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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40167

FusionGeneSummary for TUSC3_ASAH1

check button Fusion gene summary
Fusion gene informationFusion gene name: TUSC3_ASAH1
Fusion gene ID: 40167
HgeneTgene
Gene symbol

TUSC3

ASAH1

Gene ID

7991

427

Gene nametumor suppressor candidate 3N-acylsphingosine amidohydrolase 1
SynonymsD8S1992|M33|MRT22|MRT7|MagT2|N33|OST3AAC|ACDase|ASAH|PHP|PHP32|SMAPME
Cytomap

8p22

8p22

Type of geneprotein-codingprotein-coding
Descriptiontumor suppressor candidate 3magnesium uptake/transporter TUSC3oligosaccharyltransferase 3 homolog Aputative prostate cancer tumor suppressoracid ceramidaseN-acylsphingosine amidohydrolase (acid ceramidase) 1acid CDaseacylsphingosine deacylaseputative 32 kDa heart protein
Modification date2018052320180529
UniProtAcc

Q13454

Q13510

Ensembl transtripts involved in fusion geneENST00000503191, ENST00000382020, 
ENST00000506802, ENST00000509380, 
ENST00000503731, 
ENST00000262097, 
ENST00000381733, ENST00000417108, 
ENST00000520781, ENST00000314146, 
ENST00000520051, 
Fusion gene scores* DoF score5 X 5 X 5=1256 X 6 X 5=180
# samples 57
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TUSC3 [Title/Abstract] AND ASAH1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPAADTCGA-2L-AAQI-01ATUSC3chr8

15605974

+ASAH1chr8

17933096

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000503191ENST00000262097TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-3CDSENST00000503191ENST00000381733TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-5UTRENST00000503191ENST00000417108TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-5UTRENST00000503191ENST00000520781TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-5UTRENST00000503191ENST00000314146TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-5UTRENST00000503191ENST00000520051TUSC3chr8

15605974

+ASAH1chr8

17933096

-
Frame-shitENST00000382020ENST00000262097TUSC3chr8

15605974

+ASAH1chr8

17933096

-
Frame-shitENST00000382020ENST00000381733TUSC3chr8

15605974

+ASAH1chr8

17933096

-
5CDS-5UTRENST00000382020ENST00000417108TUSC3chr8

15605974

+ASAH1chr8

17933096

-
5CDS-5UTRENST00000382020ENST00000520781TUSC3chr8

15605974

+ASAH1chr8

17933096

-
5CDS-5UTRENST00000382020ENST00000314146TUSC3chr8

15605974

+ASAH1chr8

17933096

-
5CDS-5UTRENST00000382020ENST00000520051TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-3CDSENST00000506802ENST00000262097TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-3CDSENST00000506802ENST00000381733TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-5UTRENST00000506802ENST00000417108TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-5UTRENST00000506802ENST00000520781TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-5UTRENST00000506802ENST00000314146TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-5UTRENST00000506802ENST00000520051TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-3CDSENST00000509380ENST00000262097TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-3CDSENST00000509380ENST00000381733TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-5UTRENST00000509380ENST00000417108TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-5UTRENST00000509380ENST00000520781TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-5UTRENST00000509380ENST00000314146TUSC3chr8

15605974

+ASAH1chr8

17933096

-
intron-5UTRENST00000509380ENST00000520051TUSC3chr8

15605974

+ASAH1chr8

17933096

-
Frame-shitENST00000503731ENST00000262097TUSC3chr8

15605974

+ASAH1chr8

17933096

-
Frame-shitENST00000503731ENST00000381733TUSC3chr8

15605974

+ASAH1chr8

17933096

-
5CDS-5UTRENST00000503731ENST00000417108TUSC3chr8

15605974

+ASAH1chr8

17933096

-
5CDS-5UTRENST00000503731ENST00000520781TUSC3chr8

15605974

+ASAH1chr8

17933096

-
5CDS-5UTRENST00000503731ENST00000314146TUSC3chr8

15605974

+ASAH1chr8

17933096

-
5CDS-5UTRENST00000503731ENST00000520051TUSC3chr8

15605974

+ASAH1chr8

17933096

-

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FusionProtFeatures for TUSC3_ASAH1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TUSC3

Q13454

ASAH1

Q13510

Acts as accessory component of the N-oligosaccharyltransferase (OST) complex which catalyzes the transfer of a highmannose oligosaccharide from a lipid-linked oligosaccharide donorto an asparagine residue within an Asn-X-Ser/Thr consensus motifin nascent polypeptide chains. Involved in N-glycosylation ofSTT3B-dependent substrates. Specifically required for theglycosylation of a subset of acceptor sites that are near cysteineresidues; in this function seems to act redundantly with MAGT1. Inits oxidized form proposed to form transient mixed disulfides witha glycoprotein substrate to facilitate access of STT3B to theunmodified acceptor site. Has also oxidoreductase-independentfunctions in the STT3B-containing OST complex possibly involvingsubstrate recognition. {ECO:0000269|PubMed:25135935,ECO:0000305|PubMed:12887896, ECO:0000305|PubMed:24685145}. Magnesium transporter. {ECO:0000269|PubMed:19717468}. Hydrolyzes the sphingolipid ceramide into sphingosineand free fatty acid. {ECO:0000269|PubMed:7744740}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TUSC3_ASAH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TUSC3_ASAH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TUSC3BMI1, PPP1CA, FBXO6, PEX19, MCOLN3, SYNE4, HTR3C, RPN2, FAM122B, UPK1A, HTR3A, STXBP2, LIN54, SCN3B, STXBP1, NDRG3, GGT7, GABRA3, GABRD, SLC9A3R2, RNF185, CHRND, CHEK1, MAP2K1, TUBA1AASAH1SETDB1, TSC22D1, PSMA3, FBXO6, CAMK1D, SRPK1, GSG1, PNKD, AAGAB, AAMP, NEFH, CAMK2B, HSF2, HSPB2, HERC2, CYP1A2, GLT1D1, ZIC1, ZSCAN12, FTH1, NONO, TBC1D22B, SLCO6A1, AIRE, HTATIP2, RNF6, TRMT2A, ZNF684, ZNF556, HMP19, LYPD1, NCDN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TUSC3_ASAH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TUSC3_ASAH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTUSC3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneASAH1C0268255Farber Lipogranulomatosis8CTD_human;ORPHANET;UNIPROT
TgeneASAH1C0023794Lipoidosis2CTD_human
TgeneASAH1C1834569Jankovic Rivera syndrome2ORPHANET;UNIPROT
TgeneASAH1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneASAH1C0036341Schizophrenia1PSYGENET
TgeneASAH1C0221765Chronic schizophrenia1PSYGENET