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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40095

FusionGeneSummary for TUBB3_IGFBP7

check button Fusion gene summary
Fusion gene informationFusion gene name: TUBB3_IGFBP7
Fusion gene ID: 40095
HgeneTgene
Gene symbol

TUBB3

IGFBP7

Gene ID

10381

3490

Gene nametubulin beta 3 class IIIinsulin like growth factor binding protein 7
SynonymsCDCBM|CDCBM1|CFEOM3|CFEOM3A|FEOM3|TUBB4|beta-4AGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF
Cytomap

16q24.3

4q12

Type of geneprotein-codingprotein-coding
Descriptiontubulin beta-3 chainclass III beta-tubulintubulin beta-4 chaintubulin beta-IIItubulin, beta 3insulin-like growth factor-binding protein 7IGF-binding protein 7IGFBP-rP1PGI2-stimulating factorangiomodulinprostacyclin-stimulating factortumor-derived adhesion factor
Modification date2018052320180522
UniProtAcc

Q13509

Q16270

Ensembl transtripts involved in fusion geneENST00000556922, ENST00000554444, 
ENST00000315491, ENST00000554116, 
ENST00000555576, ENST00000554336, 
ENST00000553967, ENST00000304984, 
ENST00000295666, ENST00000537922, 
ENST00000512512, 
Fusion gene scores* DoF score3 X 2 X 3=184 X 4 X 3=48
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TUBB3 [Title/Abstract] AND IGFBP7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIGFBP7

GO:0007155

cell adhesion

8117260


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI148209TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000556922ENST00000295666TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
Frame-shiftENST00000556922ENST00000537922TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
5CDS-5UTRENST00000556922ENST00000512512TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
Frame-shiftENST00000554444ENST00000295666TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
In-frameENST00000554444ENST00000537922TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
5CDS-5UTRENST00000554444ENST00000512512TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
Frame-shiftENST00000315491ENST00000295666TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
In-frameENST00000315491ENST00000537922TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
5CDS-5UTRENST00000315491ENST00000512512TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
intron-3CDSENST00000554116ENST00000295666TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
intron-3CDSENST00000554116ENST00000537922TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
intron-5UTRENST00000554116ENST00000512512TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
intron-3CDSENST00000555576ENST00000295666TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
intron-3CDSENST00000555576ENST00000537922TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
intron-5UTRENST00000555576ENST00000512512TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
intron-3CDSENST00000554336ENST00000295666TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
intron-3CDSENST00000554336ENST00000537922TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
intron-5UTRENST00000554336ENST00000512512TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
intron-3CDSENST00000553967ENST00000295666TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
intron-3CDSENST00000553967ENST00000537922TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
intron-5UTRENST00000553967ENST00000512512TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
Frame-shiftENST00000304984ENST00000295666TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
Frame-shiftENST00000304984ENST00000537922TUBB3chr16

90002210

-IGFBP7chr4

57898689

+
5CDS-5UTRENST00000304984ENST00000512512TUBB3chr16

90002210

-IGFBP7chr4

57898689

+

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FusionProtFeatures for TUBB3_IGFBP7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TUBB3

Q13509

IGFBP7

Q16270

Tubulin is the major constituent of microtubules. Itbinds two moles of GTP, one at an exchangeable site on the betachain and one at a non-exchangeable site on the alpha chain. TUBB3plays a critical role in proper axon guidance and mantainance.{ECO:0000269|PubMed:20074521}. Binds IGF-I and IGF-II with a relatively low affinity.Stimulates prostacyclin (PGI2) production. Stimulates celladhesion. {ECO:0000269|PubMed:8117260,ECO:0000269|PubMed:8939990}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TUBB3_IGFBP7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TUBB3_ENST00000556922_chr16_90002210_-_IGFBP7_ENST00000295666_chr4_57898689_+_0aa

>In-frame_TUBB3_ENST00000554444_chr16_90002210_-_IGFBP7_ENST00000537922_chr4_57898689_+_0aa

>In-frame_TUBB3_ENST00000315491_chr16_90002210_-_IGFBP7_ENST00000537922_chr4_57898689_+_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TUBB3_ENST00000556922_chr16_90002210_-_IGFBP7_ENST00000295666_chr4_57898689_+_0nt

>In-frame_TUBB3_ENST00000554444_chr16_90002210_-_IGFBP7_ENST00000537922_chr4_57898689_+_0nt

>In-frame_TUBB3_ENST00000315491_chr16_90002210_-_IGFBP7_ENST00000537922_chr4_57898689_+_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_TUBB3_ENST00000556922_chr16_90002210_-_IGFBP7_ENST00000295666_chr4_57898689_+_0nt

>In-frame_TUBB3_ENST00000554444_chr16_90002210_-_IGFBP7_ENST00000537922_chr4_57898689_+_0nt

>In-frame_TUBB3_ENST00000315491_chr16_90002210_-_IGFBP7_ENST00000537922_chr4_57898689_+_0nt


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FusionGenePPI for TUBB3_IGFBP7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TUBB3_IGFBP7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneTUBB3Q13509DB04845IxabepiloneTubulin beta-3 chainsmall moleculeapproved|investigational
TgeneIGFBP7Q16270DB00071Insulin PorkInsulin-like growth factor-binding protein 7biotechapproved
TgeneIGFBP7Q16270DB00030Insulin HumanInsulin-like growth factor-binding protein 7biotechapproved|investigational

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RelatedDiseases for TUBB3_IGFBP7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTUBB3C0919267ovarian neoplasm1CTD_human
HgeneTUBB3C1458155Mammary Neoplasms1CTD_human
HgeneTUBB3C2748801FIBROSIS OF EXTRAOCULAR MUSCLES, CONGENITAL, 3A, WITH OR WITHOUT EXTRAOCULAR INVOLVEMENT1CTD_human;UNIPROT
HgeneTUBB3C3808397CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 11ORPHANET;UNIPROT
TgeneIGFBP7C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneIGFBP7C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneIGFBP7C0033578Prostatic Neoplasms1CTD_human
TgeneIGFBP7C0038356Stomach Neoplasms1CTD_human
TgeneIGFBP7C1458155Mammary Neoplasms1CTD_human