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Fusion gene ID: 40171 |
FusionGeneSummary for TUSC3_SORBS3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TUSC3_SORBS3 | Fusion gene ID: 40171 | Hgene | Tgene | Gene symbol | TUSC3 | SORBS3 | Gene ID | 7991 | 10174 |
| Gene name | tumor suppressor candidate 3 | sorbin and SH3 domain containing 3 | |
| Synonyms | D8S1992|M33|MRT22|MRT7|MagT2|N33|OST3A | SCAM-1|SCAM1|SH3D4 | |
| Cytomap | 8p22 | 8p21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tumor suppressor candidate 3magnesium uptake/transporter TUSC3oligosaccharyltransferase 3 homolog Aputative prostate cancer tumor suppressor | vinexinsorbin and SH3 domain-containing protein 3vinexin beta (SH3-containing adaptor molecule-1) | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q13454 | O60504 | |
| Ensembl transtripts involved in fusion gene | ENST00000503191, ENST00000382020, ENST00000506802, ENST00000509380, ENST00000503731, | ENST00000240123, ENST00000523402, ENST00000523740, ENST00000428103, | |
| Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 3 X 3 X 3=27 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TUSC3 [Title/Abstract] AND SORBS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SORBS3 | GO:0051496 | positive regulation of stress fiber assembly | 9885244 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AO-A03T-01A | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000503191 | ENST00000240123 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| 3UTR-intron | ENST00000503191 | ENST00000523402 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| 3UTR-intron | ENST00000503191 | ENST00000523740 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| 3UTR-intron | ENST00000503191 | ENST00000428103 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| In-frame | ENST00000382020 | ENST00000240123 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| 5CDS-intron | ENST00000382020 | ENST00000523402 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| 5CDS-intron | ENST00000382020 | ENST00000523740 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| 5CDS-intron | ENST00000382020 | ENST00000428103 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| In-frame | ENST00000506802 | ENST00000240123 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| 5CDS-intron | ENST00000506802 | ENST00000523402 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| 5CDS-intron | ENST00000506802 | ENST00000523740 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| 5CDS-intron | ENST00000506802 | ENST00000428103 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| In-frame | ENST00000509380 | ENST00000240123 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| 5CDS-intron | ENST00000509380 | ENST00000523402 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| 5CDS-intron | ENST00000509380 | ENST00000523740 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| 5CDS-intron | ENST00000509380 | ENST00000428103 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| In-frame | ENST00000503731 | ENST00000240123 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| 5CDS-intron | ENST00000503731 | ENST00000523402 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| 5CDS-intron | ENST00000503731 | ENST00000523740 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
| 5CDS-intron | ENST00000503731 | ENST00000428103 | TUSC3 | chr8 | 15480758 | + | SORBS3 | chr8 | 22421500 | + |
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FusionProtFeatures for TUSC3_SORBS3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TUSC3 | SORBS3 |
| Acts as accessory component of the N-oligosaccharyltransferase (OST) complex which catalyzes the transfer of a highmannose oligosaccharide from a lipid-linked oligosaccharide donorto an asparagine residue within an Asn-X-Ser/Thr consensus motifin nascent polypeptide chains. Involved in N-glycosylation ofSTT3B-dependent substrates. Specifically required for theglycosylation of a subset of acceptor sites that are near cysteineresidues; in this function seems to act redundantly with MAGT1. Inits oxidized form proposed to form transient mixed disulfides witha glycoprotein substrate to facilitate access of STT3B to theunmodified acceptor site. Has also oxidoreductase-independentfunctions in the STT3B-containing OST complex possibly involvingsubstrate recognition. {ECO:0000269|PubMed:25135935,ECO:0000305|PubMed:12887896, ECO:0000305|PubMed:24685145}. Magnesium transporter. {ECO:0000269|PubMed:19717468}. | Vinexin alpha isoform promotes up-regulation of actinstress fiber formation. Vinexin beta isoform plays a role in cellspreading and enhances the activation of JNK/SAPK in response toEGF stimulation by using its third SH3 domain. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TUSC3_SORBS3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TUSC3_ENST00000382020_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_580aa MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNTSMIVMF TALQPQRQCSVCRRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIE VLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSST RDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANTVEVLPADEIPKPIKPPTYQ VLETGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARH PSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELE >In-frame_TUSC3_ENST00000506802_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_580aa MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNTSMIVMF TALQPQRQCSVCRRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIE VLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSST RDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANTVEVLPADEIPKPIKPPTYQ VLETGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARH PSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELE >In-frame_TUSC3_ENST00000509380_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_580aa MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNTSMIVMF TALQPQRQCSVCRRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIE VLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSST RDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANTVEVLPADEIPKPIKPPTYQ VLETGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARH PSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELE >In-frame_TUSC3_ENST00000503731_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_580aa MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNTSMIVMF TALQPQRQCSVCRRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIE VLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSST RDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANTVEVLPADEIPKPIKPPTYQ VLETGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARH PSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TUSC3_ENST00000382020_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_1740nt ATGGGGGCCCGGGGCGCTCCTTCACGCCGTAGGCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGCTTTCCCTTCCTTCTCCTG CTGCTGCTGCTCTGCATCCAGCTCGGGGGAGGACAGAAGAAAAAGGAGAATCTTTTAGCTGAAAAAGTAGAGCAGCTGATGGAATGGAGT TCCAGACGCTCAATCTTCCGAATGAATGGTGATAAATTCCGAAAATTTATAAAGGCACCACCTCGAAACTATTCCATGATTGTTATGTTC ACTGCTCTTCAGCCTCAGCGGCAGTGTTCTGTGTGCAGAAGAAGCTGGGACCACTCTGAAGAGTTACCTAGAAGCACCTTCAACTACAGA CCTGGAGCATTCTCCACTGTGCTGCAGCCCTCAAATCAGGTGCTCAGACGCCGGGAAAAAGTAGACAATGTCTGGACGGAAGAGTCCTGG AACCAGTTTCTGCAGGAACTAGAGACTGGGCAGAGGCCCAAGAAACCGCTGGTGGACGACCCTGGTGAGAAGCCCTCCCAGCCCATTGAG GTGCTGCTGGAGAGAGAGCTGGCCGAGCTGAGCGCCGAGCTGGACAAGGACCTGCGGGCAATTGAGACCCGACTGCCGTCCCCCAAGAGC TCGCCGGCGCCCCGACGGGCCCCGGAGCAGCGGCCCCCGGCCGGCCCGGCCTCAGCCTGGAGCTCCAGCTACCCACATGCACCTTACCTG GGTTCCGCCCGGTCCCTGAGTCCCCACAAAATGGCTGATGGAGGAAGCCCCTTCCTAGGTCGGAGGGACTTTGTCTACCCTTCCTCAACC CGAGACCCTAGTGCCTCTAACGGAGGGGGCAGCCCAGCCAGGAGGGAAGAGAAGAAGAGAAAGGCCGCCAGGCTCAAGTTTGACTTCCAG GCGCAGTCCCCCAAGGAGCTGACTCTGCAGAAGGGTGACATTGTCTACATCCACAAGGAGGTGGACAAGAACTGGCTGGAGGGAGAGCAC CACGGCCGCCTGGGCATCTTCCCTGCTAATTATGTGGAGGTGCTGCCCGCAGATGAGATCCCTAAGCCCATCAAGCCCCCGACCTACCAG GTGCTGGAGTATGGAGAGGCTGTGGCCCAGTACACCTTCAAGGGGGACCTGGAGGTGGAGCTGTCCTTCCGCAAGGGAGAGCACATCTGC CTGATCCGCAAGGTGAACGAGAACTGGTACGAGGGACGCATCACGGGCACGGGGCGCCAAGGCATATTCCCTGCCAGCTACGTGCAGGTG TCTCGTGAACCCCGGCTCCGGCTCTGTGACGACGGCCCCCAGCTCCCCACGTCTCCCCGCCTGACCGCTGCCGCCCGCTCAGCCCGTCAC CCCAGCTCCCCCTCAGCCCTGCGCAGCCCAGCTGACCCCATCGACTTGGGGGGACAGACCTCCCCCCGTCGCACTGGCTTCTCCTTCCCC ACCCAGGAGCCTAGACCCCAGACCCAGAATCTTGGCACCCCTGGTCCAGCTCTGTCCCACTCTCGAGGTCCCAGCCATCCCCTGGACCTG GGGACCTCCTCTCCTAACACCTCTCAGATACACTGGACCCCGTACCGGGCGATGTACCAGTACAGGCCCCAGAACGAAGACGAGCTGGAG CTGCGCGAGGGGGACAGGGTGGATGTCATGCAGCAGTGTGACGATGGCTGGTTTGTGGGTGTCTCCCGGAGGACCCAGAAATTCGGAACG >In-frame_TUSC3_ENST00000506802_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_1740nt ATGGGGGCCCGGGGCGCTCCTTCACGCCGTAGGCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGCTTTCCCTTCCTTCTCCTG CTGCTGCTGCTCTGCATCCAGCTCGGGGGAGGACAGAAGAAAAAGGAGAATCTTTTAGCTGAAAAAGTAGAGCAGCTGATGGAATGGAGT TCCAGACGCTCAATCTTCCGAATGAATGGTGATAAATTCCGAAAATTTATAAAGGCACCACCTCGAAACTATTCCATGATTGTTATGTTC ACTGCTCTTCAGCCTCAGCGGCAGTGTTCTGTGTGCAGAAGAAGCTGGGACCACTCTGAAGAGTTACCTAGAAGCACCTTCAACTACAGA CCTGGAGCATTCTCCACTGTGCTGCAGCCCTCAAATCAGGTGCTCAGACGCCGGGAAAAAGTAGACAATGTCTGGACGGAAGAGTCCTGG AACCAGTTTCTGCAGGAACTAGAGACTGGGCAGAGGCCCAAGAAACCGCTGGTGGACGACCCTGGTGAGAAGCCCTCCCAGCCCATTGAG GTGCTGCTGGAGAGAGAGCTGGCCGAGCTGAGCGCCGAGCTGGACAAGGACCTGCGGGCAATTGAGACCCGACTGCCGTCCCCCAAGAGC TCGCCGGCGCCCCGACGGGCCCCGGAGCAGCGGCCCCCGGCCGGCCCGGCCTCAGCCTGGAGCTCCAGCTACCCACATGCACCTTACCTG GGTTCCGCCCGGTCCCTGAGTCCCCACAAAATGGCTGATGGAGGAAGCCCCTTCCTAGGTCGGAGGGACTTTGTCTACCCTTCCTCAACC CGAGACCCTAGTGCCTCTAACGGAGGGGGCAGCCCAGCCAGGAGGGAAGAGAAGAAGAGAAAGGCCGCCAGGCTCAAGTTTGACTTCCAG GCGCAGTCCCCCAAGGAGCTGACTCTGCAGAAGGGTGACATTGTCTACATCCACAAGGAGGTGGACAAGAACTGGCTGGAGGGAGAGCAC CACGGCCGCCTGGGCATCTTCCCTGCTAATTATGTGGAGGTGCTGCCCGCAGATGAGATCCCTAAGCCCATCAAGCCCCCGACCTACCAG GTGCTGGAGTATGGAGAGGCTGTGGCCCAGTACACCTTCAAGGGGGACCTGGAGGTGGAGCTGTCCTTCCGCAAGGGAGAGCACATCTGC CTGATCCGCAAGGTGAACGAGAACTGGTACGAGGGACGCATCACGGGCACGGGGCGCCAAGGCATATTCCCTGCCAGCTACGTGCAGGTG TCTCGTGAACCCCGGCTCCGGCTCTGTGACGACGGCCCCCAGCTCCCCACGTCTCCCCGCCTGACCGCTGCCGCCCGCTCAGCCCGTCAC CCCAGCTCCCCCTCAGCCCTGCGCAGCCCAGCTGACCCCATCGACTTGGGGGGACAGACCTCCCCCCGTCGCACTGGCTTCTCCTTCCCC ACCCAGGAGCCTAGACCCCAGACCCAGAATCTTGGCACCCCTGGTCCAGCTCTGTCCCACTCTCGAGGTCCCAGCCATCCCCTGGACCTG GGGACCTCCTCTCCTAACACCTCTCAGATACACTGGACCCCGTACCGGGCGATGTACCAGTACAGGCCCCAGAACGAAGACGAGCTGGAG CTGCGCGAGGGGGACAGGGTGGATGTCATGCAGCAGTGTGACGATGGCTGGTTTGTGGGTGTCTCCCGGAGGACCCAGAAATTCGGAACG >In-frame_TUSC3_ENST00000509380_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_1740nt ATGGGGGCCCGGGGCGCTCCTTCACGCCGTAGGCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGCTTTCCCTTCCTTCTCCTG CTGCTGCTGCTCTGCATCCAGCTCGGGGGAGGACAGAAGAAAAAGGAGAATCTTTTAGCTGAAAAAGTAGAGCAGCTGATGGAATGGAGT TCCAGACGCTCAATCTTCCGAATGAATGGTGATAAATTCCGAAAATTTATAAAGGCACCACCTCGAAACTATTCCATGATTGTTATGTTC ACTGCTCTTCAGCCTCAGCGGCAGTGTTCTGTGTGCAGAAGAAGCTGGGACCACTCTGAAGAGTTACCTAGAAGCACCTTCAACTACAGA CCTGGAGCATTCTCCACTGTGCTGCAGCCCTCAAATCAGGTGCTCAGACGCCGGGAAAAAGTAGACAATGTCTGGACGGAAGAGTCCTGG AACCAGTTTCTGCAGGAACTAGAGACTGGGCAGAGGCCCAAGAAACCGCTGGTGGACGACCCTGGTGAGAAGCCCTCCCAGCCCATTGAG GTGCTGCTGGAGAGAGAGCTGGCCGAGCTGAGCGCCGAGCTGGACAAGGACCTGCGGGCAATTGAGACCCGACTGCCGTCCCCCAAGAGC TCGCCGGCGCCCCGACGGGCCCCGGAGCAGCGGCCCCCGGCCGGCCCGGCCTCAGCCTGGAGCTCCAGCTACCCACATGCACCTTACCTG GGTTCCGCCCGGTCCCTGAGTCCCCACAAAATGGCTGATGGAGGAAGCCCCTTCCTAGGTCGGAGGGACTTTGTCTACCCTTCCTCAACC CGAGACCCTAGTGCCTCTAACGGAGGGGGCAGCCCAGCCAGGAGGGAAGAGAAGAAGAGAAAGGCCGCCAGGCTCAAGTTTGACTTCCAG GCGCAGTCCCCCAAGGAGCTGACTCTGCAGAAGGGTGACATTGTCTACATCCACAAGGAGGTGGACAAGAACTGGCTGGAGGGAGAGCAC CACGGCCGCCTGGGCATCTTCCCTGCTAATTATGTGGAGGTGCTGCCCGCAGATGAGATCCCTAAGCCCATCAAGCCCCCGACCTACCAG GTGCTGGAGTATGGAGAGGCTGTGGCCCAGTACACCTTCAAGGGGGACCTGGAGGTGGAGCTGTCCTTCCGCAAGGGAGAGCACATCTGC CTGATCCGCAAGGTGAACGAGAACTGGTACGAGGGACGCATCACGGGCACGGGGCGCCAAGGCATATTCCCTGCCAGCTACGTGCAGGTG TCTCGTGAACCCCGGCTCCGGCTCTGTGACGACGGCCCCCAGCTCCCCACGTCTCCCCGCCTGACCGCTGCCGCCCGCTCAGCCCGTCAC CCCAGCTCCCCCTCAGCCCTGCGCAGCCCAGCTGACCCCATCGACTTGGGGGGACAGACCTCCCCCCGTCGCACTGGCTTCTCCTTCCCC ACCCAGGAGCCTAGACCCCAGACCCAGAATCTTGGCACCCCTGGTCCAGCTCTGTCCCACTCTCGAGGTCCCAGCCATCCCCTGGACCTG GGGACCTCCTCTCCTAACACCTCTCAGATACACTGGACCCCGTACCGGGCGATGTACCAGTACAGGCCCCAGAACGAAGACGAGCTGGAG CTGCGCGAGGGGGACAGGGTGGATGTCATGCAGCAGTGTGACGATGGCTGGTTTGTGGGTGTCTCCCGGAGGACCCAGAAATTCGGAACG >In-frame_TUSC3_ENST00000503731_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_1740nt ATGGGGGCCCGGGGCGCTCCTTCACGCCGTAGGCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGCTTTCCCTTCCTTCTCCTG CTGCTGCTGCTCTGCATCCAGCTCGGGGGAGGACAGAAGAAAAAGGAGAATCTTTTAGCTGAAAAAGTAGAGCAGCTGATGGAATGGAGT TCCAGACGCTCAATCTTCCGAATGAATGGTGATAAATTCCGAAAATTTATAAAGGCACCACCTCGAAACTATTCCATGATTGTTATGTTC ACTGCTCTTCAGCCTCAGCGGCAGTGTTCTGTGTGCAGAAGAAGCTGGGACCACTCTGAAGAGTTACCTAGAAGCACCTTCAACTACAGA CCTGGAGCATTCTCCACTGTGCTGCAGCCCTCAAATCAGGTGCTCAGACGCCGGGAAAAAGTAGACAATGTCTGGACGGAAGAGTCCTGG AACCAGTTTCTGCAGGAACTAGAGACTGGGCAGAGGCCCAAGAAACCGCTGGTGGACGACCCTGGTGAGAAGCCCTCCCAGCCCATTGAG GTGCTGCTGGAGAGAGAGCTGGCCGAGCTGAGCGCCGAGCTGGACAAGGACCTGCGGGCAATTGAGACCCGACTGCCGTCCCCCAAGAGC TCGCCGGCGCCCCGACGGGCCCCGGAGCAGCGGCCCCCGGCCGGCCCGGCCTCAGCCTGGAGCTCCAGCTACCCACATGCACCTTACCTG GGTTCCGCCCGGTCCCTGAGTCCCCACAAAATGGCTGATGGAGGAAGCCCCTTCCTAGGTCGGAGGGACTTTGTCTACCCTTCCTCAACC CGAGACCCTAGTGCCTCTAACGGAGGGGGCAGCCCAGCCAGGAGGGAAGAGAAGAAGAGAAAGGCCGCCAGGCTCAAGTTTGACTTCCAG GCGCAGTCCCCCAAGGAGCTGACTCTGCAGAAGGGTGACATTGTCTACATCCACAAGGAGGTGGACAAGAACTGGCTGGAGGGAGAGCAC CACGGCCGCCTGGGCATCTTCCCTGCTAATTATGTGGAGGTGCTGCCCGCAGATGAGATCCCTAAGCCCATCAAGCCCCCGACCTACCAG GTGCTGGAGTATGGAGAGGCTGTGGCCCAGTACACCTTCAAGGGGGACCTGGAGGTGGAGCTGTCCTTCCGCAAGGGAGAGCACATCTGC CTGATCCGCAAGGTGAACGAGAACTGGTACGAGGGACGCATCACGGGCACGGGGCGCCAAGGCATATTCCCTGCCAGCTACGTGCAGGTG TCTCGTGAACCCCGGCTCCGGCTCTGTGACGACGGCCCCCAGCTCCCCACGTCTCCCCGCCTGACCGCTGCCGCCCGCTCAGCCCGTCAC CCCAGCTCCCCCTCAGCCCTGCGCAGCCCAGCTGACCCCATCGACTTGGGGGGACAGACCTCCCCCCGTCGCACTGGCTTCTCCTTCCCC ACCCAGGAGCCTAGACCCCAGACCCAGAATCTTGGCACCCCTGGTCCAGCTCTGTCCCACTCTCGAGGTCCCAGCCATCCCCTGGACCTG GGGACCTCCTCTCCTAACACCTCTCAGATACACTGGACCCCGTACCGGGCGATGTACCAGTACAGGCCCCAGAACGAAGACGAGCTGGAG CTGCGCGAGGGGGACAGGGTGGATGTCATGCAGCAGTGTGACGATGGCTGGTTTGTGGGTGTCTCCCGGAGGACCCAGAAATTCGGAACG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TUSC3_ENST00000382020_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_3008nt GCCTTTCCAGGTCTTCTCCCGGTGAACCGGATGCTCTGTCAGTCTCCTCCTCTGCGTCCTCGGCCGCGGCCCGGGTCCCTCGCAAAGCCG CTGCCATCCCGGAGGGCCCAGCCAGCGGGCTCCCGGAGGCTGGCCGGGCAGGCGTGGTGCGCGGTAGGAGCTGGGCGCGCACGGCTACCG CGCGTGGAGGAGACACTGCCCTGCCGCGATGGGGGCCCGGGGCGCTCCTTCACGCCGTAGGCAAGCGGGGCGGCGGCTGCGGTACCTGCC CACCGGGAGCTTTCCCTTCCTTCTCCTGCTGCTGCTGCTCTGCATCCAGCTCGGGGGAGGACAGAAGAAAAAGGAGAATCTTTTAGCTGA AAAAGTAGAGCAGCTGATGGAATGGAGTTCCAGACGCTCAATCTTCCGAATGAATGGTGATAAATTCCGAAAATTTATAAAGGCACCACC TCGAAACTATTCCATGATTGTTATGTTCACTGCTCTTCAGCCTCAGCGGCAGTGTTCTGTGTGCAGAAGAAGCTGGGACCACTCTGAAGA GTTACCTAGAAGCACCTTCAACTACAGACCTGGAGCATTCTCCACTGTGCTGCAGCCCTCAAATCAGGTGCTCAGACGCCGGGAAAAAGT AGACAATGTCTGGACGGAAGAGTCCTGGAACCAGTTTCTGCAGGAACTAGAGACTGGGCAGAGGCCCAAGAAACCGCTGGTGGACGACCC TGGTGAGAAGCCCTCCCAGCCCATTGAGGTGCTGCTGGAGAGAGAGCTGGCCGAGCTGAGCGCCGAGCTGGACAAGGACCTGCGGGCAAT TGAGACCCGACTGCCGTCCCCCAAGAGCTCGCCGGCGCCCCGACGGGCCCCGGAGCAGCGGCCCCCGGCCGGCCCGGCCTCAGCCTGGAG CTCCAGCTACCCACATGCACCTTACCTGGGTTCCGCCCGGTCCCTGAGTCCCCACAAAATGGCTGATGGAGGAAGCCCCTTCCTAGGTCG GAGGGACTTTGTCTACCCTTCCTCAACCCGAGACCCTAGTGCCTCTAACGGAGGGGGCAGCCCAGCCAGGAGGGAAGAGAAGAAGAGAAA GGCCGCCAGGCTCAAGTTTGACTTCCAGGCGCAGTCCCCCAAGGAGCTGACTCTGCAGAAGGGTGACATTGTCTACATCCACAAGGAGGT GGACAAGAACTGGCTGGAGGGAGAGCACCACGGCCGCCTGGGCATCTTCCCTGCTAATTATGTGGAGGTGCTGCCCGCAGATGAGATCCC TAAGCCCATCAAGCCCCCGACCTACCAGGTGCTGGAGTATGGAGAGGCTGTGGCCCAGTACACCTTCAAGGGGGACCTGGAGGTGGAGCT GTCCTTCCGCAAGGGAGAGCACATCTGCCTGATCCGCAAGGTGAACGAGAACTGGTACGAGGGACGCATCACGGGCACGGGGCGCCAAGG CATATTCCCTGCCAGCTACGTGCAGGTGTCTCGTGAACCCCGGCTCCGGCTCTGTGACGACGGCCCCCAGCTCCCCACGTCTCCCCGCCT GACCGCTGCCGCCCGCTCAGCCCGTCACCCCAGCTCCCCCTCAGCCCTGCGCAGCCCAGCTGACCCCATCGACTTGGGGGGACAGACCTC CCCCCGTCGCACTGGCTTCTCCTTCCCCACCCAGGAGCCTAGACCCCAGACCCAGAATCTTGGCACCCCTGGTCCAGCTCTGTCCCACTC TCGAGGTCCCAGCCATCCCCTGGACCTGGGGACCTCCTCTCCTAACACCTCTCAGATACACTGGACCCCGTACCGGGCGATGTACCAGTA CAGGCCCCAGAACGAAGACGAGCTGGAGCTGCGCGAGGGGGACAGGGTGGATGTCATGCAGCAGTGTGACGATGGCTGGTTTGTGGGTGT CTCCCGGAGGACCCAGAAATTCGGAACGTTCCCTGGAAATTACGTTGCCCCGGTGTGAGTGGTCTCCATGGCAACTTGGAGCCAGCCAGG ATGGGGTGGGGAGCGGTGGCACTCGTGGGAGGGAGAGGACCCCCGCCCACATCCTCCTTCCCCAGGACCTGAGCTCCCAGCATCTGCAGA CGACCCCCGCAGCCTTTCCCTCGGACCCCCCTCGAAGCCCCCTGGACTGATTCCCACCCACGACTCACAGGCATTCCTCCCACAGCCCTT TCATTTCCTCCCCACCCCACTCCCCAAATACAGAGGTCTGCTTTGAAGCGGAGACCATTTCCAGGCCTTATTGAGACCAGACCCCAAGTC CCCCACCCCCATCCTGCTCCAGCGTTTCCTCTAACAGGGACCAGCTCTCCGCTTTGCCCCCACGGGGTTCCTCTAACCAGAACCAGCTTC CTAGCCTCGTAGAGACCAAAGGCCGCCCCCGCCTGCTGGGGTTCCTCCCAGCACCCCAGCTTGCTGGCTGCCCTCTTTGCCTTCTGGCCT CCAGCTGGGTGTGGGGGGGCGGAGCAAGGCGGGGGACAGACGCAGCACCTTCTTAGCGATCTAGGCCTGGCAAGAGCTCTGGCCCCAAGG CCTCCTCTTCCCAGGGGCTGCCAAGTCCTGGCCCTGGCCCTGGCATATCACCCCGCACTGTGGGGCCAGGCACCACTAGCCTGGCTCAAA TATTCCCCAGGGAGACTGCTGTGTGCTGCCCGCCTGCCTGCTGGCTCTCCCCCAGCCCCACATCCCCTCTGGAAGAGAATGTAAAATAAA CCTGGACACAAGGGACCTTGTCTCTGCGGCCTTTTCCTTGGGGTAGGGGATGCCTCCTCCTGTCTAGGAGATGGGAATTCCTTCTGTGGA GGGCTGTGCTGGGAGACAGGTGGGACAGGTGTGTGTGTAAGAGGAGGAGGATGGAAAAACACCATTATTACCTCCAAAGATCTCTGCCCT TGGGTGTCAGGCAGGTTGCGGCAGCCCCCACAATTGGGCAGCTGTGTGGCAAGAAGTGCTGGGAGAATGAACAGTGCCAGGCCCTGGTAG >In-frame_TUSC3_ENST00000506802_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_2998nt GTCTTCTCCCGGTGAACCGGATGCTCTGTCAGTCTCCTCCTCTGCGTCCTCGGCCGCGGCCCGGGTCCCTCGCAAAGCCGCTGCCATCCC GGAGGGCCCAGCCAGCGGGCTCCCGGAGGCTGGCCGGGCAGGCGTGGTGCGCGGTAGGAGCTGGGCGCGCACGGCTACCGCGCGTGGAGG AGACACTGCCCTGCCGCGATGGGGGCCCGGGGCGCTCCTTCACGCCGTAGGCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGC TTTCCCTTCCTTCTCCTGCTGCTGCTGCTCTGCATCCAGCTCGGGGGAGGACAGAAGAAAAAGGAGAATCTTTTAGCTGAAAAAGTAGAG CAGCTGATGGAATGGAGTTCCAGACGCTCAATCTTCCGAATGAATGGTGATAAATTCCGAAAATTTATAAAGGCACCACCTCGAAACTAT TCCATGATTGTTATGTTCACTGCTCTTCAGCCTCAGCGGCAGTGTTCTGTGTGCAGAAGAAGCTGGGACCACTCTGAAGAGTTACCTAGA AGCACCTTCAACTACAGACCTGGAGCATTCTCCACTGTGCTGCAGCCCTCAAATCAGGTGCTCAGACGCCGGGAAAAAGTAGACAATGTC TGGACGGAAGAGTCCTGGAACCAGTTTCTGCAGGAACTAGAGACTGGGCAGAGGCCCAAGAAACCGCTGGTGGACGACCCTGGTGAGAAG CCCTCCCAGCCCATTGAGGTGCTGCTGGAGAGAGAGCTGGCCGAGCTGAGCGCCGAGCTGGACAAGGACCTGCGGGCAATTGAGACCCGA CTGCCGTCCCCCAAGAGCTCGCCGGCGCCCCGACGGGCCCCGGAGCAGCGGCCCCCGGCCGGCCCGGCCTCAGCCTGGAGCTCCAGCTAC CCACATGCACCTTACCTGGGTTCCGCCCGGTCCCTGAGTCCCCACAAAATGGCTGATGGAGGAAGCCCCTTCCTAGGTCGGAGGGACTTT GTCTACCCTTCCTCAACCCGAGACCCTAGTGCCTCTAACGGAGGGGGCAGCCCAGCCAGGAGGGAAGAGAAGAAGAGAAAGGCCGCCAGG CTCAAGTTTGACTTCCAGGCGCAGTCCCCCAAGGAGCTGACTCTGCAGAAGGGTGACATTGTCTACATCCACAAGGAGGTGGACAAGAAC TGGCTGGAGGGAGAGCACCACGGCCGCCTGGGCATCTTCCCTGCTAATTATGTGGAGGTGCTGCCCGCAGATGAGATCCCTAAGCCCATC AAGCCCCCGACCTACCAGGTGCTGGAGTATGGAGAGGCTGTGGCCCAGTACACCTTCAAGGGGGACCTGGAGGTGGAGCTGTCCTTCCGC AAGGGAGAGCACATCTGCCTGATCCGCAAGGTGAACGAGAACTGGTACGAGGGACGCATCACGGGCACGGGGCGCCAAGGCATATTCCCT GCCAGCTACGTGCAGGTGTCTCGTGAACCCCGGCTCCGGCTCTGTGACGACGGCCCCCAGCTCCCCACGTCTCCCCGCCTGACCGCTGCC GCCCGCTCAGCCCGTCACCCCAGCTCCCCCTCAGCCCTGCGCAGCCCAGCTGACCCCATCGACTTGGGGGGACAGACCTCCCCCCGTCGC ACTGGCTTCTCCTTCCCCACCCAGGAGCCTAGACCCCAGACCCAGAATCTTGGCACCCCTGGTCCAGCTCTGTCCCACTCTCGAGGTCCC AGCCATCCCCTGGACCTGGGGACCTCCTCTCCTAACACCTCTCAGATACACTGGACCCCGTACCGGGCGATGTACCAGTACAGGCCCCAG AACGAAGACGAGCTGGAGCTGCGCGAGGGGGACAGGGTGGATGTCATGCAGCAGTGTGACGATGGCTGGTTTGTGGGTGTCTCCCGGAGG ACCCAGAAATTCGGAACGTTCCCTGGAAATTACGTTGCCCCGGTGTGAGTGGTCTCCATGGCAACTTGGAGCCAGCCAGGATGGGGTGGG GAGCGGTGGCACTCGTGGGAGGGAGAGGACCCCCGCCCACATCCTCCTTCCCCAGGACCTGAGCTCCCAGCATCTGCAGACGACCCCCGC AGCCTTTCCCTCGGACCCCCCTCGAAGCCCCCTGGACTGATTCCCACCCACGACTCACAGGCATTCCTCCCACAGCCCTTTCATTTCCTC CCCACCCCACTCCCCAAATACAGAGGTCTGCTTTGAAGCGGAGACCATTTCCAGGCCTTATTGAGACCAGACCCCAAGTCCCCCACCCCC ATCCTGCTCCAGCGTTTCCTCTAACAGGGACCAGCTCTCCGCTTTGCCCCCACGGGGTTCCTCTAACCAGAACCAGCTTCCTAGCCTCGT AGAGACCAAAGGCCGCCCCCGCCTGCTGGGGTTCCTCCCAGCACCCCAGCTTGCTGGCTGCCCTCTTTGCCTTCTGGCCTCCAGCTGGGT GTGGGGGGGCGGAGCAAGGCGGGGGACAGACGCAGCACCTTCTTAGCGATCTAGGCCTGGCAAGAGCTCTGGCCCCAAGGCCTCCTCTTC CCAGGGGCTGCCAAGTCCTGGCCCTGGCCCTGGCATATCACCCCGCACTGTGGGGCCAGGCACCACTAGCCTGGCTCAAATATTCCCCAG GGAGACTGCTGTGTGCTGCCCGCCTGCCTGCTGGCTCTCCCCCAGCCCCACATCCCCTCTGGAAGAGAATGTAAAATAAACCTGGACACA AGGGACCTTGTCTCTGCGGCCTTTTCCTTGGGGTAGGGGATGCCTCCTCCTGTCTAGGAGATGGGAATTCCTTCTGTGGAGGGCTGTGCT GGGAGACAGGTGGGACAGGTGTGTGTGTAAGAGGAGGAGGATGGAAAAACACCATTATTACCTCCAAAGATCTCTGCCCTTGGGTGTCAG GCAGGTTGCGGCAGCCCCCACAATTGGGCAGCTGTGTGGCAAGAAGTGCTGGGAGAATGAACAGTGCCAGGCCCTGGTAGCAGGGAGACA >In-frame_TUSC3_ENST00000509380_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_2950nt CTCGGCCGCGGCCCGGGTCCCTCGCAAAGCCGCTGCCATCCCGGAGGGCCCAGCCAGCGGGCTCCCGGAGGCTGGCCGGGCAGGCGTGGT GCGCGGTAGGAGCTGGGCGCGCACGGCTACCGCGCGTGGAGGAGACACTGCCCTGCCGCGATGGGGGCCCGGGGCGCTCCTTCACGCCGT AGGCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGCTTTCCCTTCCTTCTCCTGCTGCTGCTGCTCTGCATCCAGCTCGGGGGA GGACAGAAGAAAAAGGAGAATCTTTTAGCTGAAAAAGTAGAGCAGCTGATGGAATGGAGTTCCAGACGCTCAATCTTCCGAATGAATGGT GATAAATTCCGAAAATTTATAAAGGCACCACCTCGAAACTATTCCATGATTGTTATGTTCACTGCTCTTCAGCCTCAGCGGCAGTGTTCT GTGTGCAGAAGAAGCTGGGACCACTCTGAAGAGTTACCTAGAAGCACCTTCAACTACAGACCTGGAGCATTCTCCACTGTGCTGCAGCCC TCAAATCAGGTGCTCAGACGCCGGGAAAAAGTAGACAATGTCTGGACGGAAGAGTCCTGGAACCAGTTTCTGCAGGAACTAGAGACTGGG CAGAGGCCCAAGAAACCGCTGGTGGACGACCCTGGTGAGAAGCCCTCCCAGCCCATTGAGGTGCTGCTGGAGAGAGAGCTGGCCGAGCTG AGCGCCGAGCTGGACAAGGACCTGCGGGCAATTGAGACCCGACTGCCGTCCCCCAAGAGCTCGCCGGCGCCCCGACGGGCCCCGGAGCAG CGGCCCCCGGCCGGCCCGGCCTCAGCCTGGAGCTCCAGCTACCCACATGCACCTTACCTGGGTTCCGCCCGGTCCCTGAGTCCCCACAAA ATGGCTGATGGAGGAAGCCCCTTCCTAGGTCGGAGGGACTTTGTCTACCCTTCCTCAACCCGAGACCCTAGTGCCTCTAACGGAGGGGGC AGCCCAGCCAGGAGGGAAGAGAAGAAGAGAAAGGCCGCCAGGCTCAAGTTTGACTTCCAGGCGCAGTCCCCCAAGGAGCTGACTCTGCAG AAGGGTGACATTGTCTACATCCACAAGGAGGTGGACAAGAACTGGCTGGAGGGAGAGCACCACGGCCGCCTGGGCATCTTCCCTGCTAAT TATGTGGAGGTGCTGCCCGCAGATGAGATCCCTAAGCCCATCAAGCCCCCGACCTACCAGGTGCTGGAGTATGGAGAGGCTGTGGCCCAG TACACCTTCAAGGGGGACCTGGAGGTGGAGCTGTCCTTCCGCAAGGGAGAGCACATCTGCCTGATCCGCAAGGTGAACGAGAACTGGTAC GAGGGACGCATCACGGGCACGGGGCGCCAAGGCATATTCCCTGCCAGCTACGTGCAGGTGTCTCGTGAACCCCGGCTCCGGCTCTGTGAC GACGGCCCCCAGCTCCCCACGTCTCCCCGCCTGACCGCTGCCGCCCGCTCAGCCCGTCACCCCAGCTCCCCCTCAGCCCTGCGCAGCCCA GCTGACCCCATCGACTTGGGGGGACAGACCTCCCCCCGTCGCACTGGCTTCTCCTTCCCCACCCAGGAGCCTAGACCCCAGACCCAGAAT CTTGGCACCCCTGGTCCAGCTCTGTCCCACTCTCGAGGTCCCAGCCATCCCCTGGACCTGGGGACCTCCTCTCCTAACACCTCTCAGATA CACTGGACCCCGTACCGGGCGATGTACCAGTACAGGCCCCAGAACGAAGACGAGCTGGAGCTGCGCGAGGGGGACAGGGTGGATGTCATG CAGCAGTGTGACGATGGCTGGTTTGTGGGTGTCTCCCGGAGGACCCAGAAATTCGGAACGTTCCCTGGAAATTACGTTGCCCCGGTGTGA GTGGTCTCCATGGCAACTTGGAGCCAGCCAGGATGGGGTGGGGAGCGGTGGCACTCGTGGGAGGGAGAGGACCCCCGCCCACATCCTCCT TCCCCAGGACCTGAGCTCCCAGCATCTGCAGACGACCCCCGCAGCCTTTCCCTCGGACCCCCCTCGAAGCCCCCTGGACTGATTCCCACC CACGACTCACAGGCATTCCTCCCACAGCCCTTTCATTTCCTCCCCACCCCACTCCCCAAATACAGAGGTCTGCTTTGAAGCGGAGACCAT TTCCAGGCCTTATTGAGACCAGACCCCAAGTCCCCCACCCCCATCCTGCTCCAGCGTTTCCTCTAACAGGGACCAGCTCTCCGCTTTGCC CCCACGGGGTTCCTCTAACCAGAACCAGCTTCCTAGCCTCGTAGAGACCAAAGGCCGCCCCCGCCTGCTGGGGTTCCTCCCAGCACCCCA GCTTGCTGGCTGCCCTCTTTGCCTTCTGGCCTCCAGCTGGGTGTGGGGGGGCGGAGCAAGGCGGGGGACAGACGCAGCACCTTCTTAGCG ATCTAGGCCTGGCAAGAGCTCTGGCCCCAAGGCCTCCTCTTCCCAGGGGCTGCCAAGTCCTGGCCCTGGCCCTGGCATATCACCCCGCAC TGTGGGGCCAGGCACCACTAGCCTGGCTCAAATATTCCCCAGGGAGACTGCTGTGTGCTGCCCGCCTGCCTGCTGGCTCTCCCCCAGCCC CACATCCCCTCTGGAAGAGAATGTAAAATAAACCTGGACACAAGGGACCTTGTCTCTGCGGCCTTTTCCTTGGGGTAGGGGATGCCTCCT CCTGTCTAGGAGATGGGAATTCCTTCTGTGGAGGGCTGTGCTGGGAGACAGGTGGGACAGGTGTGTGTGTAAGAGGAGGAGGATGGAAAA ACACCATTATTACCTCCAAAGATCTCTGCCCTTGGGTGTCAGGCAGGTTGCGGCAGCCCCCACAATTGGGCAGCTGTGTGGCAAGAAGTG >In-frame_TUSC3_ENST00000503731_chr8_15480758_+_SORBS3_ENST00000240123_chr8_22421500_+_2948nt CGGCCGCGGCCCGGGTCCCTCGCAAAGCCGCTGCCATCCCGGAGGGCCCAGCCAGCGGGCTCCCGGAGGCTGGCCGGGCAGGCGTGGTGC GCGGTAGGAGCTGGGCGCGCACGGCTACCGCGCGTGGAGGAGACACTGCCCTGCCGCGATGGGGGCCCGGGGCGCTCCTTCACGCCGTAG GCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGCTTTCCCTTCCTTCTCCTGCTGCTGCTGCTCTGCATCCAGCTCGGGGGAGG ACAGAAGAAAAAGGAGAATCTTTTAGCTGAAAAAGTAGAGCAGCTGATGGAATGGAGTTCCAGACGCTCAATCTTCCGAATGAATGGTGA TAAATTCCGAAAATTTATAAAGGCACCACCTCGAAACTATTCCATGATTGTTATGTTCACTGCTCTTCAGCCTCAGCGGCAGTGTTCTGT GTGCAGAAGAAGCTGGGACCACTCTGAAGAGTTACCTAGAAGCACCTTCAACTACAGACCTGGAGCATTCTCCACTGTGCTGCAGCCCTC AAATCAGGTGCTCAGACGCCGGGAAAAAGTAGACAATGTCTGGACGGAAGAGTCCTGGAACCAGTTTCTGCAGGAACTAGAGACTGGGCA GAGGCCCAAGAAACCGCTGGTGGACGACCCTGGTGAGAAGCCCTCCCAGCCCATTGAGGTGCTGCTGGAGAGAGAGCTGGCCGAGCTGAG CGCCGAGCTGGACAAGGACCTGCGGGCAATTGAGACCCGACTGCCGTCCCCCAAGAGCTCGCCGGCGCCCCGACGGGCCCCGGAGCAGCG GCCCCCGGCCGGCCCGGCCTCAGCCTGGAGCTCCAGCTACCCACATGCACCTTACCTGGGTTCCGCCCGGTCCCTGAGTCCCCACAAAAT GGCTGATGGAGGAAGCCCCTTCCTAGGTCGGAGGGACTTTGTCTACCCTTCCTCAACCCGAGACCCTAGTGCCTCTAACGGAGGGGGCAG CCCAGCCAGGAGGGAAGAGAAGAAGAGAAAGGCCGCCAGGCTCAAGTTTGACTTCCAGGCGCAGTCCCCCAAGGAGCTGACTCTGCAGAA GGGTGACATTGTCTACATCCACAAGGAGGTGGACAAGAACTGGCTGGAGGGAGAGCACCACGGCCGCCTGGGCATCTTCCCTGCTAATTA TGTGGAGGTGCTGCCCGCAGATGAGATCCCTAAGCCCATCAAGCCCCCGACCTACCAGGTGCTGGAGTATGGAGAGGCTGTGGCCCAGTA CACCTTCAAGGGGGACCTGGAGGTGGAGCTGTCCTTCCGCAAGGGAGAGCACATCTGCCTGATCCGCAAGGTGAACGAGAACTGGTACGA GGGACGCATCACGGGCACGGGGCGCCAAGGCATATTCCCTGCCAGCTACGTGCAGGTGTCTCGTGAACCCCGGCTCCGGCTCTGTGACGA CGGCCCCCAGCTCCCCACGTCTCCCCGCCTGACCGCTGCCGCCCGCTCAGCCCGTCACCCCAGCTCCCCCTCAGCCCTGCGCAGCCCAGC TGACCCCATCGACTTGGGGGGACAGACCTCCCCCCGTCGCACTGGCTTCTCCTTCCCCACCCAGGAGCCTAGACCCCAGACCCAGAATCT TGGCACCCCTGGTCCAGCTCTGTCCCACTCTCGAGGTCCCAGCCATCCCCTGGACCTGGGGACCTCCTCTCCTAACACCTCTCAGATACA CTGGACCCCGTACCGGGCGATGTACCAGTACAGGCCCCAGAACGAAGACGAGCTGGAGCTGCGCGAGGGGGACAGGGTGGATGTCATGCA GCAGTGTGACGATGGCTGGTTTGTGGGTGTCTCCCGGAGGACCCAGAAATTCGGAACGTTCCCTGGAAATTACGTTGCCCCGGTGTGAGT GGTCTCCATGGCAACTTGGAGCCAGCCAGGATGGGGTGGGGAGCGGTGGCACTCGTGGGAGGGAGAGGACCCCCGCCCACATCCTCCTTC CCCAGGACCTGAGCTCCCAGCATCTGCAGACGACCCCCGCAGCCTTTCCCTCGGACCCCCCTCGAAGCCCCCTGGACTGATTCCCACCCA CGACTCACAGGCATTCCTCCCACAGCCCTTTCATTTCCTCCCCACCCCACTCCCCAAATACAGAGGTCTGCTTTGAAGCGGAGACCATTT CCAGGCCTTATTGAGACCAGACCCCAAGTCCCCCACCCCCATCCTGCTCCAGCGTTTCCTCTAACAGGGACCAGCTCTCCGCTTTGCCCC CACGGGGTTCCTCTAACCAGAACCAGCTTCCTAGCCTCGTAGAGACCAAAGGCCGCCCCCGCCTGCTGGGGTTCCTCCCAGCACCCCAGC TTGCTGGCTGCCCTCTTTGCCTTCTGGCCTCCAGCTGGGTGTGGGGGGGCGGAGCAAGGCGGGGGACAGACGCAGCACCTTCTTAGCGAT CTAGGCCTGGCAAGAGCTCTGGCCCCAAGGCCTCCTCTTCCCAGGGGCTGCCAAGTCCTGGCCCTGGCCCTGGCATATCACCCCGCACTG TGGGGCCAGGCACCACTAGCCTGGCTCAAATATTCCCCAGGGAGACTGCTGTGTGCTGCCCGCCTGCCTGCTGGCTCTCCCCCAGCCCCA CATCCCCTCTGGAAGAGAATGTAAAATAAACCTGGACACAAGGGACCTTGTCTCTGCGGCCTTTTCCTTGGGGTAGGGGATGCCTCCTCC TGTCTAGGAGATGGGAATTCCTTCTGTGGAGGGCTGTGCTGGGAGACAGGTGGGACAGGTGTGTGTGTAAGAGGAGGAGGATGGAAAAAC ACCATTATTACCTCCAAAGATCTCTGCCCTTGGGTGTCAGGCAGGTTGCGGCAGCCCCCACAATTGGGCAGCTGTGTGGCAAGAAGTGCT |
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FusionGenePPI for TUSC3_SORBS3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TUSC3 | BMI1, PPP1CA, FBXO6, PEX19, MCOLN3, SYNE4, HTR3C, RPN2, FAM122B, UPK1A, HTR3A, STXBP2, LIN54, SCN3B, STXBP1, NDRG3, GGT7, GABRA3, GABRD, SLC9A3R2, RNF185, CHRND, CHEK1, MAP2K1, TUBA1A | SORBS3 | KIAA0408, RBMX, KIAA1217, DMRTB1, ADAMTSL4, ZBED1, ZBTB25, CPSF7, EFS, DDX17, CBLB, DVL2, HNRNPK, MAPK1, SAFB2, DLG5, FLOT1, CBL, FASLG, SOCS7, PAK2, TXNDC17, UBE2T, ATP6V1H, ALB, BAG3, SRCIN1, WASL, SYP, ARNT2, AKT1, PAK1, TRIM23, TRIM27, EIF3H, SORBS3, HNRNPUL1, DIP2A, ZBTB7B, NCKIPSD, VPS37C, TBC1D22B, ZC4H2, PAK7, VARS2, SH2D4A, VPS37B, TRIM41, FAM154A, CPNE2, NOTCH3, KRAS, SYNCRIP, KATNA1, ANAPC15, CCDC22, TNS1, LRFN4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TUSC3_SORBS3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TUSC3_SORBS3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TUSC3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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