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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40284

FusionGeneSummary for UACA_LTK

check button Fusion gene summary
Fusion gene informationFusion gene name: UACA_LTK
Fusion gene ID: 40284
HgeneTgene
Gene symbol

UACA

LTK

Gene ID

55075

4058

Gene nameuveal autoantigen with coiled-coil domains and ankyrin repeatsleukocyte receptor tyrosine kinase
SynonymsNUCLINGTYK1
Cytomap

15q23

15q15.1

Type of geneprotein-codingprotein-coding
Descriptionuveal autoantigen with coiled-coil domains and ankyrin repeatsnuclear membrane binding proteinleukocyte tyrosine kinase receptorprotein tyrosine kinase 1
Modification date2018051920180523
UniProtAcc

Q9BZF9

P29376

Ensembl transtripts involved in fusion geneENST00000322954, ENST00000539319, 
ENST00000379983, ENST00000560441, 
ENST00000559183, 
ENST00000355166, 
ENST00000263800, ENST00000561619, 
ENST00000453182, 
Fusion gene scores* DoF score6 X 4 X 6=1441 X 1 X 1=1
# samples 61
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: UACA [Title/Abstract] AND LTK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLTK

GO:0006468

protein phosphorylation

9223670

TgeneLTK

GO:0008283

cell proliferation

10445845

TgeneLTK

GO:0010666

positive regulation of cardiac muscle cell apoptotic process

10445845


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTHCATCGA-FY-A3R6-01AUACAchr15

70957001

-LTKchr15

41799372

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000322954ENST00000355166UACAchr15

70957001

-LTKchr15

41799372

-
Frame-shiftENST00000322954ENST00000263800UACAchr15

70957001

-LTKchr15

41799372

-
Frame-shiftENST00000322954ENST00000561619UACAchr15

70957001

-LTKchr15

41799372

-
Frame-shiftENST00000322954ENST00000453182UACAchr15

70957001

-LTKchr15

41799372

-
Frame-shiftENST00000539319ENST00000355166UACAchr15

70957001

-LTKchr15

41799372

-
Frame-shiftENST00000539319ENST00000263800UACAchr15

70957001

-LTKchr15

41799372

-
Frame-shiftENST00000539319ENST00000561619UACAchr15

70957001

-LTKchr15

41799372

-
Frame-shiftENST00000539319ENST00000453182UACAchr15

70957001

-LTKchr15

41799372

-
Frame-shiftENST00000379983ENST00000355166UACAchr15

70957001

-LTKchr15

41799372

-
Frame-shiftENST00000379983ENST00000263800UACAchr15

70957001

-LTKchr15

41799372

-
Frame-shiftENST00000379983ENST00000561619UACAchr15

70957001

-LTKchr15

41799372

-
Frame-shiftENST00000379983ENST00000453182UACAchr15

70957001

-LTKchr15

41799372

-
Frame-shiftENST00000560441ENST00000355166UACAchr15

70957001

-LTKchr15

41799372

-
Frame-shiftENST00000560441ENST00000263800UACAchr15

70957001

-LTKchr15

41799372

-
Frame-shiftENST00000560441ENST00000561619UACAchr15

70957001

-LTKchr15

41799372

-
Frame-shiftENST00000560441ENST00000453182UACAchr15

70957001

-LTKchr15

41799372

-
intron-3CDSENST00000559183ENST00000355166UACAchr15

70957001

-LTKchr15

41799372

-
intron-3CDSENST00000559183ENST00000263800UACAchr15

70957001

-LTKchr15

41799372

-
intron-3CDSENST00000559183ENST00000561619UACAchr15

70957001

-LTKchr15

41799372

-
intron-3CDSENST00000559183ENST00000453182UACAchr15

70957001

-LTKchr15

41799372

-

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FusionProtFeatures for UACA_LTK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UACA

Q9BZF9

LTK

P29376

Regulates APAF1 expression and plays an important rolein the regulation of stress-induced apoptosis. Promotes apoptosisby regulating three pathways, apoptosome up-regulation,LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation.Regulates the redistribution of APAF1 into the nucleus afterproapoptotic stress. Down-regulates the expression of LGALS3 byinhibiting NFKB1 (By similarity). {ECO:0000250}. Modulates isoactin dynamics to regulate themorphological alterations required for cell growth and motility.Interaction with ARF6 may modulate cell shape and motility afterinjury. May be involved in multiple neurite formation (Bysimilarity). {ECO:0000250|UniProtKB:Q8CGB3,ECO:0000250|UniProtKB:Q8HYY4}. Receptor with a tyrosine-protein kinase activity. Theexact function of this protein is not known. Studies with chimericproteins (replacing its extracellular region with that of severalknown growth factor receptors, such as EGFR and CSFIR) demonstrateits ability to promote growth and specifically neurite outgrowth,and cell survival. Signaling appears to involve the PI3 kinasepathway. Involved in regulation of the secretory pathway involvingendoplasmic reticulum (ER) export sites (ERESs) and ER to Golgitransport. {ECO:0000269|PubMed:20548102}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UACA_LTK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UACA_LTK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UACAMED14, NRD1, FBXO25, STAMBP, RABEP1, USP48, TP63, PAN2, HIF1AN, FUS, KRT40, RNF2, TIGD7, C17orf59, PICK1, IFI16, HIF1A, MYH9, PPP1CB, SORT1, SYNCRIP, ANLN, L1TD1, WIZ, BAG6, WWP2, CDH1, RGS3, VTN, JPH4, CORO6, PNMA5, GUCY1B3, SYNC, MIS18A, CCDC102BLTKRAF1, PLCG1, PIK3R1, CBL, PTPN1, TNK2, ERRFI1, MUS81, EGFR, GRB2, SHC1, DUSP6, MTMR14


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UACA_LTK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UACA_LTK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLTKC0032460Polycystic Ovary Syndrome1CTD_human