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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40170

FusionGeneSummary for TUSC3_LOXL2

check button Fusion gene summary
Fusion gene informationFusion gene name: TUSC3_LOXL2
Fusion gene ID: 40170
HgeneTgene
Gene symbol

TUSC3

LOXL2

Gene ID

7991

4017

Gene nametumor suppressor candidate 3lysyl oxidase like 2
SynonymsD8S1992|M33|MRT22|MRT7|MagT2|N33|OST3ALOR|LOR2|WS9-14
Cytomap

8p22

8p21.3

Type of geneprotein-codingprotein-coding
Descriptiontumor suppressor candidate 3magnesium uptake/transporter TUSC3oligosaccharyltransferase 3 homolog Aputative prostate cancer tumor suppressorlysyl oxidase homolog 2lysyl oxidase related 2lysyl oxidase-like 2 delta e13lysyl oxidase-like 2 proteinlysyl oxidase-like protein 2lysyl oxidase-related protein 2lysyl oxidase-related protein WS9-14
Modification date2018052320180523
UniProtAcc

Q13454

Q9Y4K0

Ensembl transtripts involved in fusion geneENST00000503191, ENST00000382020, 
ENST00000506802, ENST00000509380, 
ENST00000503731, 
ENST00000389131, 
ENST00000518472, 
Fusion gene scores* DoF score5 X 5 X 5=1254 X 3 X 4=48
# samples 54
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TUSC3 [Title/Abstract] AND LOXL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLOXL2

GO:0000122

negative regulation of transcription by RNA polymerase II

25959397

TgeneLOXL2

GO:0001837

epithelial to mesenchymal transition

16096638

TgeneLOXL2

GO:0006464

cellular protein modification process

23319596

TgeneLOXL2

GO:0018057

peptidyl-lysine oxidation

25959397|27735137

TgeneLOXL2

GO:0045892

negative regulation of transcription, DNA-templated

16096638

TgeneLOXL2

GO:0046688

response to copper ion

23319596


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-7210-01ATUSC3chr8

15601121

+LOXL2chr8

23225947

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000503191ENST00000389131TUSC3chr8

15601121

+LOXL2chr8

23225947

-
intron-intronENST00000503191ENST00000518472TUSC3chr8

15601121

+LOXL2chr8

23225947

-
5CDS-5UTRENST00000382020ENST00000389131TUSC3chr8

15601121

+LOXL2chr8

23225947

-
5CDS-intronENST00000382020ENST00000518472TUSC3chr8

15601121

+LOXL2chr8

23225947

-
5CDS-5UTRENST00000506802ENST00000389131TUSC3chr8

15601121

+LOXL2chr8

23225947

-
5CDS-intronENST00000506802ENST00000518472TUSC3chr8

15601121

+LOXL2chr8

23225947

-
intron-5UTRENST00000509380ENST00000389131TUSC3chr8

15601121

+LOXL2chr8

23225947

-
intron-intronENST00000509380ENST00000518472TUSC3chr8

15601121

+LOXL2chr8

23225947

-
5CDS-5UTRENST00000503731ENST00000389131TUSC3chr8

15601121

+LOXL2chr8

23225947

-
5CDS-intronENST00000503731ENST00000518472TUSC3chr8

15601121

+LOXL2chr8

23225947

-

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FusionProtFeatures for TUSC3_LOXL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TUSC3

Q13454

LOXL2

Q9Y4K0

Acts as accessory component of the N-oligosaccharyltransferase (OST) complex which catalyzes the transfer of a highmannose oligosaccharide from a lipid-linked oligosaccharide donorto an asparagine residue within an Asn-X-Ser/Thr consensus motifin nascent polypeptide chains. Involved in N-glycosylation ofSTT3B-dependent substrates. Specifically required for theglycosylation of a subset of acceptor sites that are near cysteineresidues; in this function seems to act redundantly with MAGT1. Inits oxidized form proposed to form transient mixed disulfides witha glycoprotein substrate to facilitate access of STT3B to theunmodified acceptor site. Has also oxidoreductase-independentfunctions in the STT3B-containing OST complex possibly involvingsubstrate recognition. {ECO:0000269|PubMed:25135935,ECO:0000305|PubMed:12887896, ECO:0000305|PubMed:24685145}. Magnesium transporter. {ECO:0000269|PubMed:19717468}. Mediates the post-translational oxidative deamination oflysine residues on target proteins leading to the formation ofdeaminated lysine (allysine) (PubMed:27735137). Acts as atranscription corepressor and specifically mediates deamination oftrimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag forepigenetic transcriptional activation (PubMed:27735137). Shows noactivity against histone H3 when it is trimethylated on 'Lys-9'(H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated(H3K4me1) or dimethylated (H3K4me2) (PubMed:27735137). Alsomediates deamination of methylated TAF10, a member of thetranscription factor IID (TFIID) complex, which induces release ofTAF10 from promoters, leading to inhibition of TFIID-dependenttranscription (PubMed:25959397). LOXL2-mediated deamination ofTAF10 results in transcriptional repression of genes required forembryonic stem cell pluripotency including POU5F1/OCT4, NANOG,KLF4 and SOX2 (By similarity). Involved in epithelial tomesenchymal transition (EMT) via interaction with SNAI1 andparticipates in repression of E-cadherin CDH1, probably bymediating deamination of histone H3 (PubMed:16096638,PubMed:27735137, PubMed:24414204). During EMT, involved with SNAI1in negatively regulating pericentromeric heterochromatintranscription (PubMed:24239292). SNAI1 recruits LOXL2 topericentromeric regions to oxidize histone H3 and represstranscription which leads to release of heterochromatin componentCBX5/HP1A, enabling chromatin reorganization and acquisition ofmesenchymal traits (PubMed:24239292). Interacts with theendoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1pathway of the unfolded protein response, leading to expression ofseveral transcription factors involved in EMT and subsequent EMTinduction (PubMed:28332555). Involved in E-cadherin repressionfollowing hypoxia, a hallmark of EMT believed to amplify tumoraggressiveness, suggesting that it may play a role in tumorprogression (PubMed:20026874). When secreted into theextracellular matrix, promotes cross-linking of extracellularmatrix proteins by mediating oxidative deamination of peptidyllysine residues in precursors to fibrous collagen and elastin(PubMed:20306300). Acts as a regulator of sprouting angiogenesis,probably via collagen IV scaffolding (PubMed:21835952). Acts as aregulator of chondrocyte differentiation, probably by regulatingexpression of factors that control chondrocyte differentiation (Bysimilarity). {ECO:0000250|UniProtKB:P58022,ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20026874,ECO:0000269|PubMed:20306300, ECO:0000269|PubMed:21835952,ECO:0000269|PubMed:24239292, ECO:0000269|PubMed:24414204,ECO:0000269|PubMed:25959397, ECO:0000269|PubMed:27735137}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TUSC3_LOXL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TUSC3_LOXL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TUSC3BMI1, PPP1CA, FBXO6, PEX19, MCOLN3, SYNE4, HTR3C, RPN2, FAM122B, UPK1A, HTR3A, STXBP2, LIN54, SCN3B, STXBP1, NDRG3, GGT7, GABRA3, GABRD, SLC9A3R2, RNF185, CHRND, CHEK1, MAP2K1, TUBA1ALOXL2PDIA3, MTA1, MTA2, RBBP4, RBBP7, SIN3A, HDAC1, EZH2, HIST1H3A, KLK11, TAZ, KLK5, IDS, PLAUR, TMEM25, IL12RB1, TINAGL1, LYZL2, RBM14-RBM4, OS9, DEFA1, WNT7A, PSG8, ADAMTS4, SCGB2A2, INSL5, LRP1, IK, DEFA5, FBXO7, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TUSC3_LOXL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TUSC3_LOXL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTUSC3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneLOXL2C1458155Mammary Neoplasms2CTD_human
TgeneLOXL2C0007621Neoplastic Cell Transformation1CTD_human
TgeneLOXL2C0019163Hepatitis B1CTD_human
TgeneLOXL2C0019196Hepatitis C1CTD_human
TgeneLOXL2C0019202Hepatolenticular Degeneration1CTD_human
TgeneLOXL2C0023892Biliary cirrhosis1CTD_human
TgeneLOXL2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneLOXL2C0027626Neoplasm Invasiveness1CTD_human
TgeneLOXL2C0279626Squamous cell carcinoma of esophagus1CTD_human