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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40127

FusionGeneSummary for TUBGCP3_ATP11A

check button Fusion gene summary
Fusion gene informationFusion gene name: TUBGCP3_ATP11A
Fusion gene ID: 40127
HgeneTgene
Gene symbol

TUBGCP3

ATP11A

Gene ID

10426

23250

Gene nametubulin gamma complex associated protein 3ATPase phospholipid transporting 11A
Synonyms104p|ALP6|GCP3|Grip104|SPBC98|Spc98|Spc98pATPIH|ATPIS
Cytomap

13q34

13q34

Type of geneprotein-codingprotein-coding
Descriptiongamma-tubulin complex component 3gamma-ring complex protein 104 kDaspindle pole body protein Spc98 homologprobable phospholipid-transporting ATPase IHATPase, class VI, type 11AP4-ATPase flippase complex alpha subunit ATP11Aphospholipid-translocating ATPasepotential phospholipid-transporting ATPase IH
Modification date2018052320180523
UniProtAcc

Q96CW5

P98196

Ensembl transtripts involved in fusion geneENST00000261965, ENST00000375669, 
ENST00000462580, 
ENST00000283558, 
ENST00000375630, ENST00000487903, 
ENST00000375645, ENST00000419448, 
Fusion gene scores* DoF score5 X 4 X 4=8011 X 10 X 4=440
# samples 513
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/440*10)=-1.7589919004962
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TUBGCP3 [Title/Abstract] AND ATP11A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-69-7979-01ATUBGCP3chr13

113158346

-ATP11Achr13

113490492

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000261965ENST00000283558TUBGCP3chr13

113158346

-ATP11Achr13

113490492

+
Frame-shiftENST00000261965ENST00000375630TUBGCP3chr13

113158346

-ATP11Achr13

113490492

+
Frame-shiftENST00000261965ENST00000487903TUBGCP3chr13

113158346

-ATP11Achr13

113490492

+
Frame-shiftENST00000261965ENST00000375645TUBGCP3chr13

113158346

-ATP11Achr13

113490492

+
5CDS-intronENST00000261965ENST00000419448TUBGCP3chr13

113158346

-ATP11Achr13

113490492

+
Frame-shiftENST00000375669ENST00000283558TUBGCP3chr13

113158346

-ATP11Achr13

113490492

+
Frame-shiftENST00000375669ENST00000375630TUBGCP3chr13

113158346

-ATP11Achr13

113490492

+
Frame-shiftENST00000375669ENST00000487903TUBGCP3chr13

113158346

-ATP11Achr13

113490492

+
Frame-shiftENST00000375669ENST00000375645TUBGCP3chr13

113158346

-ATP11Achr13

113490492

+
5CDS-intronENST00000375669ENST00000419448TUBGCP3chr13

113158346

-ATP11Achr13

113490492

+
intron-3CDSENST00000462580ENST00000283558TUBGCP3chr13

113158346

-ATP11Achr13

113490492

+
intron-3CDSENST00000462580ENST00000375630TUBGCP3chr13

113158346

-ATP11Achr13

113490492

+
intron-3CDSENST00000462580ENST00000487903TUBGCP3chr13

113158346

-ATP11Achr13

113490492

+
intron-3CDSENST00000462580ENST00000375645TUBGCP3chr13

113158346

-ATP11Achr13

113490492

+
intron-intronENST00000462580ENST00000419448TUBGCP3chr13

113158346

-ATP11Achr13

113490492

+

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FusionProtFeatures for TUBGCP3_ATP11A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TUBGCP3

Q96CW5

ATP11A

P98196

Gamma-tubulin complex is necessary for microtubulenucleation at the centrosome. Catalytic component of a P4-ATPase flippase complexwhich catalyzes the hydrolysis of ATP coupled to the transport ofaminophospholipids from the outer to the inner leaflet of variousmembranes and ensures the maintenance of asymmetric distributionof phospholipids. Phospholipid translocation seems also to beimplicated in vesicle formation and in uptake of lipid signalingmolecules (Probable). May be involved in the uptake offarnesyltransferase inhibitor drugs, such as lonafarnib.{ECO:0000269|PubMed:15860663, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TUBGCP3_ATP11A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TUBGCP3_ATP11A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TUBGCP3AKAP9, PCNT, BTRC, FBXW11, IMMT, ELAVL1, SH3KBP1, CDK5RAP2, TUBG1, TUBGCP5, TUBGCP2, HECW2, ACSL4, ACTB, AKAP12, ANKRD40, PRRC2A, MZT1, SDE2, CAPNS1, CEP170, CEP55, CPNE7, CTPS1, TUBB, RPS18, HSPA1A, DDX5, DGCR14, DOCK7, DYNC1I2, EIF4E2, EPPK1, FABP5, MRPS18B, RCN2, RPL24, RPL23, MZT2A, MZT2B, GIGYF2, HAX1, RPL27AP6, HECTD1, HNRNPA1, HNRNPH1, HNRNPU, HSP90AB1, HSPA5, HSPA8, HSPD1, IGF2BP1, IGF2BP3, ANXA5, IQGAP1, IRS4, KLC2, LGALS3BP, LY6G5B, MAGED2, MARCKS, MRPS14, MRPS2, MRPS21, MRPS23, MRPS25, MRPS28, MRPS7, MTMR1, NEDD1, NME7, PCBP1, PCID2, CDK17, PPIL1, PPP3CB, PRICKLE3, PRPF19, PSMA1, PSME3, RBBP4, RPL11, RPL23A, RPL26, RPL31, RPL37A, RPL8, RPS10, RPS14, RPS15, RPS17, RPS2, RPS25, RPS26P11, RPS27, RPS3, RPS4X, RPS6, RPS7, RPS8, RPS9, S100A8, SCO2, SEC61G, SKP1, SNW1, SUPT6H, TUBA1A, TUBB4B, TUBGCP4, TUBGCP6, UBR4, UBR5, UGGT1, DCAF8, RPL10, YWHAQ, SHMT2, MOV10, NXF1, LPAR6, VSIG4, ANXA13, SCN2B, LYPD6, NTRK1, CNTRL, XPO1, SCAF11, LRWD1, CDC5L, DPPA4, NANOG, POU5F1, TUBG2, TXNDC12, APLNR, CD79B, OPRM1, SIGLEC12, GYPB, SIGLECL1, CD2BP2ATP11ATMEM30A, NPDC1, PICK1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TUBGCP3_ATP11A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TUBGCP3_ATP11A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneATP11AC1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET