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Fusion gene ID: 40138 |
FusionGeneSummary for TUFT1_CGN |
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Fusion gene information | Fusion gene name: TUFT1_CGN | Fusion gene ID: 40138 | Hgene | Tgene | Gene symbol | TUFT1 | CGN | Gene ID | 7286 | 57530 |
Gene name | tuftelin 1 | cingulin | |
Synonyms | - | - | |
Cytomap | 1q21.3 | 1q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | tuftelin | cingulin | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9NNX1 | Q9P2M7 | |
Ensembl transtripts involved in fusion gene | ENST00000353024, ENST00000392712, ENST00000368849, ENST00000368848, ENST00000538902, | ENST00000271636, | |
Fusion gene scores | * DoF score | 9 X 5 X 9=405 | 4 X 5 X 5=100 |
# samples | 12 | 7 | |
** MAII score | log2(12/405*10)=-1.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TUFT1 [Title/Abstract] AND CGN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-CV-7261-01A | TUFT1 | chr1 | 151512902 | + | CGN | chr1 | 151509206 | + |
TCGA | RV | LIHC | TCGA-UB-A7MA-01A | TUFT1 | chr1 | 151512902 | + | CGN | chr1 | 151490982 | + |
TCGA | RV | LUAD | TCGA-44-6775-01A | TUFT1 | chr1 | 151537090 | + | CGN | chr1 | 151492642 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000353024 | ENST00000271636 | TUFT1 | chr1 | 151512902 | + | CGN | chr1 | 151509206 | + |
In-frame | ENST00000392712 | ENST00000271636 | TUFT1 | chr1 | 151512902 | + | CGN | chr1 | 151509206 | + |
In-frame | ENST00000368849 | ENST00000271636 | TUFT1 | chr1 | 151512902 | + | CGN | chr1 | 151509206 | + |
In-frame | ENST00000368848 | ENST00000271636 | TUFT1 | chr1 | 151512902 | + | CGN | chr1 | 151509206 | + |
5UTR-3CDS | ENST00000538902 | ENST00000271636 | TUFT1 | chr1 | 151512902 | + | CGN | chr1 | 151509206 | + |
5CDS-5UTR | ENST00000353024 | ENST00000271636 | TUFT1 | chr1 | 151512902 | + | CGN | chr1 | 151490982 | + |
5CDS-5UTR | ENST00000392712 | ENST00000271636 | TUFT1 | chr1 | 151512902 | + | CGN | chr1 | 151490982 | + |
5CDS-5UTR | ENST00000368849 | ENST00000271636 | TUFT1 | chr1 | 151512902 | + | CGN | chr1 | 151490982 | + |
5CDS-5UTR | ENST00000368848 | ENST00000271636 | TUFT1 | chr1 | 151512902 | + | CGN | chr1 | 151490982 | + |
5UTR-5UTR | ENST00000538902 | ENST00000271636 | TUFT1 | chr1 | 151512902 | + | CGN | chr1 | 151490982 | + |
In-frame | ENST00000353024 | ENST00000271636 | TUFT1 | chr1 | 151537090 | + | CGN | chr1 | 151492642 | + |
intron-3CDS | ENST00000392712 | ENST00000271636 | TUFT1 | chr1 | 151537090 | + | CGN | chr1 | 151492642 | + |
In-frame | ENST00000368849 | ENST00000271636 | TUFT1 | chr1 | 151537090 | + | CGN | chr1 | 151492642 | + |
In-frame | ENST00000368848 | ENST00000271636 | TUFT1 | chr1 | 151537090 | + | CGN | chr1 | 151492642 | + |
In-frame | ENST00000538902 | ENST00000271636 | TUFT1 | chr1 | 151537090 | + | CGN | chr1 | 151492642 | + |
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FusionProtFeatures for TUFT1_CGN |
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Hgene | Tgene |
TUFT1 | CGN |
Involved in the mineralization and structuralorganization of enamel. {ECO:0000250|UniProtKB:P27628}. | Probably plays a role in the formation and regulation ofthe tight junction (TJ) paracellular permeability barrier. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TUFT1 | chr1:151537090 | chr1:151492642 | ENST00000368849 | + | 5 | 13 | 88_126 | 138 | 391 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >CGN | chr1:151537090 | chr1:151492642 | ENST00000271636 | + | 1 | 21 | 352_1154 | 291 | 1204 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >CGN | chr1:151537090 | chr1:151492642 | ENST00000271636 | + | 1 | 21 | 363_836 | 291 | 1204 | Compositional bias | Note=Glu-rich |
Tgene | >CGN | chr1:151512902 | chr1:151509206 | ENST00000271636 | + | 18 | 21 | 1155_1197 | 1102 | 1204 | Region | Note=Tail |
Tgene | >CGN | chr1:151537090 | chr1:151492642 | ENST00000271636 | + | 1 | 21 | 1155_1197 | 291 | 1204 | Region | Note=Tail |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TUFT1 | chr1:151512902 | chr1:151509206 | ENST00000353024 | + | 1 | 11 | 162_351 | 20 | 332 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >TUFT1 | chr1:151512902 | chr1:151509206 | ENST00000353024 | + | 1 | 11 | 88_126 | 20 | 332 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >TUFT1 | chr1:151512902 | chr1:151509206 | ENST00000368848 | + | 1 | 12 | 162_351 | 20 | 366 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >TUFT1 | chr1:151512902 | chr1:151509206 | ENST00000368848 | + | 1 | 12 | 88_126 | 20 | 366 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >TUFT1 | chr1:151512902 | chr1:151509206 | ENST00000368849 | + | 1 | 13 | 162_351 | 20 | 391 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >TUFT1 | chr1:151512902 | chr1:151509206 | ENST00000368849 | + | 1 | 13 | 88_126 | 20 | 391 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >TUFT1 | chr1:151537090 | chr1:151492642 | ENST00000353024 | + | 3 | 11 | 162_351 | 79 | 332 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >TUFT1 | chr1:151537090 | chr1:151492642 | ENST00000353024 | + | 3 | 11 | 88_126 | 79 | 332 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >TUFT1 | chr1:151537090 | chr1:151492642 | ENST00000368848 | + | 4 | 12 | 162_351 | 113 | 366 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >TUFT1 | chr1:151537090 | chr1:151492642 | ENST00000368848 | + | 4 | 12 | 88_126 | 113 | 366 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >TUFT1 | chr1:151537090 | chr1:151492642 | ENST00000368849 | + | 5 | 13 | 162_351 | 138 | 391 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | CGN | chr1:151512902 | chr1:151509206 | ENST00000271636 | + | 18 | 21 | 352_1154 | 1102 | 1204 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | CGN | chr1:151512902 | chr1:151509206 | ENST00000271636 | + | 18 | 21 | 363_836 | 1102 | 1204 | Compositional bias | Note=Glu-rich |
Tgene | CGN | chr1:151512902 | chr1:151509206 | ENST00000271636 | + | 18 | 21 | 42_56 | 1102 | 1204 | Motif | Note=ZIM |
Tgene | CGN | chr1:151537090 | chr1:151492642 | ENST00000271636 | + | 1 | 21 | 42_56 | 291 | 1204 | Motif | Note=ZIM |
Tgene | CGN | chr1:151512902 | chr1:151509206 | ENST00000271636 | + | 18 | 21 | 1_351 | 1102 | 1204 | Region | Note=Head |
Tgene | CGN | chr1:151537090 | chr1:151492642 | ENST00000271636 | + | 1 | 21 | 1_351 | 291 | 1204 | Region | Note=Head |
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FusionGeneSequence for TUFT1_CGN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TUFT1_CGN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TUFT1 | TFIP11, ELAVL1, ABCD3, NME7, LMO2, TRIM27, KAT5, CEP76, CCDC33, SMC6, RABGAP1, RABGAP1L, ZYX, CREB1, ATF1, NSMCE4A, BIRC2, EXOC1, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, GOLGA5, CLOCK, PSMD9, VPS53, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC132, GIT2, CCDC93, OIP5, PHF21A, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, MAX, RABGEF1, NUF2, THAP11, VPS51, TSSC1, RABEP1, STRN, KDM1A | CGN | YWHAB, YWHAG, SFN, TJP2, TJP1, SIRT7, LNX1, YWHAE, LATS1, LATS2, OBSL1, CCDC8, CAPZA2, DBN1, MYH11, IQGAP1, SYNPO, MYO5C, MYO18A, CDH1, EYA2, YWHAZ, PPP1R9A, YWHAH, CCDC102B, DAB2IP, YWHAQ, ACTA2, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, RALGPS2, RTKN, LPIN3, MAST3, LRFN1, DENND4C, CDC25C, GIGYF2, SH3RF3, PPM1H, DENND1A, NF1, SH3PXD2A, CBY1, SRGAP2, TANC2, PTPN13, EIF4E2, SIPA1L1, CAMSAP2, HDAC4, OSBPL6, NADK, INPP5E, LIMA1, MAGI1, TESK2, DCLK1, RASAL2, MAPKAP1, KIAA1804, ZNF638, TIAM1, KIF1C, NAV1, PLEKHA7, PHLDB2, CWC25, DENND4A, RPTOR, STARD13, PTPN14, MTFR1L, SRSF12, CSNK1A1, SYDE1, RAB11FIP2, HDAC5, AGAP1, HDAC7, MELK, MICALL1, CDC25B, CDK16, GAB2, CRTC3, FGD6, LARP1, KIF1B, TBC1D1, PANK2, WEE1, CRTC2, DCP1B, DLST, TRIM25, FBXL13 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | CGN | chr1:151512902 | chr1:151509206 | ENST00000271636 | + | 18 | 21 | 106_400 | 1102 | 1204 | ZO-2 |
Tgene | CGN | chr1:151537090 | chr1:151492642 | ENST00000271636 | + | 1 | 21 | 106_400 | 291 | 1204 | ZO-2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TUFT1_CGN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TUFT1_CGN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |