FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 4010

FusionGeneSummary for BCL11B_MICB

check button Fusion gene summary
Fusion gene informationFusion gene name: BCL11B_MICB
Fusion gene ID: 4010
HgeneTgene
Gene symbol

BCL11B

MICB

Gene ID

64919

4277

Gene nameB cell CLL/lymphoma 11BMHC class I polypeptide-related sequence B
SynonymsATL1|ATL1-alpha|ATL1-beta|ATL1-delta|ATL1-gamma|CTIP-2|CTIP2|IMD49|RIT1|ZNF856B|hRIT1-alphaPERB11.2
Cytomap

14q32.2

6p21.33

Type of geneprotein-codingprotein-coding
DescriptionB-cell lymphoma/leukemia 11BB-cell CLL/lymphoma 11B (zinc finger protein)B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion proteinB-cell lymphoma/leukaemia 11BBCL-11BBCL11B/TRDC fusionCOUP-TF-interacting protein 2hRit1radiation-MHC class I polypeptide-related sequence BMHC class I chain-related protein BMHC class I mic-B antigenMHC class I-like molecule PERB11.2-IMXstress inducible class I homolog
Modification date2018052320180523
UniProtAcc

Q9C0K0

Q29980

Ensembl transtripts involved in fusion geneENST00000357195, ENST00000345514, 
ENST00000443726, 
ENST00000538442, 
ENST00000399150, ENST00000252229, 
ENST00000427115, ENST00000442104, 
ENST00000451603, ENST00000546706, 
ENST00000438954, ENST00000458032, 
ENST00000551950, ENST00000437651, 
ENST00000383514, ENST00000551608, 
ENST00000436531, ENST00000436655, 
ENST00000547574, ENST00000400313, 
ENST00000428416, ENST00000549014, 
ENST00000428059, ENST00000451789, 
ENST00000443156, ENST00000551960, 
Fusion gene scores* DoF score4 X 5 X 2=406 X 4 X 4=96
# samples 156
** MAII scorelog2(15/40*10)=1.90689059560852
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BCL11B [Title/Abstract] AND MICB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMICB

GO:0002429

immune response-activating cell surface receptor signaling pathway

11491531

TgeneMICB

GO:0006979

response to oxidative stress

11287116

TgeneMICB

GO:0009408

response to heat

9497295

TgeneMICB

GO:0032526

response to retinoic acid

12569559

TgeneMICB

GO:0046629

gamma-delta T cell activation

9497295

TgeneMICB

GO:0050689

negative regulation of defense response to virus by host

11239445|12782710


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1EL582403BCL11Bchr14

99655805

+MICBchr6

2586310

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000357195ENST00000538442BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000399150BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000252229BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000427115BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000442104BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000451603BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000546706BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000438954BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000458032BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000551950BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000437651BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000383514BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000551608BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000436531BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000436655BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000547574BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000400313BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000428416BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000549014BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000428059BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000451789BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000443156BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000357195ENST00000551960BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000538442BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000399150BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000252229BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000427115BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000442104BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000451603BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000546706BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000438954BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000458032BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000551950BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000437651BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000383514BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000551608BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000436531BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000436655BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000547574BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000400313BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000428416BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000549014BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000428059BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000451789BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000443156BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000345514ENST00000551960BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000538442BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000399150BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000252229BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000427115BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000442104BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000451603BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000546706BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000438954BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000458032BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000551950BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000437651BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000383514BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000551608BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000436531BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000436655BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000547574BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000400313BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000428416BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000549014BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000428059BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000451789BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000443156BCL11Bchr14

99655805

+MICBchr6

2586310

+
intron-intronENST00000443726ENST00000551960BCL11Bchr14

99655805

+MICBchr6

2586310

+

Top

FusionProtFeatures for BCL11B_MICB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCL11B

Q9C0K0

MICB

Q29980

Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential incontrolling the responsiveness of hematopoietic stem cells tochemotactic signals by modulating the expression of the receptorsCCR7 and CCR9, which direct the movement of progenitor cells fromthe bone marrow to the thymus (PubMed:27959755). Is a regulator ofIL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that repressestranscription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in theP53-signaling pathway (By similarity).{ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611,ECO:0000269|PubMed:27959755}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for BCL11B_MICB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for BCL11B_MICB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for BCL11B_MICB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for BCL11B_MICB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBCL11BC0024299Lymphoma1CTD_human
HgeneBCL11BC1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneMICBC0019100Severe Dengue1CTD_human
TgeneMICBC0036341Schizophrenia1PSYGENET