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Fusion gene ID: 40130 |
FusionGeneSummary for TUBGCP3_PLA2G1B |
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Fusion gene information | Fusion gene name: TUBGCP3_PLA2G1B | Fusion gene ID: 40130 | Hgene | Tgene | Gene symbol | TUBGCP3 | PLA2G1B | Gene ID | 10426 | 5319 |
Gene name | tubulin gamma complex associated protein 3 | phospholipase A2 group IB | |
Synonyms | 104p|ALP6|GCP3|Grip104|SPBC98|Spc98|Spc98p | PLA2|PLA2A|PPLA2 | |
Cytomap | 13q34 | 12q24.31 | |
Type of gene | protein-coding | protein-coding | |
Description | gamma-tubulin complex component 3gamma-ring complex protein 104 kDaspindle pole body protein Spc98 homolog | phospholipase A2phosphatidylcholine 2-acylhydrolase 1Bphospholipase A2, group IB (pancreas) | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q96CW5 | P04054 | |
Ensembl transtripts involved in fusion gene | ENST00000261965, ENST00000375669, ENST00000462580, | ENST00000308366, ENST00000423423, ENST00000549767, | |
Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 5 X 3 X 7=105 |
# samples | 5 | 7 | |
** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TUBGCP3 [Title/Abstract] AND PLA2G1B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PLA2G1B | GO:0002227 | innate immune response in mucosa | 12860195 |
Tgene | PLA2G1B | GO:0006633 | fatty acid biosynthetic process | 1918029 |
Tgene | PLA2G1B | GO:0008284 | positive regulation of cell proliferation | 1918029 |
Tgene | PLA2G1B | GO:0016042 | lipid catabolic process | 7060561 |
Tgene | PLA2G1B | GO:0019731 | antibacterial humoral response | 12860195 |
Tgene | PLA2G1B | GO:0046470 | phosphatidylcholine metabolic process | 7060561 |
Tgene | PLA2G1B | GO:0048146 | positive regulation of fibroblast proliferation | 1918029 |
Tgene | PLA2G1B | GO:0050830 | defense response to Gram-positive bacterium | 12860195 |
Tgene | PLA2G1B | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 12860195 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP323855 | TUBGCP3 | chr13 | 113158346 | - | PLA2G1B | chr12 | 120765582 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000261965 | ENST00000308366 | TUBGCP3 | chr13 | 113158346 | - | PLA2G1B | chr12 | 120765582 | - |
5CDS-5UTR | ENST00000261965 | ENST00000423423 | TUBGCP3 | chr13 | 113158346 | - | PLA2G1B | chr12 | 120765582 | - |
5CDS-intron | ENST00000261965 | ENST00000549767 | TUBGCP3 | chr13 | 113158346 | - | PLA2G1B | chr12 | 120765582 | - |
5CDS-5UTR | ENST00000375669 | ENST00000308366 | TUBGCP3 | chr13 | 113158346 | - | PLA2G1B | chr12 | 120765582 | - |
5CDS-5UTR | ENST00000375669 | ENST00000423423 | TUBGCP3 | chr13 | 113158346 | - | PLA2G1B | chr12 | 120765582 | - |
5CDS-intron | ENST00000375669 | ENST00000549767 | TUBGCP3 | chr13 | 113158346 | - | PLA2G1B | chr12 | 120765582 | - |
intron-5UTR | ENST00000462580 | ENST00000308366 | TUBGCP3 | chr13 | 113158346 | - | PLA2G1B | chr12 | 120765582 | - |
intron-5UTR | ENST00000462580 | ENST00000423423 | TUBGCP3 | chr13 | 113158346 | - | PLA2G1B | chr12 | 120765582 | - |
intron-intron | ENST00000462580 | ENST00000549767 | TUBGCP3 | chr13 | 113158346 | - | PLA2G1B | chr12 | 120765582 | - |
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FusionProtFeatures for TUBGCP3_PLA2G1B |
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Hgene | Tgene |
TUBGCP3 | PLA2G1B |
Gamma-tubulin complex is necessary for microtubulenucleation at the centrosome. | PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releasesglycerophospholipids and arachidonic acid that serve as theprecursors of signal molecules. {ECO:0000269|PubMed:19297324}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TUBGCP3_PLA2G1B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TUBGCP3_PLA2G1B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TUBGCP3_PLA2G1B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PLA2G1B | P04054 | DB00795 | Sulfasalazine | Phospholipase A2 | small molecule | approved |
Tgene | PLA2G1B | P04054 | DB02659 | Cholic Acid | Phospholipase A2 | small molecule | approved |
Tgene | PLA2G1B | P04054 | DB04552 | Niflumic Acid | Phospholipase A2 | small molecule | approved |
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RelatedDiseases for TUBGCP3_PLA2G1B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PLA2G1B | C0005586 | Bipolar Disorder | 5 | PSYGENET |
Tgene | PLA2G1B | C0036341 | Schizophrenia | 3 | PSYGENET |
Tgene | PLA2G1B | C0525045 | Mood Disorders | 2 | PSYGENET |
Tgene | PLA2G1B | C0338715 | Drug-induced depressive state | 1 | PSYGENET |