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Fusion gene ID: 40233 |
FusionGeneSummary for TXN_NDST3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TXN_NDST3 | Fusion gene ID: 40233 | Hgene | Tgene | Gene symbol | TXN | NDST3 | Gene ID | 25828 | 9348 |
| Gene name | thioredoxin 2 | N-deacetylase and N-sulfotransferase 3 | |
| Synonyms | COXPD29|MT-TRX|MTRX|TRX2|TXN | HSST3 | |
| Cytomap | 22q12.3 | 4q26 | |
| Type of gene | protein-coding | protein-coding | |
| Description | thioredoxin, mitochondrialmitochondrial thioredoxin | bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3GlcNAc N-deacetylase/ N-sulfotransferase 3N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3N-deacetylase/N-sulfotransferase 3N-heparan sulfate sulfotransferase 3glucosaminyl N-dea | |
| Modification date | 20180527 | 20180329 | |
| UniProtAcc | P10599 | O95803 | |
| Ensembl transtripts involved in fusion gene | ENST00000374515, ENST00000374517, ENST00000487892, | ENST00000296499, ENST00000433996, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: TXN [Title/Abstract] AND NDST3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NDST3 | GO:0015012 | heparan sulfate proteoglycan biosynthetic process | 9915799 |
| Tgene | NDST3 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process | 9915799 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-14-0871-01A | TXN | chr9 | 113013100 | - | NDST3 | chr4 | 119059209 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000374515 | ENST00000296499 | TXN | chr9 | 113013100 | - | NDST3 | chr4 | 119059209 | + |
| intron-3CDS | ENST00000374515 | ENST00000433996 | TXN | chr9 | 113013100 | - | NDST3 | chr4 | 119059209 | + |
| In-frame | ENST00000374517 | ENST00000296499 | TXN | chr9 | 113013100 | - | NDST3 | chr4 | 119059209 | + |
| In-frame | ENST00000374517 | ENST00000433996 | TXN | chr9 | 113013100 | - | NDST3 | chr4 | 119059209 | + |
| intron-3CDS | ENST00000487892 | ENST00000296499 | TXN | chr9 | 113013100 | - | NDST3 | chr4 | 119059209 | + |
| intron-3CDS | ENST00000487892 | ENST00000433996 | TXN | chr9 | 113013100 | - | NDST3 | chr4 | 119059209 | + |
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FusionProtFeatures for TXN_NDST3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TXN | NDST3 |
| Participates in various redox reactions through thereversible oxidation of its active center dithiol to a disulfideand catalyzes dithiol-disulfide exchange reactions. Plays a rolein the reversible S-nitrosylation of cysteine residues in targetproteins, and thereby contributes to the response to intracellularnitric oxide. Nitrosylates the active site Cys of CASP3 inresponse to nitric oxide (NO), and thereby inhibits caspase-3activity. Induces the FOS/JUN AP-1 DNA-binding activity inionizing radiation (IR) cells through its oxidation/reductionstatus and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2receptor TAC (IL2R/P55). | Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of theglycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcAdisaccharide repeating sugar backbone to make N-sulfatedheparosan, a prerequisite substrate for later modifications inheparin biosynthesis. Has high deacetylase activity but lowsulfotransferase activity. {ECO:0000269|PubMed:9915799}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TXN_NDST3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TXN_ENST00000374517_chr9_113013100_-_NDST3_ENST00000296499_chr4_119059209_+_529aa MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQEHGIPTDMGYAVAPHHSGVYPVHVQLY EAWKKVWNIKITSTEEYPHLKPARYRRGFIHKNIMVLPRQTCGLFTHTIFYKEYPGGPKELDKSIQGGELFFTVVLNPISIFMTHLSNYG NDRLGLYTFVNLANFVKSWTNLRLQTLPPVQLAHKYFELFPDQKDPLWQNPCDDKRHRDIWSKEKTCDRLPKFLVIGPQKTGTTALYLFL VMHPSILSNSPSPKTFEEVQFFNRNNYHRGIDWYMDFFPVPSNVTTDFLFEKSANYFHSEEAPKRAASLVPKAKIITILIDPSDRAYSWY QHQRSHEDPAALKFSFYEVISAGPRAPSELRALQKRCLVPGWYASHIERWLVYFPPFQLLIIDGQQLRTDPATVMDEVQKFLGVLPHYNY >In-frame_TXN_ENST00000374517_chr9_113013100_-_NDST3_ENST00000433996_chr4_119059209_+_298aa MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQEHGIPTDMGYAVAPHHSGVYPVHVQLY EAWKKVWNIKITSTEEYPHLKPARYRRGFIHKNIMVLPRQTCGLFTHTIFYKEYPGGPKELDKSIQGGELFFTVVLNPISIFMTHLSNYG NDRLGLYTFVNLANFVKSWTNLRLQTLPPVQLAHKYFELFPDQKDPLWQNPCDDKRHRDIWSKEKTCDRLPKFLVIGPQKTGTTALYLFL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TXN_ENST00000374517_chr9_113013100_-_NDST3_ENST00000296499_chr4_119059209_+_1587nt ATGGTGAAGCAGATCGAGAGCAAGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACG TGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATTCCCTCTCTGAAAAGTATTCCAACGTGATATTCCTTGAAGTAGATGTGGAT GACTGTCAGGAGCACGGCATTCCAACGGACATGGGCTACGCTGTGGCCCCTCACCATTCGGGCGTCTACCCTGTACATGTTCAGCTTTAT GAGGCCTGGAAGAAGGTCTGGAATATTAAAATCACCAGCACTGAAGAATATCCACATCTGAAGCCAGCTAGATACCGGAGGGGTTTTATC CACAAAAACATCATGGTTCTCCCAAGACAAACCTGTGGGCTTTTCACTCACACCATTTTCTACAAAGAATATCCAGGGGGTCCTAAAGAG CTGGATAAGAGTATCCAAGGAGGAGAACTTTTCTTCACTGTCGTCCTCAACCCTATCAGCATTTTCATGACCCATTTGTCCAACTATGGG AATGACCGACTGGGATTATATACATTTGTTAATCTGGCCAACTTTGTGAAGAGCTGGACCAACCTGCGACTTCAGACTCTGCCTCCAGTA CAACTGGCCCACAAGTATTTTGAGCTGTTTCCTGATCAGAAAGACCCTCTCTGGCAGAATCCTTGCGATGACAAACGCCACAGAGACATT TGGTCTAAAGAAAAAACTTGTGATCGCTTACCAAAATTCTTGGTAATAGGACCCCAGAAAACTGGTACCACTGCTTTGTATTTGTTCCTG GTTATGCATCCTTCCATCCTTAGTAACTCCCCCAGCCCAAAAACCTTTGAGGAGGTACAGTTCTTTAATAGAAATAACTACCACAGGGGG ATTGATTGGTATATGGATTTCTTCCCAGTCCCATCTAATGTCACTACCGACTTTTTGTTTGAGAAGAGTGCCAATTACTTCCACTCAGAG GAAGCCCCTAAAAGAGCTGCTTCTCTGGTTCCCAAAGCCAAGATTATCACCATTCTCATTGACCCTTCAGACCGAGCATACTCCTGGTAC CAGCATCAGCGATCACATGAAGACCCTGCAGCTCTGAAGTTTAGCTTCTACGAAGTGATCTCAGCAGGGCCCCGTGCACCCTCGGAGCTC AGAGCCTTGCAGAAGAGATGTTTGGTCCCGGGGTGGTATGCCAGCCACATCGAGAGATGGCTTGTTTATTTCCCCCCATTTCAGTTGCTA ATTATTGATGGGCAACAACTAAGAACTGATCCTGCTACAGTGATGGATGAAGTACAGAAGTTTCTAGGAGTCTTGCCTCATTATAATTAC TCAGAAGCTTTAACGTTTGATTCTCATAAAGGTTTCTGGTGTCAGTTACTGGAAGAAGGTAAAACAAAATGCCTTGGAAAGAGCAAAGGA AGAAAATACCCTCCAATGGATTCTGATAGCAGGACATTTCTGTCAAGCTACTATCGAGATCACAACGTGGAACTCTCAAAGCTGCTGCAC >In-frame_TXN_ENST00000374517_chr9_113013100_-_NDST3_ENST00000433996_chr4_119059209_+_894nt ATGGTGAAGCAGATCGAGAGCAAGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACG TGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATTCCCTCTCTGAAAAGTATTCCAACGTGATATTCCTTGAAGTAGATGTGGAT GACTGTCAGGAGCACGGCATTCCAACGGACATGGGCTACGCTGTGGCCCCTCACCATTCGGGCGTCTACCCTGTACATGTTCAGCTTTAT GAGGCCTGGAAGAAGGTCTGGAATATTAAAATCACCAGCACTGAAGAATATCCACATCTGAAGCCAGCTAGATACCGGAGGGGTTTTATC CACAAAAACATCATGGTTCTCCCAAGACAAACCTGTGGGCTTTTCACTCACACCATTTTCTACAAAGAATATCCAGGGGGTCCTAAAGAG CTGGATAAGAGTATCCAAGGAGGAGAACTTTTCTTCACTGTCGTCCTCAACCCTATCAGCATTTTCATGACCCATTTGTCCAACTATGGG AATGACCGACTGGGATTATATACATTTGTTAATCTGGCCAACTTTGTGAAGAGCTGGACCAACCTGCGACTTCAGACTCTGCCTCCAGTA CAACTGGCCCACAAGTATTTTGAGCTGTTTCCTGATCAGAAAGACCCTCTCTGGCAGAATCCTTGCGATGACAAACGCCACAGAGACATT TGGTCTAAAGAAAAAACTTGTGATCGCTTACCAAAATTCTTGGTAATAGGACCCCAGAAAACTGGTACCACTGCTTTGTATTTGTTCCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TXN_ENST00000374517_chr9_113013100_-_NDST3_ENST00000296499_chr4_119059209_+_4728nt CTCGCAGGCTCCAGGGGCGGGGCGTGGCCGGGGCGCAGCGACGGGCGCGGAGGTCCGGCCGGGCGCGCGCGCCCCCGCCACACGCACGCC GGGCGTGCCAGTTTATAAAGGGAGAGAGCAAGCAGCGAGTCTTGAAGCTCTGTTTGGTGCTTTGGATCCATTTCCATCGGTCCTTACAGC CGCTCGTCAGACTCCAGCAGCCAAGATGGTGAAGCAGATCGAGAGCAAGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACT TGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATTCCCTCTCTGAAAAGTATTCCAACGT GATATTCCTTGAAGTAGATGTGGATGACTGTCAGGAGCACGGCATTCCAACGGACATGGGCTACGCTGTGGCCCCTCACCATTCGGGCGT CTACCCTGTACATGTTCAGCTTTATGAGGCCTGGAAGAAGGTCTGGAATATTAAAATCACCAGCACTGAAGAATATCCACATCTGAAGCC AGCTAGATACCGGAGGGGTTTTATCCACAAAAACATCATGGTTCTCCCAAGACAAACCTGTGGGCTTTTCACTCACACCATTTTCTACAA AGAATATCCAGGGGGTCCTAAAGAGCTGGATAAGAGTATCCAAGGAGGAGAACTTTTCTTCACTGTCGTCCTCAACCCTATCAGCATTTT CATGACCCATTTGTCCAACTATGGGAATGACCGACTGGGATTATATACATTTGTTAATCTGGCCAACTTTGTGAAGAGCTGGACCAACCT GCGACTTCAGACTCTGCCTCCAGTACAACTGGCCCACAAGTATTTTGAGCTGTTTCCTGATCAGAAAGACCCTCTCTGGCAGAATCCTTG CGATGACAAACGCCACAGAGACATTTGGTCTAAAGAAAAAACTTGTGATCGCTTACCAAAATTCTTGGTAATAGGACCCCAGAAAACTGG TACCACTGCTTTGTATTTGTTCCTGGTTATGCATCCTTCCATCCTTAGTAACTCCCCCAGCCCAAAAACCTTTGAGGAGGTACAGTTCTT TAATAGAAATAACTACCACAGGGGGATTGATTGGTATATGGATTTCTTCCCAGTCCCATCTAATGTCACTACCGACTTTTTGTTTGAGAA GAGTGCCAATTACTTCCACTCAGAGGAAGCCCCTAAAAGAGCTGCTTCTCTGGTTCCCAAAGCCAAGATTATCACCATTCTCATTGACCC TTCAGACCGAGCATACTCCTGGTACCAGCATCAGCGATCACATGAAGACCCTGCAGCTCTGAAGTTTAGCTTCTACGAAGTGATCTCAGC AGGGCCCCGTGCACCCTCGGAGCTCAGAGCCTTGCAGAAGAGATGTTTGGTCCCGGGGTGGTATGCCAGCCACATCGAGAGATGGCTTGT TTATTTCCCCCCATTTCAGTTGCTAATTATTGATGGGCAACAACTAAGAACTGATCCTGCTACAGTGATGGATGAAGTACAGAAGTTTCT AGGAGTCTTGCCTCATTATAATTACTCAGAAGCTTTAACGTTTGATTCTCATAAAGGTTTCTGGTGTCAGTTACTGGAAGAAGGTAAAAC AAAATGCCTTGGAAAGAGCAAAGGAAGAAAATACCCTCCAATGGATTCTGATAGCAGGACATTTCTGTCAAGCTACTATCGAGATCACAA CGTGGAACTCTCAAAGCTGCTGCACAAACTGGGTCAGCCTCTGCCATCCTGGCTGAGACAGGAGCTGCAGAAAGTAAGATAGCACTGAGA GAAAACTTGAGACTTCATCGTCCATGTAGAACACACCTTTTCCAAAGCTTCCAGAAGCTACCAAAAGGCAGTTGAAAAATATACCTCTTC AAATGAGAAAAAAGAACAGTTTCTTCCATGTGCTGGCACGTGGATGATTAGAAAAAAAGAAAAAGTATGTGTTACAAGCCTTGAGGCCTG TGGCCTTTCTCTTAACCCATATCTGAGCCTGTGGGATTATTGTAGACTACTGTGCACTCATGTGGAAGTCAATTGCAACCAACATAAATA TCAAACACAAATGCAGAACTGTTCCATTTCATAGTAATATTTACACTTTTATATATCAACTAAGATTGTGTCTCTGTAGGTTTTTAGACC ACTGTTTGCCTGTACGATGTTTTCTTATTATTTTATTCTATAAAGTGTCCTATGAAACAAGAAGCAAAATAAACATCACAATGTAGCATA AAATGTCAAAAGCATAACACCCATGAAAAATGCTTGCCAAAATTTAAATCCACTTAAGTATTTAGAAATAATTGTAAATTATAATTTGTG CTAGATCAGAGTGGAAAAGTTATATATGAGTGTTATCTGCACCAAAAAAAAATAAGTGCTATAGCAAAAGTGATTTTTTCATATACATAG TCTAGTGAATATATGTAAAAATTACTAACTCTTCCATCACAACGTAATTGTTATACTGAAATATATACTGTAAAGCTGTTGGATGGTAAA TAGAAACACATCAAGTACACCAAAACAGTAAATAACAATGTAAAGTGTACTGACTGAATCCTCTAAAAGGGAGAAATTGTAGGGGTCTAA AAACATATCATCGAGAATTCTATGTCCACTTGCTGTAAGCTGTGAATCTATCCCAGTAGTCCTCACTAGTTCTACAGAAATGCATGCCTA GAGTCTGAGGTATGTGTCATCTCCAGAAACAGGTTGACTTTTAAATGTGAATAGCTATTTTTAATGCTCCCCAAAACAAAACCTATTAAA CTAAAACTAAAAACAGTTTCCCTAGATGATGTGGTTAGGCTATTTACATTTAGGTTATTAAAAAATTGCATTTTCCCAGATAGTTCAAAA TAAAATTATGTAATGTAGTAGAGATTTATAACAAAAAACAAATTAATATATTATTTGTAATCTAATGTTTGCAATGATACTTTTGATATA AGGCAAAGAAACATAAGCAGAGCAGAGGCCCATTTTTGAAAATATTTCACCCATCACTCTGGTGGAAGTAACAGATCATAGGTACAATTA AGGATTAGCTACTAAATTAAATGCAGGAAGTACAAAGATGAGCAAGTCATGCTCTTGAAATATATTTACATTTCAATTGTAAATAATATA TATGGTTAATAAAGTTTCCAAAAAAGAAAAGAATACATCATACTTATTTTCCTGTTAATATTTACTTAATTTTTTTTTTTGAGAGGGGGA CAGAGTCTCACTATGTCACCCAGGCTGGAGTGCAATGGTGTGATCTCAGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCT GCCTCAGCCTCCTGAGGAGCTGGGATTACAGCCATGCACCACCACGCCCGGGTAATTTTTGTATTTTTAGTAGTGACAGGGTTTCACCAT GTTGACTAGGCTGATCTTGAACTCCTGACCTCATGATCCACCCACCTTGGCCTCTCAAAGTGCTGAGATTACAAGCGTGAGCCACCATGC CCTGACTACTTAATTTTTAAATGTACTGTACATATACATAAAATTTAAGTAGTAAATTAATTCCCTGCTATGATTATAAGCCTTTATAAA ATATTATCAAAGGTATGATTAGAAACAAATGGGAGGAAAACCCATAGTAAAAATATTTTCATTGTCATTTTAATGGGTAAAACTATCAAT TACTAATTAGAAAATGAATTGTGAGATCCACTTACTATAAATTTTTAACTGTACATTATAATTACTTTTTTAAAGTTTCATGTACCTAAA GCATATGCTAATTTTTAAATATACTATTAGCAGAAAAAATTGGAAAAATCACCAATTTTTAAGACTCTTGACTCTAAAAGCAAAATCAAA GTGATTTGGACAAATATGGGAAACACAGTCTTCATGCTTACTGCTGTCTCTTTTATAGCAGCAGATGCCAGACATGCTAGGAAAATTACT ATAGTCTTCCATCTCCACCAACTTAAGAAAACTGGCTTAGGAAGGTTAAACATGAGAATAGGCCTCAGCAGTTATATACAGTGTCATGTT TTCATTTGGCAACAACATTTATTCTAATAAAAAAAGAAAAGAAAAACTGATACATTTATGCTTTAATGGTAAGATGTACATTTGAACTGC TAAGCAAAGCTGCTAATGGCCTATTTTGTTTAGGTAAATCGAGTTGACTGAACACTTCATCCTTTTAAATAGATGTCAAAAACATACTCC GTGTTTGTATAAAGACAGGAGAAAAAGGAAGAGATCTTACCAAAATTTATTCATTCACAAGTACATGTATTACGCTAGCTAGAGCAGCAA ACCTGTGAAAGGATTTTTGACCACTCAATGTGTCTTGAAGACAGCATCAAATTCTAGAGGACATGCATACTTTCCACATTATATACTCCA ACTGGTTAATATGCTAATCTGAAAGTAACATAAATACATATGAGAGAATAATGAGAGATAATCTGATTTAAAACTAGCTTTGTATAGAAT TCCCTTTTTCATTGTTTAAAATATGAAACTTCCTCAGGAAGAAATGAAATGGTTATTTCAATGTTTATAGCTGTAATATTCTTGTCATTC ACATTGAATGAAAATTACTGGAAACATTTTTTTCTCTGAGTTTTTTAAAATAAAAAACCTAGATATAATTCTGATAGTAGCATGGTACCT >In-frame_TXN_ENST00000374517_chr9_113013100_-_NDST3_ENST00000433996_chr4_119059209_+_1160nt CTCGCAGGCTCCAGGGGCGGGGCGTGGCCGGGGCGCAGCGACGGGCGCGGAGGTCCGGCCGGGCGCGCGCGCCCCCGCCACACGCACGCC GGGCGTGCCAGTTTATAAAGGGAGAGAGCAAGCAGCGAGTCTTGAAGCTCTGTTTGGTGCTTTGGATCCATTTCCATCGGTCCTTACAGC CGCTCGTCAGACTCCAGCAGCCAAGATGGTGAAGCAGATCGAGAGCAAGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACT TGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATTCCCTCTCTGAAAAGTATTCCAACGT GATATTCCTTGAAGTAGATGTGGATGACTGTCAGGAGCACGGCATTCCAACGGACATGGGCTACGCTGTGGCCCCTCACCATTCGGGCGT CTACCCTGTACATGTTCAGCTTTATGAGGCCTGGAAGAAGGTCTGGAATATTAAAATCACCAGCACTGAAGAATATCCACATCTGAAGCC AGCTAGATACCGGAGGGGTTTTATCCACAAAAACATCATGGTTCTCCCAAGACAAACCTGTGGGCTTTTCACTCACACCATTTTCTACAA AGAATATCCAGGGGGTCCTAAAGAGCTGGATAAGAGTATCCAAGGAGGAGAACTTTTCTTCACTGTCGTCCTCAACCCTATCAGCATTTT CATGACCCATTTGTCCAACTATGGGAATGACCGACTGGGATTATATACATTTGTTAATCTGGCCAACTTTGTGAAGAGCTGGACCAACCT GCGACTTCAGACTCTGCCTCCAGTACAACTGGCCCACAAGTATTTTGAGCTGTTTCCTGATCAGAAAGACCCTCTCTGGCAGAATCCTTG CGATGACAAACGCCACAGAGACATTTGGTCTAAAGAAAAAACTTGTGATCGCTTACCAAAATTCTTGGTAATAGGACCCCAGAAAACTGG TACCACTGCTTTGTATTTGTTCCTGGTTATGCATCCTTCCATCCTTAGTAACTCCCCCAGCCCAAAAACCTTTGAGGAGGTATATGGATT |
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FusionGenePPI for TXN_NDST3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TXN | COL1A1, NCF4, PINX1, VHL, CD40, GAPDH, NR3C1, FST, VIM, TXNIP, MAP3K5, NFKB1, TP53, UCHL5, CUL4B, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, PTPN6, WDR1, UBQLN4, AHCYL1, UBE2V1, SSSCA1, ATP6V1F, SFPQ, SFXN1, UBL5, UBE2D2, SYNCRIP, ATIC, UBE2K, TAX1BP3, PRDX1, MYC, IFIT3, UBL4A, PAN2, NPM1, MYD88, GPRASP2, DYNLT1, CDKN1A, MLH1, NFE2, SIAH1, ACTN4, PARK2, APEX1, SRP9, GPX1, UNK, NTRK1, AKR7A2, ARHGDIA, CCS, EEF2, EIF4EBP2, GLOD4, GSTO1, HINT1, HSPE1, IMPA2, PDCD6, PRDX2, RAB1A, SOD1, STIP1, TAGLN2, TAGLN3, ASS1, C4orf27, ENO1, ENO2, ENO3, FKBP1A, FKBP2, GLRX5, GSTO2, HSPA5, IMPA1, LGALS3, MAP2K2, PGAM1, PGAM2, PSMD14, RAE1, TMX1, TXN2, TYMS, REV3L, PTEN, EWSR1, SRPK2, GEMIN5, TOR1AIP1, EGFR, CRY1, MCM2, OTUB1, PCGF1, DPPA4, NANOG, POU5F1, CRBN, DUSP13, CDK1, COQ2, COX15, DLD, DNM1L, PARK7, SOAT1, VDAC1, G3BP1 | NDST3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TXN_NDST3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TXN_NDST3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TXN | C0006287 | Bronchopulmonary Dysplasia | 1 | CTD_human |
| Hgene | TXN | C0011616 | Contact Dermatitis | 1 | CTD_human |
| Hgene | TXN | C0023895 | Liver diseases | 1 | CTD_human |
| Hgene | TXN | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | TXN | C0242488 | Acute Lung Injury | 1 | CTD_human |
| Hgene | TXN | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | NDST3 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Tgene | NDST3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
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