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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40130

FusionGeneSummary for TUBGCP3_PLA2G1B

check button Fusion gene summary
Fusion gene informationFusion gene name: TUBGCP3_PLA2G1B
Fusion gene ID: 40130
HgeneTgene
Gene symbol

TUBGCP3

PLA2G1B

Gene ID

10426

5319

Gene nametubulin gamma complex associated protein 3phospholipase A2 group IB
Synonyms104p|ALP6|GCP3|Grip104|SPBC98|Spc98|Spc98pPLA2|PLA2A|PPLA2
Cytomap

13q34

12q24.31

Type of geneprotein-codingprotein-coding
Descriptiongamma-tubulin complex component 3gamma-ring complex protein 104 kDaspindle pole body protein Spc98 homologphospholipase A2phosphatidylcholine 2-acylhydrolase 1Bphospholipase A2, group IB (pancreas)
Modification date2018052320180519
UniProtAcc

Q96CW5

P04054

Ensembl transtripts involved in fusion geneENST00000261965, ENST00000375669, 
ENST00000462580, 
ENST00000308366, 
ENST00000423423, ENST00000549767, 
Fusion gene scores* DoF score5 X 4 X 4=805 X 3 X 7=105
# samples 57
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TUBGCP3 [Title/Abstract] AND PLA2G1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLA2G1B

GO:0002227

innate immune response in mucosa

12860195

TgenePLA2G1B

GO:0006633

fatty acid biosynthetic process

1918029

TgenePLA2G1B

GO:0008284

positive regulation of cell proliferation

1918029

TgenePLA2G1B

GO:0016042

lipid catabolic process

7060561

TgenePLA2G1B

GO:0019731

antibacterial humoral response

12860195

TgenePLA2G1B

GO:0046470

phosphatidylcholine metabolic process

7060561

TgenePLA2G1B

GO:0048146

positive regulation of fibroblast proliferation

1918029

TgenePLA2G1B

GO:0050830

defense response to Gram-positive bacterium

12860195

TgenePLA2G1B

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

12860195


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP323855TUBGCP3chr13

113158346

-PLA2G1Bchr12

120765582

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000261965ENST00000308366TUBGCP3chr13

113158346

-PLA2G1Bchr12

120765582

-
5CDS-5UTRENST00000261965ENST00000423423TUBGCP3chr13

113158346

-PLA2G1Bchr12

120765582

-
5CDS-intronENST00000261965ENST00000549767TUBGCP3chr13

113158346

-PLA2G1Bchr12

120765582

-
5CDS-5UTRENST00000375669ENST00000308366TUBGCP3chr13

113158346

-PLA2G1Bchr12

120765582

-
5CDS-5UTRENST00000375669ENST00000423423TUBGCP3chr13

113158346

-PLA2G1Bchr12

120765582

-
5CDS-intronENST00000375669ENST00000549767TUBGCP3chr13

113158346

-PLA2G1Bchr12

120765582

-
intron-5UTRENST00000462580ENST00000308366TUBGCP3chr13

113158346

-PLA2G1Bchr12

120765582

-
intron-5UTRENST00000462580ENST00000423423TUBGCP3chr13

113158346

-PLA2G1Bchr12

120765582

-
intron-intronENST00000462580ENST00000549767TUBGCP3chr13

113158346

-PLA2G1Bchr12

120765582

-

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FusionProtFeatures for TUBGCP3_PLA2G1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TUBGCP3

Q96CW5

PLA2G1B

P04054

Gamma-tubulin complex is necessary for microtubulenucleation at the centrosome. PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releasesglycerophospholipids and arachidonic acid that serve as theprecursors of signal molecules. {ECO:0000269|PubMed:19297324}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TUBGCP3_PLA2G1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TUBGCP3_PLA2G1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TUBGCP3_PLA2G1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePLA2G1BP04054DB00795SulfasalazinePhospholipase A2small moleculeapproved
TgenePLA2G1BP04054DB02659Cholic AcidPhospholipase A2small moleculeapproved
TgenePLA2G1BP04054DB04552Niflumic AcidPhospholipase A2small moleculeapproved

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RelatedDiseases for TUBGCP3_PLA2G1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePLA2G1BC0005586Bipolar Disorder5PSYGENET
TgenePLA2G1BC0036341Schizophrenia3PSYGENET
TgenePLA2G1BC0525045Mood Disorders2PSYGENET
TgenePLA2G1BC0338715Drug-induced depressive state1PSYGENET