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Fusion gene ID: 40277 |
FusionGeneSummary for U2SURP_PARP9 |
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Fusion gene information | Fusion gene name: U2SURP_PARP9 | Fusion gene ID: 40277 | Hgene | Tgene | Gene symbol | U2SURP | PARP9 | Gene ID | 23350 | 83666 |
Gene name | U2 snRNP associated SURP domain containing | poly(ADP-ribose) polymerase family member 9 | |
Synonyms | SR140|fSAPa | ARTD9|BAL|BAL1|MGC:7868 | |
Cytomap | 3q23 | 3q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | U2 snRNP-associated SURP motif-containing protein140 kDa Ser/Arg-rich domain proteinSer/Arg-rich domain protein, 140 kDaU2-associated SR140 proteinU2-associated protein SR140functional spliceosome-associated protein a | poly [ADP-ribose] polymerase 9ADP-ribosyltransferase diphtheria toxin-like 9PARP-9b aggressive lymphoma proteinpoly (ADP-ribose) polymerase 9 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O15042 | Q8IXQ6 | |
Ensembl transtripts involved in fusion gene | ENST00000397933, ENST00000473835, ENST00000493598, | ENST00000477522, ENST00000492382, ENST00000360356, ENST00000471785, ENST00000462315, | |
Fusion gene scores | * DoF score | 4 X 5 X 2=40 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: U2SURP [Title/Abstract] AND PARP9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PARP9 | GO:0006471 | protein ADP-ribosylation | 28525742 |
Tgene | PARP9 | GO:0043086 | negative regulation of catalytic activity | 27796300 |
Tgene | PARP9 | GO:0060330 | regulation of response to interferon-gamma | 16809771 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-KK-A6E1-01A | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000397933 | ENST00000477522 | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
Frame-shift | ENST00000397933 | ENST00000492382 | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
Frame-shift | ENST00000397933 | ENST00000360356 | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
Frame-shift | ENST00000397933 | ENST00000471785 | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
Frame-shift | ENST00000397933 | ENST00000462315 | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
Frame-shift | ENST00000473835 | ENST00000477522 | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
Frame-shift | ENST00000473835 | ENST00000492382 | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
Frame-shift | ENST00000473835 | ENST00000360356 | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
Frame-shift | ENST00000473835 | ENST00000471785 | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
Frame-shift | ENST00000473835 | ENST00000462315 | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
Frame-shift | ENST00000493598 | ENST00000477522 | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
Frame-shift | ENST00000493598 | ENST00000492382 | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
Frame-shift | ENST00000493598 | ENST00000360356 | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
Frame-shift | ENST00000493598 | ENST00000471785 | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
Frame-shift | ENST00000493598 | ENST00000462315 | U2SURP | chr3 | 142757802 | + | PARP9 | chr3 | 122255920 | - |
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FusionProtFeatures for U2SURP_PARP9 |
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Hgene | Tgene |
U2SURP | PARP9 |
ADP-ribosyltransferase which, in association with E3ligase DTX3L, plays a role in DNA damage repair and in immuneresponses including interferon-mediated antiviral defenses(PubMed:16809771, PubMed:23230272, PubMed:26479788,PubMed:27796300). Within the complex, enhances DTX3L E3 ligaseactivity which is further enhanced by PARP9 binding to poly(ADP-ribose) (PubMed:28525742). In association with DTX3L and inpresence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation tosubstrates such as histones (PubMed:28525742). During DNA repair,PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites viaPARP9 binding to ribosylated PARP1 (PubMed:23230272). SubsequentPARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotesthe rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80,and BRCA1 to DNA damage sites (PubMed:23230272, PubMed:28525742).In response to DNA damage, PARP9-DTX3L complex is required forefficient non-homologous end joining (NHEJ); the complex functionis negatively modulated by PARP9 activity (PubMed:28525742).Dispensable for B-cell receptor (BCR) assembly through V(D)Jrecombination and class switch recombination (CSR) (Bysimilarity). In macrophages, positively regulates pro-inflammatorycytokines production in response to IFNG stimulation bysuppressing PARP14-mediated STAT1 ADP-ribosylation and thuspromoting STAT1 phosphorylation (PubMed:27796300). Also suppressesPARP14-mediated STAT6 ADP-ribosylation (PubMed:27796300).{ECO:0000250|UniProtKB:Q8CAS9, ECO:0000269|PubMed:16809771,ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:26479788,ECO:0000269|PubMed:27796300, ECO:0000269|PubMed:28525742}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for U2SURP_PARP9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for U2SURP_PARP9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
U2SURP | SF3A2, MYC, TBC1D4, SIRT7, CUL3, CUL1, COPS5, CAND1, GRK5, MFAP1, ESR1, BARD1, MDC1, PAXIP1, PRPF40A, RBM17, RBM10, RBM5, CTNNBL1, DDX42, TRA2A, LMNA, TERT, TARDBP, RPA3, RPA2, RPA1, WWOX, DROSHA, CUL7, OBSL1, RPS2, RPSA, RPS8, WDFY2, ZRSR2, NTRK1, CHERP, SF3A1, HIST1H3E, MYO1C, SNW1, CDC5L, PLOD1, SNRPE, FGFR2, CSTF2T, U2AF2, JMJD6, HIST1H1T, NCL, CYLD, CD2BP2 | PARP9 | DTX3L, NAA25, RPA3, RPA2, RPA1, PARP1, PARP14, SORT1, STAT1, HIST1H2BJ |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for U2SURP_PARP9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for U2SURP_PARP9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | U2SURP | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |