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Fusion gene ID: 40287 |
FusionGeneSummary for UAP1L1_PLG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UAP1L1_PLG | Fusion gene ID: 40287 | Hgene | Tgene | Gene symbol | UAP1L1 | PLG | Gene ID | 91373 | 5340 |
| Gene name | UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 | plasminogen | |
| Synonyms | - | - | |
| Cytomap | 9q34.3 | 6q26 | |
| Type of gene | protein-coding | protein-coding | |
| Description | UDP-N-acetylhexosamine pyrophosphorylase-like protein 1UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 | plasminogenplasmin | |
| Modification date | 20180526 | 20180523 | |
| UniProtAcc | Q3KQV9 | P00747 | |
| Ensembl transtripts involved in fusion gene | ENST00000409858, ENST00000476184, ENST00000360271, | ENST00000366924, ENST00000308192, ENST00000462918, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: UAP1L1 [Title/Abstract] AND PLG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PLG | GO:0006508 | proteolysis | 9603964 |
| Tgene | PLG | GO:0010812 | negative regulation of cell-substrate adhesion | 14699093 |
| Tgene | PLG | GO:0022617 | extracellular matrix disassembly | 14699093 |
| Tgene | PLG | GO:0042730 | fibrinolysis | 14688145|17307854|22025510 |
| Tgene | PLG | GO:0051702 | interaction with symbiont | 12818429 |
| Tgene | PLG | GO:0051918 | negative regulation of fibrinolysis | 14726399 |
| Tgene | PLG | GO:0051919 | positive regulation of fibrinolysis | 6438154|26667841 |
| Tgene | PLG | GO:0052182 | modification by host of symbiont morphology or physiology via secreted substance | 14688145|17307854 |
| Tgene | PLG | GO:0052213 | interaction with symbiont via secreted substance involved in symbiotic interaction | 19270100|22025510|22087329 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW301153 | UAP1L1 | chr9 | 139978897 | - | PLG | chr6 | 161139002 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000409858 | ENST00000366924 | UAP1L1 | chr9 | 139978897 | - | PLG | chr6 | 161139002 | - |
| 3UTR-intron | ENST00000409858 | ENST00000308192 | UAP1L1 | chr9 | 139978897 | - | PLG | chr6 | 161139002 | - |
| 3UTR-intron | ENST00000409858 | ENST00000462918 | UAP1L1 | chr9 | 139978897 | - | PLG | chr6 | 161139002 | - |
| intron-intron | ENST00000476184 | ENST00000366924 | UAP1L1 | chr9 | 139978897 | - | PLG | chr6 | 161139002 | - |
| intron-intron | ENST00000476184 | ENST00000308192 | UAP1L1 | chr9 | 139978897 | - | PLG | chr6 | 161139002 | - |
| intron-intron | ENST00000476184 | ENST00000462918 | UAP1L1 | chr9 | 139978897 | - | PLG | chr6 | 161139002 | - |
| 3UTR-intron | ENST00000360271 | ENST00000366924 | UAP1L1 | chr9 | 139978897 | - | PLG | chr6 | 161139002 | - |
| 3UTR-intron | ENST00000360271 | ENST00000308192 | UAP1L1 | chr9 | 139978897 | - | PLG | chr6 | 161139002 | - |
| 3UTR-intron | ENST00000360271 | ENST00000462918 | UAP1L1 | chr9 | 139978897 | - | PLG | chr6 | 161139002 | - |
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FusionProtFeatures for UAP1L1_PLG |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UAP1L1 | PLG |
| Plasmin dissolves the fibrin of blood clots and acts asa proteolytic factor in a variety of other processes includingembryonic development, tissue remodeling, tumor invasion, andinflammation. In ovulation, weakens the walls of the Graafianfollicle. It activates the urokinase-type plasminogen activator,collagenases and several complement zymogens, such as C1 and C5.Cleavage of fibronectin and laminin leads to cell detachment andapoptosis. Also cleaves fibrin, thrombospondin and von Willebrandfactor. Its role in tissue remodeling and tumor invasion may bemodulated by CSPG4. Binds to cells. {ECO:0000269|PubMed:14699093}. Angiostatin is an angiogenesis inhibitor that blocksneovascularization and growth of experimental primary andmetastatic tumors in vivo. {ECO:0000269|PubMed:14699093}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UAP1L1_PLG |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UAP1L1_PLG |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UAP1L1_PLG |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | PLG | P00747 | DB00009 | Alteplase | Plasminogen | biotech | approved |
| Tgene | PLG | P00747 | DB00029 | Anistreplase | Plasminogen | biotech | approved |
| Tgene | PLG | P00747 | DB00031 | Tenecteplase | Plasminogen | biotech | approved |
| Tgene | PLG | P00747 | DB00302 | Tranexamic Acid | Plasminogen | small molecule | approved |
| Tgene | PLG | P00747 | DB00015 | Reteplase | Plasminogen | biotech | approved|investigational |
| Tgene | PLG | P00747 | DB00086 | Streptokinase | Plasminogen | biotech | approved|investigational |
| Tgene | PLG | P00747 | DB00513 | Aminocaproic Acid | Plasminogen | small molecule | approved|investigational |
| Tgene | PLG | P00747 | DB00013 | Urokinase | Plasminogen | biotech | approved|investigational|withdrawn |
| Tgene | PLG | P00747 | DB06692 | Aprotinin | Plasminogen | biotech | approved|investigational|withdrawn |
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RelatedDiseases for UAP1L1_PLG |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PLG | C1968804 | Plasminogen Deficiency, Type I | 6 | CTD_human;UNIPROT |
| Tgene | PLG | C0020538 | Hypertensive disease | 1 | CTD_human |
| Tgene | PLG | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | PLG | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | PLG | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | PLG | C0042487 | Venous Thrombosis | 1 | CTD_human |
| Tgene | PLG | C0740858 | Substance abuse problem | 1 | PSYGENET |
| Tgene | PLG | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | PLG | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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