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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40138

FusionGeneSummary for TUFT1_CGN

check button Fusion gene summary
Fusion gene informationFusion gene name: TUFT1_CGN
Fusion gene ID: 40138
HgeneTgene
Gene symbol

TUFT1

CGN

Gene ID

7286

57530

Gene nametuftelin 1cingulin
Synonyms--
Cytomap

1q21.3

1q21.3

Type of geneprotein-codingprotein-coding
Descriptiontuftelincingulin
Modification date2018052320180522
UniProtAcc

Q9NNX1

Q9P2M7

Ensembl transtripts involved in fusion geneENST00000353024, ENST00000392712, 
ENST00000368849, ENST00000368848, 
ENST00000538902, 		ENST00000271636, 
Fusion gene scores* DoF score9 X 5 X 9=4054 X 5 X 5=100
# samples 127
** MAII scorelog2(12/405*10)=-1.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TUFT1 [Title/Abstract] AND CGN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CV-7261-01ATUFT1chr1

151512902

+CGNchr1

151509206

+
TCGARVLIHCTCGA-UB-A7MA-01ATUFT1chr1

151512902

+CGNchr1

151490982

+
TCGARVLUADTCGA-44-6775-01ATUFT1chr1

151537090

+CGNchr1

151492642

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000353024ENST00000271636TUFT1chr1

151512902

+CGNchr1

151509206

+
In-frameENST00000392712ENST00000271636TUFT1chr1

151512902

+CGNchr1

151509206

+
In-frameENST00000368849ENST00000271636TUFT1chr1

151512902

+CGNchr1

151509206

+
In-frameENST00000368848ENST00000271636TUFT1chr1

151512902

+CGNchr1

151509206

+
5UTR-3CDSENST00000538902ENST00000271636TUFT1chr1

151512902

+CGNchr1

151509206

+
5CDS-5UTRENST00000353024ENST00000271636TUFT1chr1

151512902

+CGNchr1

151490982

+
5CDS-5UTRENST00000392712ENST00000271636TUFT1chr1

151512902

+CGNchr1

151490982

+
5CDS-5UTRENST00000368849ENST00000271636TUFT1chr1

151512902

+CGNchr1

151490982

+
5CDS-5UTRENST00000368848ENST00000271636TUFT1chr1

151512902

+CGNchr1

151490982

+
5UTR-5UTRENST00000538902ENST00000271636TUFT1chr1

151512902

+CGNchr1

151490982

+
In-frameENST00000353024ENST00000271636TUFT1chr1

151537090

+CGNchr1

151492642

+
intron-3CDSENST00000392712ENST00000271636TUFT1chr1

151537090

+CGNchr1

151492642

+
In-frameENST00000368849ENST00000271636TUFT1chr1

151537090

+CGNchr1

151492642

+
In-frameENST00000368848ENST00000271636TUFT1chr1

151537090

+CGNchr1

151492642

+
In-frameENST00000538902ENST00000271636TUFT1chr1

151537090

+CGNchr1

151492642

+

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FusionProtFeatures for TUFT1_CGN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TUFT1

Q9NNX1

CGN

Q9P2M7

Involved in the mineralization and structuralorganization of enamel. {ECO:0000250|UniProtKB:P27628}. Probably plays a role in the formation and regulation ofthe tight junction (TJ) paracellular permeability barrier.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTUFT1chr1:151537090chr1:151492642ENST00000368849+51388_126138391Coiled coilOntology_term=ECO:0000255
TgeneCGNchr1:151537090chr1:151492642ENST00000271636+121352_11542911204Coiled coilOntology_term=ECO:0000255
TgeneCGNchr1:151537090chr1:151492642ENST00000271636+121363_8362911204Compositional biasNote=Glu-rich
TgeneCGNchr1:151512902chr1:151509206ENST00000271636+18211155_119711021204RegionNote=Tail
TgeneCGNchr1:151537090chr1:151492642ENST00000271636+1211155_11972911204RegionNote=Tail

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTUFT1chr1:151512902chr1:151509206ENST00000353024+111162_35120332Coiled coilOntology_term=ECO:0000255
HgeneTUFT1chr1:151512902chr1:151509206ENST00000353024+11188_12620332Coiled coilOntology_term=ECO:0000255
HgeneTUFT1chr1:151512902chr1:151509206ENST00000368848+112162_35120366Coiled coilOntology_term=ECO:0000255
HgeneTUFT1chr1:151512902chr1:151509206ENST00000368848+11288_12620366Coiled coilOntology_term=ECO:0000255
HgeneTUFT1chr1:151512902chr1:151509206ENST00000368849+113162_35120391Coiled coilOntology_term=ECO:0000255
HgeneTUFT1chr1:151512902chr1:151509206ENST00000368849+11388_12620391Coiled coilOntology_term=ECO:0000255
HgeneTUFT1chr1:151537090chr1:151492642ENST00000353024+311162_35179332Coiled coilOntology_term=ECO:0000255
HgeneTUFT1chr1:151537090chr1:151492642ENST00000353024+31188_12679332Coiled coilOntology_term=ECO:0000255
HgeneTUFT1chr1:151537090chr1:151492642ENST00000368848+412162_351113366Coiled coilOntology_term=ECO:0000255
HgeneTUFT1chr1:151537090chr1:151492642ENST00000368848+41288_126113366Coiled coilOntology_term=ECO:0000255
HgeneTUFT1chr1:151537090chr1:151492642ENST00000368849+513162_351138391Coiled coilOntology_term=ECO:0000255
TgeneCGNchr1:151512902chr1:151509206ENST00000271636+1821352_115411021204Coiled coilOntology_term=ECO:0000255
TgeneCGNchr1:151512902chr1:151509206ENST00000271636+1821363_83611021204Compositional biasNote=Glu-rich
TgeneCGNchr1:151512902chr1:151509206ENST00000271636+182142_5611021204MotifNote=ZIM
TgeneCGNchr1:151537090chr1:151492642ENST00000271636+12142_562911204MotifNote=ZIM
TgeneCGNchr1:151512902chr1:151509206ENST00000271636+18211_35111021204RegionNote=Head
TgeneCGNchr1:151537090chr1:151492642ENST00000271636+1211_3512911204RegionNote=Head


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FusionGeneSequence for TUFT1_CGN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TUFT1_CGN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TUFT1TFIP11, ELAVL1, ABCD3, NME7, LMO2, TRIM27, KAT5, CEP76, CCDC33, SMC6, RABGAP1, RABGAP1L, ZYX, CREB1, ATF1, NSMCE4A, BIRC2, EXOC1, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, GOLGA5, CLOCK, PSMD9, VPS53, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC132, GIT2, CCDC93, OIP5, PHF21A, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, MAX, RABGEF1, NUF2, THAP11, VPS51, TSSC1, RABEP1, STRN, KDM1ACGNYWHAB, YWHAG, SFN, TJP2, TJP1, SIRT7, LNX1, YWHAE, LATS1, LATS2, OBSL1, CCDC8, CAPZA2, DBN1, MYH11, IQGAP1, SYNPO, MYO5C, MYO18A, CDH1, EYA2, YWHAZ, PPP1R9A, YWHAH, CCDC102B, DAB2IP, YWHAQ, ACTA2, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, RALGPS2, RTKN, LPIN3, MAST3, LRFN1, DENND4C, CDC25C, GIGYF2, SH3RF3, PPM1H, DENND1A, NF1, SH3PXD2A, CBY1, SRGAP2, TANC2, PTPN13, EIF4E2, SIPA1L1, CAMSAP2, HDAC4, OSBPL6, NADK, INPP5E, LIMA1, MAGI1, TESK2, DCLK1, RASAL2, MAPKAP1, KIAA1804, ZNF638, TIAM1, KIF1C, NAV1, PLEKHA7, PHLDB2, CWC25, DENND4A, RPTOR, STARD13, PTPN14, MTFR1L, SRSF12, CSNK1A1, SYDE1, RAB11FIP2, HDAC5, AGAP1, HDAC7, MELK, MICALL1, CDC25B, CDK16, GAB2, CRTC3, FGD6, LARP1, KIF1B, TBC1D1, PANK2, WEE1, CRTC2, DCP1B, DLST, TRIM25, FBXL13


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCGNchr1:151512902chr1:151509206ENST00000271636+1821106_40011021204ZO-2
TgeneCGNchr1:151537090chr1:151492642ENST00000271636+121106_4002911204ZO-2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TUFT1_CGN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TUFT1_CGN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource