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Fusion gene ID: 402 |
FusionGeneSummary for ACO2_AHRR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACO2_AHRR | Fusion gene ID: 402 | Hgene | Tgene | Gene symbol | ACO2 | AHRR | Gene ID | 50 | 57491 |
| Gene name | aconitase 2 | aryl-hydrocarbon receptor repressor | |
| Synonyms | ACONM|HEL-S-284|ICRD|OCA8|OPA9 | AHH|AHHR|bHLHe77 | |
| Cytomap | 22q13.2 | 5p15.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | aconitate hydratase, mitochondrialaconitase 2, mitochondrialcitrate hydro-lyaseepididymis secretory sperm binding protein Li 284mitochondrial aconitase | aryl hydrocarbon receptor repressorahR repressoraryl hydrocarbon hydroxylase regulatorclass E basic helix-loop-helix protein 77dioxin receptor repressor | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q99798 | A9YTQ3 | |
| Ensembl transtripts involved in fusion gene | ENST00000216254, ENST00000396512, ENST00000466237, | ENST00000505113, ENST00000316418, ENST00000512529, ENST00000515206, ENST00000506456, | |
| Fusion gene scores | * DoF score | 12 X 4 X 8=384 | 6 X 4 X 4=96 |
| # samples | 12 | 7 | |
| ** MAII score | log2(12/384*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ACO2 [Title/Abstract] AND AHRR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACO2 | GO:0006099 | tricarboxylic acid cycle | 9630632 |
| Hgene | ACO2 | GO:0006101 | citrate metabolic process | 9630632 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-EB-A5KH-06A | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000216254 | ENST00000505113 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
| In-frame | ENST00000216254 | ENST00000316418 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
| 5CDS-5UTR | ENST00000216254 | ENST00000512529 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
| 5CDS-intron | ENST00000216254 | ENST00000515206 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
| 5CDS-intron | ENST00000216254 | ENST00000506456 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
| In-frame | ENST00000396512 | ENST00000505113 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
| In-frame | ENST00000396512 | ENST00000316418 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
| 5CDS-5UTR | ENST00000396512 | ENST00000512529 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
| 5CDS-intron | ENST00000396512 | ENST00000515206 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
| 5CDS-intron | ENST00000396512 | ENST00000506456 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
| intron-3CDS | ENST00000466237 | ENST00000505113 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
| intron-3CDS | ENST00000466237 | ENST00000316418 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
| intron-5UTR | ENST00000466237 | ENST00000512529 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
| intron-intron | ENST00000466237 | ENST00000515206 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
| intron-intron | ENST00000466237 | ENST00000506456 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
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FusionProtFeatures for ACO2_AHRR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACO2 | AHRR |
| Catalyzes the isomerization of citrate to isocitrate viacis-aconitate. {ECO:0000250|UniProtKB:P16276}. | Mediates dioxin toxicity and is involved in regulationof cell growth and differentiation. Represses the transcriptionactivity of AHR by competing with this transcription factor forheterodimer formation with the ARNT and subsequently binding tothe xenobiotic response element (XRE) sequence present in thepromoter regulatory region of variety of genes. Represses CYP1A1by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/orHDAC5. Autoregulates its expression by associating with its ownXRE site. {ECO:0000269|PubMed:17890447,ECO:0000269|PubMed:18172554}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >AHRR | chr22:41865186 | chr5:422844 | ENST00000316418 | + | 4 | 12 | 551_701 | 151 | 720 | Region | Needed for transcriptional repression |
| Tgene | >AHRR | chr22:41865186 | chr5:422844 | ENST00000505113 | + | 4 | 11 | 551_701 | 151 | 702 | Region | Needed for transcriptional repression |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ACO2 | chr22:41865186 | chr5:422844 | ENST00000216254 | + | 1 | 18 | 192_194 | 12 | 781 | Region | Substrate binding |
| Hgene | >ACO2 | chr22:41865186 | chr5:422844 | ENST00000216254 | + | 1 | 18 | 670_671 | 12 | 781 | Region | Substrate binding |
| Tgene | AHRR | chr22:41865186 | chr5:422844 | ENST00000316418 | + | 4 | 12 | 112_182 | 151 | 720 | Domain | PAS |
| Tgene | AHRR | chr22:41865186 | chr5:422844 | ENST00000316418 | + | 4 | 12 | 28_81 | 151 | 720 | Domain | bHLH |
| Tgene | AHRR | chr22:41865186 | chr5:422844 | ENST00000505113 | + | 4 | 11 | 112_182 | 151 | 702 | Domain | PAS |
| Tgene | AHRR | chr22:41865186 | chr5:422844 | ENST00000505113 | + | 4 | 11 | 28_81 | 151 | 702 | Domain | bHLH |
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FusionGeneSequence for ACO2_AHRR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ACO2_ENST00000216254_chr22_41865186_+_AHRR_ENST00000505113_chr5_422844_+_563aa MAPYSLLVTRLQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRV RCLLDSTSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAATADAKVKATTSLCESEL HGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPLPWTAG KHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQHQLPQP GAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQQVYIS HLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKREPLDSPQWATHSQGMVPG >In-frame_ACO2_ENST00000216254_chr22_41865186_+_AHRR_ENST00000316418_chr5_422844_+_581aa MAPYSLLVTRLQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRV RCLLDSTSGFLARGSQAWQLRLCCPEPLMTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTA ATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGV TGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVH PPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATFP TRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKR >In-frame_ACO2_ENST00000396512_chr22_41865186_+_AHRR_ENST00000505113_chr5_422844_+_563aa MAPYSLLVTRLQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRV RCLLDSTSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAATADAKVKATTSLCESEL HGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPLPWTAG KHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQHQLPQP GAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQQVYIS HLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKREPLDSPQWATHSQGMVPG >In-frame_ACO2_ENST00000396512_chr22_41865186_+_AHRR_ENST00000316418_chr5_422844_+_581aa MAPYSLLVTRLQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRV RCLLDSTSGFLARGSQAWQLRLCCPEPLMTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTA ATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGV TGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVH PPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATFP TRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ACO2_ENST00000216254_chr22_41865186_+_AHRR_ENST00000505113_chr5_422844_+_1689nt ATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTACATCCACGTGGACGACCGCCAG GACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGACAGGAGATGATGCTATC CTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGACCCGCTGCTTCATCTGCCGTGTG CGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCG TCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGC GCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTG CATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCA CAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAG GAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGA AAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTG CCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGC AGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCT GGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCG ACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTG GGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCG CACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACAC TGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACC TGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGG >In-frame_ACO2_ENST00000216254_chr22_41865186_+_AHRR_ENST00000316418_chr5_422844_+_1743nt ATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTACATCCACGTGGACGACCGCCAG GACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGACAGGAGATGATGCTATC CTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGACCCGCTGCTTCATCTGCCGTGTG CGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGGCCCGGGGGTCACAGGCTTGGCAGCTGCGGCTCTGCTGTCCCGAGCCACTCATGACG ATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTC TGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCA GCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGC AGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGG GGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTG ACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAG CCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCG CCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCAC CCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATG GAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAG GACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCT ACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCAT GGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAG TCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGG GAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCG >In-frame_ACO2_ENST00000396512_chr22_41865186_+_AHRR_ENST00000505113_chr5_422844_+_1689nt ATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTACATCCACGTGGACGACCGCCAG GACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGACAGGAGATGATGCTATC CTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGACCCGCTGCTTCATCTGCCGTGTG CGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCG TCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGC GCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTG CATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCA CAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAG GAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGA AAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTG CCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGC AGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCT GGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCG ACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTG GGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCG CACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACAC TGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACC TGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGG >In-frame_ACO2_ENST00000396512_chr22_41865186_+_AHRR_ENST00000316418_chr5_422844_+_1743nt ATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTACATCCACGTGGACGACCGCCAG GACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGACAGGAGATGATGCTATC CTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGACCCGCTGCTTCATCTGCCGTGTG CGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGGCCCGGGGGTCACAGGCTTGGCAGCTGCGGCTCTGCTGTCCCGAGCCACTCATGACG ATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTC TGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCA GCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGC AGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGG GGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTG ACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAG CCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCG CCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCAC CCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATG GAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAG GACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCT ACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCAT GGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAG TCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGG GAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ACO2_ENST00000216254_chr22_41865186_+_AHRR_ENST00000505113_chr5_422844_+_1734nt CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTA CATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTT GGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGAC CCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTT TGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGC AGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCAC CAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACA GACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGG GGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAA GCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCC CATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAG TGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCT GCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCC TCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTG TGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTC TCGGCAACAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCT GACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGG CCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCA CAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATA >In-frame_ACO2_ENST00000216254_chr22_41865186_+_AHRR_ENST00000316418_chr5_422844_+_5222nt CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTA CATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTT GGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGAC CCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGGCCCGGGGGTCACAGGCTTGGCAGCTGCGGCTCTG CTGTCCCGAGCCACTCATGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCT CCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGC AAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAA TTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAG GGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGAT GCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGA TGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGT CCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGA TGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTT TGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGA TGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAG GAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCGCACCTGGGGCACGG CGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGA GCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGA GGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAG TGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATAGCGCAGTGACCACCATCCAAGCTCAGATCTGTGTGT CTACGCTCAGATGCGTCGGTGGCTGGGCTGCCCTGCTCCTGGTCAGGCCGGAGCCCGTCCTAAGACACACGCTTTGCAGAGCTGTGCATG CGCAGTCTGCTAGTGTGTGTGTGCAGCATACGCAGGAGCCTATCCTGAATTTTGTAAAATATCCCAACAGTTCTTAAATGAAAACTGGCC TTAAGTCTATTCAAGCATGACAGCATTTCTCTTTGAGGAATTAAAATCTTTAGGAAAGTGATCATGGCTGGACAGCTTCATGCCCCAGAG GCAGCGAGCACCCGTCCCATGGCTGCCAAGTCCACAGTCGGGGATGAAGCAGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGC GGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCGGGTGACACACCTAGCTCAGCCCTCCCAGGCCACCTGCAGCTCCCA GCCTGTGCTGTGCAGGCAGGGTCAGCCCATCGCCACAGTGCACTGTAGAGGCCAGCACACGGCAAATTAGAAATACAACACGCGGAGAAA GGGGTCCGTGAGCCCACTCATAGAGGAATCTAGAACGTTCCAGGCAGCAGAGGCTGGCAGCGTGGGTCCCACACTGCCCCACACCGTGCG GCAGGTGCTCCATGGCGCCATGACAGAGTCTGAGGCCAGACCTGGACTGGAATTGACAGCATAACCCCTGTTCCTTCTGGACATCTCCCG AGTTCTCAGTGGGTCTCTGCGGACGGTTCTTCCTAATCTGCCTCTTGGTACATCACGTAATACAGAGTTCACAGACTCCGGGTTTGGAAG TACAGAGAAACACACAACGTAGAGAGAAGACACAGGAAACTGCGCTGCCTGTGGGGGTTTCTCTCTGGCTGGCTGTACAGTTCACTCAAA TGAGGGTTCCCATTGCCATCCTAGGAGAATAATTAGGGACAAGACAGACAAGTATTAATAGCATTAAAACAGTTGTAAAGGCGATATTTT CTGAGAGTAGGAAATTTGGATACAAAAGCATAAGTCAGAAAGTGAAGGTCACCAATCCACCAACCCGAGAACCTACAGCTGATGGTGCAT TTCAGGCTTCTTCCACGGTCTGGCCTGGAACCCCACCCGGCTGGTGCAGGCATCAGATCAGGGTGTAGAAGTCACCCCAAGCAAGAGGAA GCCAGGCAGTGAGGCCCTGGGGTGTGGCTGCAGCTGGGCCCACCTGTGCGGGGGTGGGAAGGCCCCATCCTCAGGGAGAGGGCATCGGCG CCCTGACGTCAGCTCCACTGGGAGTGGCAGGAGCTGTGGGAGCCCATGGGTGAGGGACCCACCACCCCGCTGCACTGTGCATTGTGCCTC CCGTGTGGACGCCCTCTCTGTTGTTGGCCCGCGGGTGAGGGACCCACCACCCCTAGGGACCCACCACCCCGCCGCACTGTGCATTCTGCC TCCTGTGTGGACGCCCTCTCTGTTGTCAGTGGCTTTGAGGTGTCAGTGCTTACTTAGATGCTGGTTTAATGCTGGACCCATTTGTTAAAC GCACCTTCACTTTGTCAAAACCCAGGTTTGGTTGGCAGGACTGGGTCTTCTGCCCAATGCCAGGTGCCTGCGCCTCTCAGTGGCCTGGTT CTTGGACAGTTTGCCCCCATGTGGCAGGGATAGGGATAAGGATCTCCTCTCAGTACTGGAAGAGAACAGCCAACCATCTGAGCCCAGAGT CACAGATCCATCGTGGCCCCCTATGACCCCCAAGCCCTACCGAGGGGGCACTCACTCTCTGCTTAGCCAGGGGGCGTCTTTCAAAAGGTG ACCTCCATGCTGTGCTGTCGTGGGTGTGAGACGTGCTCATGGCCTTCCACTGCCATCTCTCCCTTATCTGATGCCTAAAGTCACGATGGG GACAGAGCTACCCAGGGGCCAGCCATGGGGTGACCAGCCACCTGAGGGTCAGTCACCTGTGGAGAGCAGGCACCTGTGAAGACCAGGCAC CTGAGGACTGGCGCCTACTTCCCACTTTGGCCCTACACTGGCACAGAGCCCCTCTTTATTCATTTCTCATGCTGAGCATGGCACACTTCT GGCCTCTGGGCATTTATGGATTTAAGACCAGGATGGTATTTCAGAAGCTTCCCACTTCCTTCCTATTCTAACCGAGTGCCCAGCTCCTTT GCTGATCATGGAAAGACCCTTAATAATTAGGCCTGCAGGCCAGGCGCAGTGGCTCATGCCTATAATCCCAGCACTTTAGGAGGTCAAGGT AGGAGGATCGCTTAAGCCCAGGAGTTCAAGACCAGCCTGGGCAACACAGGAAGAATGTGTCTCTACAAAAAATAATTAAAAATCAGATCT GCTGTATCCCTGAAAAAGTCTCAATCAACATGCATGTTCCACTCTTGGAGTTCCCTGTTCTGAGGGCCAGCCACGTCCTGTGTCCTGGAG CTTAGCCCTCAGCAGCTCCCTTCAGCCTGGGCGCCGCCTGGGTCCCAAACGTGGCAGCTGCTCTTCCAGTCTCGGGGCCGAGGAGGGCAG GGAGCTCAGTGACTGAGAGTCTTGTGTATCACATGTCTTGAGTGTCCTGGAGCCAACGGCTGTCACTGGGAAAAACACCAGGCCCCAAAG ATCGAATCAGAGACGTGGCTGCGTGTTTGCGATTGTAGCCAGGCCCTTCAGTGTCATCAAAGGAGCACTGGGGCCTCCTTAAGCACAGAC GGCAGCCCCTGCCCAGGAGGCTTCTTCACCACGTCCTGCCCTGCAGCCTCCCAGACCTTTAGATGCGCCCCTGCCCAAGGCCCTCCTGGT GACAGGTGCCAGATTGAGTGGTGGGTTGCTGCCAGGCAGGCCACGCTGTGTTGACGCTGCACTCAGCACGTGGGTGTTGGCTCTGCCGGT TTTGTGGTGTGGGGACCCTACAGGAGGCTGCGGCCCTGAGAGCCTGGGATCAGCGAGGTGTCCGACATCCCTTCCTCAACGGCAACAAAA ACTCCCCAAGTCAGCACTTTGGTTATTTTATAGCCACAACCCTCTTGGAAAACAGTGGGGAAGACTATGGAACATAGAAAGTGTGGATGT ATCACTTCTCTCTAAAATGTCATTGTTAGCACTAATTACAGGTTCATGTTTTTCTGTGTATGTAGCTTTTCCCTATATAGCTGAAAAAGT ATTAAAGTCAAATATAAGGTGGGAATGGGATGGAAGGGAGGAGATCAATACAACTTATATTTTTGCAGTTTCTACTGGAAGAAAAAAGTT TTCAATACCTAGACCAACTTGTTGAATTTTTAAAACTTATGCACTATAAATGCAACTTTCTCTACTGCTTTCTCAGTGCCTTTAGGAAGC TTTCAAATTTTTTTGTACTGTGGTTTGTATTAAATTTGCAATATTGATGTAAAATACATGACATGCTAGTACATGTTTAACAAAAATTTA >In-frame_ACO2_ENST00000396512_chr22_41865186_+_AHRR_ENST00000505113_chr5_422844_+_1729nt CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTACATCC ACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGA CAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGACCCGCT GCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGAC AGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGG AGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTC TGTGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTG ACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCT CAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCC TGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGC CCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCT ACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGC ACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGG GGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGC CCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGC AACAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCC CTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAG GTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCC AGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATAGCGCA >In-frame_ACO2_ENST00000396512_chr22_41865186_+_AHRR_ENST00000316418_chr5_422844_+_5217nt CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTACATCC ACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGA CAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGACCCGCT GCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGGCCCGGGGGTCACAGGCTTGGCAGCTGCGGCTCTGCTGTC CCGAGCCACTCATGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGC CGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAAC CCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAATTACT CAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCC CATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGA GCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTG CCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGG GCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCG GTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCA CGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGT CCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCC ACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCGCACCTGGGGCACGGCGTGC GGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCA CAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCG CCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCT TGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATAGCGCAGTGACCACCATCCAAGCTCAGATCTGTGTGTCTACG CTCAGATGCGTCGGTGGCTGGGCTGCCCTGCTCCTGGTCAGGCCGGAGCCCGTCCTAAGACACACGCTTTGCAGAGCTGTGCATGCGCAG TCTGCTAGTGTGTGTGTGCAGCATACGCAGGAGCCTATCCTGAATTTTGTAAAATATCCCAACAGTTCTTAAATGAAAACTGGCCTTAAG TCTATTCAAGCATGACAGCATTTCTCTTTGAGGAATTAAAATCTTTAGGAAAGTGATCATGGCTGGACAGCTTCATGCCCCAGAGGCAGC GAGCACCCGTCCCATGGCTGCCAAGTCCACAGTCGGGGATGAAGCAGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCG GGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCGGGTGACACACCTAGCTCAGCCCTCCCAGGCCACCTGCAGCTCCCAGCCTG TGCTGTGCAGGCAGGGTCAGCCCATCGCCACAGTGCACTGTAGAGGCCAGCACACGGCAAATTAGAAATACAACACGCGGAGAAAGGGGT CCGTGAGCCCACTCATAGAGGAATCTAGAACGTTCCAGGCAGCAGAGGCTGGCAGCGTGGGTCCCACACTGCCCCACACCGTGCGGCAGG TGCTCCATGGCGCCATGACAGAGTCTGAGGCCAGACCTGGACTGGAATTGACAGCATAACCCCTGTTCCTTCTGGACATCTCCCGAGTTC TCAGTGGGTCTCTGCGGACGGTTCTTCCTAATCTGCCTCTTGGTACATCACGTAATACAGAGTTCACAGACTCCGGGTTTGGAAGTACAG AGAAACACACAACGTAGAGAGAAGACACAGGAAACTGCGCTGCCTGTGGGGGTTTCTCTCTGGCTGGCTGTACAGTTCACTCAAATGAGG GTTCCCATTGCCATCCTAGGAGAATAATTAGGGACAAGACAGACAAGTATTAATAGCATTAAAACAGTTGTAAAGGCGATATTTTCTGAG AGTAGGAAATTTGGATACAAAAGCATAAGTCAGAAAGTGAAGGTCACCAATCCACCAACCCGAGAACCTACAGCTGATGGTGCATTTCAG GCTTCTTCCACGGTCTGGCCTGGAACCCCACCCGGCTGGTGCAGGCATCAGATCAGGGTGTAGAAGTCACCCCAAGCAAGAGGAAGCCAG GCAGTGAGGCCCTGGGGTGTGGCTGCAGCTGGGCCCACCTGTGCGGGGGTGGGAAGGCCCCATCCTCAGGGAGAGGGCATCGGCGCCCTG ACGTCAGCTCCACTGGGAGTGGCAGGAGCTGTGGGAGCCCATGGGTGAGGGACCCACCACCCCGCTGCACTGTGCATTGTGCCTCCCGTG TGGACGCCCTCTCTGTTGTTGGCCCGCGGGTGAGGGACCCACCACCCCTAGGGACCCACCACCCCGCCGCACTGTGCATTCTGCCTCCTG TGTGGACGCCCTCTCTGTTGTCAGTGGCTTTGAGGTGTCAGTGCTTACTTAGATGCTGGTTTAATGCTGGACCCATTTGTTAAACGCACC TTCACTTTGTCAAAACCCAGGTTTGGTTGGCAGGACTGGGTCTTCTGCCCAATGCCAGGTGCCTGCGCCTCTCAGTGGCCTGGTTCTTGG ACAGTTTGCCCCCATGTGGCAGGGATAGGGATAAGGATCTCCTCTCAGTACTGGAAGAGAACAGCCAACCATCTGAGCCCAGAGTCACAG ATCCATCGTGGCCCCCTATGACCCCCAAGCCCTACCGAGGGGGCACTCACTCTCTGCTTAGCCAGGGGGCGTCTTTCAAAAGGTGACCTC CATGCTGTGCTGTCGTGGGTGTGAGACGTGCTCATGGCCTTCCACTGCCATCTCTCCCTTATCTGATGCCTAAAGTCACGATGGGGACAG AGCTACCCAGGGGCCAGCCATGGGGTGACCAGCCACCTGAGGGTCAGTCACCTGTGGAGAGCAGGCACCTGTGAAGACCAGGCACCTGAG GACTGGCGCCTACTTCCCACTTTGGCCCTACACTGGCACAGAGCCCCTCTTTATTCATTTCTCATGCTGAGCATGGCACACTTCTGGCCT CTGGGCATTTATGGATTTAAGACCAGGATGGTATTTCAGAAGCTTCCCACTTCCTTCCTATTCTAACCGAGTGCCCAGCTCCTTTGCTGA TCATGGAAAGACCCTTAATAATTAGGCCTGCAGGCCAGGCGCAGTGGCTCATGCCTATAATCCCAGCACTTTAGGAGGTCAAGGTAGGAG GATCGCTTAAGCCCAGGAGTTCAAGACCAGCCTGGGCAACACAGGAAGAATGTGTCTCTACAAAAAATAATTAAAAATCAGATCTGCTGT ATCCCTGAAAAAGTCTCAATCAACATGCATGTTCCACTCTTGGAGTTCCCTGTTCTGAGGGCCAGCCACGTCCTGTGTCCTGGAGCTTAG CCCTCAGCAGCTCCCTTCAGCCTGGGCGCCGCCTGGGTCCCAAACGTGGCAGCTGCTCTTCCAGTCTCGGGGCCGAGGAGGGCAGGGAGC TCAGTGACTGAGAGTCTTGTGTATCACATGTCTTGAGTGTCCTGGAGCCAACGGCTGTCACTGGGAAAAACACCAGGCCCCAAAGATCGA ATCAGAGACGTGGCTGCGTGTTTGCGATTGTAGCCAGGCCCTTCAGTGTCATCAAAGGAGCACTGGGGCCTCCTTAAGCACAGACGGCAG CCCCTGCCCAGGAGGCTTCTTCACCACGTCCTGCCCTGCAGCCTCCCAGACCTTTAGATGCGCCCCTGCCCAAGGCCCTCCTGGTGACAG GTGCCAGATTGAGTGGTGGGTTGCTGCCAGGCAGGCCACGCTGTGTTGACGCTGCACTCAGCACGTGGGTGTTGGCTCTGCCGGTTTTGT GGTGTGGGGACCCTACAGGAGGCTGCGGCCCTGAGAGCCTGGGATCAGCGAGGTGTCCGACATCCCTTCCTCAACGGCAACAAAAACTCC CCAAGTCAGCACTTTGGTTATTTTATAGCCACAACCCTCTTGGAAAACAGTGGGGAAGACTATGGAACATAGAAAGTGTGGATGTATCAC TTCTCTCTAAAATGTCATTGTTAGCACTAATTACAGGTTCATGTTTTTCTGTGTATGTAGCTTTTCCCTATATAGCTGAAAAAGTATTAA AGTCAAATATAAGGTGGGAATGGGATGGAAGGGAGGAGATCAATACAACTTATATTTTTGCAGTTTCTACTGGAAGAAAAAAGTTTTCAA TACCTAGACCAACTTGTTGAATTTTTAAAACTTATGCACTATAAATGCAACTTTCTCTACTGCTTTCTCAGTGCCTTTAGGAAGCTTTCA |
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FusionGenePPI for ACO2_AHRR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ACO2 | SRRM2, PSMD4, ATXN1L, APP, AK3, ACAT1, SIN3A, ACAA2, VCAM1, ITGA4, ASB9, CKB, IDH3A, IDH3G, MYH7B, SOD2, ALDH5A1, ALDOA, ALDOC, ATP1B1, ATP5F1, ATP5J, ESD, GPD1, GPD1L, GPD2, PITPNB, VAPA, NTRK1, SOD1, TRIM25 | AHRR | ARNT, ESR1, HDAC4, HDAC5, ANKRA2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACO2_AHRR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACO2_AHRR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ACO2 | C3281192 | INFANTILE CEREBELLAR-RETINAL DEGENERATION | 2 | ORPHANET;UNIPROT |
| Hgene | ACO2 | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human |
| Hgene | ACO2 | C2239176 | Liver carcinoma | 1 | CTD_human |
| Hgene | ACO2 | C4225384 | OPTIC ATROPHY 9 | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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