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Fusion gene ID: 40203 |
FusionGeneSummary for TXNDC5_RREB1 |
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Fusion gene information | Fusion gene name: TXNDC5_RREB1 | Fusion gene ID: 40203 | Hgene | Tgene | Gene symbol | TXNDC5 | RREB1 | Gene ID | 81567 | 6239 |
Gene name | thioredoxin domain containing 5 | ras responsive element binding protein 1 | |
Synonyms | ENDOPDI|ERP46|HCC-2|HCC2|PDIA15|STRF8|UNQ364 | FINB|HNT|LZ321|RREB-1|Zep-1 | |
Cytomap | 6p24.3 | 6p24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | thioredoxin domain-containing protein 5ER protein 46endoplasmic reticulum protein ERp46endoplasmic reticulum resident protein 46endothelial protein disulphide isomeraseprotein disulfide isomerase family A, member 15thioredoxin domain containing 5 (e | ras-responsive element-binding protein 1DNA-binding proteinfinger protein in nuclear bodieshindsight homolograf-responsive zinc finger protein LZ321zinc finger motif enhancer-binding protein 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8NBS9 | Q92766 | |
Ensembl transtripts involved in fusion gene | ENST00000539054, ENST00000379757, ENST00000473453, | ENST00000379933, ENST00000379938, ENST00000334984, ENST00000349384, | |
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 9 X 7 X 4=252 |
# samples | 6 | 9 | |
** MAII score | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TXNDC5 [Title/Abstract] AND RREB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RREB1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 8816445 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-EJ-7782-01A | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000539054 | ENST00000379933 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
5CDS-5UTR | ENST00000539054 | ENST00000379938 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
5CDS-5UTR | ENST00000539054 | ENST00000334984 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
5CDS-5UTR | ENST00000539054 | ENST00000349384 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
5CDS-5UTR | ENST00000379757 | ENST00000379933 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
5CDS-5UTR | ENST00000379757 | ENST00000379938 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
5CDS-5UTR | ENST00000379757 | ENST00000334984 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
5CDS-5UTR | ENST00000379757 | ENST00000349384 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
5CDS-5UTR | ENST00000473453 | ENST00000379933 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
5CDS-5UTR | ENST00000473453 | ENST00000379938 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
5CDS-5UTR | ENST00000473453 | ENST00000334984 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
5CDS-5UTR | ENST00000473453 | ENST00000349384 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
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FusionProtFeatures for TXNDC5_RREB1 |
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Hgene | Tgene |
TXNDC5 | RREB1 |
Possesses thioredoxin activity. Has been shown to reduceinsulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TXNDC5_RREB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TXNDC5_RREB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TXNDC5 | CUL3, DCUN1D1, APP, VCP, TRMT1, TWF1, CSE1L, DBN1, ZNF706, NENF, ZNHIT2, TBCB, HSP90AA1, PRPF4, NDUFB11, UBXN1, UNC45A, PPP1R21, ZNF207, ATP6V1A, HDAC2, HDAC10, GNAI3, ALDOC, BZW1, LDHB, PGD, TGM2, UBE2V1, YWHAG, YWHAQ, TRIM23, EFEMP1, TRIP6, BLZF1, KRT38, SPRY2, GMPPB, KRTAP4-12, KRTAP4-2, LHX4, KRT40, ALS2CR12, MGAT5B, TRIM42, KRTAP10-7, KRTAP10-9, KRTAP10-5, KRTAP10-8, KRTAP10-3, NOTCH2NL, CUL7, EED, SPTB, WDR59, IMPDH1, KLHL26, VRK3, JMJD8, RNF20, RNF40, GDI2, RPA2, SND1, NTRK1, TCTN3, TCTN1, RAB3IP, RBPJ, FOXN1, PTPRN, DUSP13, MTMR8, PTPN2, PTPN5, PTPRA, DCAF7, RNF157 | RREB1 | KDM1A, CTBP1, AR, HIST3H3, HDAC2, HDAC3, HDAC1, BLM, SNCA, SPATA20, ARL6, NEK7, TOR1AIP2, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TXNDC5_RREB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TXNDC5_RREB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TXNDC5 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Hgene | TXNDC5 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | TXNDC5 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | TXNDC5 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | TXNDC5 | C0993582 | Arthritis, Experimental | 1 | CTD_human |