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Fusion gene ID: 40200 |
FusionGeneSummary for TXNDC5_BMP6 |
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Fusion gene information | Fusion gene name: TXNDC5_BMP6 | Fusion gene ID: 40200 | Hgene | Tgene | Gene symbol | TXNDC5 | BMP6 | Gene ID | 81567 | 654 |
Gene name | thioredoxin domain containing 5 | bone morphogenetic protein 6 | |
Synonyms | ENDOPDI|ERP46|HCC-2|HCC2|PDIA15|STRF8|UNQ364 | VGR|VGR1 | |
Cytomap | 6p24.3 | 6p24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | thioredoxin domain-containing protein 5ER protein 46endoplasmic reticulum protein ERp46endoplasmic reticulum resident protein 46endothelial protein disulphide isomeraseprotein disulfide isomerase family A, member 15thioredoxin domain containing 5 (e | bone morphogenetic protein 6VG-1-RVG-1-related proteinvegetal related growth factor (TGFB-related) | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8NBS9 | P22004 | |
Ensembl transtripts involved in fusion gene | ENST00000539054, ENST00000379757, ENST00000473453, | ENST00000283147, | |
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 3 X 3 X 2=18 |
# samples | 6 | 3 | |
** MAII score | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TXNDC5 [Title/Abstract] AND BMP6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | BMP6 | GO:0003323 | type B pancreatic cell development | 11865031 |
Tgene | BMP6 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 17244894|19366699 |
Tgene | BMP6 | GO:0030501 | positive regulation of bone mineralization | 18436533 |
Tgene | BMP6 | GO:0030509 | BMP signaling pathway | 18436533 |
Tgene | BMP6 | GO:0032349 | positive regulation of aldosterone biosynthetic process | 16527843 |
Tgene | BMP6 | GO:0045669 | positive regulation of osteoblast differentiation | 18436533 |
Tgene | BMP6 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16527843 |
Tgene | BMP6 | GO:0050679 | positive regulation of epithelial cell proliferation | 11865031 |
Tgene | BMP6 | GO:0060395 | SMAD protein signal transduction | 17244894 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF924220 | TXNDC5 | chr6 | 7882394 | + | BMP6 | chr6 | 7881967 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000539054 | ENST00000283147 | TXNDC5 | chr6 | 7882394 | + | BMP6 | chr6 | 7881967 | - |
intron-intron | ENST00000379757 | ENST00000283147 | TXNDC5 | chr6 | 7882394 | + | BMP6 | chr6 | 7881967 | - |
intron-intron | ENST00000473453 | ENST00000283147 | TXNDC5 | chr6 | 7882394 | + | BMP6 | chr6 | 7881967 | - |
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FusionProtFeatures for TXNDC5_BMP6 |
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Hgene | Tgene |
TXNDC5 | BMP6 |
Possesses thioredoxin activity. Has been shown to reduceinsulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity). {ECO:0000250}. | Induces cartilage and bone formation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TXNDC5_BMP6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TXNDC5_BMP6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TXNDC5_BMP6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TXNDC5_BMP6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TXNDC5 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Hgene | TXNDC5 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | TXNDC5 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | TXNDC5 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | TXNDC5 | C0993582 | Arthritis, Experimental | 1 | CTD_human |
Tgene | BMP6 | C0018995 | Hemochromatosis | 2 | CTD_human |
Tgene | BMP6 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Tgene | BMP6 | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
Tgene | BMP6 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | BMP6 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |