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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 40171

FusionGeneSummary for TUSC3_SORBS3

check button Fusion gene summary
Fusion gene informationFusion gene name: TUSC3_SORBS3
Fusion gene ID: 40171
HgeneTgene
Gene symbol

TUSC3

SORBS3

Gene ID

7991

10174

Gene nametumor suppressor candidate 3sorbin and SH3 domain containing 3
SynonymsD8S1992|M33|MRT22|MRT7|MagT2|N33|OST3ASCAM-1|SCAM1|SH3D4
Cytomap

8p22

8p21.3

Type of geneprotein-codingprotein-coding
Descriptiontumor suppressor candidate 3magnesium uptake/transporter TUSC3oligosaccharyltransferase 3 homolog Aputative prostate cancer tumor suppressorvinexinsorbin and SH3 domain-containing protein 3vinexin beta (SH3-containing adaptor molecule-1)
Modification date2018052320180522
UniProtAcc

Q13454

O60504

Ensembl transtripts involved in fusion geneENST00000503191, ENST00000382020, 
ENST00000506802, ENST00000509380, 
ENST00000503731, 
ENST00000240123, 
ENST00000523402, ENST00000523740, 
ENST00000428103, 
Fusion gene scores* DoF score5 X 5 X 5=1253 X 3 X 3=27
# samples 53
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TUSC3 [Title/Abstract] AND SORBS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSORBS3

GO:0051496

positive regulation of stress fiber assembly

9885244


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AO-A03T-01ATUSC3chr8

15480758

+SORBS3chr8

22421500

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000503191ENST00000240123TUSC3chr8

15480758

+SORBS3chr8

22421500

+
3UTR-intronENST00000503191ENST00000523402TUSC3chr8

15480758

+SORBS3chr8

22421500

+
3UTR-intronENST00000503191ENST00000523740TUSC3chr8

15480758

+SORBS3chr8

22421500

+
3UTR-intronENST00000503191ENST00000428103TUSC3chr8

15480758

+SORBS3chr8

22421500

+
In-frameENST00000382020ENST00000240123TUSC3chr8

15480758

+SORBS3chr8

22421500

+
5CDS-intronENST00000382020ENST00000523402TUSC3chr8

15480758

+SORBS3chr8

22421500

+
5CDS-intronENST00000382020ENST00000523740TUSC3chr8

15480758

+SORBS3chr8

22421500

+
5CDS-intronENST00000382020ENST00000428103TUSC3chr8

15480758

+SORBS3chr8

22421500

+
In-frameENST00000506802ENST00000240123TUSC3chr8

15480758

+SORBS3chr8

22421500

+
5CDS-intronENST00000506802ENST00000523402TUSC3chr8

15480758

+SORBS3chr8

22421500

+
5CDS-intronENST00000506802ENST00000523740TUSC3chr8

15480758

+SORBS3chr8

22421500

+
5CDS-intronENST00000506802ENST00000428103TUSC3chr8

15480758

+SORBS3chr8

22421500

+
In-frameENST00000509380ENST00000240123TUSC3chr8

15480758

+SORBS3chr8

22421500

+
5CDS-intronENST00000509380ENST00000523402TUSC3chr8

15480758

+SORBS3chr8

22421500

+
5CDS-intronENST00000509380ENST00000523740TUSC3chr8

15480758

+SORBS3chr8

22421500

+
5CDS-intronENST00000509380ENST00000428103TUSC3chr8

15480758

+SORBS3chr8

22421500

+
In-frameENST00000503731ENST00000240123TUSC3chr8

15480758

+SORBS3chr8

22421500

+
5CDS-intronENST00000503731ENST00000523402TUSC3chr8

15480758

+SORBS3chr8

22421500

+
5CDS-intronENST00000503731ENST00000523740TUSC3chr8

15480758

+SORBS3chr8

22421500

+
5CDS-intronENST00000503731ENST00000428103TUSC3chr8

15480758

+SORBS3chr8

22421500

+

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FusionProtFeatures for TUSC3_SORBS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TUSC3

Q13454

SORBS3

O60504

Acts as accessory component of the N-oligosaccharyltransferase (OST) complex which catalyzes the transfer of a highmannose oligosaccharide from a lipid-linked oligosaccharide donorto an asparagine residue within an Asn-X-Ser/Thr consensus motifin nascent polypeptide chains. Involved in N-glycosylation ofSTT3B-dependent substrates. Specifically required for theglycosylation of a subset of acceptor sites that are near cysteineresidues; in this function seems to act redundantly with MAGT1. Inits oxidized form proposed to form transient mixed disulfides witha glycoprotein substrate to facilitate access of STT3B to theunmodified acceptor site. Has also oxidoreductase-independentfunctions in the STT3B-containing OST complex possibly involvingsubstrate recognition. {ECO:0000269|PubMed:25135935,ECO:0000305|PubMed:12887896, ECO:0000305|PubMed:24685145}. Magnesium transporter. {ECO:0000269|PubMed:19717468}. Vinexin alpha isoform promotes up-regulation of actinstress fiber formation. Vinexin beta isoform plays a role in cellspreading and enhances the activation of JNK/SAPK in response toEGF stimulation by using its third SH3 domain.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TUSC3_SORBS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TUSC3_ENST00000382020_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_580aa
MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNTSMIVMF
TALQPQRQCSVCRRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIE
VLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSST
RDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANTVEVLPADEIPKPIKPPTYQ
VLETGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARH
PSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELE

>In-frame_TUSC3_ENST00000506802_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_580aa
MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNTSMIVMF
TALQPQRQCSVCRRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIE
VLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSST
RDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANTVEVLPADEIPKPIKPPTYQ
VLETGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARH
PSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELE

>In-frame_TUSC3_ENST00000509380_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_580aa
MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNTSMIVMF
TALQPQRQCSVCRRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIE
VLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSST
RDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANTVEVLPADEIPKPIKPPTYQ
VLETGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARH
PSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELE

>In-frame_TUSC3_ENST00000503731_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_580aa
MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNTSMIVMF
TALQPQRQCSVCRRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIE
VLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSST
RDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANTVEVLPADEIPKPIKPPTYQ
VLETGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARH
PSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TUSC3_ENST00000382020_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_1740nt
ATGGGGGCCCGGGGCGCTCCTTCACGCCGTAGGCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGCTTTCCCTTCCTTCTCCTG
CTGCTGCTGCTCTGCATCCAGCTCGGGGGAGGACAGAAGAAAAAGGAGAATCTTTTAGCTGAAAAAGTAGAGCAGCTGATGGAATGGAGT
TCCAGACGCTCAATCTTCCGAATGAATGGTGATAAATTCCGAAAATTTATAAAGGCACCACCTCGAAACTATTCCATGATTGTTATGTTC
ACTGCTCTTCAGCCTCAGCGGCAGTGTTCTGTGTGCAGAAGAAGCTGGGACCACTCTGAAGAGTTACCTAGAAGCACCTTCAACTACAGA
CCTGGAGCATTCTCCACTGTGCTGCAGCCCTCAAATCAGGTGCTCAGACGCCGGGAAAAAGTAGACAATGTCTGGACGGAAGAGTCCTGG
AACCAGTTTCTGCAGGAACTAGAGACTGGGCAGAGGCCCAAGAAACCGCTGGTGGACGACCCTGGTGAGAAGCCCTCCCAGCCCATTGAG
GTGCTGCTGGAGAGAGAGCTGGCCGAGCTGAGCGCCGAGCTGGACAAGGACCTGCGGGCAATTGAGACCCGACTGCCGTCCCCCAAGAGC
TCGCCGGCGCCCCGACGGGCCCCGGAGCAGCGGCCCCCGGCCGGCCCGGCCTCAGCCTGGAGCTCCAGCTACCCACATGCACCTTACCTG
GGTTCCGCCCGGTCCCTGAGTCCCCACAAAATGGCTGATGGAGGAAGCCCCTTCCTAGGTCGGAGGGACTTTGTCTACCCTTCCTCAACC
CGAGACCCTAGTGCCTCTAACGGAGGGGGCAGCCCAGCCAGGAGGGAAGAGAAGAAGAGAAAGGCCGCCAGGCTCAAGTTTGACTTCCAG
GCGCAGTCCCCCAAGGAGCTGACTCTGCAGAAGGGTGACATTGTCTACATCCACAAGGAGGTGGACAAGAACTGGCTGGAGGGAGAGCAC
CACGGCCGCCTGGGCATCTTCCCTGCTAATTATGTGGAGGTGCTGCCCGCAGATGAGATCCCTAAGCCCATCAAGCCCCCGACCTACCAG
GTGCTGGAGTATGGAGAGGCTGTGGCCCAGTACACCTTCAAGGGGGACCTGGAGGTGGAGCTGTCCTTCCGCAAGGGAGAGCACATCTGC
CTGATCCGCAAGGTGAACGAGAACTGGTACGAGGGACGCATCACGGGCACGGGGCGCCAAGGCATATTCCCTGCCAGCTACGTGCAGGTG
TCTCGTGAACCCCGGCTCCGGCTCTGTGACGACGGCCCCCAGCTCCCCACGTCTCCCCGCCTGACCGCTGCCGCCCGCTCAGCCCGTCAC
CCCAGCTCCCCCTCAGCCCTGCGCAGCCCAGCTGACCCCATCGACTTGGGGGGACAGACCTCCCCCCGTCGCACTGGCTTCTCCTTCCCC
ACCCAGGAGCCTAGACCCCAGACCCAGAATCTTGGCACCCCTGGTCCAGCTCTGTCCCACTCTCGAGGTCCCAGCCATCCCCTGGACCTG
GGGACCTCCTCTCCTAACACCTCTCAGATACACTGGACCCCGTACCGGGCGATGTACCAGTACAGGCCCCAGAACGAAGACGAGCTGGAG
CTGCGCGAGGGGGACAGGGTGGATGTCATGCAGCAGTGTGACGATGGCTGGTTTGTGGGTGTCTCCCGGAGGACCCAGAAATTCGGAACG

>In-frame_TUSC3_ENST00000506802_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_1740nt
ATGGGGGCCCGGGGCGCTCCTTCACGCCGTAGGCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGCTTTCCCTTCCTTCTCCTG
CTGCTGCTGCTCTGCATCCAGCTCGGGGGAGGACAGAAGAAAAAGGAGAATCTTTTAGCTGAAAAAGTAGAGCAGCTGATGGAATGGAGT
TCCAGACGCTCAATCTTCCGAATGAATGGTGATAAATTCCGAAAATTTATAAAGGCACCACCTCGAAACTATTCCATGATTGTTATGTTC
ACTGCTCTTCAGCCTCAGCGGCAGTGTTCTGTGTGCAGAAGAAGCTGGGACCACTCTGAAGAGTTACCTAGAAGCACCTTCAACTACAGA
CCTGGAGCATTCTCCACTGTGCTGCAGCCCTCAAATCAGGTGCTCAGACGCCGGGAAAAAGTAGACAATGTCTGGACGGAAGAGTCCTGG
AACCAGTTTCTGCAGGAACTAGAGACTGGGCAGAGGCCCAAGAAACCGCTGGTGGACGACCCTGGTGAGAAGCCCTCCCAGCCCATTGAG
GTGCTGCTGGAGAGAGAGCTGGCCGAGCTGAGCGCCGAGCTGGACAAGGACCTGCGGGCAATTGAGACCCGACTGCCGTCCCCCAAGAGC
TCGCCGGCGCCCCGACGGGCCCCGGAGCAGCGGCCCCCGGCCGGCCCGGCCTCAGCCTGGAGCTCCAGCTACCCACATGCACCTTACCTG
GGTTCCGCCCGGTCCCTGAGTCCCCACAAAATGGCTGATGGAGGAAGCCCCTTCCTAGGTCGGAGGGACTTTGTCTACCCTTCCTCAACC
CGAGACCCTAGTGCCTCTAACGGAGGGGGCAGCCCAGCCAGGAGGGAAGAGAAGAAGAGAAAGGCCGCCAGGCTCAAGTTTGACTTCCAG
GCGCAGTCCCCCAAGGAGCTGACTCTGCAGAAGGGTGACATTGTCTACATCCACAAGGAGGTGGACAAGAACTGGCTGGAGGGAGAGCAC
CACGGCCGCCTGGGCATCTTCCCTGCTAATTATGTGGAGGTGCTGCCCGCAGATGAGATCCCTAAGCCCATCAAGCCCCCGACCTACCAG
GTGCTGGAGTATGGAGAGGCTGTGGCCCAGTACACCTTCAAGGGGGACCTGGAGGTGGAGCTGTCCTTCCGCAAGGGAGAGCACATCTGC
CTGATCCGCAAGGTGAACGAGAACTGGTACGAGGGACGCATCACGGGCACGGGGCGCCAAGGCATATTCCCTGCCAGCTACGTGCAGGTG
TCTCGTGAACCCCGGCTCCGGCTCTGTGACGACGGCCCCCAGCTCCCCACGTCTCCCCGCCTGACCGCTGCCGCCCGCTCAGCCCGTCAC
CCCAGCTCCCCCTCAGCCCTGCGCAGCCCAGCTGACCCCATCGACTTGGGGGGACAGACCTCCCCCCGTCGCACTGGCTTCTCCTTCCCC
ACCCAGGAGCCTAGACCCCAGACCCAGAATCTTGGCACCCCTGGTCCAGCTCTGTCCCACTCTCGAGGTCCCAGCCATCCCCTGGACCTG
GGGACCTCCTCTCCTAACACCTCTCAGATACACTGGACCCCGTACCGGGCGATGTACCAGTACAGGCCCCAGAACGAAGACGAGCTGGAG
CTGCGCGAGGGGGACAGGGTGGATGTCATGCAGCAGTGTGACGATGGCTGGTTTGTGGGTGTCTCCCGGAGGACCCAGAAATTCGGAACG

>In-frame_TUSC3_ENST00000509380_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_1740nt
ATGGGGGCCCGGGGCGCTCCTTCACGCCGTAGGCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGCTTTCCCTTCCTTCTCCTG
CTGCTGCTGCTCTGCATCCAGCTCGGGGGAGGACAGAAGAAAAAGGAGAATCTTTTAGCTGAAAAAGTAGAGCAGCTGATGGAATGGAGT
TCCAGACGCTCAATCTTCCGAATGAATGGTGATAAATTCCGAAAATTTATAAAGGCACCACCTCGAAACTATTCCATGATTGTTATGTTC
ACTGCTCTTCAGCCTCAGCGGCAGTGTTCTGTGTGCAGAAGAAGCTGGGACCACTCTGAAGAGTTACCTAGAAGCACCTTCAACTACAGA
CCTGGAGCATTCTCCACTGTGCTGCAGCCCTCAAATCAGGTGCTCAGACGCCGGGAAAAAGTAGACAATGTCTGGACGGAAGAGTCCTGG
AACCAGTTTCTGCAGGAACTAGAGACTGGGCAGAGGCCCAAGAAACCGCTGGTGGACGACCCTGGTGAGAAGCCCTCCCAGCCCATTGAG
GTGCTGCTGGAGAGAGAGCTGGCCGAGCTGAGCGCCGAGCTGGACAAGGACCTGCGGGCAATTGAGACCCGACTGCCGTCCCCCAAGAGC
TCGCCGGCGCCCCGACGGGCCCCGGAGCAGCGGCCCCCGGCCGGCCCGGCCTCAGCCTGGAGCTCCAGCTACCCACATGCACCTTACCTG
GGTTCCGCCCGGTCCCTGAGTCCCCACAAAATGGCTGATGGAGGAAGCCCCTTCCTAGGTCGGAGGGACTTTGTCTACCCTTCCTCAACC
CGAGACCCTAGTGCCTCTAACGGAGGGGGCAGCCCAGCCAGGAGGGAAGAGAAGAAGAGAAAGGCCGCCAGGCTCAAGTTTGACTTCCAG
GCGCAGTCCCCCAAGGAGCTGACTCTGCAGAAGGGTGACATTGTCTACATCCACAAGGAGGTGGACAAGAACTGGCTGGAGGGAGAGCAC
CACGGCCGCCTGGGCATCTTCCCTGCTAATTATGTGGAGGTGCTGCCCGCAGATGAGATCCCTAAGCCCATCAAGCCCCCGACCTACCAG
GTGCTGGAGTATGGAGAGGCTGTGGCCCAGTACACCTTCAAGGGGGACCTGGAGGTGGAGCTGTCCTTCCGCAAGGGAGAGCACATCTGC
CTGATCCGCAAGGTGAACGAGAACTGGTACGAGGGACGCATCACGGGCACGGGGCGCCAAGGCATATTCCCTGCCAGCTACGTGCAGGTG
TCTCGTGAACCCCGGCTCCGGCTCTGTGACGACGGCCCCCAGCTCCCCACGTCTCCCCGCCTGACCGCTGCCGCCCGCTCAGCCCGTCAC
CCCAGCTCCCCCTCAGCCCTGCGCAGCCCAGCTGACCCCATCGACTTGGGGGGACAGACCTCCCCCCGTCGCACTGGCTTCTCCTTCCCC
ACCCAGGAGCCTAGACCCCAGACCCAGAATCTTGGCACCCCTGGTCCAGCTCTGTCCCACTCTCGAGGTCCCAGCCATCCCCTGGACCTG
GGGACCTCCTCTCCTAACACCTCTCAGATACACTGGACCCCGTACCGGGCGATGTACCAGTACAGGCCCCAGAACGAAGACGAGCTGGAG
CTGCGCGAGGGGGACAGGGTGGATGTCATGCAGCAGTGTGACGATGGCTGGTTTGTGGGTGTCTCCCGGAGGACCCAGAAATTCGGAACG

>In-frame_TUSC3_ENST00000503731_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_1740nt
ATGGGGGCCCGGGGCGCTCCTTCACGCCGTAGGCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGCTTTCCCTTCCTTCTCCTG
CTGCTGCTGCTCTGCATCCAGCTCGGGGGAGGACAGAAGAAAAAGGAGAATCTTTTAGCTGAAAAAGTAGAGCAGCTGATGGAATGGAGT
TCCAGACGCTCAATCTTCCGAATGAATGGTGATAAATTCCGAAAATTTATAAAGGCACCACCTCGAAACTATTCCATGATTGTTATGTTC
ACTGCTCTTCAGCCTCAGCGGCAGTGTTCTGTGTGCAGAAGAAGCTGGGACCACTCTGAAGAGTTACCTAGAAGCACCTTCAACTACAGA
CCTGGAGCATTCTCCACTGTGCTGCAGCCCTCAAATCAGGTGCTCAGACGCCGGGAAAAAGTAGACAATGTCTGGACGGAAGAGTCCTGG
AACCAGTTTCTGCAGGAACTAGAGACTGGGCAGAGGCCCAAGAAACCGCTGGTGGACGACCCTGGTGAGAAGCCCTCCCAGCCCATTGAG
GTGCTGCTGGAGAGAGAGCTGGCCGAGCTGAGCGCCGAGCTGGACAAGGACCTGCGGGCAATTGAGACCCGACTGCCGTCCCCCAAGAGC
TCGCCGGCGCCCCGACGGGCCCCGGAGCAGCGGCCCCCGGCCGGCCCGGCCTCAGCCTGGAGCTCCAGCTACCCACATGCACCTTACCTG
GGTTCCGCCCGGTCCCTGAGTCCCCACAAAATGGCTGATGGAGGAAGCCCCTTCCTAGGTCGGAGGGACTTTGTCTACCCTTCCTCAACC
CGAGACCCTAGTGCCTCTAACGGAGGGGGCAGCCCAGCCAGGAGGGAAGAGAAGAAGAGAAAGGCCGCCAGGCTCAAGTTTGACTTCCAG
GCGCAGTCCCCCAAGGAGCTGACTCTGCAGAAGGGTGACATTGTCTACATCCACAAGGAGGTGGACAAGAACTGGCTGGAGGGAGAGCAC
CACGGCCGCCTGGGCATCTTCCCTGCTAATTATGTGGAGGTGCTGCCCGCAGATGAGATCCCTAAGCCCATCAAGCCCCCGACCTACCAG
GTGCTGGAGTATGGAGAGGCTGTGGCCCAGTACACCTTCAAGGGGGACCTGGAGGTGGAGCTGTCCTTCCGCAAGGGAGAGCACATCTGC
CTGATCCGCAAGGTGAACGAGAACTGGTACGAGGGACGCATCACGGGCACGGGGCGCCAAGGCATATTCCCTGCCAGCTACGTGCAGGTG
TCTCGTGAACCCCGGCTCCGGCTCTGTGACGACGGCCCCCAGCTCCCCACGTCTCCCCGCCTGACCGCTGCCGCCCGCTCAGCCCGTCAC
CCCAGCTCCCCCTCAGCCCTGCGCAGCCCAGCTGACCCCATCGACTTGGGGGGACAGACCTCCCCCCGTCGCACTGGCTTCTCCTTCCCC
ACCCAGGAGCCTAGACCCCAGACCCAGAATCTTGGCACCCCTGGTCCAGCTCTGTCCCACTCTCGAGGTCCCAGCCATCCCCTGGACCTG
GGGACCTCCTCTCCTAACACCTCTCAGATACACTGGACCCCGTACCGGGCGATGTACCAGTACAGGCCCCAGAACGAAGACGAGCTGGAG
CTGCGCGAGGGGGACAGGGTGGATGTCATGCAGCAGTGTGACGATGGCTGGTTTGTGGGTGTCTCCCGGAGGACCCAGAAATTCGGAACG


* Fusion transcript sequences (Full-length transcript).
>In-frame_TUSC3_ENST00000382020_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_3008nt
GCCTTTCCAGGTCTTCTCCCGGTGAACCGGATGCTCTGTCAGTCTCCTCCTCTGCGTCCTCGGCCGCGGCCCGGGTCCCTCGCAAAGCCG
CTGCCATCCCGGAGGGCCCAGCCAGCGGGCTCCCGGAGGCTGGCCGGGCAGGCGTGGTGCGCGGTAGGAGCTGGGCGCGCACGGCTACCG
CGCGTGGAGGAGACACTGCCCTGCCGCGATGGGGGCCCGGGGCGCTCCTTCACGCCGTAGGCAAGCGGGGCGGCGGCTGCGGTACCTGCC
CACCGGGAGCTTTCCCTTCCTTCTCCTGCTGCTGCTGCTCTGCATCCAGCTCGGGGGAGGACAGAAGAAAAAGGAGAATCTTTTAGCTGA
AAAAGTAGAGCAGCTGATGGAATGGAGTTCCAGACGCTCAATCTTCCGAATGAATGGTGATAAATTCCGAAAATTTATAAAGGCACCACC
TCGAAACTATTCCATGATTGTTATGTTCACTGCTCTTCAGCCTCAGCGGCAGTGTTCTGTGTGCAGAAGAAGCTGGGACCACTCTGAAGA
GTTACCTAGAAGCACCTTCAACTACAGACCTGGAGCATTCTCCACTGTGCTGCAGCCCTCAAATCAGGTGCTCAGACGCCGGGAAAAAGT
AGACAATGTCTGGACGGAAGAGTCCTGGAACCAGTTTCTGCAGGAACTAGAGACTGGGCAGAGGCCCAAGAAACCGCTGGTGGACGACCC
TGGTGAGAAGCCCTCCCAGCCCATTGAGGTGCTGCTGGAGAGAGAGCTGGCCGAGCTGAGCGCCGAGCTGGACAAGGACCTGCGGGCAAT
TGAGACCCGACTGCCGTCCCCCAAGAGCTCGCCGGCGCCCCGACGGGCCCCGGAGCAGCGGCCCCCGGCCGGCCCGGCCTCAGCCTGGAG
CTCCAGCTACCCACATGCACCTTACCTGGGTTCCGCCCGGTCCCTGAGTCCCCACAAAATGGCTGATGGAGGAAGCCCCTTCCTAGGTCG
GAGGGACTTTGTCTACCCTTCCTCAACCCGAGACCCTAGTGCCTCTAACGGAGGGGGCAGCCCAGCCAGGAGGGAAGAGAAGAAGAGAAA
GGCCGCCAGGCTCAAGTTTGACTTCCAGGCGCAGTCCCCCAAGGAGCTGACTCTGCAGAAGGGTGACATTGTCTACATCCACAAGGAGGT
GGACAAGAACTGGCTGGAGGGAGAGCACCACGGCCGCCTGGGCATCTTCCCTGCTAATTATGTGGAGGTGCTGCCCGCAGATGAGATCCC
TAAGCCCATCAAGCCCCCGACCTACCAGGTGCTGGAGTATGGAGAGGCTGTGGCCCAGTACACCTTCAAGGGGGACCTGGAGGTGGAGCT
GTCCTTCCGCAAGGGAGAGCACATCTGCCTGATCCGCAAGGTGAACGAGAACTGGTACGAGGGACGCATCACGGGCACGGGGCGCCAAGG
CATATTCCCTGCCAGCTACGTGCAGGTGTCTCGTGAACCCCGGCTCCGGCTCTGTGACGACGGCCCCCAGCTCCCCACGTCTCCCCGCCT
GACCGCTGCCGCCCGCTCAGCCCGTCACCCCAGCTCCCCCTCAGCCCTGCGCAGCCCAGCTGACCCCATCGACTTGGGGGGACAGACCTC
CCCCCGTCGCACTGGCTTCTCCTTCCCCACCCAGGAGCCTAGACCCCAGACCCAGAATCTTGGCACCCCTGGTCCAGCTCTGTCCCACTC
TCGAGGTCCCAGCCATCCCCTGGACCTGGGGACCTCCTCTCCTAACACCTCTCAGATACACTGGACCCCGTACCGGGCGATGTACCAGTA
CAGGCCCCAGAACGAAGACGAGCTGGAGCTGCGCGAGGGGGACAGGGTGGATGTCATGCAGCAGTGTGACGATGGCTGGTTTGTGGGTGT
CTCCCGGAGGACCCAGAAATTCGGAACGTTCCCTGGAAATTACGTTGCCCCGGTGTGAGTGGTCTCCATGGCAACTTGGAGCCAGCCAGG
ATGGGGTGGGGAGCGGTGGCACTCGTGGGAGGGAGAGGACCCCCGCCCACATCCTCCTTCCCCAGGACCTGAGCTCCCAGCATCTGCAGA
CGACCCCCGCAGCCTTTCCCTCGGACCCCCCTCGAAGCCCCCTGGACTGATTCCCACCCACGACTCACAGGCATTCCTCCCACAGCCCTT
TCATTTCCTCCCCACCCCACTCCCCAAATACAGAGGTCTGCTTTGAAGCGGAGACCATTTCCAGGCCTTATTGAGACCAGACCCCAAGTC
CCCCACCCCCATCCTGCTCCAGCGTTTCCTCTAACAGGGACCAGCTCTCCGCTTTGCCCCCACGGGGTTCCTCTAACCAGAACCAGCTTC
CTAGCCTCGTAGAGACCAAAGGCCGCCCCCGCCTGCTGGGGTTCCTCCCAGCACCCCAGCTTGCTGGCTGCCCTCTTTGCCTTCTGGCCT
CCAGCTGGGTGTGGGGGGGCGGAGCAAGGCGGGGGACAGACGCAGCACCTTCTTAGCGATCTAGGCCTGGCAAGAGCTCTGGCCCCAAGG
CCTCCTCTTCCCAGGGGCTGCCAAGTCCTGGCCCTGGCCCTGGCATATCACCCCGCACTGTGGGGCCAGGCACCACTAGCCTGGCTCAAA
TATTCCCCAGGGAGACTGCTGTGTGCTGCCCGCCTGCCTGCTGGCTCTCCCCCAGCCCCACATCCCCTCTGGAAGAGAATGTAAAATAAA
CCTGGACACAAGGGACCTTGTCTCTGCGGCCTTTTCCTTGGGGTAGGGGATGCCTCCTCCTGTCTAGGAGATGGGAATTCCTTCTGTGGA
GGGCTGTGCTGGGAGACAGGTGGGACAGGTGTGTGTGTAAGAGGAGGAGGATGGAAAAACACCATTATTACCTCCAAAGATCTCTGCCCT
TGGGTGTCAGGCAGGTTGCGGCAGCCCCCACAATTGGGCAGCTGTGTGGCAAGAAGTGCTGGGAGAATGAACAGTGCCAGGCCCTGGTAG

>In-frame_TUSC3_ENST00000506802_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_2998nt
GTCTTCTCCCGGTGAACCGGATGCTCTGTCAGTCTCCTCCTCTGCGTCCTCGGCCGCGGCCCGGGTCCCTCGCAAAGCCGCTGCCATCCC
GGAGGGCCCAGCCAGCGGGCTCCCGGAGGCTGGCCGGGCAGGCGTGGTGCGCGGTAGGAGCTGGGCGCGCACGGCTACCGCGCGTGGAGG
AGACACTGCCCTGCCGCGATGGGGGCCCGGGGCGCTCCTTCACGCCGTAGGCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGC
TTTCCCTTCCTTCTCCTGCTGCTGCTGCTCTGCATCCAGCTCGGGGGAGGACAGAAGAAAAAGGAGAATCTTTTAGCTGAAAAAGTAGAG
CAGCTGATGGAATGGAGTTCCAGACGCTCAATCTTCCGAATGAATGGTGATAAATTCCGAAAATTTATAAAGGCACCACCTCGAAACTAT
TCCATGATTGTTATGTTCACTGCTCTTCAGCCTCAGCGGCAGTGTTCTGTGTGCAGAAGAAGCTGGGACCACTCTGAAGAGTTACCTAGA
AGCACCTTCAACTACAGACCTGGAGCATTCTCCACTGTGCTGCAGCCCTCAAATCAGGTGCTCAGACGCCGGGAAAAAGTAGACAATGTC
TGGACGGAAGAGTCCTGGAACCAGTTTCTGCAGGAACTAGAGACTGGGCAGAGGCCCAAGAAACCGCTGGTGGACGACCCTGGTGAGAAG
CCCTCCCAGCCCATTGAGGTGCTGCTGGAGAGAGAGCTGGCCGAGCTGAGCGCCGAGCTGGACAAGGACCTGCGGGCAATTGAGACCCGA
CTGCCGTCCCCCAAGAGCTCGCCGGCGCCCCGACGGGCCCCGGAGCAGCGGCCCCCGGCCGGCCCGGCCTCAGCCTGGAGCTCCAGCTAC
CCACATGCACCTTACCTGGGTTCCGCCCGGTCCCTGAGTCCCCACAAAATGGCTGATGGAGGAAGCCCCTTCCTAGGTCGGAGGGACTTT
GTCTACCCTTCCTCAACCCGAGACCCTAGTGCCTCTAACGGAGGGGGCAGCCCAGCCAGGAGGGAAGAGAAGAAGAGAAAGGCCGCCAGG
CTCAAGTTTGACTTCCAGGCGCAGTCCCCCAAGGAGCTGACTCTGCAGAAGGGTGACATTGTCTACATCCACAAGGAGGTGGACAAGAAC
TGGCTGGAGGGAGAGCACCACGGCCGCCTGGGCATCTTCCCTGCTAATTATGTGGAGGTGCTGCCCGCAGATGAGATCCCTAAGCCCATC
AAGCCCCCGACCTACCAGGTGCTGGAGTATGGAGAGGCTGTGGCCCAGTACACCTTCAAGGGGGACCTGGAGGTGGAGCTGTCCTTCCGC
AAGGGAGAGCACATCTGCCTGATCCGCAAGGTGAACGAGAACTGGTACGAGGGACGCATCACGGGCACGGGGCGCCAAGGCATATTCCCT
GCCAGCTACGTGCAGGTGTCTCGTGAACCCCGGCTCCGGCTCTGTGACGACGGCCCCCAGCTCCCCACGTCTCCCCGCCTGACCGCTGCC
GCCCGCTCAGCCCGTCACCCCAGCTCCCCCTCAGCCCTGCGCAGCCCAGCTGACCCCATCGACTTGGGGGGACAGACCTCCCCCCGTCGC
ACTGGCTTCTCCTTCCCCACCCAGGAGCCTAGACCCCAGACCCAGAATCTTGGCACCCCTGGTCCAGCTCTGTCCCACTCTCGAGGTCCC
AGCCATCCCCTGGACCTGGGGACCTCCTCTCCTAACACCTCTCAGATACACTGGACCCCGTACCGGGCGATGTACCAGTACAGGCCCCAG
AACGAAGACGAGCTGGAGCTGCGCGAGGGGGACAGGGTGGATGTCATGCAGCAGTGTGACGATGGCTGGTTTGTGGGTGTCTCCCGGAGG
ACCCAGAAATTCGGAACGTTCCCTGGAAATTACGTTGCCCCGGTGTGAGTGGTCTCCATGGCAACTTGGAGCCAGCCAGGATGGGGTGGG
GAGCGGTGGCACTCGTGGGAGGGAGAGGACCCCCGCCCACATCCTCCTTCCCCAGGACCTGAGCTCCCAGCATCTGCAGACGACCCCCGC
AGCCTTTCCCTCGGACCCCCCTCGAAGCCCCCTGGACTGATTCCCACCCACGACTCACAGGCATTCCTCCCACAGCCCTTTCATTTCCTC
CCCACCCCACTCCCCAAATACAGAGGTCTGCTTTGAAGCGGAGACCATTTCCAGGCCTTATTGAGACCAGACCCCAAGTCCCCCACCCCC
ATCCTGCTCCAGCGTTTCCTCTAACAGGGACCAGCTCTCCGCTTTGCCCCCACGGGGTTCCTCTAACCAGAACCAGCTTCCTAGCCTCGT
AGAGACCAAAGGCCGCCCCCGCCTGCTGGGGTTCCTCCCAGCACCCCAGCTTGCTGGCTGCCCTCTTTGCCTTCTGGCCTCCAGCTGGGT
GTGGGGGGGCGGAGCAAGGCGGGGGACAGACGCAGCACCTTCTTAGCGATCTAGGCCTGGCAAGAGCTCTGGCCCCAAGGCCTCCTCTTC
CCAGGGGCTGCCAAGTCCTGGCCCTGGCCCTGGCATATCACCCCGCACTGTGGGGCCAGGCACCACTAGCCTGGCTCAAATATTCCCCAG
GGAGACTGCTGTGTGCTGCCCGCCTGCCTGCTGGCTCTCCCCCAGCCCCACATCCCCTCTGGAAGAGAATGTAAAATAAACCTGGACACA
AGGGACCTTGTCTCTGCGGCCTTTTCCTTGGGGTAGGGGATGCCTCCTCCTGTCTAGGAGATGGGAATTCCTTCTGTGGAGGGCTGTGCT
GGGAGACAGGTGGGACAGGTGTGTGTGTAAGAGGAGGAGGATGGAAAAACACCATTATTACCTCCAAAGATCTCTGCCCTTGGGTGTCAG
GCAGGTTGCGGCAGCCCCCACAATTGGGCAGCTGTGTGGCAAGAAGTGCTGGGAGAATGAACAGTGCCAGGCCCTGGTAGCAGGGAGACA

>In-frame_TUSC3_ENST00000509380_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_2950nt
CTCGGCCGCGGCCCGGGTCCCTCGCAAAGCCGCTGCCATCCCGGAGGGCCCAGCCAGCGGGCTCCCGGAGGCTGGCCGGGCAGGCGTGGT
GCGCGGTAGGAGCTGGGCGCGCACGGCTACCGCGCGTGGAGGAGACACTGCCCTGCCGCGATGGGGGCCCGGGGCGCTCCTTCACGCCGT
AGGCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGCTTTCCCTTCCTTCTCCTGCTGCTGCTGCTCTGCATCCAGCTCGGGGGA
GGACAGAAGAAAAAGGAGAATCTTTTAGCTGAAAAAGTAGAGCAGCTGATGGAATGGAGTTCCAGACGCTCAATCTTCCGAATGAATGGT
GATAAATTCCGAAAATTTATAAAGGCACCACCTCGAAACTATTCCATGATTGTTATGTTCACTGCTCTTCAGCCTCAGCGGCAGTGTTCT
GTGTGCAGAAGAAGCTGGGACCACTCTGAAGAGTTACCTAGAAGCACCTTCAACTACAGACCTGGAGCATTCTCCACTGTGCTGCAGCCC
TCAAATCAGGTGCTCAGACGCCGGGAAAAAGTAGACAATGTCTGGACGGAAGAGTCCTGGAACCAGTTTCTGCAGGAACTAGAGACTGGG
CAGAGGCCCAAGAAACCGCTGGTGGACGACCCTGGTGAGAAGCCCTCCCAGCCCATTGAGGTGCTGCTGGAGAGAGAGCTGGCCGAGCTG
AGCGCCGAGCTGGACAAGGACCTGCGGGCAATTGAGACCCGACTGCCGTCCCCCAAGAGCTCGCCGGCGCCCCGACGGGCCCCGGAGCAG
CGGCCCCCGGCCGGCCCGGCCTCAGCCTGGAGCTCCAGCTACCCACATGCACCTTACCTGGGTTCCGCCCGGTCCCTGAGTCCCCACAAA
ATGGCTGATGGAGGAAGCCCCTTCCTAGGTCGGAGGGACTTTGTCTACCCTTCCTCAACCCGAGACCCTAGTGCCTCTAACGGAGGGGGC
AGCCCAGCCAGGAGGGAAGAGAAGAAGAGAAAGGCCGCCAGGCTCAAGTTTGACTTCCAGGCGCAGTCCCCCAAGGAGCTGACTCTGCAG
AAGGGTGACATTGTCTACATCCACAAGGAGGTGGACAAGAACTGGCTGGAGGGAGAGCACCACGGCCGCCTGGGCATCTTCCCTGCTAAT
TATGTGGAGGTGCTGCCCGCAGATGAGATCCCTAAGCCCATCAAGCCCCCGACCTACCAGGTGCTGGAGTATGGAGAGGCTGTGGCCCAG
TACACCTTCAAGGGGGACCTGGAGGTGGAGCTGTCCTTCCGCAAGGGAGAGCACATCTGCCTGATCCGCAAGGTGAACGAGAACTGGTAC
GAGGGACGCATCACGGGCACGGGGCGCCAAGGCATATTCCCTGCCAGCTACGTGCAGGTGTCTCGTGAACCCCGGCTCCGGCTCTGTGAC
GACGGCCCCCAGCTCCCCACGTCTCCCCGCCTGACCGCTGCCGCCCGCTCAGCCCGTCACCCCAGCTCCCCCTCAGCCCTGCGCAGCCCA
GCTGACCCCATCGACTTGGGGGGACAGACCTCCCCCCGTCGCACTGGCTTCTCCTTCCCCACCCAGGAGCCTAGACCCCAGACCCAGAAT
CTTGGCACCCCTGGTCCAGCTCTGTCCCACTCTCGAGGTCCCAGCCATCCCCTGGACCTGGGGACCTCCTCTCCTAACACCTCTCAGATA
CACTGGACCCCGTACCGGGCGATGTACCAGTACAGGCCCCAGAACGAAGACGAGCTGGAGCTGCGCGAGGGGGACAGGGTGGATGTCATG
CAGCAGTGTGACGATGGCTGGTTTGTGGGTGTCTCCCGGAGGACCCAGAAATTCGGAACGTTCCCTGGAAATTACGTTGCCCCGGTGTGA
GTGGTCTCCATGGCAACTTGGAGCCAGCCAGGATGGGGTGGGGAGCGGTGGCACTCGTGGGAGGGAGAGGACCCCCGCCCACATCCTCCT
TCCCCAGGACCTGAGCTCCCAGCATCTGCAGACGACCCCCGCAGCCTTTCCCTCGGACCCCCCTCGAAGCCCCCTGGACTGATTCCCACC
CACGACTCACAGGCATTCCTCCCACAGCCCTTTCATTTCCTCCCCACCCCACTCCCCAAATACAGAGGTCTGCTTTGAAGCGGAGACCAT
TTCCAGGCCTTATTGAGACCAGACCCCAAGTCCCCCACCCCCATCCTGCTCCAGCGTTTCCTCTAACAGGGACCAGCTCTCCGCTTTGCC
CCCACGGGGTTCCTCTAACCAGAACCAGCTTCCTAGCCTCGTAGAGACCAAAGGCCGCCCCCGCCTGCTGGGGTTCCTCCCAGCACCCCA
GCTTGCTGGCTGCCCTCTTTGCCTTCTGGCCTCCAGCTGGGTGTGGGGGGGCGGAGCAAGGCGGGGGACAGACGCAGCACCTTCTTAGCG
ATCTAGGCCTGGCAAGAGCTCTGGCCCCAAGGCCTCCTCTTCCCAGGGGCTGCCAAGTCCTGGCCCTGGCCCTGGCATATCACCCCGCAC
TGTGGGGCCAGGCACCACTAGCCTGGCTCAAATATTCCCCAGGGAGACTGCTGTGTGCTGCCCGCCTGCCTGCTGGCTCTCCCCCAGCCC
CACATCCCCTCTGGAAGAGAATGTAAAATAAACCTGGACACAAGGGACCTTGTCTCTGCGGCCTTTTCCTTGGGGTAGGGGATGCCTCCT
CCTGTCTAGGAGATGGGAATTCCTTCTGTGGAGGGCTGTGCTGGGAGACAGGTGGGACAGGTGTGTGTGTAAGAGGAGGAGGATGGAAAA
ACACCATTATTACCTCCAAAGATCTCTGCCCTTGGGTGTCAGGCAGGTTGCGGCAGCCCCCACAATTGGGCAGCTGTGTGGCAAGAAGTG

>In-frame_TUSC3_ENST00000503731_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_2948nt
CGGCCGCGGCCCGGGTCCCTCGCAAAGCCGCTGCCATCCCGGAGGGCCCAGCCAGCGGGCTCCCGGAGGCTGGCCGGGCAGGCGTGGTGC
GCGGTAGGAGCTGGGCGCGCACGGCTACCGCGCGTGGAGGAGACACTGCCCTGCCGCGATGGGGGCCCGGGGCGCTCCTTCACGCCGTAG
GCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGCTTTCCCTTCCTTCTCCTGCTGCTGCTGCTCTGCATCCAGCTCGGGGGAGG
ACAGAAGAAAAAGGAGAATCTTTTAGCTGAAAAAGTAGAGCAGCTGATGGAATGGAGTTCCAGACGCTCAATCTTCCGAATGAATGGTGA
TAAATTCCGAAAATTTATAAAGGCACCACCTCGAAACTATTCCATGATTGTTATGTTCACTGCTCTTCAGCCTCAGCGGCAGTGTTCTGT
GTGCAGAAGAAGCTGGGACCACTCTGAAGAGTTACCTAGAAGCACCTTCAACTACAGACCTGGAGCATTCTCCACTGTGCTGCAGCCCTC
AAATCAGGTGCTCAGACGCCGGGAAAAAGTAGACAATGTCTGGACGGAAGAGTCCTGGAACCAGTTTCTGCAGGAACTAGAGACTGGGCA
GAGGCCCAAGAAACCGCTGGTGGACGACCCTGGTGAGAAGCCCTCCCAGCCCATTGAGGTGCTGCTGGAGAGAGAGCTGGCCGAGCTGAG
CGCCGAGCTGGACAAGGACCTGCGGGCAATTGAGACCCGACTGCCGTCCCCCAAGAGCTCGCCGGCGCCCCGACGGGCCCCGGAGCAGCG
GCCCCCGGCCGGCCCGGCCTCAGCCTGGAGCTCCAGCTACCCACATGCACCTTACCTGGGTTCCGCCCGGTCCCTGAGTCCCCACAAAAT
GGCTGATGGAGGAAGCCCCTTCCTAGGTCGGAGGGACTTTGTCTACCCTTCCTCAACCCGAGACCCTAGTGCCTCTAACGGAGGGGGCAG
CCCAGCCAGGAGGGAAGAGAAGAAGAGAAAGGCCGCCAGGCTCAAGTTTGACTTCCAGGCGCAGTCCCCCAAGGAGCTGACTCTGCAGAA
GGGTGACATTGTCTACATCCACAAGGAGGTGGACAAGAACTGGCTGGAGGGAGAGCACCACGGCCGCCTGGGCATCTTCCCTGCTAATTA
TGTGGAGGTGCTGCCCGCAGATGAGATCCCTAAGCCCATCAAGCCCCCGACCTACCAGGTGCTGGAGTATGGAGAGGCTGTGGCCCAGTA
CACCTTCAAGGGGGACCTGGAGGTGGAGCTGTCCTTCCGCAAGGGAGAGCACATCTGCCTGATCCGCAAGGTGAACGAGAACTGGTACGA
GGGACGCATCACGGGCACGGGGCGCCAAGGCATATTCCCTGCCAGCTACGTGCAGGTGTCTCGTGAACCCCGGCTCCGGCTCTGTGACGA
CGGCCCCCAGCTCCCCACGTCTCCCCGCCTGACCGCTGCCGCCCGCTCAGCCCGTCACCCCAGCTCCCCCTCAGCCCTGCGCAGCCCAGC
TGACCCCATCGACTTGGGGGGACAGACCTCCCCCCGTCGCACTGGCTTCTCCTTCCCCACCCAGGAGCCTAGACCCCAGACCCAGAATCT
TGGCACCCCTGGTCCAGCTCTGTCCCACTCTCGAGGTCCCAGCCATCCCCTGGACCTGGGGACCTCCTCTCCTAACACCTCTCAGATACA
CTGGACCCCGTACCGGGCGATGTACCAGTACAGGCCCCAGAACGAAGACGAGCTGGAGCTGCGCGAGGGGGACAGGGTGGATGTCATGCA
GCAGTGTGACGATGGCTGGTTTGTGGGTGTCTCCCGGAGGACCCAGAAATTCGGAACGTTCCCTGGAAATTACGTTGCCCCGGTGTGAGT
GGTCTCCATGGCAACTTGGAGCCAGCCAGGATGGGGTGGGGAGCGGTGGCACTCGTGGGAGGGAGAGGACCCCCGCCCACATCCTCCTTC
CCCAGGACCTGAGCTCCCAGCATCTGCAGACGACCCCCGCAGCCTTTCCCTCGGACCCCCCTCGAAGCCCCCTGGACTGATTCCCACCCA
CGACTCACAGGCATTCCTCCCACAGCCCTTTCATTTCCTCCCCACCCCACTCCCCAAATACAGAGGTCTGCTTTGAAGCGGAGACCATTT
CCAGGCCTTATTGAGACCAGACCCCAAGTCCCCCACCCCCATCCTGCTCCAGCGTTTCCTCTAACAGGGACCAGCTCTCCGCTTTGCCCC
CACGGGGTTCCTCTAACCAGAACCAGCTTCCTAGCCTCGTAGAGACCAAAGGCCGCCCCCGCCTGCTGGGGTTCCTCCCAGCACCCCAGC
TTGCTGGCTGCCCTCTTTGCCTTCTGGCCTCCAGCTGGGTGTGGGGGGGCGGAGCAAGGCGGGGGACAGACGCAGCACCTTCTTAGCGAT
CTAGGCCTGGCAAGAGCTCTGGCCCCAAGGCCTCCTCTTCCCAGGGGCTGCCAAGTCCTGGCCCTGGCCCTGGCATATCACCCCGCACTG
TGGGGCCAGGCACCACTAGCCTGGCTCAAATATTCCCCAGGGAGACTGCTGTGTGCTGCCCGCCTGCCTGCTGGCTCTCCCCCAGCCCCA
CATCCCCTCTGGAAGAGAATGTAAAATAAACCTGGACACAAGGGACCTTGTCTCTGCGGCCTTTTCCTTGGGGTAGGGGATGCCTCCTCC
TGTCTAGGAGATGGGAATTCCTTCTGTGGAGGGCTGTGCTGGGAGACAGGTGGGACAGGTGTGTGTGTAAGAGGAGGAGGATGGAAAAAC
ACCATTATTACCTCCAAAGATCTCTGCCCTTGGGTGTCAGGCAGGTTGCGGCAGCCCCCACAATTGGGCAGCTGTGTGGCAAGAAGTGCT


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FusionGenePPI for TUSC3_SORBS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TUSC3BMI1, PPP1CA, FBXO6, PEX19, MCOLN3, SYNE4, HTR3C, RPN2, FAM122B, UPK1A, HTR3A, STXBP2, LIN54, SCN3B, STXBP1, NDRG3, GGT7, GABRA3, GABRD, SLC9A3R2, RNF185, CHRND, CHEK1, MAP2K1, TUBA1ASORBS3KIAA0408, RBMX, KIAA1217, DMRTB1, ADAMTSL4, ZBED1, ZBTB25, CPSF7, EFS, DDX17, CBLB, DVL2, HNRNPK, MAPK1, SAFB2, DLG5, FLOT1, CBL, FASLG, SOCS7, PAK2, TXNDC17, UBE2T, ATP6V1H, ALB, BAG3, SRCIN1, WASL, SYP, ARNT2, AKT1, PAK1, TRIM23, TRIM27, EIF3H, SORBS3, HNRNPUL1, DIP2A, ZBTB7B, NCKIPSD, VPS37C, TBC1D22B, ZC4H2, PAK7, VARS2, SH2D4A, VPS37B, TRIM41, FAM154A, CPNE2, NOTCH3, KRAS, SYNCRIP, KATNA1, ANAPC15, CCDC22, TNS1, LRFN4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TUSC3_SORBS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TUSC3_SORBS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTUSC3C0023893Liver Cirrhosis, Experimental1CTD_human