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Fusion gene ID: 40131 |
FusionGeneSummary for TUBGCP3_TFDP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TUBGCP3_TFDP1 | Fusion gene ID: 40131 | Hgene | Tgene | Gene symbol | TUBGCP3 | TFDP1 | Gene ID | 10426 | 7027 |
| Gene name | tubulin gamma complex associated protein 3 | transcription factor Dp-1 | |
| Synonyms | 104p|ALP6|GCP3|Grip104|SPBC98|Spc98|Spc98p | DILC|DP1|DRTF1|Dp-1 | |
| Cytomap | 13q34 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | gamma-tubulin complex component 3gamma-ring complex protein 104 kDaspindle pole body protein Spc98 homolog | transcription factor Dp-1DRTF1-polypeptide 1E2F dimerization partner 1E2F-related transcription factordown-regulated in liver cancer stem cells | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96CW5 | Q14186 | |
| Ensembl transtripts involved in fusion gene | ENST00000261965, ENST00000375669, ENST00000462580, | ENST00000375370, ENST00000538138, ENST00000465174, ENST00000544902, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 6 X 4 X 6=144 |
| # samples | 5 | 7 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TUBGCP3 [Title/Abstract] AND TFDP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TFDP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7739537 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CV-7416-01A | TUBGCP3 | chr13 | 113219425 | - | TFDP1 | chr13 | 114265311 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261965 | ENST00000375370 | TUBGCP3 | chr13 | 113219425 | - | TFDP1 | chr13 | 114265311 | + |
| 5CDS-5UTR | ENST00000261965 | ENST00000538138 | TUBGCP3 | chr13 | 113219425 | - | TFDP1 | chr13 | 114265311 | + |
| 5CDS-3UTR | ENST00000261965 | ENST00000465174 | TUBGCP3 | chr13 | 113219425 | - | TFDP1 | chr13 | 114265311 | + |
| 5CDS-5UTR | ENST00000261965 | ENST00000544902 | TUBGCP3 | chr13 | 113219425 | - | TFDP1 | chr13 | 114265311 | + |
| In-frame | ENST00000375669 | ENST00000375370 | TUBGCP3 | chr13 | 113219425 | - | TFDP1 | chr13 | 114265311 | + |
| 5CDS-5UTR | ENST00000375669 | ENST00000538138 | TUBGCP3 | chr13 | 113219425 | - | TFDP1 | chr13 | 114265311 | + |
| 5CDS-3UTR | ENST00000375669 | ENST00000465174 | TUBGCP3 | chr13 | 113219425 | - | TFDP1 | chr13 | 114265311 | + |
| 5CDS-5UTR | ENST00000375669 | ENST00000544902 | TUBGCP3 | chr13 | 113219425 | - | TFDP1 | chr13 | 114265311 | + |
| intron-3CDS | ENST00000462580 | ENST00000375370 | TUBGCP3 | chr13 | 113219425 | - | TFDP1 | chr13 | 114265311 | + |
| intron-5UTR | ENST00000462580 | ENST00000538138 | TUBGCP3 | chr13 | 113219425 | - | TFDP1 | chr13 | 114265311 | + |
| intron-3UTR | ENST00000462580 | ENST00000465174 | TUBGCP3 | chr13 | 113219425 | - | TFDP1 | chr13 | 114265311 | + |
| intron-5UTR | ENST00000462580 | ENST00000544902 | TUBGCP3 | chr13 | 113219425 | - | TFDP1 | chr13 | 114265311 | + |
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FusionProtFeatures for TUBGCP3_TFDP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TUBGCP3 | TFDP1 |
| Gamma-tubulin complex is necessary for microtubulenucleation at the centrosome. | Can stimulate E2F-dependent transcription. Binds DNAcooperatively with E2F family members through the E2 recognitionsite, 5'-TTTC[CG]CGC-3', found in the promoter region of a numberof genes whose products are involved in cell cycle regulation orin DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DPcomplex appears to mediate both cell proliferation and apoptosis.Blocks adipocyte differentiation by repressing CEBPA binding toits target gene promoters (PubMed:20176812).{ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:7739537,ECO:0000269|PubMed:8405995}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TFDP1 | chr13:113219425 | chr13:114265311 | ENST00000375370 | + | 1 | 12 | 250_253 | 4 | 411 | Compositional bias | Note=Poly-Pro |
| Tgene | >TFDP1 | chr13:113219425 | chr13:114265311 | ENST00000375370 | + | 1 | 12 | 394_410 | 4 | 411 | Compositional bias | Note=Asp/Glu-rich (acidic%3B NCB domain) |
| Tgene | >TFDP1 | chr13:113219425 | chr13:114265311 | ENST00000375370 | + | 1 | 12 | 113_195 | 4 | 411 | DNA binding | Ontology_term=ECO:0000255 |
| Tgene | >TFDP1 | chr13:113219425 | chr13:114265311 | ENST00000375370 | + | 1 | 12 | 161_195 | 4 | 411 | Motif | Note=DEF box |
| Tgene | >TFDP1 | chr13:113219425 | chr13:114265311 | ENST00000375370 | + | 1 | 12 | 204_277 | 4 | 411 | Region | Dimerization |
| Tgene | >TFDP1 | chr13:113219425 | chr13:114265311 | ENST00000375370 | + | 1 | 12 | 211_327 | 4 | 411 | Region | Note=Enhances binding of RB protein to E2F |
| Tgene | >TFDP1 | chr13:113219425 | chr13:114265311 | ENST00000375370 | + | 1 | 12 | 214_246 | 4 | 411 | Region | Note=DCB1 |
| Tgene | >TFDP1 | chr13:113219425 | chr13:114265311 | ENST00000375370 | + | 1 | 12 | 259_315 | 4 | 411 | Region | Note=DCB2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TUBGCP3 | chr13:113219425 | chr13:114265311 | ENST00000261965 | - | 3 | 22 | 825_829 | 84 | 908 | Compositional bias | Note=Poly-Glu |
| Hgene | >TUBGCP3 | chr13:113219425 | chr13:114265311 | ENST00000375669 | - | 3 | 21 | 825_829 | 84 | 825 | Compositional bias | Note=Poly-Glu |
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FusionGeneSequence for TUBGCP3_TFDP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TUBGCP3_ENST00000261965_chr13_113219425_-_TFDP1_ENST00000375370_chr13_114265311_+_491aa MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKKELIRQRREADAALFSELHRKLHSQAGLIEA NGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVIGTPQRPAASNTLVVGSPHTPSTHFASQNQPSDSSPW SAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIISKEKKEIK WIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRHAEQQASRPPPPNSVIHLPFIIVNTSKKTVIDCSISNDK FEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKMARSLVPKALEPYVTEMAQGTVGGVFITTAGSTSNGTRFSASDLTNGADG >In-frame_TUBGCP3_ENST00000375669_chr13_113219425_-_TFDP1_ENST00000375370_chr13_114265311_+_491aa MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKKELIRQRREADAALFSELHRKLHSQAGLIEA NGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVIGTPQRPAASNTLVVGSPHTPSTHFASQNQPSDSSPW SAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIISKEKKEIK WIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRHAEQQASRPPPPNSVIHLPFIIVNTSKKTVIDCSISNDK FEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKMARSLVPKALEPYVTEMAQGTVGGVFITTAGSTSNGTRFSASDLTNGADG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TUBGCP3_ENST00000261965_chr13_113219425_-_TFDP1_ENST00000375370_chr13_114265311_+_1473nt ATGGCGACCCCGGACCAGAAGTCGCCGAACGTTCTGCTGCAGAACCTGTGCTGCAGGATCCTGGGCAGGAGCGAAGCTGATGTAGCCCAG CAGTTCCAGTATGCTGTGCGGGTGATTGGCAGCAACTTCGCCCCAACTGTTGAAAGAGATGAATTTTTAGTAGCTGAAAAAATCAAGAAA GAGCTTATTCGACAACGAAGAGAAGCAGATGCTGCATTATTTTCAGAACTCCACAGAAAACTTCATTCACAGGCCGGTCTAATTGAAGCC AACGGAGAACTCAAGGTCTTCATAGACCAGAACCTTAGTCCCGGGAAAGGCGTGGTGTCCCTCGTGGCCGTTCACCCCTCCACCGTCAAC CCGCTCGGGAAGCAGCTCTTGCCAAAAACCTTTGGACAGTCCAATGTCAACATTGCCCAGCAAGTGGTAATTGGTACGCCTCAGAGACCG GCAGCGTCAAACACCCTGGTGGTAGGAAGCCCACACACCCCCAGCACTCACTTTGCCTCTCAGAACCAGCCTTCCGACTCCTCACCTTGG TCTGCCGGGAAGCGCAACAGGAAAGGAGAGAAGAATGGCAAGGGCCTACGGCATTTCTCCATGAAGGTCTGCGAGAAGGTGCAGAGGAAA GGGACCACTTCCTACAACGAAGTGGCAGACGAGCTGGTTGCGGAGTTCAGTGCTGCCGACAACCACATCTTACCAAACGAGTCAGCTTAT GACCAGAAAAACATAAGACGGCGCGTCTACGATGCCTTAAACGTGCTAATGGCCATGAACATCATCTCCAAGGAGAAGAAGGAGATCAAG TGGATTGGTCTGCCCACCAACTCGGCTCAGGAATGTCAGAACTTAGAGGTGGAAAGACAGAGGAGACTTGAAAGAATAAAACAGAAACAG TCTCAACTTCAAGAACTTATTCTACAGCAAATTGCCTTCAAGAACCTGGTGCAGAGAAACCGGCATGCGGAGCAGCAGGCCAGCCGGCCA CCGCCACCCAACTCAGTCATCCACCTGCCCTTCATCATCGTCAACACCAGCAAGAAGACGGTCATCGACTGCAGCATCTCCAATGACAAA TTTGAGTATCTGTTTAATTTTGACAACACATTTGAAATCCACGATGACATAGAAGTGCTGAAGCGGATGGGCATGGCTTGCGGGCTGGAG TCGGGGAGCTGCTCTGCCGAAGACCTTAAAATGGCCAGAAGTCTGGTCCCCAAGGCTCTGGAGCCATACGTGACAGAAATGGCTCAGGGA ACTGTTGGAGGCGTGTTCATCACGACGGCAGGTTCCACGTCTAACGGCACAAGGTTCTCTGCCAGTGACCTGACCAACGGTGCAGATGGG ATGCTGGCCACAAGCTCCAATGGGTCTCAGTACAGCGGCTCCAGGGTGGAGACTCCGGTGTCCTACGTCGGGGAGGACGACGAGGAGGAC >In-frame_TUBGCP3_ENST00000375669_chr13_113219425_-_TFDP1_ENST00000375370_chr13_114265311_+_1473nt ATGGCGACCCCGGACCAGAAGTCGCCGAACGTTCTGCTGCAGAACCTGTGCTGCAGGATCCTGGGCAGGAGCGAAGCTGATGTAGCCCAG CAGTTCCAGTATGCTGTGCGGGTGATTGGCAGCAACTTCGCCCCAACTGTTGAAAGAGATGAATTTTTAGTAGCTGAAAAAATCAAGAAA GAGCTTATTCGACAACGAAGAGAAGCAGATGCTGCATTATTTTCAGAACTCCACAGAAAACTTCATTCACAGGCCGGTCTAATTGAAGCC AACGGAGAACTCAAGGTCTTCATAGACCAGAACCTTAGTCCCGGGAAAGGCGTGGTGTCCCTCGTGGCCGTTCACCCCTCCACCGTCAAC CCGCTCGGGAAGCAGCTCTTGCCAAAAACCTTTGGACAGTCCAATGTCAACATTGCCCAGCAAGTGGTAATTGGTACGCCTCAGAGACCG GCAGCGTCAAACACCCTGGTGGTAGGAAGCCCACACACCCCCAGCACTCACTTTGCCTCTCAGAACCAGCCTTCCGACTCCTCACCTTGG TCTGCCGGGAAGCGCAACAGGAAAGGAGAGAAGAATGGCAAGGGCCTACGGCATTTCTCCATGAAGGTCTGCGAGAAGGTGCAGAGGAAA GGGACCACTTCCTACAACGAAGTGGCAGACGAGCTGGTTGCGGAGTTCAGTGCTGCCGACAACCACATCTTACCAAACGAGTCAGCTTAT GACCAGAAAAACATAAGACGGCGCGTCTACGATGCCTTAAACGTGCTAATGGCCATGAACATCATCTCCAAGGAGAAGAAGGAGATCAAG TGGATTGGTCTGCCCACCAACTCGGCTCAGGAATGTCAGAACTTAGAGGTGGAAAGACAGAGGAGACTTGAAAGAATAAAACAGAAACAG TCTCAACTTCAAGAACTTATTCTACAGCAAATTGCCTTCAAGAACCTGGTGCAGAGAAACCGGCATGCGGAGCAGCAGGCCAGCCGGCCA CCGCCACCCAACTCAGTCATCCACCTGCCCTTCATCATCGTCAACACCAGCAAGAAGACGGTCATCGACTGCAGCATCTCCAATGACAAA TTTGAGTATCTGTTTAATTTTGACAACACATTTGAAATCCACGATGACATAGAAGTGCTGAAGCGGATGGGCATGGCTTGCGGGCTGGAG TCGGGGAGCTGCTCTGCCGAAGACCTTAAAATGGCCAGAAGTCTGGTCCCCAAGGCTCTGGAGCCATACGTGACAGAAATGGCTCAGGGA ACTGTTGGAGGCGTGTTCATCACGACGGCAGGTTCCACGTCTAACGGCACAAGGTTCTCTGCCAGTGACCTGACCAACGGTGCAGATGGG ATGCTGGCCACAAGCTCCAATGGGTCTCAGTACAGCGGCTCCAGGGTGGAGACTCCGGTGTCCTACGTCGGGGAGGACGACGAGGAGGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TUBGCP3_ENST00000261965_chr13_113219425_-_TFDP1_ENST00000375370_chr13_114265311_+_2863nt TGTGGGAAGCGCCCGCGCTTTCGGCGGGTTCCGTTAAAATGGCGCCCTGGTGGCCGGCGGCGCCCGCGCCTTAGCCTGTCAGGAGCAGGG AGCTTGCGGGGCGCAGGAAGGGCGCGGGCCGCGGTCCCTGCGCGTGCGGCGGCAGTGGCGGCTCTGCCCGGACCACCGTGCACGGCTCCG GGCGAGGATGGCGACCCCGGACCAGAAGTCGCCGAACGTTCTGCTGCAGAACCTGTGCTGCAGGATCCTGGGCAGGAGCGAAGCTGATGT AGCCCAGCAGTTCCAGTATGCTGTGCGGGTGATTGGCAGCAACTTCGCCCCAACTGTTGAAAGAGATGAATTTTTAGTAGCTGAAAAAAT CAAGAAAGAGCTTATTCGACAACGAAGAGAAGCAGATGCTGCATTATTTTCAGAACTCCACAGAAAACTTCATTCACAGGCCGGTCTAAT TGAAGCCAACGGAGAACTCAAGGTCTTCATAGACCAGAACCTTAGTCCCGGGAAAGGCGTGGTGTCCCTCGTGGCCGTTCACCCCTCCAC CGTCAACCCGCTCGGGAAGCAGCTCTTGCCAAAAACCTTTGGACAGTCCAATGTCAACATTGCCCAGCAAGTGGTAATTGGTACGCCTCA GAGACCGGCAGCGTCAAACACCCTGGTGGTAGGAAGCCCACACACCCCCAGCACTCACTTTGCCTCTCAGAACCAGCCTTCCGACTCCTC ACCTTGGTCTGCCGGGAAGCGCAACAGGAAAGGAGAGAAGAATGGCAAGGGCCTACGGCATTTCTCCATGAAGGTCTGCGAGAAGGTGCA GAGGAAAGGGACCACTTCCTACAACGAAGTGGCAGACGAGCTGGTTGCGGAGTTCAGTGCTGCCGACAACCACATCTTACCAAACGAGTC AGCTTATGACCAGAAAAACATAAGACGGCGCGTCTACGATGCCTTAAACGTGCTAATGGCCATGAACATCATCTCCAAGGAGAAGAAGGA GATCAAGTGGATTGGTCTGCCCACCAACTCGGCTCAGGAATGTCAGAACTTAGAGGTGGAAAGACAGAGGAGACTTGAAAGAATAAAACA GAAACAGTCTCAACTTCAAGAACTTATTCTACAGCAAATTGCCTTCAAGAACCTGGTGCAGAGAAACCGGCATGCGGAGCAGCAGGCCAG CCGGCCACCGCCACCCAACTCAGTCATCCACCTGCCCTTCATCATCGTCAACACCAGCAAGAAGACGGTCATCGACTGCAGCATCTCCAA TGACAAATTTGAGTATCTGTTTAATTTTGACAACACATTTGAAATCCACGATGACATAGAAGTGCTGAAGCGGATGGGCATGGCTTGCGG GCTGGAGTCGGGGAGCTGCTCTGCCGAAGACCTTAAAATGGCCAGAAGTCTGGTCCCCAAGGCTCTGGAGCCATACGTGACAGAAATGGC TCAGGGAACTGTTGGAGGCGTGTTCATCACGACGGCAGGTTCCACGTCTAACGGCACAAGGTTCTCTGCCAGTGACCTGACCAACGGTGC AGATGGGATGCTGGCCACAAGCTCCAATGGGTCTCAGTACAGCGGCTCCAGGGTGGAGACTCCGGTGTCCTACGTCGGGGAGGACGACGA GGAGGACGATGACTTCAACGAGAATGACGAGGACGACTGACGTCCTCCCCACTTCAGATTCGGCTTCAGGAAAACGTTTAGCGAAAAGAA ACTTTTTTTTTAATGTGGGTTTTCTGTTTCCTTTTGGCCTACTCCCAAGAAGATATTGGTAAGCTATTGAATTTAGATATGCACCTCTGA TAAGCAAGGATTGTTTCCCGTAGGATTAGGACGTGCTGTGGATGTGTGTTTTGATACCAGTGTGCTGATGCAGAGCGTTTATTTACTTGT TAGGATTTTGTGTTTTCATTTGCTATTTTTCTTTAAGTGCAGAGTTCATTTTTGCCCCTGAAAAGTTTTTGCTGAGTTTGCTGAAGAAAT TGTATTTCAACCACATCCATGAAAATAAAACACCTCCTGTTGTGGATGGTGAGCCCCTGATGCCGCTTATTTGCCGTGAGTTTGGACGGC ACCCCTGCTGGCGGATAGCAAGACTCTGTGGAGTTTGTTCAGTGGTACGGTGTCCAAGCAAACAGCAGAATGCAACTTTCTAAACAGCCC CAAGCAAACAGCAGAATTCAACTTTTTAAACAATAAACACCATCAACCTTATTGACTTTATTGTCCCTTAAATTATATTGACTGTTGTGA TTCCATCAAGTTTGTACACTCTTTTCTCTCCCTGTTTTGCAGCAACAAATTGCGAAGTGCTTTTGTTTGTTTGTTTTCGTTTGGTTAAAG CTTATTGCCATGCTGGTGCGGCTATGGAGACTGTCTGGAAGGCTTGGAATGGTTTATTGCTTATGGTAAAATTTGCCTGATTTCTTACAG GCAGCGTTTGGAAACCTTTTATTATATAGTTGTTTACATACTTATAAGTCTATCATTTAAAGACATGTACTGAAACAAATGTATTTGTTT CATAAGCATCTTCCTGTAATCTATTATAAAATTGAAATTAAATATAGAGAATGTTTTAACAATTTTTTAACTCAAAATTTGTCAATCATT TTTAATAGTTCTTTTTTTATAAAAAGAAAAAGGAATTTAAGGACAGGCAGTAGTCTCTTTTAAAATTTATTCACAAAACCCATTAACTGC ACAGTTGCTATTAGCTGCCTGTTCTAAAACGATAGTCTTTTTATTGAAACACAAATAAACTTTTCTGTAATATTTTATGGTATATAAAGA >In-frame_TUBGCP3_ENST00000375669_chr13_113219425_-_TFDP1_ENST00000375370_chr13_114265311_+_2821nt CGCCCTGGTGGCCGGCGGCGCCCGCGCCTTAGCCTGTCAGGAGCAGGGAGCTTGCGGGGCGCAGGAAGGGCGCGGGCCGCGGTCCCTGCG CGTGCGGCGGCAGTGGCGGCTCTGCCCGGACCACCGTGCACGGCTCCGGGCGAGGATGGCGACCCCGGACCAGAAGTCGCCGAACGTTCT GCTGCAGAACCTGTGCTGCAGGATCCTGGGCAGGAGCGAAGCTGATGTAGCCCAGCAGTTCCAGTATGCTGTGCGGGTGATTGGCAGCAA CTTCGCCCCAACTGTTGAAAGAGATGAATTTTTAGTAGCTGAAAAAATCAAGAAAGAGCTTATTCGACAACGAAGAGAAGCAGATGCTGC ATTATTTTCAGAACTCCACAGAAAACTTCATTCACAGGCCGGTCTAATTGAAGCCAACGGAGAACTCAAGGTCTTCATAGACCAGAACCT TAGTCCCGGGAAAGGCGTGGTGTCCCTCGTGGCCGTTCACCCCTCCACCGTCAACCCGCTCGGGAAGCAGCTCTTGCCAAAAACCTTTGG ACAGTCCAATGTCAACATTGCCCAGCAAGTGGTAATTGGTACGCCTCAGAGACCGGCAGCGTCAAACACCCTGGTGGTAGGAAGCCCACA CACCCCCAGCACTCACTTTGCCTCTCAGAACCAGCCTTCCGACTCCTCACCTTGGTCTGCCGGGAAGCGCAACAGGAAAGGAGAGAAGAA TGGCAAGGGCCTACGGCATTTCTCCATGAAGGTCTGCGAGAAGGTGCAGAGGAAAGGGACCACTTCCTACAACGAAGTGGCAGACGAGCT GGTTGCGGAGTTCAGTGCTGCCGACAACCACATCTTACCAAACGAGTCAGCTTATGACCAGAAAAACATAAGACGGCGCGTCTACGATGC CTTAAACGTGCTAATGGCCATGAACATCATCTCCAAGGAGAAGAAGGAGATCAAGTGGATTGGTCTGCCCACCAACTCGGCTCAGGAATG TCAGAACTTAGAGGTGGAAAGACAGAGGAGACTTGAAAGAATAAAACAGAAACAGTCTCAACTTCAAGAACTTATTCTACAGCAAATTGC CTTCAAGAACCTGGTGCAGAGAAACCGGCATGCGGAGCAGCAGGCCAGCCGGCCACCGCCACCCAACTCAGTCATCCACCTGCCCTTCAT CATCGTCAACACCAGCAAGAAGACGGTCATCGACTGCAGCATCTCCAATGACAAATTTGAGTATCTGTTTAATTTTGACAACACATTTGA AATCCACGATGACATAGAAGTGCTGAAGCGGATGGGCATGGCTTGCGGGCTGGAGTCGGGGAGCTGCTCTGCCGAAGACCTTAAAATGGC CAGAAGTCTGGTCCCCAAGGCTCTGGAGCCATACGTGACAGAAATGGCTCAGGGAACTGTTGGAGGCGTGTTCATCACGACGGCAGGTTC CACGTCTAACGGCACAAGGTTCTCTGCCAGTGACCTGACCAACGGTGCAGATGGGATGCTGGCCACAAGCTCCAATGGGTCTCAGTACAG CGGCTCCAGGGTGGAGACTCCGGTGTCCTACGTCGGGGAGGACGACGAGGAGGACGATGACTTCAACGAGAATGACGAGGACGACTGACG TCCTCCCCACTTCAGATTCGGCTTCAGGAAAACGTTTAGCGAAAAGAAACTTTTTTTTTAATGTGGGTTTTCTGTTTCCTTTTGGCCTAC TCCCAAGAAGATATTGGTAAGCTATTGAATTTAGATATGCACCTCTGATAAGCAAGGATTGTTTCCCGTAGGATTAGGACGTGCTGTGGA TGTGTGTTTTGATACCAGTGTGCTGATGCAGAGCGTTTATTTACTTGTTAGGATTTTGTGTTTTCATTTGCTATTTTTCTTTAAGTGCAG AGTTCATTTTTGCCCCTGAAAAGTTTTTGCTGAGTTTGCTGAAGAAATTGTATTTCAACCACATCCATGAAAATAAAACACCTCCTGTTG TGGATGGTGAGCCCCTGATGCCGCTTATTTGCCGTGAGTTTGGACGGCACCCCTGCTGGCGGATAGCAAGACTCTGTGGAGTTTGTTCAG TGGTACGGTGTCCAAGCAAACAGCAGAATGCAACTTTCTAAACAGCCCCAAGCAAACAGCAGAATTCAACTTTTTAAACAATAAACACCA TCAACCTTATTGACTTTATTGTCCCTTAAATTATATTGACTGTTGTGATTCCATCAAGTTTGTACACTCTTTTCTCTCCCTGTTTTGCAG CAACAAATTGCGAAGTGCTTTTGTTTGTTTGTTTTCGTTTGGTTAAAGCTTATTGCCATGCTGGTGCGGCTATGGAGACTGTCTGGAAGG CTTGGAATGGTTTATTGCTTATGGTAAAATTTGCCTGATTTCTTACAGGCAGCGTTTGGAAACCTTTTATTATATAGTTGTTTACATACT TATAAGTCTATCATTTAAAGACATGTACTGAAACAAATGTATTTGTTTCATAAGCATCTTCCTGTAATCTATTATAAAATTGAAATTAAA TATAGAGAATGTTTTAACAATTTTTTAACTCAAAATTTGTCAATCATTTTTAATAGTTCTTTTTTTATAAAAAGAAAAAGGAATTTAAGG ACAGGCAGTAGTCTCTTTTAAAATTTATTCACAAAACCCATTAACTGCACAGTTGCTATTAGCTGCCTGTTCTAAAACGATAGTCTTTTT ATTGAAACACAAATAAACTTTTCTGTAATATTTTATGGTATATAAAGAGACTTTAATTGTTTGACTTGTTTAACTTGGCACTGTTAGTTT |
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FusionGenePPI for TUBGCP3_TFDP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TUBGCP3 | AKAP9, PCNT, BTRC, FBXW11, IMMT, ELAVL1, SH3KBP1, CDK5RAP2, TUBG1, TUBGCP5, TUBGCP2, HECW2, ACSL4, ACTB, AKAP12, ANKRD40, PRRC2A, MZT1, SDE2, CAPNS1, CEP170, CEP55, CPNE7, CTPS1, TUBB, RPS18, HSPA1A, DDX5, DGCR14, DOCK7, DYNC1I2, EIF4E2, EPPK1, FABP5, MRPS18B, RCN2, RPL24, RPL23, MZT2A, MZT2B, GIGYF2, HAX1, RPL27AP6, HECTD1, HNRNPA1, HNRNPH1, HNRNPU, HSP90AB1, HSPA5, HSPA8, HSPD1, IGF2BP1, IGF2BP3, ANXA5, IQGAP1, IRS4, KLC2, LGALS3BP, LY6G5B, MAGED2, MARCKS, MRPS14, MRPS2, MRPS21, MRPS23, MRPS25, MRPS28, MRPS7, MTMR1, NEDD1, NME7, PCBP1, PCID2, CDK17, PPIL1, PPP3CB, PRICKLE3, PRPF19, PSMA1, PSME3, RBBP4, RPL11, RPL23A, RPL26, RPL31, RPL37A, RPL8, RPS10, RPS14, RPS15, RPS17, RPS2, RPS25, RPS26P11, RPS27, RPS3, RPS4X, RPS6, RPS7, RPS8, RPS9, S100A8, SCO2, SEC61G, SKP1, SNW1, SUPT6H, TUBA1A, TUBB4B, TUBGCP4, TUBGCP6, UBR4, UBR5, UGGT1, DCAF8, RPL10, YWHAQ, SHMT2, MOV10, NXF1, LPAR6, VSIG4, ANXA13, SCN2B, LYPD6, NTRK1, CNTRL, XPO1, SCAF11, LRWD1, CDC5L, DPPA4, NANOG, POU5F1, TUBG2, TXNDC12, APLNR, CD79B, OPRM1, SIGLEC12, GYPB, SIGLECL1, CD2BP2 | TFDP1 | E2F6, E2F5, TP53BP1, TP53, NPDC1, CDK3, E2F1, E2F4, RB1, RBL1, RBL2, LIN9, LIN37, LIN54, ELAVL1, PCGF6, RNF2, RYBP, YAF2, SOCS3, CDK2, CDK1, PRPF31, E2F2, E2F3, CDK6, SIAH1, CREBBP, CDC20, CDC27, ANAPC5, MIER2, COMMD4, CDT1, MAX, L3MBTL2, GGA1, COMMD8, COMMD1, GMNN, COMMD6, HDAC1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | TFDP1 | chr13:113219425 | chr13:114265311 | ENST00000375370 | + | 1 | 12 | 105_127 | 4 | 411 | CEBPA |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TUBGCP3_TFDP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TUBGCP3_TFDP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TFDP1 | C3495559 | Juvenile arthritis | 1 | CTD_human |
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