FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 40202

FusionGeneSummary for TXNDC5_PXK

check button Fusion gene summary
Fusion gene informationFusion gene name: TXNDC5_PXK
Fusion gene ID: 40202
HgeneTgene
Gene symbol

TXNDC5

PXK

Gene ID

81567

54899

Gene namethioredoxin domain containing 5PX domain containing serine/threonine kinase like
SynonymsENDOPDI|ERP46|HCC-2|HCC2|PDIA15|STRF8|UNQ364MONAKA|SLOB
Cytomap

6p24.3

3p14.3

Type of geneprotein-codingprotein-coding
Descriptionthioredoxin domain-containing protein 5ER protein 46endoplasmic reticulum protein ERp46endoplasmic reticulum resident protein 46endothelial protein disulphide isomeraseprotein disulfide isomerase family A, member 15thioredoxin domain containing 5 (ePX domain-containing protein kinase-like proteinPX ser/thr kinase v2PX serine/threonine kinasemodulator of Na,K-ATPase long form
Modification date2018052320180523
UniProtAcc

Q8NBS9

Q7Z7A4

Ensembl transtripts involved in fusion geneENST00000539054, ENST00000379757, 
ENST00000473453, 
ENST00000356151, 
ENST00000302779, ENST00000383716, 
ENST00000463280, ENST00000383715, 
ENST00000484288, ENST00000479241, 
ENST00000536660, 
Fusion gene scores* DoF score5 X 5 X 2=503 X 3 X 1=9
# samples 65
** MAII scorelog2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/9*10)=2.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TXNDC5 [Title/Abstract] AND PXK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF445488TXNDC5chr6

7894980

+PXKchr3

58382850

-
ChiTaRS3.1AW290957TXNDC5chr6

7894980

+PXKchr3

58382850

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000539054ENST00000356151TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000539054ENST00000302779TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000539054ENST00000383716TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000539054ENST00000463280TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000539054ENST00000383715TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000539054ENST00000484288TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000539054ENST00000479241TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000539054ENST00000536660TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000379757ENST00000356151TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000379757ENST00000302779TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000379757ENST00000383716TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000379757ENST00000463280TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000379757ENST00000383715TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000379757ENST00000484288TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000379757ENST00000479241TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000379757ENST00000536660TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000473453ENST00000356151TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000473453ENST00000302779TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000473453ENST00000383716TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000473453ENST00000463280TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000473453ENST00000383715TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000473453ENST00000484288TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000473453ENST00000479241TXNDC5chr6

7894980

+PXKchr3

58382850

-
intron-3CDSENST00000473453ENST00000536660TXNDC5chr6

7894980

+PXKchr3

58382850

-

Top

FusionProtFeatures for TXNDC5_PXK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TXNDC5

Q8NBS9

PXK

Q7Z7A4

Possesses thioredoxin activity. Has been shown to reduceinsulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TXNDC5_PXK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TXNDC5_PXK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TXNDC5_PXK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TXNDC5_PXK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTXNDC5C0003873Rheumatoid Arthritis1CTD_human
HgeneTXNDC5C0027627Neoplasm Metastasis1CTD_human
HgeneTXNDC5C0033578Prostatic Neoplasms1CTD_human
HgeneTXNDC5C0036341Schizophrenia1PSYGENET
HgeneTXNDC5C0993582Arthritis, Experimental1CTD_human
TgenePXKC0003873Rheumatoid Arthritis1CTD_human
TgenePXKC0024141Lupus Erythematosus, Systemic1CTD_human