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Fusion gene ID: 40238 |
FusionGeneSummary for TYK2_SHC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TYK2_SHC2 | Fusion gene ID: 40238 | Hgene | Tgene | Gene symbol | TYK2 | SHC2 | Gene ID | 7297 | 25759 |
| Gene name | tyrosine kinase 2 | SHC adaptor protein 2 | |
| Synonyms | IMD35|JTK1 | SCK|SHCB|SLI | |
| Cytomap | 19p13.2 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | non-receptor tyrosine-protein kinase TYK2 | SHC-transforming protein 2SH2 domain protein C2SHC (Src homology 2 domain containing) transforming protein 2SHC-transforming protein Bneuronal Shc adaptor homologprotein Scksrc homology 2 domain-containing-transforming protein C2 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P29597 | P98077 | |
| Ensembl transtripts involved in fusion gene | ENST00000264818, ENST00000524462, ENST00000525621, ENST00000529370, ENST00000529422, | ENST00000264554, | |
| Fusion gene scores | * DoF score | 8 X 6 X 7=336 | 4 X 3 X 4=48 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TYK2 [Title/Abstract] AND SHC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A0BP-01A | TYK2 | chr19 | 10468440 | - | SHC2 | chr19 | 430747 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000264818 | ENST00000264554 | TYK2 | chr19 | 10468440 | - | SHC2 | chr19 | 430747 | - |
| In-frame | ENST00000524462 | ENST00000264554 | TYK2 | chr19 | 10468440 | - | SHC2 | chr19 | 430747 | - |
| In-frame | ENST00000525621 | ENST00000264554 | TYK2 | chr19 | 10468440 | - | SHC2 | chr19 | 430747 | - |
| intron-3CDS | ENST00000529370 | ENST00000264554 | TYK2 | chr19 | 10468440 | - | SHC2 | chr19 | 430747 | - |
| intron-3CDS | ENST00000529422 | ENST00000264554 | TYK2 | chr19 | 10468440 | - | SHC2 | chr19 | 430747 | - |
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FusionProtFeatures for TYK2_SHC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TYK2 | SHC2 |
| Probably involved in intracellular signal transductionby being involved in the initiation of type I IFN signaling.Phosphorylates the interferon-alpha/beta receptor alpha chain.{ECO:0000269|PubMed:7526154}. | Signaling adapter that couples activated growth factorreceptors to signaling pathway in neurons. Involved in the signaltransduction pathways of neurotrophin-activated Trk receptors incortical neurons (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TYK2 | chr19:10468440 | chr19:430747 | ENST00000264818 | - | 15 | 23 | 26_431 | 822 | 1188 | Domain | FERM |
| Hgene | TYK2 | chr19:10468440 | chr19:430747 | ENST00000264818 | - | 15 | 23 | 450_529 | 822 | 1188 | Domain | Note=SH2%3B atypical |
| Hgene | TYK2 | chr19:10468440 | chr19:430747 | ENST00000525621 | - | 17 | 25 | 26_431 | 822 | 1188 | Domain | FERM |
| Hgene | TYK2 | chr19:10468440 | chr19:430747 | ENST00000525621 | - | 17 | 25 | 450_529 | 822 | 1188 | Domain | Note=SH2%3B atypical |
| Tgene | >SHC2 | chr19:10468440 | chr19:430747 | ENST00000264554 | - | 7 | 13 | 487_578 | 370 | 694 | Domain | SH2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TYK2 | chr19:10468440 | chr19:430747 | ENST00000264818 | - | 15 | 23 | 589_875 | 822 | 1188 | Domain | Protein kinase 1 |
| Hgene | >TYK2 | chr19:10468440 | chr19:430747 | ENST00000264818 | - | 15 | 23 | 897_1176 | 822 | 1188 | Domain | Protein kinase 2 |
| Hgene | >TYK2 | chr19:10468440 | chr19:430747 | ENST00000525621 | - | 17 | 25 | 589_875 | 822 | 1188 | Domain | Protein kinase 1 |
| Hgene | >TYK2 | chr19:10468440 | chr19:430747 | ENST00000525621 | - | 17 | 25 | 897_1176 | 822 | 1188 | Domain | Protein kinase 2 |
| Hgene | >TYK2 | chr19:10468440 | chr19:430747 | ENST00000264818 | - | 15 | 23 | 903_911 | 822 | 1188 | Nucleotide binding | ATP |
| Hgene | >TYK2 | chr19:10468440 | chr19:430747 | ENST00000525621 | - | 17 | 25 | 903_911 | 822 | 1188 | Nucleotide binding | ATP |
| Tgene | SHC2 | chr19:10468440 | chr19:430747 | ENST00000264554 | - | 7 | 13 | 147_329 | 370 | 694 | Domain | PID |
| Tgene | SHC2 | chr19:10468440 | chr19:430747 | ENST00000264554 | - | 7 | 13 | 330_486 | 370 | 694 | Region | Note=CH1 |
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FusionGeneSequence for TYK2_SHC2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TYK2_ENST00000264818_chr19_10468440_-_SHC2_ENST00000264554_chr19_430747_-_1035aa MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHI LEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRF GTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDG IHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPG RDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFD GEAPLQSRSPSEGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGLDAPEPEDSPKKDLFDMRPFEDALKLHEC SVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPE >In-frame_TYK2_ENST00000524462_chr19_10468440_-_SHC2_ENST00000264554_chr19_430747_-_850aa MAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERV PVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQP ADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPL LEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCF SLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQ ELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYL ENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPL QSRSPSEGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGLDAPEPEDSPKKDLFDMRPFEDALKLHECSVAAG VTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRT >In-frame_TYK2_ENST00000525621_chr19_10468440_-_SHC2_ENST00000264554_chr19_430747_-_1035aa MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHI LEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRF GTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDG IHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPG RDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFD GEAPLQSRSPSEGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGLDAPEPEDSPKKDLFDMRPFEDALKLHEC SVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TYK2_ENST00000264818_chr19_10468440_-_SHC2_ENST00000264554_chr19_430747_-_3105nt ATGCCTCTGCGCCACTGGGGGATGGCCAGGGGCAGTAAGCCCGTTGGGGATGGAGCCCAGCCCATGGCTGCCATGGGAGGCCTGAAGGTG CTTCTGCACTGGGCTGGTCCAGGCGGCGGGGAGCCCTGGGTCACTTTCAGTGAGTCATCGCTGACAGCTGAGGAAGTCTGCATCCACATT GCACATAAAGTTGGTATCACTCCTCCTTGCTTCAATCTCTTTGCCCTCTTCGATGCTCAGGCCCAAGTCTGGTTGCCCCCAAACCACATC CTAGAGATCCCCAGAGATGCAAGCCTGATGCTATATTTCCGCATAAGGTTTTATTTCCGGAACTGGCATGGCATGAATCCTCGGGAACCG GCTGTGTACCGTTGTGGGCCCCCAGGAACCGAGGCATCCTCAGATCAGACAGCACAGGGGATGCAACTCCTGGACCCAGCCTCATTTGAG TACCTCTTTGAGCAGGGCAAGCATGAGTTTGTGAATGACGTGGCATCACTGTGGGAGCTGTCGACCGAGGAGGAGATCCACCACTTTAAG AATGAGAGCCTGGGCATGGCCTTTCTGCACCTCTGTCACCTCGCTCTCCGCCATGGCATCCCCCTGGAGGAGGTGGCCAAGAAGACCAGC TTCAAGGACTGCATCCCGCGCTCCTTCCGCCGGCATATCCGGCAGCACAGCGCCCTGACCCGGCTGCGCCTTCGGAACGTCTTCCGCAGG TTCCTGCGGGACTTCCAGCCGGGCCGACTCTCCCAGCAGATGGTCATGGTCAAATACCTAGCCACACTCGAGCGGCTGGCACCCCGCTTC GGCACAGAGCGTGTGCCCGTGTGCCACCTGAGGCTGCTGGCCCAGGCCGAGGGGGAGCCCTGCTACATCCGGGACAGTGGGGTGGCCCCT ACAGACCCTGGCCCTGAGTCTGCTGCTGGGCCCCCAACCCACGAGGTGCTGGTGACAGGCACTGGTGGCATCCAGTGGTGGCCAGTAGAG GAGGAGGTGAACAAGGAGGAGGGTTCTAGTGGCAGCAGTGGCAGGAACCCCCAAGCCAGCCTGTTTGGGAAGAAGGCCAAGGCTCACAAG GCAGTCGGCCAGCCGGCAGACAGGCCGCGGGAGCCACTGTGGGCCTACTTCTGTGACTTCCGGGACATCACCCACGTGGTGCTGAAAGAG CACTGTGTCAGCATCCACCGGCAGGACAACAAGTGCCTGGAGCTGAGCTTGCCTTCCCGGGCTGCGGCGCTGTCCTTCGTGTCGCTGGTG GACGGCTATTTCCGCCTGACGGCCGACTCCAGCCACTACCTGTGCCACGAGGTGGCTCCCCCACGGCTGGTGATGAGCATCCGGGATGGG ATCCACGGACCCCTGCTGGAGCCATTTGTGCAGGCCAAGCTGCGGCCCGAGGACGGCCTGTACCTCATTCACTGGAGCACCAGCCACCCC TACCGCCTGATCCTCACAGTGGCCCAGCGTAGCCAGGCACCAGACGGCATGCAGAGCTTGCGGCTCCGAAAGTTCCCCATTGAGCAGCAG GACGGGGCCTTCGTGCTGGAGGGCTGGGGCCGGTCCTTCCCCAGCGTTCGGGAACTTGGGGCTGCCTTGCAGGGCTGCTTGCTGAGGGCC GGGGATGACTGCTTCTCTCTGCGTCGCTGTTGCCTGCCCCAACCAGGAGAAACCTCCAATCTCATCATCATGCGGGGGGCTCGGGCCAGC CCCAGGACACTCAACCTCAGCCAGCTCAGCTTCCACCGGGTTGACCAGAAGGAGATCACCCAGCTGTCCCACTTGGGCCAGGGCACAAGG ACCAACGTGTATGAGGGCCGCCTGCGAGTGGAGGGCAGCGGGGACCCTGAGGAGGGCAAGATGGATGACGAGGACCCCCTCGTGCCTGGC AGGGACCGTGGGCAGGAGCTACGAGTGGTGCTCAAAGTGCTGGACCCTAGTCACCATGACATCGCCCTGGCCTTCTACGAGACAGCCAGC CTCATGAGCCAGGTCTCCCACACGCACCTGGCCTTCGTGCATGGCGTCTGTGTGCGCGGCCCTGAAAATATCATGGTGACAGAGTACGTG GAGCACGGACCCCTGGATGTGTGGCTGCGGAGGGAGCGGGGCCATGTGCCCATGGCTTGGAAGATGGTGGTGGCCCAGCAGCTGGCCAGC GCCCTCAGCTACCTGGAGAACAAGAACCTGGTTCATGGTAATGTGTGTGGCCGGAACATCCTGCTGGCCCGGCTGGGGTTGGCAGAGGGC ACCAGCCCCTTCATCAAGCTGAGTGATCCTGGCGTGGGCCTGGGCGCCCTCTCCAGGGAGGAGCGGGTGGAGAGGATCCCCTGGCTGGCC CCCGAATGCCTACCAGGTGGGGCCAACAGCCTAAGCACCGCCATGGACAAGTGGGGGTTTGGCGCCACCCTCCTGGAGATCTGCTTTGAC GGAGAGGCCCCTCTGCAGAGCCGCAGTCCCTCCGAGGGCCCATCTCCTTCTCTAAGAGATGCCTGCAGCCTGCCATGGGACGTGGGGTCC ACCGGTACAGCTCCACCGGGGGACGGCTACGTGCAGGCGGACGCCCGGGGCCCCCCGGACCACGAGGAGCACCTGTATGTCAACACCCAG GGTCTGGACGCCCCCGAGCCGGAGGACAGCCCCAAAAAGGATCTGTTTGACATGCGACCCTTTGAGGATGCCCTGAAGTTGCATGAGTGC TCAGTGGCGGCAGGCGTGACAGCAGCCCCTCTTCCCTTGGAGGACCAGTGGCCCAGCCCCCCTACCCGCCGGGCCCCTGTGGCCCCCACG GAGGAACAGCTGCGTCAGGAGCCCTGGTACCACGGCCGGATGAGCCGCCGGGCGGCAGAGAGGATGCTTCGAGCTGACGGGGACTTCCTT GTGCGAGACAGCGTCACCAACCCCGGGCAGTATGTCCTCACCGGCATGCACGCCGGGCAGCCCAAGCACCTGCTGCTCGTGGACCCCGAG GGCGTGGTACGGACGAAGGACGTGCTGTTTGAGAGCATCAGCCACCTGATCGACCACCACCTGCAGAACGGGCAGCCCATCGTGGCCGCC >In-frame_TYK2_ENST00000524462_chr19_10468440_-_SHC2_ENST00000264554_chr19_430747_-_2550nt ATGGCCTTTCTGCACCTCTGTCACCTCGCTCTCCGCCATGGCATCCCCCTGGAGGAGGTGGCCAAGAAGACCAGCTTCAAGGACTGCATC CCGCGCTCCTTCCGCCGGCATATCCGGCAGCACAGCGCCCTGACCCGGCTGCGCCTTCGGAACGTCTTCCGCAGGTTCCTGCGGGACTTC CAGCCGGGCCGACTCTCCCAGCAGATGGTCATGGTCAAATACCTAGCCACACTCGAGCGGCTGGCACCCCGCTTCGGCACAGAGCGTGTG CCCGTGTGCCACCTGAGGCTGCTGGCCCAGGCCGAGGGGGAGCCCTGCTACATCCGGGACAGTGGGGTGGCCCCTACAGACCCTGGCCCT GAGTCTGCTGCTGGGCCCCCAACCCACGAGGTGCTGGTGACAGGCACTGGTGGCATCCAGTGGTGGCCAGTAGAGGAGGAGGTGAACAAG GAGGAGGGTTCTAGTGGCAGCAGTGGCAGGAACCCCCAAGCCAGCCTGTTTGGGAAGAAGGCCAAGGCTCACAAGGCAGTCGGCCAGCCG GCAGACAGGCCGCGGGAGCCACTGTGGGCCTACTTCTGTGACTTCCGGGACATCACCCACGTGGTGCTGAAAGAGCACTGTGTCAGCATC CACCGGCAGGACAACAAGTGCCTGGAGCTGAGCTTGCCTTCCCGGGCTGCGGCGCTGTCCTTCGTGTCGCTGGTGGACGGCTATTTCCGC CTGACGGCCGACTCCAGCCACTACCTGTGCCACGAGGTGGCTCCCCCACGGCTGGTGATGAGCATCCGGGATGGGATCCACGGACCCCTG CTGGAGCCATTTGTGCAGGCCAAGCTGCGGCCCGAGGACGGCCTGTACCTCATTCACTGGAGCACCAGCCACCCCTACCGCCTGATCCTC ACAGTGGCCCAGCGTAGCCAGGCACCAGACGGCATGCAGAGCTTGCGGCTCCGAAAGTTCCCCATTGAGCAGCAGGACGGGGCCTTCGTG CTGGAGGGCTGGGGCCGGTCCTTCCCCAGCGTTCGGGAACTTGGGGCTGCCTTGCAGGGCTGCTTGCTGAGGGCCGGGGATGACTGCTTC TCTCTGCGTCGCTGTTGCCTGCCCCAACCAGGAGAAACCTCCAATCTCATCATCATGCGGGGGGCTCGGGCCAGCCCCAGGACACTCAAC CTCAGCCAGCTCAGCTTCCACCGGGTTGACCAGAAGGAGATCACCCAGCTGTCCCACTTGGGCCAGGGCACAAGGACCAACGTGTATGAG GGCCGCCTGCGAGTGGAGGGCAGCGGGGACCCTGAGGAGGGCAAGATGGATGACGAGGACCCCCTCGTGCCTGGCAGGGACCGTGGGCAG GAGCTACGAGTGGTGCTCAAAGTGCTGGACCCTAGTCACCATGACATCGCCCTGGCCTTCTACGAGACAGCCAGCCTCATGAGCCAGGTC TCCCACACGCACCTGGCCTTCGTGCATGGCGTCTGTGTGCGCGGCCCTGAAAATATCATGGTGACAGAGTACGTGGAGCACGGACCCCTG GATGTGTGGCTGCGGAGGGAGCGGGGCCATGTGCCCATGGCTTGGAAGATGGTGGTGGCCCAGCAGCTGGCCAGCGCCCTCAGCTACCTG GAGAACAAGAACCTGGTTCATGGTAATGTGTGTGGCCGGAACATCCTGCTGGCCCGGCTGGGGTTGGCAGAGGGCACCAGCCCCTTCATC AAGCTGAGTGATCCTGGCGTGGGCCTGGGCGCCCTCTCCAGGGAGGAGCGGGTGGAGAGGATCCCCTGGCTGGCCCCCGAATGCCTACCA GGTGGGGCCAACAGCCTAAGCACCGCCATGGACAAGTGGGGGTTTGGCGCCACCCTCCTGGAGATCTGCTTTGACGGAGAGGCCCCTCTG CAGAGCCGCAGTCCCTCCGAGGGCCCATCTCCTTCTCTAAGAGATGCCTGCAGCCTGCCATGGGACGTGGGGTCCACCGGTACAGCTCCA CCGGGGGACGGCTACGTGCAGGCGGACGCCCGGGGCCCCCCGGACCACGAGGAGCACCTGTATGTCAACACCCAGGGTCTGGACGCCCCC GAGCCGGAGGACAGCCCCAAAAAGGATCTGTTTGACATGCGACCCTTTGAGGATGCCCTGAAGTTGCATGAGTGCTCAGTGGCGGCAGGC GTGACAGCAGCCCCTCTTCCCTTGGAGGACCAGTGGCCCAGCCCCCCTACCCGCCGGGCCCCTGTGGCCCCCACGGAGGAACAGCTGCGT CAGGAGCCCTGGTACCACGGCCGGATGAGCCGCCGGGCGGCAGAGAGGATGCTTCGAGCTGACGGGGACTTCCTTGTGCGAGACAGCGTC ACCAACCCCGGGCAGTATGTCCTCACCGGCATGCACGCCGGGCAGCCCAAGCACCTGCTGCTCGTGGACCCCGAGGGCGTGGTACGGACG AAGGACGTGCTGTTTGAGAGCATCAGCCACCTGATCGACCACCACCTGCAGAACGGGCAGCCCATCGTGGCCGCCGAGAGTGAGCTGCAC >In-frame_TYK2_ENST00000525621_chr19_10468440_-_SHC2_ENST00000264554_chr19_430747_-_3105nt ATGCCTCTGCGCCACTGGGGGATGGCCAGGGGCAGTAAGCCCGTTGGGGATGGAGCCCAGCCCATGGCTGCCATGGGAGGCCTGAAGGTG CTTCTGCACTGGGCTGGTCCAGGCGGCGGGGAGCCCTGGGTCACTTTCAGTGAGTCATCGCTGACAGCTGAGGAAGTCTGCATCCACATT GCACATAAAGTTGGTATCACTCCTCCTTGCTTCAATCTCTTTGCCCTCTTCGATGCTCAGGCCCAAGTCTGGTTGCCCCCAAACCACATC CTAGAGATCCCCAGAGATGCAAGCCTGATGCTATATTTCCGCATAAGGTTTTATTTCCGGAACTGGCATGGCATGAATCCTCGGGAACCG GCTGTGTACCGTTGTGGGCCCCCAGGAACCGAGGCATCCTCAGATCAGACAGCACAGGGGATGCAACTCCTGGACCCAGCCTCATTTGAG TACCTCTTTGAGCAGGGCAAGCATGAGTTTGTGAATGACGTGGCATCACTGTGGGAGCTGTCGACCGAGGAGGAGATCCACCACTTTAAG AATGAGAGCCTGGGCATGGCCTTTCTGCACCTCTGTCACCTCGCTCTCCGCCATGGCATCCCCCTGGAGGAGGTGGCCAAGAAGACCAGC TTCAAGGACTGCATCCCGCGCTCCTTCCGCCGGCATATCCGGCAGCACAGCGCCCTGACCCGGCTGCGCCTTCGGAACGTCTTCCGCAGG TTCCTGCGGGACTTCCAGCCGGGCCGACTCTCCCAGCAGATGGTCATGGTCAAATACCTAGCCACACTCGAGCGGCTGGCACCCCGCTTC GGCACAGAGCGTGTGCCCGTGTGCCACCTGAGGCTGCTGGCCCAGGCCGAGGGGGAGCCCTGCTACATCCGGGACAGTGGGGTGGCCCCT ACAGACCCTGGCCCTGAGTCTGCTGCTGGGCCCCCAACCCACGAGGTGCTGGTGACAGGCACTGGTGGCATCCAGTGGTGGCCAGTAGAG GAGGAGGTGAACAAGGAGGAGGGTTCTAGTGGCAGCAGTGGCAGGAACCCCCAAGCCAGCCTGTTTGGGAAGAAGGCCAAGGCTCACAAG GCAGTCGGCCAGCCGGCAGACAGGCCGCGGGAGCCACTGTGGGCCTACTTCTGTGACTTCCGGGACATCACCCACGTGGTGCTGAAAGAG CACTGTGTCAGCATCCACCGGCAGGACAACAAGTGCCTGGAGCTGAGCTTGCCTTCCCGGGCTGCGGCGCTGTCCTTCGTGTCGCTGGTG GACGGCTATTTCCGCCTGACGGCCGACTCCAGCCACTACCTGTGCCACGAGGTGGCTCCCCCACGGCTGGTGATGAGCATCCGGGATGGG ATCCACGGACCCCTGCTGGAGCCATTTGTGCAGGCCAAGCTGCGGCCCGAGGACGGCCTGTACCTCATTCACTGGAGCACCAGCCACCCC TACCGCCTGATCCTCACAGTGGCCCAGCGTAGCCAGGCACCAGACGGCATGCAGAGCTTGCGGCTCCGAAAGTTCCCCATTGAGCAGCAG GACGGGGCCTTCGTGCTGGAGGGCTGGGGCCGGTCCTTCCCCAGCGTTCGGGAACTTGGGGCTGCCTTGCAGGGCTGCTTGCTGAGGGCC GGGGATGACTGCTTCTCTCTGCGTCGCTGTTGCCTGCCCCAACCAGGAGAAACCTCCAATCTCATCATCATGCGGGGGGCTCGGGCCAGC CCCAGGACACTCAACCTCAGCCAGCTCAGCTTCCACCGGGTTGACCAGAAGGAGATCACCCAGCTGTCCCACTTGGGCCAGGGCACAAGG ACCAACGTGTATGAGGGCCGCCTGCGAGTGGAGGGCAGCGGGGACCCTGAGGAGGGCAAGATGGATGACGAGGACCCCCTCGTGCCTGGC AGGGACCGTGGGCAGGAGCTACGAGTGGTGCTCAAAGTGCTGGACCCTAGTCACCATGACATCGCCCTGGCCTTCTACGAGACAGCCAGC CTCATGAGCCAGGTCTCCCACACGCACCTGGCCTTCGTGCATGGCGTCTGTGTGCGCGGCCCTGAAAATATCATGGTGACAGAGTACGTG GAGCACGGACCCCTGGATGTGTGGCTGCGGAGGGAGCGGGGCCATGTGCCCATGGCTTGGAAGATGGTGGTGGCCCAGCAGCTGGCCAGC GCCCTCAGCTACCTGGAGAACAAGAACCTGGTTCATGGTAATGTGTGTGGCCGGAACATCCTGCTGGCCCGGCTGGGGTTGGCAGAGGGC ACCAGCCCCTTCATCAAGCTGAGTGATCCTGGCGTGGGCCTGGGCGCCCTCTCCAGGGAGGAGCGGGTGGAGAGGATCCCCTGGCTGGCC CCCGAATGCCTACCAGGTGGGGCCAACAGCCTAAGCACCGCCATGGACAAGTGGGGGTTTGGCGCCACCCTCCTGGAGATCTGCTTTGAC GGAGAGGCCCCTCTGCAGAGCCGCAGTCCCTCCGAGGGCCCATCTCCTTCTCTAAGAGATGCCTGCAGCCTGCCATGGGACGTGGGGTCC ACCGGTACAGCTCCACCGGGGGACGGCTACGTGCAGGCGGACGCCCGGGGCCCCCCGGACCACGAGGAGCACCTGTATGTCAACACCCAG GGTCTGGACGCCCCCGAGCCGGAGGACAGCCCCAAAAAGGATCTGTTTGACATGCGACCCTTTGAGGATGCCCTGAAGTTGCATGAGTGC TCAGTGGCGGCAGGCGTGACAGCAGCCCCTCTTCCCTTGGAGGACCAGTGGCCCAGCCCCCCTACCCGCCGGGCCCCTGTGGCCCCCACG GAGGAACAGCTGCGTCAGGAGCCCTGGTACCACGGCCGGATGAGCCGCCGGGCGGCAGAGAGGATGCTTCGAGCTGACGGGGACTTCCTT GTGCGAGACAGCGTCACCAACCCCGGGCAGTATGTCCTCACCGGCATGCACGCCGGGCAGCCCAAGCACCTGCTGCTCGTGGACCCCGAG GGCGTGGTACGGACGAAGGACGTGCTGTTTGAGAGCATCAGCCACCTGATCGACCACCACCTGCAGAACGGGCAGCCCATCGTGGCCGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TYK2_ENST00000264818_chr19_10468440_-_SHC2_ENST00000264554_chr19_430747_-_3850nt ATGCCTCTGCGCCACTGGGGGATGGCCAGGGGCAGTAAGCCCGTTGGGGATGGAGCCCAGCCCATGGCTGCCATGGGAGGCCTGAAGGTG CTTCTGCACTGGGCTGGTCCAGGCGGCGGGGAGCCCTGGGTCACTTTCAGTGAGTCATCGCTGACAGCTGAGGAAGTCTGCATCCACATT GCACATAAAGTTGGTATCACTCCTCCTTGCTTCAATCTCTTTGCCCTCTTCGATGCTCAGGCCCAAGTCTGGTTGCCCCCAAACCACATC CTAGAGATCCCCAGAGATGCAAGCCTGATGCTATATTTCCGCATAAGGTTTTATTTCCGGAACTGGCATGGCATGAATCCTCGGGAACCG GCTGTGTACCGTTGTGGGCCCCCAGGAACCGAGGCATCCTCAGATCAGACAGCACAGGGGATGCAACTCCTGGACCCAGCCTCATTTGAG TACCTCTTTGAGCAGGGCAAGCATGAGTTTGTGAATGACGTGGCATCACTGTGGGAGCTGTCGACCGAGGAGGAGATCCACCACTTTAAG AATGAGAGCCTGGGCATGGCCTTTCTGCACCTCTGTCACCTCGCTCTCCGCCATGGCATCCCCCTGGAGGAGGTGGCCAAGAAGACCAGC TTCAAGGACTGCATCCCGCGCTCCTTCCGCCGGCATATCCGGCAGCACAGCGCCCTGACCCGGCTGCGCCTTCGGAACGTCTTCCGCAGG TTCCTGCGGGACTTCCAGCCGGGCCGACTCTCCCAGCAGATGGTCATGGTCAAATACCTAGCCACACTCGAGCGGCTGGCACCCCGCTTC GGCACAGAGCGTGTGCCCGTGTGCCACCTGAGGCTGCTGGCCCAGGCCGAGGGGGAGCCCTGCTACATCCGGGACAGTGGGGTGGCCCCT ACAGACCCTGGCCCTGAGTCTGCTGCTGGGCCCCCAACCCACGAGGTGCTGGTGACAGGCACTGGTGGCATCCAGTGGTGGCCAGTAGAG GAGGAGGTGAACAAGGAGGAGGGTTCTAGTGGCAGCAGTGGCAGGAACCCCCAAGCCAGCCTGTTTGGGAAGAAGGCCAAGGCTCACAAG GCAGTCGGCCAGCCGGCAGACAGGCCGCGGGAGCCACTGTGGGCCTACTTCTGTGACTTCCGGGACATCACCCACGTGGTGCTGAAAGAG CACTGTGTCAGCATCCACCGGCAGGACAACAAGTGCCTGGAGCTGAGCTTGCCTTCCCGGGCTGCGGCGCTGTCCTTCGTGTCGCTGGTG GACGGCTATTTCCGCCTGACGGCCGACTCCAGCCACTACCTGTGCCACGAGGTGGCTCCCCCACGGCTGGTGATGAGCATCCGGGATGGG ATCCACGGACCCCTGCTGGAGCCATTTGTGCAGGCCAAGCTGCGGCCCGAGGACGGCCTGTACCTCATTCACTGGAGCACCAGCCACCCC TACCGCCTGATCCTCACAGTGGCCCAGCGTAGCCAGGCACCAGACGGCATGCAGAGCTTGCGGCTCCGAAAGTTCCCCATTGAGCAGCAG GACGGGGCCTTCGTGCTGGAGGGCTGGGGCCGGTCCTTCCCCAGCGTTCGGGAACTTGGGGCTGCCTTGCAGGGCTGCTTGCTGAGGGCC GGGGATGACTGCTTCTCTCTGCGTCGCTGTTGCCTGCCCCAACCAGGAGAAACCTCCAATCTCATCATCATGCGGGGGGCTCGGGCCAGC CCCAGGACACTCAACCTCAGCCAGCTCAGCTTCCACCGGGTTGACCAGAAGGAGATCACCCAGCTGTCCCACTTGGGCCAGGGCACAAGG ACCAACGTGTATGAGGGCCGCCTGCGAGTGGAGGGCAGCGGGGACCCTGAGGAGGGCAAGATGGATGACGAGGACCCCCTCGTGCCTGGC AGGGACCGTGGGCAGGAGCTACGAGTGGTGCTCAAAGTGCTGGACCCTAGTCACCATGACATCGCCCTGGCCTTCTACGAGACAGCCAGC CTCATGAGCCAGGTCTCCCACACGCACCTGGCCTTCGTGCATGGCGTCTGTGTGCGCGGCCCTGAAAATATCATGGTGACAGAGTACGTG GAGCACGGACCCCTGGATGTGTGGCTGCGGAGGGAGCGGGGCCATGTGCCCATGGCTTGGAAGATGGTGGTGGCCCAGCAGCTGGCCAGC GCCCTCAGCTACCTGGAGAACAAGAACCTGGTTCATGGTAATGTGTGTGGCCGGAACATCCTGCTGGCCCGGCTGGGGTTGGCAGAGGGC ACCAGCCCCTTCATCAAGCTGAGTGATCCTGGCGTGGGCCTGGGCGCCCTCTCCAGGGAGGAGCGGGTGGAGAGGATCCCCTGGCTGGCC CCCGAATGCCTACCAGGTGGGGCCAACAGCCTAAGCACCGCCATGGACAAGTGGGGGTTTGGCGCCACCCTCCTGGAGATCTGCTTTGAC GGAGAGGCCCCTCTGCAGAGCCGCAGTCCCTCCGAGGGCCCATCTCCTTCTCTAAGAGATGCCTGCAGCCTGCCATGGGACGTGGGGTCC ACCGGTACAGCTCCACCGGGGGACGGCTACGTGCAGGCGGACGCCCGGGGCCCCCCGGACCACGAGGAGCACCTGTATGTCAACACCCAG GGTCTGGACGCCCCCGAGCCGGAGGACAGCCCCAAAAAGGATCTGTTTGACATGCGACCCTTTGAGGATGCCCTGAAGTTGCATGAGTGC TCAGTGGCGGCAGGCGTGACAGCAGCCCCTCTTCCCTTGGAGGACCAGTGGCCCAGCCCCCCTACCCGCCGGGCCCCTGTGGCCCCCACG GAGGAACAGCTGCGTCAGGAGCCCTGGTACCACGGCCGGATGAGCCGCCGGGCGGCAGAGAGGATGCTTCGAGCTGACGGGGACTTCCTT GTGCGAGACAGCGTCACCAACCCCGGGCAGTATGTCCTCACCGGCATGCACGCCGGGCAGCCCAAGCACCTGCTGCTCGTGGACCCCGAG GGCGTGGTACGGACGAAGGACGTGCTGTTTGAGAGCATCAGCCACCTGATCGACCACCACCTGCAGAACGGGCAGCCCATCGTGGCCGCC GAGAGTGAGCTGCACCTGCGTGGCGTGGTCTCACGGGAGCCCTGAGCCAGGTGACCGTTCTCAGCCCTGGCTCCTGCCTGTTCTCAGCCC CGGCTCCTGCCTGTCATGGCCTTGGGGCTCTCAGCCCTCCTCCTGGATCCTGGTCAGGCCGAACCACCGCTGCCTCTCCTTCCTCCGCAT GAGCCTCTGGCATGGTCCTTCCTCCAGCTGGCCCCGGGCTGGGCAGAGCCTCCTCCTGCCGGGGCCCCTGCCCACCCCCTCCTTTGCCTG GAGTGAGGGTGTTCATACCAAAGACGGAACCATTTCGCCTTTAAAGAAAATATATCCAGAAGCAGCCGCTGCCTCGGAGCCCTGGCCCTT GGGTCCCCCTCTCGCCTGGCTGGTTCGGTCTAACGCCCCGGAGAGTCAGGGCTCCCAGGACCCTGGGGAGGAGGCGGATTCCGGGCCTGG CTGGGCTTCCTCTTCCCACCTGAGGACTGGGTGCACAGTTGTCTTTGAGGGGGGACGCTTAAGGTGCTTTGGGGTTCTCAGGCCAGGATA CATGCTGGCGCTGAAGTGCAGGCAGCCTTGAGGTCACCTGGGATCTCGGGGTAGCCAGGCTGCTCCAAGACAGTGGATATCGAGGCAGTC GTGAGGCCCCTACTCCACCTGGGAGCAGGGGAAGGACGTGGTTGCCTGGCCTGGGCTGCGCCCAGCAGCTTCCCCCCAGTCCTGCCCTCC >In-frame_TYK2_ENST00000524462_chr19_10468440_-_SHC2_ENST00000264554_chr19_430747_-_3441nt AGCTACCCGCGGGAGCGGGGAGGGGTCCGGGTTCGAGCTTGTGTTCCCCCGGAAGGGGCAAGCATGAGTTTGTGAATGACGTGGCATCAC TGTGGGAGCTGTCGACCGAGGAGGAGATCCACCACTTTAAGAATGAGAGCCTGGGCATGGCCTTTCTGCACCTCTGTCACCTCGCTCTCC GCCATGGCATCCCCCTGGAGGAGGTGGCCAAGAAGACCAGCTTCAAGGACTGCATCCCGCGCTCCTTCCGCCGGCATATCCGGCAGCACA GCGCCCTGACCCGGCTGCGCCTTCGGAACGTCTTCCGCAGGTTCCTGCGGGACTTCCAGCCGGGCCGACTCTCCCAGCAGATGGTCATGG TCAAATACCTAGCCACACTCGAGCGGCTGGCACCCCGCTTCGGCACAGAGCGTGTGCCCGTGTGCCACCTGAGGCTGCTGGCCCAGGCCG AGGGGGAGCCCTGCTACATCCGGGACAGTGGGGTGGCCCCTACAGACCCTGGCCCTGAGTCTGCTGCTGGGCCCCCAACCCACGAGGTGC TGGTGACAGGCACTGGTGGCATCCAGTGGTGGCCAGTAGAGGAGGAGGTGAACAAGGAGGAGGGTTCTAGTGGCAGCAGTGGCAGGAACC CCCAAGCCAGCCTGTTTGGGAAGAAGGCCAAGGCTCACAAGGCAGTCGGCCAGCCGGCAGACAGGCCGCGGGAGCCACTGTGGGCCTACT TCTGTGACTTCCGGGACATCACCCACGTGGTGCTGAAAGAGCACTGTGTCAGCATCCACCGGCAGGACAACAAGTGCCTGGAGCTGAGCT TGCCTTCCCGGGCTGCGGCGCTGTCCTTCGTGTCGCTGGTGGACGGCTATTTCCGCCTGACGGCCGACTCCAGCCACTACCTGTGCCACG AGGTGGCTCCCCCACGGCTGGTGATGAGCATCCGGGATGGGATCCACGGACCCCTGCTGGAGCCATTTGTGCAGGCCAAGCTGCGGCCCG AGGACGGCCTGTACCTCATTCACTGGAGCACCAGCCACCCCTACCGCCTGATCCTCACAGTGGCCCAGCGTAGCCAGGCACCAGACGGCA TGCAGAGCTTGCGGCTCCGAAAGTTCCCCATTGAGCAGCAGGACGGGGCCTTCGTGCTGGAGGGCTGGGGCCGGTCCTTCCCCAGCGTTC GGGAACTTGGGGCTGCCTTGCAGGGCTGCTTGCTGAGGGCCGGGGATGACTGCTTCTCTCTGCGTCGCTGTTGCCTGCCCCAACCAGGAG AAACCTCCAATCTCATCATCATGCGGGGGGCTCGGGCCAGCCCCAGGACACTCAACCTCAGCCAGCTCAGCTTCCACCGGGTTGACCAGA AGGAGATCACCCAGCTGTCCCACTTGGGCCAGGGCACAAGGACCAACGTGTATGAGGGCCGCCTGCGAGTGGAGGGCAGCGGGGACCCTG AGGAGGGCAAGATGGATGACGAGGACCCCCTCGTGCCTGGCAGGGACCGTGGGCAGGAGCTACGAGTGGTGCTCAAAGTGCTGGACCCTA GTCACCATGACATCGCCCTGGCCTTCTACGAGACAGCCAGCCTCATGAGCCAGGTCTCCCACACGCACCTGGCCTTCGTGCATGGCGTCT GTGTGCGCGGCCCTGAAAATATCATGGTGACAGAGTACGTGGAGCACGGACCCCTGGATGTGTGGCTGCGGAGGGAGCGGGGCCATGTGC CCATGGCTTGGAAGATGGTGGTGGCCCAGCAGCTGGCCAGCGCCCTCAGCTACCTGGAGAACAAGAACCTGGTTCATGGTAATGTGTGTG GCCGGAACATCCTGCTGGCCCGGCTGGGGTTGGCAGAGGGCACCAGCCCCTTCATCAAGCTGAGTGATCCTGGCGTGGGCCTGGGCGCCC TCTCCAGGGAGGAGCGGGTGGAGAGGATCCCCTGGCTGGCCCCCGAATGCCTACCAGGTGGGGCCAACAGCCTAAGCACCGCCATGGACA AGTGGGGGTTTGGCGCCACCCTCCTGGAGATCTGCTTTGACGGAGAGGCCCCTCTGCAGAGCCGCAGTCCCTCCGAGGGCCCATCTCCTT CTCTAAGAGATGCCTGCAGCCTGCCATGGGACGTGGGGTCCACCGGTACAGCTCCACCGGGGGACGGCTACGTGCAGGCGGACGCCCGGG GCCCCCCGGACCACGAGGAGCACCTGTATGTCAACACCCAGGGTCTGGACGCCCCCGAGCCGGAGGACAGCCCCAAAAAGGATCTGTTTG ACATGCGACCCTTTGAGGATGCCCTGAAGTTGCATGAGTGCTCAGTGGCGGCAGGCGTGACAGCAGCCCCTCTTCCCTTGGAGGACCAGT GGCCCAGCCCCCCTACCCGCCGGGCCCCTGTGGCCCCCACGGAGGAACAGCTGCGTCAGGAGCCCTGGTACCACGGCCGGATGAGCCGCC GGGCGGCAGAGAGGATGCTTCGAGCTGACGGGGACTTCCTTGTGCGAGACAGCGTCACCAACCCCGGGCAGTATGTCCTCACCGGCATGC ACGCCGGGCAGCCCAAGCACCTGCTGCTCGTGGACCCCGAGGGCGTGGTACGGACGAAGGACGTGCTGTTTGAGAGCATCAGCCACCTGA TCGACCACCACCTGCAGAACGGGCAGCCCATCGTGGCCGCCGAGAGTGAGCTGCACCTGCGTGGCGTGGTCTCACGGGAGCCCTGAGCCA GGTGACCGTTCTCAGCCCTGGCTCCTGCCTGTTCTCAGCCCCGGCTCCTGCCTGTCATGGCCTTGGGGCTCTCAGCCCTCCTCCTGGATC CTGGTCAGGCCGAACCACCGCTGCCTCTCCTTCCTCCGCATGAGCCTCTGGCATGGTCCTTCCTCCAGCTGGCCCCGGGCTGGGCAGAGC CTCCTCCTGCCGGGGCCCCTGCCCACCCCCTCCTTTGCCTGGAGTGAGGGTGTTCATACCAAAGACGGAACCATTTCGCCTTTAAAGAAA ATATATCCAGAAGCAGCCGCTGCCTCGGAGCCCTGGCCCTTGGGTCCCCCTCTCGCCTGGCTGGTTCGGTCTAACGCCCCGGAGAGTCAG GGCTCCCAGGACCCTGGGGAGGAGGCGGATTCCGGGCCTGGCTGGGCTTCCTCTTCCCACCTGAGGACTGGGTGCACAGTTGTCTTTGAG GGGGGACGCTTAAGGTGCTTTGGGGTTCTCAGGCCAGGATACATGCTGGCGCTGAAGTGCAGGCAGCCTTGAGGTCACCTGGGATCTCGG GGTAGCCAGGCTGCTCCAAGACAGTGGATATCGAGGCAGTCGTGAGGCCCCTACTCCACCTGGGAGCAGGGGAAGGACGTGGTTGCCTGG CCTGGGCTGCGCCCAGCAGCTTCCCCCCAGTCCTGCCCTCCCAGCTGTCGACCCAGATGGGATGTTCGGATCGGTTTGTAATTAAACCTG >In-frame_TYK2_ENST00000525621_chr19_10468440_-_SHC2_ENST00000264554_chr19_430747_-_4332nt AAAAAAAAAAAAATCCAATGGTGACGAGCAGGGAGAACAGAGCAGCTGCCAATGGGCGTGTGCGTTTCAGGCGGCCAATGGGAGGAGGCG TCTCGGCGGGGGACAAGCAGTAGCTACCCGCGGGAGCGGGGAGGGGTCCGGGTTCGAGCTTGTGTTCCCCCGGAAGGGTGAGTCTGGACG CGGGCGCGGAAGGAGCGCGGCCGGAGGTCCTCAGGAAGAAGCCGCGGGGACTGGCTGCGCTTGACAGGCTGCACTTGGATGGGAGCACCT GGTGCCTCGGGACTGCTCCGATGCCCGGGTCTGTGCTGAATGTGTAATATGCGGAACTATATTGAAACATTACAACCATCTTTTGATGGC AACACCCTGAGGACCTCCCTTTTCCAGATGGGGAAACTGAGGCCCAGAATTGCTAAGTGGCTTGCTTGAGTTGACACAGGGAGCTCCAGG ACTCACCCTCAGCTGAGCCACCTGCCGGGAGCATGCCTCTGCGCCACTGGGGGATGGCCAGGGGCAGTAAGCCCGTTGGGGATGGAGCCC AGCCCATGGCTGCCATGGGAGGCCTGAAGGTGCTTCTGCACTGGGCTGGTCCAGGCGGCGGGGAGCCCTGGGTCACTTTCAGTGAGTCAT CGCTGACAGCTGAGGAAGTCTGCATCCACATTGCACATAAAGTTGGTATCACTCCTCCTTGCTTCAATCTCTTTGCCCTCTTCGATGCTC AGGCCCAAGTCTGGTTGCCCCCAAACCACATCCTAGAGATCCCCAGAGATGCAAGCCTGATGCTATATTTCCGCATAAGGTTTTATTTCC GGAACTGGCATGGCATGAATCCTCGGGAACCGGCTGTGTACCGTTGTGGGCCCCCAGGAACCGAGGCATCCTCAGATCAGACAGCACAGG GGATGCAACTCCTGGACCCAGCCTCATTTGAGTACCTCTTTGAGCAGGGCAAGCATGAGTTTGTGAATGACGTGGCATCACTGTGGGAGC TGTCGACCGAGGAGGAGATCCACCACTTTAAGAATGAGAGCCTGGGCATGGCCTTTCTGCACCTCTGTCACCTCGCTCTCCGCCATGGCA TCCCCCTGGAGGAGGTGGCCAAGAAGACCAGCTTCAAGGACTGCATCCCGCGCTCCTTCCGCCGGCATATCCGGCAGCACAGCGCCCTGA CCCGGCTGCGCCTTCGGAACGTCTTCCGCAGGTTCCTGCGGGACTTCCAGCCGGGCCGACTCTCCCAGCAGATGGTCATGGTCAAATACC TAGCCACACTCGAGCGGCTGGCACCCCGCTTCGGCACAGAGCGTGTGCCCGTGTGCCACCTGAGGCTGCTGGCCCAGGCCGAGGGGGAGC CCTGCTACATCCGGGACAGTGGGGTGGCCCCTACAGACCCTGGCCCTGAGTCTGCTGCTGGGCCCCCAACCCACGAGGTGCTGGTGACAG GCACTGGTGGCATCCAGTGGTGGCCAGTAGAGGAGGAGGTGAACAAGGAGGAGGGTTCTAGTGGCAGCAGTGGCAGGAACCCCCAAGCCA GCCTGTTTGGGAAGAAGGCCAAGGCTCACAAGGCAGTCGGCCAGCCGGCAGACAGGCCGCGGGAGCCACTGTGGGCCTACTTCTGTGACT TCCGGGACATCACCCACGTGGTGCTGAAAGAGCACTGTGTCAGCATCCACCGGCAGGACAACAAGTGCCTGGAGCTGAGCTTGCCTTCCC GGGCTGCGGCGCTGTCCTTCGTGTCGCTGGTGGACGGCTATTTCCGCCTGACGGCCGACTCCAGCCACTACCTGTGCCACGAGGTGGCTC CCCCACGGCTGGTGATGAGCATCCGGGATGGGATCCACGGACCCCTGCTGGAGCCATTTGTGCAGGCCAAGCTGCGGCCCGAGGACGGCC TGTACCTCATTCACTGGAGCACCAGCCACCCCTACCGCCTGATCCTCACAGTGGCCCAGCGTAGCCAGGCACCAGACGGCATGCAGAGCT TGCGGCTCCGAAAGTTCCCCATTGAGCAGCAGGACGGGGCCTTCGTGCTGGAGGGCTGGGGCCGGTCCTTCCCCAGCGTTCGGGAACTTG GGGCTGCCTTGCAGGGCTGCTTGCTGAGGGCCGGGGATGACTGCTTCTCTCTGCGTCGCTGTTGCCTGCCCCAACCAGGAGAAACCTCCA ATCTCATCATCATGCGGGGGGCTCGGGCCAGCCCCAGGACACTCAACCTCAGCCAGCTCAGCTTCCACCGGGTTGACCAGAAGGAGATCA CCCAGCTGTCCCACTTGGGCCAGGGCACAAGGACCAACGTGTATGAGGGCCGCCTGCGAGTGGAGGGCAGCGGGGACCCTGAGGAGGGCA AGATGGATGACGAGGACCCCCTCGTGCCTGGCAGGGACCGTGGGCAGGAGCTACGAGTGGTGCTCAAAGTGCTGGACCCTAGTCACCATG ACATCGCCCTGGCCTTCTACGAGACAGCCAGCCTCATGAGCCAGGTCTCCCACACGCACCTGGCCTTCGTGCATGGCGTCTGTGTGCGCG GCCCTGAAAATATCATGGTGACAGAGTACGTGGAGCACGGACCCCTGGATGTGTGGCTGCGGAGGGAGCGGGGCCATGTGCCCATGGCTT GGAAGATGGTGGTGGCCCAGCAGCTGGCCAGCGCCCTCAGCTACCTGGAGAACAAGAACCTGGTTCATGGTAATGTGTGTGGCCGGAACA TCCTGCTGGCCCGGCTGGGGTTGGCAGAGGGCACCAGCCCCTTCATCAAGCTGAGTGATCCTGGCGTGGGCCTGGGCGCCCTCTCCAGGG AGGAGCGGGTGGAGAGGATCCCCTGGCTGGCCCCCGAATGCCTACCAGGTGGGGCCAACAGCCTAAGCACCGCCATGGACAAGTGGGGGT TTGGCGCCACCCTCCTGGAGATCTGCTTTGACGGAGAGGCCCCTCTGCAGAGCCGCAGTCCCTCCGAGGGCCCATCTCCTTCTCTAAGAG ATGCCTGCAGCCTGCCATGGGACGTGGGGTCCACCGGTACAGCTCCACCGGGGGACGGCTACGTGCAGGCGGACGCCCGGGGCCCCCCGG ACCACGAGGAGCACCTGTATGTCAACACCCAGGGTCTGGACGCCCCCGAGCCGGAGGACAGCCCCAAAAAGGATCTGTTTGACATGCGAC CCTTTGAGGATGCCCTGAAGTTGCATGAGTGCTCAGTGGCGGCAGGCGTGACAGCAGCCCCTCTTCCCTTGGAGGACCAGTGGCCCAGCC CCCCTACCCGCCGGGCCCCTGTGGCCCCCACGGAGGAACAGCTGCGTCAGGAGCCCTGGTACCACGGCCGGATGAGCCGCCGGGCGGCAG AGAGGATGCTTCGAGCTGACGGGGACTTCCTTGTGCGAGACAGCGTCACCAACCCCGGGCAGTATGTCCTCACCGGCATGCACGCCGGGC AGCCCAAGCACCTGCTGCTCGTGGACCCCGAGGGCGTGGTACGGACGAAGGACGTGCTGTTTGAGAGCATCAGCCACCTGATCGACCACC ACCTGCAGAACGGGCAGCCCATCGTGGCCGCCGAGAGTGAGCTGCACCTGCGTGGCGTGGTCTCACGGGAGCCCTGAGCCAGGTGACCGT TCTCAGCCCTGGCTCCTGCCTGTTCTCAGCCCCGGCTCCTGCCTGTCATGGCCTTGGGGCTCTCAGCCCTCCTCCTGGATCCTGGTCAGG CCGAACCACCGCTGCCTCTCCTTCCTCCGCATGAGCCTCTGGCATGGTCCTTCCTCCAGCTGGCCCCGGGCTGGGCAGAGCCTCCTCCTG CCGGGGCCCCTGCCCACCCCCTCCTTTGCCTGGAGTGAGGGTGTTCATACCAAAGACGGAACCATTTCGCCTTTAAAGAAAATATATCCA GAAGCAGCCGCTGCCTCGGAGCCCTGGCCCTTGGGTCCCCCTCTCGCCTGGCTGGTTCGGTCTAACGCCCCGGAGAGTCAGGGCTCCCAG GACCCTGGGGAGGAGGCGGATTCCGGGCCTGGCTGGGCTTCCTCTTCCCACCTGAGGACTGGGTGCACAGTTGTCTTTGAGGGGGGACGC TTAAGGTGCTTTGGGGTTCTCAGGCCAGGATACATGCTGGCGCTGAAGTGCAGGCAGCCTTGAGGTCACCTGGGATCTCGGGGTAGCCAG GCTGCTCCAAGACAGTGGATATCGAGGCAGTCGTGAGGCCCCTACTCCACCTGGGAGCAGGGGAAGGACGTGGTTGCCTGGCCTGGGCTG CGCCCAGCAGCTTCCCCCCAGTCCTGCCCTCCCAGCTGTCGACCCAGATGGGATGTTCGGATCGGTTTGTAATTAAACCTGGGAATGGCC 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FusionGenePPI for TYK2_SHC2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TYK2 | GNB2L1, STAT1, PRMT5, XRCC5, VAV1, IFNAR1, CRKL, JAK1, TYK2, ELP2, IL13RA1, LYN, CBL, PTPN6, PLAUR, IL6ST, FYN, PTPN1, STAM2, GHR, IRS2, DNM2, TK1, SOCS1, KLF10, LNX1, PTAFR, EIF2AK2, HSP90AA1, JAK3, COPS5, FHL3, HNRNPK, TRAF4, KRT40, KHDRBS2, SIVA1, SHMT2, MOV10, NXF1, BAG2, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8, DDX5, HNRNPH1, HSPB1, CEP170B, RAN, RUVBL1, RUVBL2, SLC2A1, TCP1, ALYREF, TRIM28, TUBA4A, WDR20, EFNB2, PIH1D1, TGFBR2, LRRC46, LPAR6, RNF13, ZNF333, MIER2, SIAH2, UBE2L6, LRP8, IFT43, PMEL, TNFRSF19, GMNN, IL4R, TMCO3, GPR156, CDH8, CD79A, TNFRSF13B, HAVCR2, PROSER2, LGALS3BP, C16orf71, MAS1, NLGN3 | SHC2 | KDR, ARHGAP32, FLT1, EGFR, ERBB2, ERRFI1, GRB2, SHC1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TYK2_SHC2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | TYK2 | P29597 | DB08895 | Tofacitinib | Non-receptor tyrosine-protein kinase TYK2 | small molecule | approved|investigational |
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RelatedDiseases for TYK2_SHC2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TYK2 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Hgene | TYK2 | C0010346 | Crohn Disease | 1 | CTD_human |
| Hgene | TYK2 | C0023892 | Biliary cirrhosis | 1 | CTD_human |
| Hgene | TYK2 | C0026769 | Multiple Sclerosis | 1 | CTD_human |
| Hgene | TYK2 | C0033860 | Psoriasis | 1 | CTD_human |
| Hgene | TYK2 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | TYK2 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Hgene | TYK2 | C0344315 | Depressed mood | 1 | PSYGENET |
| Hgene | TYK2 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Hgene | TYK2 | C1456784 | Paranoia | 1 | CTD_human |
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