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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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RelatedDiseases

Fusion gene ID: 40211

FusionGeneSummary for TXNL1_LRP1B

check button Fusion gene summary
Fusion gene informationFusion gene name: TXNL1_LRP1B
Fusion gene ID: 40211
HgeneTgene
Gene symbol

TXNL1

LRP1B

Gene ID

9352

53353

Gene namethioredoxin like 1LDL receptor related protein 1B
SynonymsHEL-S-114|TRP32|TXL-1|TXNL|TxlLRP-1B|LRP-DIT|LRPDIT
Cytomap

18q21.31

2q22.1-q22.2

Type of geneprotein-codingprotein-coding
Descriptionthioredoxin-like protein 132 kDa thioredoxin-related proteinepididymis secretory protein Li 114thioredoxin-related 32 kDa proteinthioredoxin-related protein 1low-density lipoprotein receptor-related protein 1BLRP-deleted in tumorslow density lipoprotein receptor related protein-deleted in tumorlow density lipoprotein receptor-related protein 1Blow density lipoprotein-related protein 1B (deleted in tumors)
Modification date2018052220180519
UniProtAcc

O43396

Q9NZR2

Ensembl transtripts involved in fusion geneENST00000217515, ENST00000585497, 
ENST00000590954, ENST00000540155, 
ENST00000389484, ENST00000486364, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 5 X 4=100
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TXNL1 [Title/Abstract] AND LRP1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-G2-A2EF-01ATXNL1chr18

54305574

-LRP1Bchr2

141299540

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000217515ENST00000389484TXNL1chr18

54305574

-LRP1Bchr2

141299540

-
5CDS-intronENST00000217515ENST00000486364TXNL1chr18

54305574

-LRP1Bchr2

141299540

-
intron-3CDSENST00000585497ENST00000389484TXNL1chr18

54305574

-LRP1Bchr2

141299540

-
intron-intronENST00000585497ENST00000486364TXNL1chr18

54305574

-LRP1Bchr2

141299540

-
Frame-shiftENST00000590954ENST00000389484TXNL1chr18

54305574

-LRP1Bchr2

141299540

-
5CDS-intronENST00000590954ENST00000486364TXNL1chr18

54305574

-LRP1Bchr2

141299540

-
5UTR-3CDSENST00000540155ENST00000389484TXNL1chr18

54305574

-LRP1Bchr2

141299540

-
5UTR-intronENST00000540155ENST00000486364TXNL1chr18

54305574

-LRP1Bchr2

141299540

-

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FusionProtFeatures for TXNL1_LRP1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TXNL1

O43396

LRP1B

Q9NZR2

Active thioredoxin with a redox potential of about -250mV. {ECO:0000269|PubMed:19349277}. Potential cell surface proteins that bind andinternalize ligands in the process of receptor-mediatedendocytosis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912464_250423984600DomainEGF-like 10
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912509_254823984600DomainLDL-receptor class A 11
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912551_258723984600DomainLDL-receptor class A 12
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912590_262623984600DomainLDL-receptor class A 13
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912629_267523984600DomainLDL-receptor class A 14
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912681_271723984600DomainLDL-receptor class A 15
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912719_275723984600DomainLDL-receptor class A 16
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912760_280023984600DomainLDL-receptor class A 17
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912804_284123984600DomainLDL-receptor class A 18
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912844_288523984600DomainLDL-receptor class A 19
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912890_292623984600DomainLDL-receptor class A 20
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912927_296723984600DomainEGF-like 11
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912968_300823984600DomainEGF-like 12%3B calcium-binding
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913273_331423984600DomainEGF-like 13
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913316_335323984600DomainLDL-receptor class A 21
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913356_339223984600DomainLDL-receptor class A 22
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913395_343223984600DomainLDL-receptor class A 23
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913435_347223984600DomainLDL-receptor class A 24
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913475_351123984600DomainLDL-receptor class A 25
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913514_355023984600DomainLDL-receptor class A 26
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913552_358823984600DomainLDL-receptor class A 27
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913593_362923984600DomainLDL-receptor class A 28
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913631_366823984600DomainLDL-receptor class A 29
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913673_371123984600DomainLDL-receptor class A 30
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913714_375223984600DomainLDL-receptor class A 31
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913761_379723984600DomainLDL-receptor class A 32
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913801_384323984600DomainEGF-like 14
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913844_388123984600DomainEGF-like 15
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42914171_420823984600DomainEGF-like 16
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42914213_424923984600DomainEGF-like 17
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42914249_428523984600DomainEGF-like 18
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42914285_432123984600DomainEGF-like 19
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42914321_435723984600DomainEGF-like 20
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42914357_439223984600DomainEGF-like 21
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42914390_442723984600DomainEGF-like 22
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42914492_449523984600MotifEndocytosis signal
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42914559_456223984600MotifEndocytosis signal
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912417_245923984600RepeatNote=LDL-receptor class B 25
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913055_309823984600RepeatNote=LDL-receptor class B 26
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913099_314123984600RepeatNote=LDL-receptor class B 27
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913142_318523984600RepeatNote=LDL-receptor class B 28
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913186_322423984600RepeatNote=LDL-receptor class B 29
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913225_326823984600RepeatNote=LDL-receptor class B 30
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913933_398023984600RepeatNote=LDL-receptor class B 31
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42913981_403823984600RepeatNote=LDL-receptor class B 32
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42914039_408223984600RepeatNote=LDL-receptor class B 33
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42914083_412723984600RepeatNote=LDL-receptor class B 34
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42914468_459923984600Topological domainCytoplasmic
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42914445_446723984600TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTXNL1chr18:54305574chr2:141299540ENST00000217515-18115_28532290DomainPITH
HgeneTXNL1chr18:54305574chr2:141299540ENST00000217515-182_10932290DomainNote=Thioredoxin
HgeneTXNL1chr18:54305574chr2:141299540ENST00000590954-310115_28532290DomainPITH
HgeneTXNL1chr18:54305574chr2:141299540ENST00000590954-3102_10932290DomainNote=Thioredoxin
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911005_104323984600DomainLDL-receptor class A 7
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911052_108923984600DomainLDL-receptor class A 8
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911094_113223984600DomainLDL-receptor class A 9
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911135_117423984600DomainLDL-receptor class A 10
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-4291116_15423984600DomainEGF-like 1
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911174_121323984600DomainEGF-like 5
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911214_125323984600DomainEGF-like 6
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911527_157023984600DomainEGF-like 7
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-4291155_19423984600DomainEGF-like 2%3B calcium-binding
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911834_187523984600DomainEGF-like 8
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912143_218323984600DomainEGF-like 9
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-429131_7023984600DomainLDL-receptor class A 1
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-4291471_51723984600DomainEGF-like 3
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-429176_11423984600DomainLDL-receptor class A 2
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-4291794_83423984600DomainEGF-like 4
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-4291844_88223984600DomainLDL-receptor class A 3
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-4291885_92323984600DomainLDL-receptor class A 4
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-4291926_96323984600DomainLDL-receptor class A 5
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-4291966_100323984600DomainLDL-receptor class A 6
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911300_134623984600RepeatNote=LDL-receptor class B 8
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911347_138923984600RepeatNote=LDL-receptor class B 9
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911390_143623984600RepeatNote=LDL-receptor class B 10
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911437_148023984600RepeatNote=LDL-receptor class B 11
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911481_152223984600RepeatNote=LDL-receptor class B 12
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911618_166023984600RepeatNote=LDL-receptor class B 13
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911661_170423984600RepeatNote=LDL-receptor class B 14
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911705_174423984600RepeatNote=LDL-receptor class B 15
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911745_178723984600RepeatNote=LDL-receptor class B 16
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911922_196423984600RepeatNote=LDL-receptor class B 17
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42911965_200723984600RepeatNote=LDL-receptor class B 28
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912008_205123984600RepeatNote=LDL-receptor class B 19
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912052_209523984600RepeatNote=LDL-receptor class B 20
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912239_228023984600RepeatNote=LDL-receptor class B 21
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912281_232923984600RepeatNote=LDL-receptor class B 22
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912330_237423984600RepeatNote=LDL-receptor class B 23
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-42912375_241623984600RepeatNote=LDL-receptor class B 24
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-4291295_33723984600RepeatNote=LDL-receptor class B 1
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-4291338_38123984600RepeatNote=LDL-receptor class B 2
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-4291382_42523984600RepeatNote=LDL-receptor class B 3
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-4291568_61023984600RepeatNote=LDL-receptor class B 4
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-4291611_65623984600RepeatNote=LDL-receptor class B 5
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-4291657_70623984600RepeatNote=LDL-receptor class B 6
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-4291707_75023984600RepeatNote=LDL-receptor class B 7
TgeneLRP1Bchr18:54305574chr2:141299540ENST00000389484-429125_444423984600Topological domainExtracellular


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FusionGeneSequence for TXNL1_LRP1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TXNL1_ENST00000217515_chr18_54305574_-_LRP1B_ENST00000389484_chr2_141299540_-_2234aa
MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGXXLNLGQGLSSVWLFMTIIYSGRTGEEELYCGPTSTQEEIQKFFVPIFHISQWESXL
LPMTPIAVNFLHVHYXMEAAMTCAFXLPMGEXIVPAEGTEYCXRTTDVXLKIPPATLIRSLNVEMVSALTTSSPVMAFLTVKINQMKNCS
TVKTEAVEEASSHAIIAAAFLMASYVMEKMTAETTLMNXIVKFQPVPRLSSAVQMGLVFQDQHDATRTXIVQMLQMKRTAITQTAHISIS
LEXKPQGSXDVILPHCVFCQPGYATGLMTVETIQMNXSAQFKTNTNVKKIILVVLVEDAFXIPGYAMVRKIVRMDVMNSTVILLALGTNL
LVPHKNVFLSIGFVMEKMTVGMGXMKVTAFVVPXPVLLTCSAARALVPACPDIGFVMVKGTVQMEAMSFPQQAALPIIHVMKMLSCAIIK
YAFPSNLFVTMMTTVEMALMSHRSVDIDSVVQKNLVVLMGGVFXILNGSVMETLTVLTILMKHLXTQSVKVQNSHATVHFLCAKMAGAFP
VEVFATIRMTVAMVQMRETAIXMNVXVRKSVDVLKTVKTFRSVISANAGLDSNXRMTAKHVXTLMNALQAFPVASNASIHTGLTSASVQM
GMKYNLITQMAANRSQMKNLFXFLLIIMRXGKLALMAPTTHFXNRDXTMLLLXTLITEKNSSIGSILADPMAVAXIECVXMEVTLRXFIT
QRSPMHLLSIGLEKTSIGLTQKKESLKYPNSMACTLLYSLAKGXSFPETCLXILKLDICIGLTAASILILAVLEWMEPIRVLSXKPRFLD
LWHXQXIMLIVDSTGPMKITLNLATWMDLIDTKSLIKIFQGXLHXHCLKTTSTGLMGKPSHSAVPIKHREQTDSHXFTHGMPSQISRCII
LIDNLMSPNISAXXIMVVAVICAFXPLEKPTLVHVPLTSIWQLIIGLAYPTAQPASFVAKLTNVFHSGGNVTPWMTVVMDLMNLMTVLNL
DVSQADFSVGLDSVLYQLSSVMERMIVETILMNSTVTHMSACQVNSNVPRTRNVSQXTXDVMGKMTVVMRKMKETVLKTAVLQTISSVRL
RSIAFPSCGFVTRIQTVQMHQTRPTAIKRLVDLMNSSVKTTTVFPITGGVIAKMTAVIIQMKKTVSHRHVHXKISSVPMGTVFLQGFGVM
EILTVQMALMREIVRQVVPKISSGVPMVSVYQQNGNVMAMKTANMGKMRKAVSQLLLLAHHVNIYVPVMDVFQHLXNVMENMIVLMVQMR
WTVXLNVRKISFGAKIKPTVFQLDGCVMEFMTVWMAVMKRTVKEEEIYVELMSSFAIILSANYISGCVMERTTVETTLMKPLICVSNFFV
HPRDLTDAEITEYAYSRSKCAMGLMNAVTIQMKITVVVSXHIKQGLVKRMSLLVVIKNASLWISSVIDLMTAEMVQMSKDAEXLLLNIPV
KIMXIHVEMMHIVIKXKHLFSVAVSLDFRETXKTDNVKTLMNVWCLAHVPINVXMWKDHINVCVTRIFKKEITPAXQKALKIKFSTLLMT
LISWVLYIHSTTVAIINKFLILNIIQEXQGWMYIIKEIXLFGVLSLIQAEFSTKGSMAEKKGKQTVAXFVLNLKGPGTLQLTGWLETFTG
LIILECIGSVTTLLTGPVXGTLSTXGSXMAPTAPDSXQIWLENPMLLQXILKEGXCTGLLLGIIPIXKKQPWMVHXEGFXYKRTYRDPQV
WLWIILVNAYIGLTLSSPSLAVFCMMALIQXSLSAANKVYYIHIGSISLKIIYMEQDLKMVYFEFKNLAMVQXSTXLXILIKQKVFXYLI
VINNXIYPIHAWIXHANFFACXILLGPLVCVQKENIXLMAPAMMTACXMIHVSXLVKMEEDAFXMRKVIXGVTVGPVIQEKDVKSTTVAT
TARMEELAYHQFXGDPPAAVHWVSLGQTVVRQSVRIFVKMEEPALXLLETSLTATASRNTPETDVSTTCATTIVXILNHVPLGMMEVLNV
SVQRAMKDQNVRLTSVXGAMGGTALXIKTVKIYFATALMERLPLAVSYVMATVTMVAHASWTPRQMYLCVYAPPTGQAHSVKGQPQRAAS
LIISAQEALPSLCLSSSWXLXXPPXXLVXCFVKEKEGQKQLEDNLLSMEEXMXKLAIHLITCMRXIMITTMEVFXILALXXTQQRPGTXG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TXNL1_ENST00000217515_chr18_54305574_-_LRP1B_ENST00000389484_chr2_141299540_-_6704nt
ATGGTGGGGGTGAAGCCCGTCGGGAGCGACCCGGATTTCCAGCCAGAGCTGAGCGGCGCGGGCTCCAGACTCGCCGTGGTCAAGTTCACC
ATGAGAGGGTGATAGTTAAATCTGGGCCAGGGACTTTCCTCAGTTTGGCTGTTTATGACAATTATATATTCTGGTCGGACTGGGGAAGAA
GAGCTATACTGCGGTCCAACAAGTACACAGGAGGAGATACAAAAATTCTTCGTTCCGATATTCCACATCAGCCAATGGGAATCATAGCTG
TTGCCAATGACACCAATAGCTGTGAACTTTCTCCATGTGCATTATTGAATGGAGGCTGCCATGACTTGTGCCTTTTAACTCCCAATGGGA
GAGTGAATTGTTCCTGCAGAGGGGACCGAATATTGCTAGAGGACAACAGATGTGTGACTAAAAATTCCTCCTGCAACGCTTATTCGGAGT
TTGAATGTGGAAATGGTGAGTGCATTGACTACCAGCTCACCTGTGATGGCATTCCTCACTGTAAAGATAAATCAGATGAAAAACTGCTCT
ACTGTGAAAACAGAAGCTGTCGAAGAGGCTTCAAGCCATGCTATAATCGCCGCTGCATTCCTCATGGCAAGTTATGTGATGGAGAAAATG
ACTGCGGAGACAACTCTGATGAATTAGATTGTAAAGTTTCAACCTGTGCCACGGTTGAGTTCCGCTGTGCAGATGGGACTTGTATTCCAA
GATCAGCACGATGCAACCAGAACATAGATTGTGCAGATGCTTCAGATGAAAAGAACTGCAATAACACAGACTGCACACATTTCTATAAGC
TTGGAGTGAAAACCACAGGGTTCATAAGATGTAATTCTACCTCACTGTGTGTTCTGCCAACCTGGATATGCGACGGGTCTAATGACTGTG
GAGACTATTCAGATGAATTAAAGTGCCCAGTTCAAAACAAACACAAATGTGAAGAAAATTATTTTAGTTGTCCTAGTGGAAGATGCATTT
TGAATACCTGGATATGCGATGGTCAGAAAGATTGTGAGGATGGACGTGATGAATTCCACTGTGATTCTTCTTGCTCTTGGAACCAATTTG
CTTGTTCCGCACAAAAATGTATTTCTAAGCATTGGATTTGTGATGGAGAAGATGACTGTGGGGATGGGTTAGATGAAAGTGACAGCATTT
GTGGTGCCATAACCTGTGCTGCTGACATGTTCAGCTGCCAGGGCTCTCGTGCCTGCGTGCCCCGACATTGGCTTTGTGATGGTGAAAGGG
ACTGTCCAGATGGAAGCGATGAGCTTTCCACAGCAGGCTGCGCTCCCAATAATACATGTGATGAAAATGCTTTCATGTGCCATAATAAAG
TATGCATTCCCAAGCAATTTGTTTGTGACCATGATGACGACTGTGGAGATGGCTCTGATGAGTCACCGCAGTGTGGATATCGACAGTGTG
GTACAGAAGAATTTAGTTGTGCTGATGGGCGGTGTCTTCTAAATACTCAATGGCAGTGTGATGGAGACTTTGACTGTCCTGACCATTCTG
ATGAAGCACCTTTAAACCCAAAGTGTAAAAGTGCAGAACAGTCATGCAACAGTTCATTTTTTATGTGCAAAAATGGCAGGTGCATTCCCA
GTGGAGGTCTTTGCGACAATAAGGATGACTGTGGCGATGGTTCAGATGAGAGAAACTGCCATATAAATGAATGTTTGAGTAAGAAAGTCA
GTGGATGTTCTCAAGACTGTCAAGACCTTCCGGTCAGTTATAAGTGCAAATGCTGGCCTGGATTCCAACTGAAGGATGACGGCAAAACAT
GTGTAGACATTGATGAATGCTCTTCAGGCTTTCCCTGTAGCCAGCAATGCATCAATACATACGGGACTTACAAGTGCCTCTGTACAGATG
GGTATGAAATACAACCTGATAACCCAAATGGCTGCAAATCGCTCTCAGATGAAGAACCTTTTTTAATTCTTGCTGATCATCATGAGATAA
GGAAAATTAGCACTGATGGCTCCAACTACACACTTTTAAAACAGGGATTAAACAATGTTATTGCTATAGACTTTGATTACAGAGAAGAAT
TCATCTATTGGATCGATTCTAGCCGACCCAATGGCAGTCGCATAAATAGAATGTGTTTAAATGGAAGTGACATTAAGGTAGTTCATAACA
CAGCGGTCCCCAATGCACTTGCTGTCGATTGGATTGGAAAAAACCTCTATTGGTCTGACACAGAAAAAAGAATCATTGAAGTATCCAAAC
TCAATGGCTTGTACCCTACTATACTCGTTAGCAAAAGGCTGAAGTTTCCCAGAGACTTGTCTTTAGATCCTCAAGCTGGATATTTGTATT
GGATTGACTGCTGCGAGTATCCTCATATTGGCCGTGTTGGAATGGATGGAACCAATCAGAGTGTTGTCATAGAAACCAAGATTTCTAGAC
CTATGGCACTAACAATAGATTATGTTAATCGTAGACTCTACTGGGCCGATGAAAATCACATTGAATTTAGCAACATGGATGGATCTCATA
GACACAAAGTCCCTAATCAAGATATTCCAGGGGTGATTGCACTAACATTGTTTGAAGACTACATCTACTGGACTGATGGGAAAACCAAGT
CACTCAGCCGTGCCCATAAAACATCGGGAGCAGACAGACTCTCACTGATTTACTCATGGCATGCCATCACAGATATCCAGGTGTATCATT
CTTATAGACAACCTGATGTCTCCAAACATCTCTGCATGATAAATAATGGTGGTTGCAGTCATTTGTGCCTTTTAGCCCCTGGAAAAACCC
ACACTTGTGCATGTCCCACTAACTTCTATCTGGCAGCTGATAATAGGACTTGCTTATCCAACTGCACAGCCAGCCAGTTTCGTTGCAAAA
CTGACAAATGTATTCCATTCTGGTGGAAATGTGACACCGTGGATGACTGTGGTGATGGATCTGATGAACCTGATGACTGTCCTGAATTTA
GATGTCAGCCAGGCCGATTTCAGTGTGGGACTGGACTCTGTGCTCTACCAGCTTTCATCTGTGATGGAGAGAATGATTGTGGAGACAATT
CTGATGAACTCAACTGTGACACACATGTCTGCCTGTCAGGTCAATTCAAATGTACCAAGAACCAGAAATGTATCCCAGTAAACTTAAGAT
GTAATGGGCAAGATGACTGTGGTGATGAGGAAGATGAAAGAGACTGTCCTGAAAACAGCTGTTCTCCAGACTATTTCCAGTGTAAGACTA
CGAAGCATTGCATTTCCAAGCTGTGGGTTTGTGACGAGGATCCAGACTGTGCAGATGCATCAGACGAGGCCAACTGCGATAAAAAGACTT
GTGGACCTCATGAATTCCAGTGTAAAAACAACAACTGTATTCCCGATCACTGGCGGTGTGATAGCCAAAATGACTGCAGTGATAATTCAG
ATGAAGAAAACTGTAAGCCACAGACATGTACATTGAAAGATTTCCTCTGTGCCAATGGGGACTGTGTTTCTTCAAGGTTTTGGTGTGATG
GAGATTTTGACTGTGCAGATGGCTCTGATGAGAGAAATTGTGAGACAAGTTGTTCCAAAGATCAGTTCCGGTGTTCCAATGGTCAGTGTA
TACCAGCAAAATGGAAATGTGATGGCCATGAAGACTGCAAATATGGGGAAGATGAGAAAAGCTGTGAGCCAGCTTCTCCTACTTGCTCAT
CACGTGAATATATATGTGCCAGTGATGGATGTATTTCAGCATCTTTGAAATGTAATGGAGAATATGATTGTGCTGATGGTTCAGATGAGA
TGGACTGTGTGACTGAATGTAAGGAAGATCAGTTTCGGTGCAAAAATAAAGCCCACTGTATTCCAATTAGATGGCTGTGTGATGGAATTC
ATGACTGTGTGGATGGCAGTGATGAAGAGAACTGTGAAAGAGGAGGAAATATATGTAGAGCTGATGAGTTCCTTTGCAATAATTCTCTCT
GCAAACTACATTTCTGGGTGTGTGATGGAGAGGACGACTGTGGAGACAACTCTGATGAAGCCCCTGATATGTGTGTCAAATTTCTTTGTC
CATCCACGAGACCTCACAGATGCAGAAATAACAGAATATGCCTACAGTCGGAGCAAATGTGCAATGGGATTGATGAATGCGGTGACAATT
CAGATGAAGATCACTGTGGTGGTAAGCTGACATATAAAGCAAGGCCTTGTAAAAAGGATGAGTTTGCTTGTAGTAATAAAAAATGCATCC
CTATGGATCTCCAGTGTGATCGACTTGATGACTGCGGAGATGGTTCAGATGAGCAAGGATGCAGAATAGCTCCTACTGAATATACCTGTG
AAGATAATGTGAATCCATGTGGAGATGATGCATATTGTAATCAAATAAAAACATCTGTTTTCTGTCGCTGTAAGCCTGGATTTCAGAGAA
ACATGAAAAACAGACAATGTGAAGACCTTAATGAATGTTTGGTGTTTGGCACATGTTCCCATCAATGTATAAATGTGGAAGGATCATATA
AATGTGTGTGTGACCAGAATTTTCAAGAAAGAAATAACACCTGCATAGCAGAAGGCTCTGAAGATCAAGTTCTCTACATTGCTAATGACA
CTGATATCCTGGGTTTTATATATCCATTCAACTACAGTGGCGATCATCAACAAATTTCTCATATTGAACATAATTCAAGAATAACAGGGA
TGGATGTATATTATCAAAGAGATATGATTATTTGGAGTACTCAGTTTAATCCAGGCGGAATTTTCTACAAAAGGATCCATGGCAGAGAAA
AAAGGCAAGCAAACAGTGGCTTGATTTGTCCTGAATTTAAAAGGCCCAGGGACATTGCAGTTGACTGGGTGGCTGGAAACATTTACTGGA
CTGATCATTCTAGAATGCATTGGTTCAGTTACTACACTACTCACTGGACCAGTCTGAGGTACTCTATCAACGTAGGGCAGCTGAATGGCC
CCAACTGCACCAGACTCTTAACAAATATGGCTGGAGAACCCTATGCTATTGCAGTAAATCCTAAAAGAGGGATGATGTACTGGACTGTTG
TTGGGGATCATTCCCATATAGAAGAAGCAGCCATGGATGGTACACTGAGAAGGATTTTAGTACAAAAGAACTTACAGAGACCCACAGGTT
TGGCTGTGGATTATTTTAGTGAACGCATATATTGGGCTGACTTTGAGCTCTCCATCATTGGCAGTGTTCTGTATGATGGCTCTAATTCAG
TAGTCTCTGTCAGCAGCAAACAAGGTTTATTACATCCACATAGGATCGATATCTTTGAAGATTATATATATGGAGCAGGACCTAAAAATG
GTGTATTTCGAGTTCAAAAATTTGGCCATGGTTCAGTAGAGTACTTAGCTTTAAATATTGATAAAACAAAAGGTGTTTTGATATCTCATC
GTTATAAACAACTAGATTTACCCAATCCATGCTTGGATTTAGCATGCGAATTTCTTTGCTTGCTAAATCCTTCTGGGGCCACTTGTGTGT
GTCCAGAAGGAAAATATTTGATTAATGGCACCTGCAATGATGACAGCCTGTTAGATGATTCATGTAAGTTAACTTGTGAAAATGGAGGAA
GATGCATTTTAAATGAGAAAGGTGATTTGAGGTGTCACTGTTGGCCCAGTTATTCAGGAGAAAGATGTGAAGTCAACCACTGTAGCAACT
ACTGCCAGAATGGAGGAACTTGCGTACCATCAGTTCTAGGGAGACCCACCTGCAGCTGTGCACTGGGTTTCACTGGGCCAAACTGTGGTA
AGACAGTCTGTGAGGATTTTTGTCAAAATGGAGGAACCTGCATTGTGACTGCTGGAAACCAGCCTTACTGCCACTGCCAGCCGGAATACA
CCGGAGACAGATGTCAGTACTACGTGTGCCACCACTATTGTGTGAATTCTGAATCATGTACCATTGGGGATGATGGAAGTGTTGAATGTG
TCTGTCCAACGCGCTATGAAGGACCAAAATGTGAGGTTGACAAGTGTGTAAGGTGCCATGGGGGGCACTGCATTATAAATAAAGACAGTG
AAGATATATTTTGCAACTGCACTAATGGAAAGATTGCCTCTAGCTGTCAGTTATGTGATGGCTACTGTTACAATGGTGGCACATGCCAGC
TGGACCCCGAGACAAATGTACCTGTGTGTCTATGCTCCACCAACTGGTCAGGCACACAGTGTGAAAGGCCAGCCCCAAAGAGCAGCAAGT
CTGATCATATCAGCACAAGAAGCATTGCCATCATTGTGCCTCTCGTCCTCTTGGTGACTTTGATAACCACCTTAGTAATTGGTTTAGTGC
TTTGTAAAAGAAAAAGAAGGACAAAAACAATTAGAAGACAACCTATTATCAATGGAGGAATAAATGTAGAAATTGGCAATCCATCTTATA
ACATGTATGAGGTAGATCATGATCACAACGATGGAGGTCTTTTAGATCCTGGCTTTATGATAGACCCAACAAAGGCCAGGTACATAGGGG
GAGGACCCAGTGCTTTCAAGCTTCCACACACAGCGCCGCCCATCTACCTAAACTCTGATTTGAAAGGACCACTAACTGCTGGGCCAACAA
ATTACTCCAATCCGGTATATGCAAAATTATATATGGATGGGCAAAACTGTCGAAACTCCTTAGGAAGTGTTGATGAAAGGAAAGAACTGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_TXNL1_ENST00000217515_chr18_54305574_-_LRP1B_ENST00000389484_chr2_141299540_-_8672nt
TCCCCCATCCCTCCCCGCCCCCTCGGCCGCTCCGCTCCCTGGCGTGACTCGGCACTGAGAGTCCCGGGAGAAGACTCGGCGGTCGCCACC
TCTTCTGTCCAGGCCTCGGCCTTCCTGAGCATCTCTCCTTCCTCTCCCAGATCGTCTTCTCCTTCAGTTTCAAAGCCAGTGGCGTCGCGG
CCACCCTGCCGGGCTCTCTGTGAGGATGGTGGGGGTGAAGCCCGTCGGGAGCGACCCGGATTTCCAGCCAGAGCTGAGCGGCGCGGGCTC
CAGACTCGCCGTGGTCAAGTTCACCATGAGAGGGTGATAGTTAAATCTGGGCCAGGGACTTTCCTCAGTTTGGCTGTTTATGACAATTAT
ATATTCTGGTCGGACTGGGGAAGAAGAGCTATACTGCGGTCCAACAAGTACACAGGAGGAGATACAAAAATTCTTCGTTCCGATATTCCA
CATCAGCCAATGGGAATCATAGCTGTTGCCAATGACACCAATAGCTGTGAACTTTCTCCATGTGCATTATTGAATGGAGGCTGCCATGAC
TTGTGCCTTTTAACTCCCAATGGGAGAGTGAATTGTTCCTGCAGAGGGGACCGAATATTGCTAGAGGACAACAGATGTGTGACTAAAAAT
TCCTCCTGCAACGCTTATTCGGAGTTTGAATGTGGAAATGGTGAGTGCATTGACTACCAGCTCACCTGTGATGGCATTCCTCACTGTAAA
GATAAATCAGATGAAAAACTGCTCTACTGTGAAAACAGAAGCTGTCGAAGAGGCTTCAAGCCATGCTATAATCGCCGCTGCATTCCTCAT
GGCAAGTTATGTGATGGAGAAAATGACTGCGGAGACAACTCTGATGAATTAGATTGTAAAGTTTCAACCTGTGCCACGGTTGAGTTCCGC
TGTGCAGATGGGACTTGTATTCCAAGATCAGCACGATGCAACCAGAACATAGATTGTGCAGATGCTTCAGATGAAAAGAACTGCAATAAC
ACAGACTGCACACATTTCTATAAGCTTGGAGTGAAAACCACAGGGTTCATAAGATGTAATTCTACCTCACTGTGTGTTCTGCCAACCTGG
ATATGCGACGGGTCTAATGACTGTGGAGACTATTCAGATGAATTAAAGTGCCCAGTTCAAAACAAACACAAATGTGAAGAAAATTATTTT
AGTTGTCCTAGTGGAAGATGCATTTTGAATACCTGGATATGCGATGGTCAGAAAGATTGTGAGGATGGACGTGATGAATTCCACTGTGAT
TCTTCTTGCTCTTGGAACCAATTTGCTTGTTCCGCACAAAAATGTATTTCTAAGCATTGGATTTGTGATGGAGAAGATGACTGTGGGGAT
GGGTTAGATGAAAGTGACAGCATTTGTGGTGCCATAACCTGTGCTGCTGACATGTTCAGCTGCCAGGGCTCTCGTGCCTGCGTGCCCCGA
CATTGGCTTTGTGATGGTGAAAGGGACTGTCCAGATGGAAGCGATGAGCTTTCCACAGCAGGCTGCGCTCCCAATAATACATGTGATGAA
AATGCTTTCATGTGCCATAATAAAGTATGCATTCCCAAGCAATTTGTTTGTGACCATGATGACGACTGTGGAGATGGCTCTGATGAGTCA
CCGCAGTGTGGATATCGACAGTGTGGTACAGAAGAATTTAGTTGTGCTGATGGGCGGTGTCTTCTAAATACTCAATGGCAGTGTGATGGA
GACTTTGACTGTCCTGACCATTCTGATGAAGCACCTTTAAACCCAAAGTGTAAAAGTGCAGAACAGTCATGCAACAGTTCATTTTTTATG
TGCAAAAATGGCAGGTGCATTCCCAGTGGAGGTCTTTGCGACAATAAGGATGACTGTGGCGATGGTTCAGATGAGAGAAACTGCCATATA
AATGAATGTTTGAGTAAGAAAGTCAGTGGATGTTCTCAAGACTGTCAAGACCTTCCGGTCAGTTATAAGTGCAAATGCTGGCCTGGATTC
CAACTGAAGGATGACGGCAAAACATGTGTAGACATTGATGAATGCTCTTCAGGCTTTCCCTGTAGCCAGCAATGCATCAATACATACGGG
ACTTACAAGTGCCTCTGTACAGATGGGTATGAAATACAACCTGATAACCCAAATGGCTGCAAATCGCTCTCAGATGAAGAACCTTTTTTA
ATTCTTGCTGATCATCATGAGATAAGGAAAATTAGCACTGATGGCTCCAACTACACACTTTTAAAACAGGGATTAAACAATGTTATTGCT
ATAGACTTTGATTACAGAGAAGAATTCATCTATTGGATCGATTCTAGCCGACCCAATGGCAGTCGCATAAATAGAATGTGTTTAAATGGA
AGTGACATTAAGGTAGTTCATAACACAGCGGTCCCCAATGCACTTGCTGTCGATTGGATTGGAAAAAACCTCTATTGGTCTGACACAGAA
AAAAGAATCATTGAAGTATCCAAACTCAATGGCTTGTACCCTACTATACTCGTTAGCAAAAGGCTGAAGTTTCCCAGAGACTTGTCTTTA
GATCCTCAAGCTGGATATTTGTATTGGATTGACTGCTGCGAGTATCCTCATATTGGCCGTGTTGGAATGGATGGAACCAATCAGAGTGTT
GTCATAGAAACCAAGATTTCTAGACCTATGGCACTAACAATAGATTATGTTAATCGTAGACTCTACTGGGCCGATGAAAATCACATTGAA
TTTAGCAACATGGATGGATCTCATAGACACAAAGTCCCTAATCAAGATATTCCAGGGGTGATTGCACTAACATTGTTTGAAGACTACATC
TACTGGACTGATGGGAAAACCAAGTCACTCAGCCGTGCCCATAAAACATCGGGAGCAGACAGACTCTCACTGATTTACTCATGGCATGCC
ATCACAGATATCCAGGTGTATCATTCTTATAGACAACCTGATGTCTCCAAACATCTCTGCATGATAAATAATGGTGGTTGCAGTCATTTG
TGCCTTTTAGCCCCTGGAAAAACCCACACTTGTGCATGTCCCACTAACTTCTATCTGGCAGCTGATAATAGGACTTGCTTATCCAACTGC
ACAGCCAGCCAGTTTCGTTGCAAAACTGACAAATGTATTCCATTCTGGTGGAAATGTGACACCGTGGATGACTGTGGTGATGGATCTGAT
GAACCTGATGACTGTCCTGAATTTAGATGTCAGCCAGGCCGATTTCAGTGTGGGACTGGACTCTGTGCTCTACCAGCTTTCATCTGTGAT
GGAGAGAATGATTGTGGAGACAATTCTGATGAACTCAACTGTGACACACATGTCTGCCTGTCAGGTCAATTCAAATGTACCAAGAACCAG
AAATGTATCCCAGTAAACTTAAGATGTAATGGGCAAGATGACTGTGGTGATGAGGAAGATGAAAGAGACTGTCCTGAAAACAGCTGTTCT
CCAGACTATTTCCAGTGTAAGACTACGAAGCATTGCATTTCCAAGCTGTGGGTTTGTGACGAGGATCCAGACTGTGCAGATGCATCAGAC
GAGGCCAACTGCGATAAAAAGACTTGTGGACCTCATGAATTCCAGTGTAAAAACAACAACTGTATTCCCGATCACTGGCGGTGTGATAGC
CAAAATGACTGCAGTGATAATTCAGATGAAGAAAACTGTAAGCCACAGACATGTACATTGAAAGATTTCCTCTGTGCCAATGGGGACTGT
GTTTCTTCAAGGTTTTGGTGTGATGGAGATTTTGACTGTGCAGATGGCTCTGATGAGAGAAATTGTGAGACAAGTTGTTCCAAAGATCAG
TTCCGGTGTTCCAATGGTCAGTGTATACCAGCAAAATGGAAATGTGATGGCCATGAAGACTGCAAATATGGGGAAGATGAGAAAAGCTGT
GAGCCAGCTTCTCCTACTTGCTCATCACGTGAATATATATGTGCCAGTGATGGATGTATTTCAGCATCTTTGAAATGTAATGGAGAATAT
GATTGTGCTGATGGTTCAGATGAGATGGACTGTGTGACTGAATGTAAGGAAGATCAGTTTCGGTGCAAAAATAAAGCCCACTGTATTCCA
ATTAGATGGCTGTGTGATGGAATTCATGACTGTGTGGATGGCAGTGATGAAGAGAACTGTGAAAGAGGAGGAAATATATGTAGAGCTGAT
GAGTTCCTTTGCAATAATTCTCTCTGCAAACTACATTTCTGGGTGTGTGATGGAGAGGACGACTGTGGAGACAACTCTGATGAAGCCCCT
GATATGTGTGTCAAATTTCTTTGTCCATCCACGAGACCTCACAGATGCAGAAATAACAGAATATGCCTACAGTCGGAGCAAATGTGCAAT
GGGATTGATGAATGCGGTGACAATTCAGATGAAGATCACTGTGGTGGTAAGCTGACATATAAAGCAAGGCCTTGTAAAAAGGATGAGTTT
GCTTGTAGTAATAAAAAATGCATCCCTATGGATCTCCAGTGTGATCGACTTGATGACTGCGGAGATGGTTCAGATGAGCAAGGATGCAGA
ATAGCTCCTACTGAATATACCTGTGAAGATAATGTGAATCCATGTGGAGATGATGCATATTGTAATCAAATAAAAACATCTGTTTTCTGT
CGCTGTAAGCCTGGATTTCAGAGAAACATGAAAAACAGACAATGTGAAGACCTTAATGAATGTTTGGTGTTTGGCACATGTTCCCATCAA
TGTATAAATGTGGAAGGATCATATAAATGTGTGTGTGACCAGAATTTTCAAGAAAGAAATAACACCTGCATAGCAGAAGGCTCTGAAGAT
CAAGTTCTCTACATTGCTAATGACACTGATATCCTGGGTTTTATATATCCATTCAACTACAGTGGCGATCATCAACAAATTTCTCATATT
GAACATAATTCAAGAATAACAGGGATGGATGTATATTATCAAAGAGATATGATTATTTGGAGTACTCAGTTTAATCCAGGCGGAATTTTC
TACAAAAGGATCCATGGCAGAGAAAAAAGGCAAGCAAACAGTGGCTTGATTTGTCCTGAATTTAAAAGGCCCAGGGACATTGCAGTTGAC
TGGGTGGCTGGAAACATTTACTGGACTGATCATTCTAGAATGCATTGGTTCAGTTACTACACTACTCACTGGACCAGTCTGAGGTACTCT
ATCAACGTAGGGCAGCTGAATGGCCCCAACTGCACCAGACTCTTAACAAATATGGCTGGAGAACCCTATGCTATTGCAGTAAATCCTAAA
AGAGGGATGATGTACTGGACTGTTGTTGGGGATCATTCCCATATAGAAGAAGCAGCCATGGATGGTACACTGAGAAGGATTTTAGTACAA
AAGAACTTACAGAGACCCACAGGTTTGGCTGTGGATTATTTTAGTGAACGCATATATTGGGCTGACTTTGAGCTCTCCATCATTGGCAGT
GTTCTGTATGATGGCTCTAATTCAGTAGTCTCTGTCAGCAGCAAACAAGGTTTATTACATCCACATAGGATCGATATCTTTGAAGATTAT
ATATATGGAGCAGGACCTAAAAATGGTGTATTTCGAGTTCAAAAATTTGGCCATGGTTCAGTAGAGTACTTAGCTTTAAATATTGATAAA
ACAAAAGGTGTTTTGATATCTCATCGTTATAAACAACTAGATTTACCCAATCCATGCTTGGATTTAGCATGCGAATTTCTTTGCTTGCTA
AATCCTTCTGGGGCCACTTGTGTGTGTCCAGAAGGAAAATATTTGATTAATGGCACCTGCAATGATGACAGCCTGTTAGATGATTCATGT
AAGTTAACTTGTGAAAATGGAGGAAGATGCATTTTAAATGAGAAAGGTGATTTGAGGTGTCACTGTTGGCCCAGTTATTCAGGAGAAAGA
TGTGAAGTCAACCACTGTAGCAACTACTGCCAGAATGGAGGAACTTGCGTACCATCAGTTCTAGGGAGACCCACCTGCAGCTGTGCACTG
GGTTTCACTGGGCCAAACTGTGGTAAGACAGTCTGTGAGGATTTTTGTCAAAATGGAGGAACCTGCATTGTGACTGCTGGAAACCAGCCT
TACTGCCACTGCCAGCCGGAATACACCGGAGACAGATGTCAGTACTACGTGTGCCACCACTATTGTGTGAATTCTGAATCATGTACCATT
GGGGATGATGGAAGTGTTGAATGTGTCTGTCCAACGCGCTATGAAGGACCAAAATGTGAGGTTGACAAGTGTGTAAGGTGCCATGGGGGG
CACTGCATTATAAATAAAGACAGTGAAGATATATTTTGCAACTGCACTAATGGAAAGATTGCCTCTAGCTGTCAGTTATGTGATGGCTAC
TGTTACAATGGTGGCACATGCCAGCTGGACCCCGAGACAAATGTACCTGTGTGTCTATGCTCCACCAACTGGTCAGGCACACAGTGTGAA
AGGCCAGCCCCAAAGAGCAGCAAGTCTGATCATATCAGCACAAGAAGCATTGCCATCATTGTGCCTCTCGTCCTCTTGGTGACTTTGATA
ACCACCTTAGTAATTGGTTTAGTGCTTTGTAAAAGAAAAAGAAGGACAAAAACAATTAGAAGACAACCTATTATCAATGGAGGAATAAAT
GTAGAAATTGGCAATCCATCTTATAACATGTATGAGGTAGATCATGATCACAACGATGGAGGTCTTTTAGATCCTGGCTTTATGATAGAC
CCAACAAAGGCCAGGTACATAGGGGGAGGACCCAGTGCTTTCAAGCTTCCACACACAGCGCCGCCCATCTACCTAAACTCTGATTTGAAA
GGACCACTAACTGCTGGGCCAACAAATTACTCCAATCCGGTATATGCAAAATTATATATGGATGGGCAAAACTGTCGAAACTCCTTAGGA
AGTGTTGATGAAAGGAAAGAACTGCTTCCAAAGAAAATAGAAATTGGTATAAGAGAGACAGTGGCATAATCAGTGATATCTTTTATATGC
TGTATAAATGTATAAAATATAAGGATTACTTTTGTATGTTCCAACAGTATTATACTTGTTTTGGCATCAGCATTACCTCTTTCTTTATCT
TTTTCCTGGTTAATTGTTTTCTGAGTTTTTTGGGTTTTATTTTTTGCTGATGACTATTGATTGACCATTTGTATGGTATTTTTATGAAAA
AGAACTGCACTACAGTACAATTTACAACAATGCTGCTGATATGACACACCTTTGAATTTGTTAAAATTAAAAACAACGTATTCCTTTGTA
GTGTGAATATGAGCAATCTATTTTATATGAACTTTTTTGGTTGTACTTAATCAACGAGGAGAATCTCTGCACTTTTCCATTATACGGTTT
GAAGGCTGTAATACAGTGTCATATTATTTTTCTGTTTAAATTGATGGAAAAATGATTGAATGGTCAACTCTCTTCTTTGTGCCCATAAAG
ATCGATTCAGACTCTGCTGAAAATATATAGCTCTCACAAGTTCAGCATCACCTGCTTTGAAATTAGCCTTAGATTGCCAACCAATAGATG
AGAATTTTGAGGAAAAAAATTAAAAATATGTAAAATTAATAATTTGCATGAACACAGATGACTACATTTTCCAAAACTTAGTGGACTCTA
TGTGATGTACTAAATGTATACACCTTGTAAGCAATAGTTATATTTAGGTGGTAGAACATAGCAAAAATATAACCGAAAGTTGGCCGACTG
CACTTGCTATGGAATAAGACCTTTTATTCTCCCTCAGTCTCGAGATAAATAGCCAGCCTAGAGCACAACAGGGCATTGGGTACTTGCATC
TTAGGTATTTCTTCCCAGTCACATCCATTTTGTGGAAGATTAACCCAACCCCTTACACTACACTGAACACTAAAGAATAATATATAAGCA
CACAAATTGGTGACAGAATTTCAATTACGTGAACGCATCCTCTTTGCTAGGTCAAAAAACAAAGGGCAAAGCAGACATTTTAGTATACAG
AGTGATTGGCAAATATTTTCAAGATTTAATATGAGCAACCCATTATTTGCCCTATCCAAAATATATTCAAGGGCCTTCCAAGTTGTAGAA
GAACAATGATCTTCCCATAATCAAAAGTGGAGAGTCGAAATGCTGTGCCAGTTGCTCTGGTATTCAGGTTTCTCTGGGTTTTACAGAACG
CATGGACCCCATTCACGTTTGGTTTGTTTATCTTCAAATTTGAGTTGAAACGAGTGCGATTTATTTAAGTTGTATATAAAAATAAAAGGA
TAGCATTTTTATACAAATATCTTTAAAGGCACAAAAGATTTATTCACAAGTTTTGGAGGGCTTTTTGTTCCTCTGATAGACATGACTGAC
TTTTAGCTGTCATAATGTATTAACCTAACAGATGAAATATGTTAAATATGTGGTTGCTCTTTATCCCTTTGTACAAGCATTAAAAAAACT
GCTGTTTTATAAGAAGACTTTTTGTTGTACTATGTGCATGCATACTACCTATTTCTAAACTTTGCCATATTGAGGCCTTTATAAACTATT
GATTTATGTAATACTAGTGCAATTTTGCTTGAACAATGTTATGCATATCATAAACTTTTTCAGGTTCTTGTTTAAGTACATTTTTTAAAT
TGAACAGTATTTTTCATTTTGGTTATAATATAGTCATTTTGCCTATGTTTCTACAATGAAGTGTTAAATACTTTATAAAAAATTGTTGAC


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FusionGenePPI for TXNL1_LRP1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TXNL1UCHL5, USP14, UBC, SH3BP4, PSMA6, PSMD14, RAD23A, PSMA1, PSMD7, PSMD4, PSMC3, EEF1A1, UBE3A, DDX39B, USP5, ATP6V1A, TXNDC17, VCL, USP7, XPOT, URM1, UBE2H, LACTB2, USP16, PDIA6, MINA, P4HB, CCT5, CSE1L, CCT2, CCT4, ADRM1, FLNB, NCAPD2, PSMC1, PSMC2, PSMC6, PSMD12, PSMD1, PSMD3, PSMD8, SQSTM1, KIAA0368, FLNC, KCMF1, PPP1R2P4, PSMD13, PSMD2, SHFM1, HSPB1, UNK, CORO1B, DHX9, LSM7, SFN, DNAJC10, NTRK1, BTRC, TXNIPLRP1BARRB1, CUL4B, TAZ, RSPO1, SFRP4, PTPRK, FOXD4L6, ZFP41, EWSR1, LRPAP1, ZNF408, ZNF224, ZNF331, FAM19A3, ZNF563, ZNF517, ZNF169, SCGB1D1, DNAJC10, CHRDL1, OLFM3, EGFL6, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TXNL1_LRP1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TXNL1_LRP1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLRP1BC0007134Renal Cell Carcinoma1CTD_human
TgeneLRP1BC0025202melanoma1CTD_human