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Fusion gene ID: 40173 |
FusionGeneSummary for TVP23C-CDRT4_PCBP2 |
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Fusion gene information | Fusion gene name: TVP23C-CDRT4_PCBP2 | Fusion gene ID: 40173 | Hgene | Tgene | Gene symbol | TVP23C-CDRT4 | PCBP2 | Gene ID | 100533496 | 5094 |
Gene name | TVP23C-CDRT4 readthrough | poly(rC) binding protein 2 | |
Synonyms | FAM18B2-CDRT4 | HNRNPE2|HNRPE2|hnRNP-E2 | |
Cytomap | 17p12 | 12q13.13 | |
Type of gene | protein-coding | protein-coding | |
Description | uncharacterized protein LOC100533496FAM18B2-CDRT4 readthrough | poly(rC)-binding protein 2alpha-CP2heterogeneous nuclear ribonucleoprotein E2heterogenous nuclear ribonucleoprotein E2hnRNP E2 | |
Modification date | 20180329 | 20180522 | |
UniProtAcc | Q15366 | ||
Ensembl transtripts involved in fusion gene | ENST00000522212, | ENST00000359282, ENST00000603815, ENST00000437231, ENST00000447282, ENST00000549863, ENST00000359462, ENST00000546463, ENST00000552296, ENST00000552819, ENST00000455667, ENST00000439930, ENST00000548933, ENST00000541275, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 14 X 14 X 7=1372 |
# samples | 2 | 15 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(15/1372*10)=-3.19324607567693 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TVP23C-CDRT4 [Title/Abstract] AND PCBP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PCBP2 | GO:0039694 | viral RNA genome replication | 12414943 |
Tgene | PCBP2 | GO:0075522 | IRES-dependent viral translational initiation | 12414943 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE837740 | TVP23C-CDRT4 | chr17 | 15393064 | + | PCBP2 | chr12 | 53869500 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000522212 | ENST00000359282 | TVP23C-CDRT4 | chr17 | 15393064 | + | PCBP2 | chr12 | 53869500 | + |
intron-intron | ENST00000522212 | ENST00000603815 | TVP23C-CDRT4 | chr17 | 15393064 | + | PCBP2 | chr12 | 53869500 | + |
intron-intron | ENST00000522212 | ENST00000437231 | TVP23C-CDRT4 | chr17 | 15393064 | + | PCBP2 | chr12 | 53869500 | + |
intron-intron | ENST00000522212 | ENST00000447282 | TVP23C-CDRT4 | chr17 | 15393064 | + | PCBP2 | chr12 | 53869500 | + |
intron-intron | ENST00000522212 | ENST00000549863 | TVP23C-CDRT4 | chr17 | 15393064 | + | PCBP2 | chr12 | 53869500 | + |
intron-intron | ENST00000522212 | ENST00000359462 | TVP23C-CDRT4 | chr17 | 15393064 | + | PCBP2 | chr12 | 53869500 | + |
intron-intron | ENST00000522212 | ENST00000546463 | TVP23C-CDRT4 | chr17 | 15393064 | + | PCBP2 | chr12 | 53869500 | + |
intron-intron | ENST00000522212 | ENST00000552296 | TVP23C-CDRT4 | chr17 | 15393064 | + | PCBP2 | chr12 | 53869500 | + |
intron-intron | ENST00000522212 | ENST00000552819 | TVP23C-CDRT4 | chr17 | 15393064 | + | PCBP2 | chr12 | 53869500 | + |
intron-intron | ENST00000522212 | ENST00000455667 | TVP23C-CDRT4 | chr17 | 15393064 | + | PCBP2 | chr12 | 53869500 | + |
intron-intron | ENST00000522212 | ENST00000439930 | TVP23C-CDRT4 | chr17 | 15393064 | + | PCBP2 | chr12 | 53869500 | + |
intron-intron | ENST00000522212 | ENST00000548933 | TVP23C-CDRT4 | chr17 | 15393064 | + | PCBP2 | chr12 | 53869500 | + |
intron-intron | ENST00000522212 | ENST00000541275 | TVP23C-CDRT4 | chr17 | 15393064 | + | PCBP2 | chr12 | 53869500 | + |
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FusionProtFeatures for TVP23C-CDRT4_PCBP2 |
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Hgene | Tgene |
TVP23C-CDRT4 | PCBP2 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TVP23C-CDRT4_PCBP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TVP23C-CDRT4_PCBP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TVP23C-CDRT4_PCBP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TVP23C-CDRT4_PCBP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |