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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40249

FusionGeneSummary for TYRO3_TJP1

check button Fusion gene summary
Fusion gene informationFusion gene name: TYRO3_TJP1
Fusion gene ID: 40249
HgeneTgene
Gene symbol

TYRO3

TJP1

Gene ID

7301

7082

Gene nameTYRO3 protein tyrosine kinasetight junction protein 1
SynonymsBYK|Dtk|Etk-2|RSE|Rek|Sky|TifZO-1
Cytomap

15q15.1

15q13.1

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase receptor TYRO3tyrosine-protein kinase DTKtyrosine-protein kinase RSEtyrosine-protein kinase SKYtyrosine-protein kinase TIFtyrosine-protein kinase byktight junction protein ZO-1zona occludens 1zonula occludens 1 protein
Modification date2018052320180522
UniProtAcc

Q06418

Q07157

Ensembl transtripts involved in fusion geneENST00000559066, ENST00000263798, 
ENST00000346128, ENST00000400011, 
ENST00000356107, ENST00000545208, 
ENST00000495972, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 6 X 3=90
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TYRO3 [Title/Abstract] AND TJP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTYRO3

GO:0046777

protein autophosphorylation

7511603|7537495


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE843213TYRO3chr15

41866613

+TJP1chr15

30093030

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000559066ENST00000346128TYRO3chr15

41866613

+TJP1chr15

30093030

-
intron-intronENST00000559066ENST00000400011TYRO3chr15

41866613

+TJP1chr15

30093030

-
intron-intronENST00000559066ENST00000356107TYRO3chr15

41866613

+TJP1chr15

30093030

-
intron-intronENST00000559066ENST00000545208TYRO3chr15

41866613

+TJP1chr15

30093030

-
intron-intronENST00000559066ENST00000495972TYRO3chr15

41866613

+TJP1chr15

30093030

-
intron-intronENST00000263798ENST00000346128TYRO3chr15

41866613

+TJP1chr15

30093030

-
intron-intronENST00000263798ENST00000400011TYRO3chr15

41866613

+TJP1chr15

30093030

-
intron-intronENST00000263798ENST00000356107TYRO3chr15

41866613

+TJP1chr15

30093030

-
intron-intronENST00000263798ENST00000545208TYRO3chr15

41866613

+TJP1chr15

30093030

-
intron-intronENST00000263798ENST00000495972TYRO3chr15

41866613

+TJP1chr15

30093030

-

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FusionProtFeatures for TYRO3_TJP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TYRO3

Q06418

TJP1

Q07157

Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to severalligands including TULP1 or GAS6. Regulates many physiologicalprocesses including cell survival, migration and differentiation.Ligand binding at the cell surface induces dimerization andautophosphorylation of TYRO3 on its intracellular domain thatprovides docking sites for downstream signaling molecules.Following activation by ligand, interacts with PIK3R1 and therebyenhances PI3-kinase activity. Activates the AKT survival pathway,including nuclear translocation of NF-kappa-B and up-regulation oftranscription of NF-kappa-B-regulated genes. TYRO3 signaling playsa role in various processes such as neuron protection fromexcitotoxic injury, platelet aggregation and cytoskeletonreorganization. Plays also an important role in inhibition ofToll-like receptors (TLRs)-mediated innate immune response byactivating STAT1, which selectively induces production ofsuppressors of cytokine signaling SOCS1 and SOCS3.{ECO:0000269|PubMed:20546121}. (Microbial infection) Acts as a receptor for lassa virusand lymphocytic choriomeningitis virus, possibly through GAS6binding to phosphatidyl-serine at the surface of virion envelope.{ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:22673088,ECO:0000269|PubMed:25277499}. (Microbial infection) Acts as a receptor for Ebolavirus,possibly through GAS6 binding to phosphatidyl-serine at thesurface of virion envelope. {ECO:0000269|PubMed:17005688}. TJP1, TJP2, and TJP3 are closely related scaffoldingproteins that link tight junction (TJ) transmembrane proteins suchas claudins, junctional adhesion molecules, and occludin to theactin cytoskeleton (PubMed:7798316, PubMed:9792688). The tightjunction acts to limit movement of substances through theparacellular space and as a boundary between the compositionallydistinct apical and basolateral plasma membrane domains ofepithelial and endothelial cells. Necessary for lumenogenesis, andparticularly efficient epithelial polarization and barrierformation (By similarity). Plays a role in the regulation of cellmigration by targeting CDC42BPB to the leading edge of migratingcells (PubMed:21240187). Plays an important role in podosomeformation and associated function, thus regulating cell adhesionand matrix remodeling (PubMed:20930113). With TJP2 and TJP3,participates to the junctional retention and stability of thetranscription factor DBPA, but is not involved in its shuttling tothe nucleus (By similarity). {ECO:0000250|UniProtKB:O97758,ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TYRO3_TJP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TYRO3_TJP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TYRO3_TJP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TYRO3_TJP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTYRO3C0040053Thrombosis1CTD_human