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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40214

FusionGeneSummary for TXNL4B_CFB

check button Fusion gene summary
Fusion gene informationFusion gene name: TXNL4B_CFB
Fusion gene ID: 40214
HgeneTgene
Gene symbol

TXNL4B

CFB

Gene ID

54957

629

Gene namethioredoxin like 4Bcomplement factor B
SynonymsDLP|Dim2AHUS4|ARMD14|BF|BFD|CFAB|CFBD|FB|FBI12|GBG|H2-Bf|PBF2
Cytomap

16q22.2

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionthioredoxin-like protein 4BDim1-like proteincomplement factor BB-factor, properdinC3 proacceleratorC3 proactivatorC3/C5 convertaseglycine-rich beta-glycoproteinproperdin factor B
Modification date2018052320180520
UniProtAcc

Q9NX01

P00751

Ensembl transtripts involved in fusion geneENST00000268483, ENST00000423037, 
ENST00000426362, 		ENST00000556679, 
ENST00000456570, ENST00000477310, 
ENST00000425368, ENST00000497841, 
ENST00000417261, ENST00000427888, 
ENST00000459734, ENST00000455591, 
ENST00000433503, ENST00000474621, 
ENST00000424727, ENST00000436692, 
ENST00000473139, ENST00000399981, 
ENST00000419920, ENST00000465211, 
ENST00000375455, ENST00000489605, 
ENST00000426239, ENST00000419411, 
ENST00000460958, 
Fusion gene scores* DoF score6 X 6 X 1=3611 X 5 X 7=385
# samples 715
** MAII scorelog2(7/36*10)=0.959358015502654
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/385*10)=-1.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TXNL4B [Title/Abstract] AND CFB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC007464TXNL4Bchr16

72093066

+CFBchr6

3251654

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000268483ENST00000556679TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000456570TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000477310TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000425368TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000497841TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000417261TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000427888TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000459734TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000455591TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000433503TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000474621TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000424727TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000436692TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000473139TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000399981TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000419920TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000465211TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000375455TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000489605TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000426239TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000419411TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000268483ENST00000460958TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000556679TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000456570TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000477310TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000425368TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000497841TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000417261TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000427888TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000459734TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000455591TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000433503TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000474621TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000424727TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000436692TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000473139TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000399981TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000419920TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000465211TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000375455TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000489605TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000426239TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000419411TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000423037ENST00000460958TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000556679TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000456570TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000477310TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000425368TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000497841TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000417261TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000427888TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000459734TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000455591TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000433503TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000474621TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000424727TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000436692TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000473139TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000399981TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000419920TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000465211TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000375455TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000489605TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000426239TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000419411TXNL4Bchr16

72093066

+CFBchr6

3251654

+
intron-intronENST00000426362ENST00000460958TXNL4Bchr16

72093066

+CFBchr6

3251654

+

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FusionProtFeatures for TXNL4B_CFB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TXNL4B

Q9NX01

CFB

P00751

Essential role in pre-mRNA splicing. Required in cellcycle progression for S/G(2) transition.{ECO:0000269|PubMed:15161931}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TXNL4B_CFB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TXNL4B_CFB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TXNL4B_CFB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCFBP00751DB01593ZincComplement factor Bsmall moleculeapproved|investigational

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RelatedDiseases for TXNL4B_CFB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCFBC2752038HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 42ORPHANET;UNIPROT
TgeneCFBC0024141Lupus Erythematosus, Systemic1CTD_human
TgeneCFBC0026896Myasthenia Gravis1CTD_human
TgeneCFBC0242383Age related macular degeneration1CTD_human
TgeneCFBC2931788Atypical Hemolytic Uremic Syndrome1CTD_human