGTGACAACGGCAAGTGCCTGCCCGGCCCGTGGCAG TGCAACACGGTGGACGAGTGTGGAGACGGCTCTGATGAGGGCAACTGCTCGGCGCCCGCCTCCGAGCCTCCAGGCAGCCTGTGCCCCGGG GGGACCTTCCCATGCAGCGGGGCGCGCTCCACGCGCTGCCTGCCTGTGGAGCGGCGCTGTGACGGCTTGCAGGACTGCGGCGACGGCTCG GATGAGGCGGGCTGCCCCGACCTGGCGTGCGGCCGGCGGCTGGGCAGCTTCTACGGCTCCTTTGCCTCCCCAGACCTGTTCGGCGCCGCT CGCGGGCCCTCAGACCTTCACTGCACGTGGCTGGTGGACACACAGGACTCCCGGCGGGTGCTGCTGCAGCTGGAACTGCGGCTGGGCTAT GACGACTACGTGCAGGTATACGAGGGCCTGGGCGAGCGCGGGGACCGCCTGCTGCAGACGCTGTCCTACCGCAGCAACCACCGGCCCGTG AGCCTGGAGGCCGCCCAGGGCCGCCTCACTGTGGCCTACCACGCGCGCGCCCGCAGCGCCGGCCACGGCTTCAATGCCACCTACCAGGTG AAGGGCTATTGCCTCCCCTGGGAGCAGCCGTGCGGGAGCAGTAGTGACAGTGACGGGGGCAGCCTGGGCGACCAGGGCTGCTTCTCAGAG CCACAGCGCTGTGATGGCTGGTGGCATTGTGCCAGCGGCCGAGACGAGCAGGGCTGCCCTGCCTGCCCGCCCGACCAGTACCCCTGCGAG GGTGGCAGTGGTCTGTGCTACACGCCTGCCGACCGCTGCAACAACCAGAAAAGCTGTCCCGACGGCGCCGACGAGAAGAACTGCTTCTCC TGCCAGCCCGGCACCTTCCACTGCGGTACCAACCTGTGCATCTTCGAGACGTGGCGCTGTGACGGCCAGGAAGACTGCCAGGACGGCAGC GATGAGCATGGGTGCCTGGCCGCCGTGCCCCGCAAGGTCATCACGGCGGCGCTCATTGGCAGCCTGGTGTGTGGCCTGCTGCTGGTCATC GCGCTGGGCTGCGCCTTCAAGCTCTACTCACTGCGCACGCAGGAATACAGGGCCTTCGAGACCCAGATGACGCGCCTGGAGGCTGAGTTC GTGCGGCGGGAGGCACCCCCATCCTATGGTCAGCTCATCGCCCAGGGCCTCATTCCACCCGTGGAGGACTTTCCTGTCTACAGTGCGTCC CAGGCCTCTGTGCTGCAGAATCTTCGCACAGCCATGCGGAGACAGATGCGTCGGCACGCCTCCCGCCGGGGGCCCTCCCGCCGCCGCCTC GGCCGCCTCTGGAACCGGCTCTTTCACCGGCCGCGGGCGCCCCGAGGCCAGATCCCACTGCTGACCGCAGCACGCCCCTCACAGACCGTG CTGGGCGATGGCTTCCTCCAGCCTGCTCCAGGGGCTGCCCCCGACCCCCCAGCACCGCTCATGGACACAGGCAGCACCAGGGCGGCCGGA GACAGGCCCCCCAGTGCCCCCGGCCGTGCACCGGAGGTGGGACCTTCAGGGCCACCCTTGCCCTCGGGCCTGCGAGACCCAGAGTGCAGG CCCGTGGACAAGGACAGAAAGGTCTGCAGGGAGCCACTGGTAGACGGCCCAGCTCCTGCAGATGCACCTCGGGAGCCCTGCTCAGCCCAG GACCCGCACCCCCAGGTCTCCACTGCCAGCAGCACCCTGGGCCCCCACTCGCCAGAGCCACTGGGGGTCTGCAGGAACCCCCCGCCCCCC TGCTCCCCAATGCTGGAGGCCAGCGATGATGAGGCCCTGTTGGTCTGTTGACCGCTGGGCTCGCTGGTGACCGCCACAGCCCCGCTTTGT AACCAGGGAATACACAGTCATTTCTACCCTGCCTCTGCGTCCTTTCTTATGGAGAGGCCCTCCGGGGACCCCAGCGGAGGGGCTGGCCCC >In-frame_UBA2_ENST00000592791_chr19_34957919_+_LRP3_ENST00000253193_chr19_33687636_+_3004nt GGCGTATAAAATTACAGCACGTTTCCGATTTCTGCCTGTTATTTCTCCTCCAAAGATTTTTTTGAATAAACAACCAAACCCAAGAAAGAA GCTTCTTGTGCCTTGTGCACTGGATCCTCCCAACCCCAATTGTTATGTATGTGCCAGCAAGCCAGAGGTGACTGTGCGGCTGAATGTCCA TAAAGTGACTGTTCTCACCTTACAAGACAAGATAGTGAAAGAAAAATTTGCTATGGTAGCACCAGATGTCCAAATTGAAGATGGGAAAGG AACAATCCTAATATCTTCCGAAGAGGGAGAGACGGAAGCTAATAATCACAAGAAGTTGTCAGAATTTGGAATTAGAAATGGCAGCCGGCT TCAAGCAGATGACTTCCTCCAGGACTATACTTTATTGATCAACATCCTTCATAGTGAAGACCTAGGAAAGGACGTTGAATTTGAAGTTGT TGGTGATGCCCCGGAAAAAGTGGGGCCCAAACAAGCTGAAGATGCTGCCAAAAGCATAACCAATGGCAGTGATGATGGAGCTCAGCCCTC CACCTCCACAGTGAACATCTTTCTCACCGGGAGACTCAGCAGTGCGGTTCCTGCCTTAGCGGCCTGCAGTGGGAAGCTGGAGCAGCACAC GGAGCGGCGTGGGGTCATCTACAGCCCGGCCTGGCCCCTCAACTACCCGCCAGGCACCAACTGCAGCTGGTACATCCAGGGCGACCGTGG TGACATGATTACCATCAGCTTCCGCAACTTTGACGTGGAGGAGTCCCACCAGTGCTCCCTGGACTGGCTCCTGCTGGGCCCAGCAGCCCC ACCCCGCCAGGAGGCCTTCCGCCTCTGTGGCTCCGCCATCCCACCTGCCTTCATCTCTGCCCGCGACCATGTCTGGATTTTCTTCCACTC AGACGCCTCCAGCTCCGGCCAGGCCCAGGGCTTCCGTCTGTCTTACATCCGAGGGAAGCTGGGCCAGGCATCCTGCCAGGCAGATGAGTT CCGCTGTGACAACGGCAAGTGCCTGCCCGGCCCGTGGCAGTGCAACACGGTGGACGAGTGTGGAGACGGCTCTGATGAGGGCAACTGCTC GGCGCCCGCCTCCGAGCCTCCAGGCAGCCTGTGCCCCGGGGGGACCTTCCCATGCAGCGGGGCGCGCTCCACGCGCTGCCTGCCTGTGGA GCGGCGCTGTGACGGCTTGCAGGACTGCGGCGACGGCTCGGATGAGGCGGGCTGCCCCGACCTGGCGTGCGGCCGGCGGCTGGGCAGCTT CTACGGCTCCTTTGCCTCCCCAGACCTGTTCGGCGCCGCTCGCGGGCCCTCAGACCTTCACTGCACGTGGCTGGTGGACACACAGGACTC CCGGCGGGTGCTGCTGCAGCTGGAACTGCGGCTGGGCTATGACGACTACGTGCAGGTATACGAGGGCCTGGGCGAGCGCGGGGACCGCCT GCTGCAGACGCTGTCCTACCGCAGCAACCACCGGCCCGTGAGCCTGGAGGCCGCCCAGGGCCGCCTCACTGTGGCCTACCACGCGCGCGC CCGCAGCGCCGGCCACGGCTTCAATGCCACCTACCAGGTGAAGGGCTATTGCCTCCCCTGGGAGCAGCCGTGCGGGAGCAGTAGTGACAG TGACGGGGGCAGCCTGGGCGACCAGGGCTGCTTCTCAGAGCCACAGCGCTGTGATGGCTGGTGGCATTGTGCCAGCGGCCGAGACGAGCA GGGCTGCCCTGCCTGCCCGCCCGACCAGTACCCCTGCGAGGGTGGCAGTGGTCTGTGCTACACGCCTGCCGACCGCTGCAACAACCAGAA AAGCTGTCCCGACGGCGCCGACGAGAAGAACTGCTTCTCCTGCCAGCCCGGCACCTTCCACTGCGGTACCAACCTGTGCATCTTCGAGAC GTGGCGCTGTGACGGCCAGGAAGACTGCCAGGACGGCAGCGATGAGCATGGGTGCCTGGCCGCCGTGCCCCGCAAGGTCATCACGGCGGC GCTCATTGGCAGCCTGGTGTGTGGCCTGCTGCTGGTCATCGCGCTGGGCTGCGCCTTCAAGCTCTACTCACTGCGCACGCAGGAATACAG GGCCTTCGAGACCCAGATGACGCGCCTGGAGGCTGAGTTCGTGCGGCGGGAGGCACCCCCATCCTATGGTCAGCTCATCGCCCAGGGCCT CATTCCACCCGTGGAGGACTTTCCTGTCTACAGTGCGTCCCAGGCCTCTGTGCTGCAGAATCTTCGCACAGCCATGCGGAGACAGATGCG TCGGCACGCCTCCCGCCGGGGGCCCTCCCGCCGCCGCCTCGGCCGCCTCTGGAACCGGCTCTTTCACCGGCCGCGGGCGCCCCGAGGCCA GATCCCACTGCTGACCGCAGCACGCCCCTCACAGACCGTGCTGGGCGATGGCTTCCTCCAGCCTGCTCCAGGGGCTGCCCCCGACCCCCC AGCACCGCTCATGGACACAGGCAGCACCAGGGCGGCCGGAGACAGGCCCCCCAGTGCCCCCGGCCGTGCACCGGAGGTGGGACCTTCAGG GCCACCCTTGCCCTCGGGCCTGCGAGACCCAGAGTGCAGGCCCGTGGACAAGGACAGAAAGGTCTGCAGGGAGCCACTGGTAGACGGCCC AGCTCCTGCAGATGCACCTCGGGAGCCCTGCTCAGCCCAGGACCCGCACCCCCAGGTCTCCACTGCCAGCAGCACCCTGGGCCCCCACTC GCCAGAGCCACTGGGGGTCTGCAGGAACCCCCCGCCCCCCTGCTCCCCAATGCTGGAGGCCAGCGATGATGAGGCCCTGTTGGTCTGTTG ACCGCTGGGCTCGCTGGTGACCGCCACAGCCCCGCTTTGTAACCAGGGAATACACAGTCATTTCTACCCTGCCTCTGCGTCCTTTCTTAT GGAGAGGCCCTCCGGGGACCCCAGCGGAGGGGCTGGCCCCTAAGCCAGCTGGCTGCACTGGTGGGCGGGAGCTGTGGGACTGAACGGCGG |
Top |
FusionGenePPI for UBA2_LRP3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBA2 | SAE1, UBE2I, SUMO1, BRIX1, NEDD8, SUMO2, SUMO3, ETV4, SERBP1, PARK7, UBQLN2, THADA, CHMP5, AHCYL1, SRSF2, SEPHS2, TRIP6, UNK, ZFYVE19, USP34, YAP1, NAP1L1, RPS15A, SULT1A1, UBE2B, KIAA1598, STMN2, TACC3, CLNS1A, SNCG, TLE3, TTC9C, MYL1, TOM1L2, SRXN1, ATP6V1B2, BAG3, CALU, CTSC, P4HB, PDE12, PDLIM5, RAD23B, SSB, TCEAL4, ARIH1, CBS, EHD4, IREB2, NPLOC4, PKM, PLIN3, RABGGTA, SRP14, ZPR1, UBC, EGFR, SUMO1P1, FOXK1, PSMA3, PSMA4, PSMB3, CLIC4, HSPB1, PCF11, PSMA1, PSMA2, PSMA5, PSMB4, WDR11, NTRK1, MYC, CEP162, LCA5, OFD1, WAS, RANBP2, CHEK1, DERL1, CPNE5, HSD17B10, EDEM3, TRIM25 | LRP3 | GGA1, MTNR1A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBA2_LRP3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBA2_LRP3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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